Article
Materials Science, Characterization & Testing
Chunlan Jing, Shenmao Chen, Sehajdev Singh Bhatia, Bowen Li, Hongze Liang, Chaozong Liu, Zhenjiang Liang, Junying Liu, Haiyan Li, Ziyu Liu, Hui Tan, Lingling Zhao
Summary: Bone-targeted polymeric nanoparticles for alendronate delivery were fabricated and shown to have sustained release and good cytocompatibility, with high affinity to bone cells.
Review
Endocrinology & Metabolism
Dinglin Li, Zhonghua Gao, Qian Li, Xiangjie Liu, Hao Liu
Summary: Osteoporosis is an age-related disease characterized by reduced bone density and strength, leading to increased vulnerability to fractures. Current treatments involve the use of medications with side effects. Copper has been shown to be related to osteoporosis, and targeting intracellular copper toxicity and cuproptosis may provide new therapeutic options. Inhibition of cuproptosis in the hypoxic bone environment and glycolysis pathway may promote the survival and proliferation of various cells involved in osteoporosis. This study aims to explore a new treatment approach for osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, Research & Experimental
Nabila Bourebaba, ThuHa Ngo, Agnieszka Smieszek, Lynda Bourebaba, Krzysztof Marycz
Summary: Sex hormone binding globulin (SHBG) is an important biomarker that regulates the concentration of hormones in the blood. It is considered a reliable marker for insulin resistance and can predict the development of type 2 diabetes. Furthermore, decreased levels of SHBG are strongly correlated with increased levels of pro-inflammatory mediators. SHBG has the potential to be used as a drug candidate in the treatment of metabolic disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Medicine, Research & Experimental
Guanzhuang Gao, Fei Liu, Zhihua Xu, Daiwei Wan, Ye Han, Yuting Kuang, Qiang Wang, Qiaoming Zhi
Summary: Nigericin, an ionophore of H+, K+, and Pb2+, has shown promising anticancer activity in various cancers by decreasing intracellular pH, inactivating key signaling pathways, and targeting cancer stem cells. It may offer a novel therapeutic strategy for cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Fei Wang, Gabriele Multhoff
Summary: In recent years, evidence has shown that cannabinoids, especially cannabidiol (CBD), have promising anti-tumor activities by inhibiting tumor growth through different mechanisms and participating in anti-inflammatory activities. Although limited clinical trials have been conducted, CBD is believed to have potential as a new drug in cancer therapy.
Review
Plant Sciences
Yikang Yu, Danqing Fu, Hengpu Zhou, Jie Su, Suhong Chen, Guiyuan Lv
Summary: The root of Atractylodes macrocephala Koidz. (AM) has been used in China for thousands of years and contains various constituents with pharmacological effects. Recently, researchers have focused on its potential mechanism of action in regulating bone mass.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Liangge Li, Yiming Qin, Xijian Xin, Shendong Wang, Zhaojun Liu, Xiujing Feng
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease with a high morbidity and mortality rate. The pathogenesis of NAFLD involves excess lipid accumulation and inflammation. Currently, there are no specific drugs for NAFLD, but phytochemicals such as flavonoids have shown potential in preventing and treating excess lipid accumulation. Understanding the classification, properties, and functions of flavonoids will contribute to the development of effective therapies for NAFLD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Gregory Livshits, Alexander Kalinkovich
Summary: Systemic, chronic, low-grade inflammation (SCLGI) is associated with the pathogenesis of osteoporosis, and estrogen deficiency may contribute to the persistence of SCLGI in osteoporosis. Specialized, pro-resolving mediators (SPMs) show promising therapeutic effects in bone pathology and other inflammatory disorders. Restoring balanced gut microbiota may aid in the efficient resolution of SCGLI.
Article
Biochemistry & Molecular Biology
Mariusz Sandomierski, Katarzyna Adamska, Maria Ratajczak, Adam Voelkel
Summary: Chitosan scaffolds have great potential in biomedical applications, particularly in bone tissue engineering. This study successfully achieved controlled drug release in chitosan scaffolds by incorporating drug carriers, specifically for the osteoporosis drug risedronate. The addition of zeolite to the chitosan scaffold resulted in better drug retention compared to hydroxyapatite, demonstrating promising results for the potential use of this material in bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Medicine, Research & Experimental
Larissa Costa de Almeida, Jorge Antonio Elias Godoy Carlos, Paula Rezende-Teixeira, Joao Agosrinho Machado-Neto, Leticia Veras Costa-Lotufo
Summary: This study investigated the potential of the multikinase inhibitor AD80 as a drug option for colorectal cancer therapy. Results showed that AD80 selectively reduces cell viability of CRC cells by targeting the upregulated PI3K/AKT/mTOR and MAPK signaling pathways, suggesting AD80 as a promising candidate for colorectal cancer treatment by inhibiting tumor growth via multiple mechanisms, including clonogenicity inhibition, G(2)/M arrest, DNA damage, apoptosis, and inhibition of S6RP phosphorylation.
Review
Biochemistry & Molecular Biology
Parvaneh Mehrbod, Dorota Hudy, Divine Shyntum, Jaroslaw Markowski, Marek J. Los, Saeid Ghavami
Summary: This article discusses the medical burden caused by influenza and its related symptoms, as well as the application of quercetin and its derivatives in the treatment of this disease. Research shows that quercetin has therapeutic effects against the influenza virus and has potential for treating the new coronavirus.
Review
Medicine, General & Internal
Xinyun Tang, Yuxin Huang, Xuliang Fang, Xuanying Tong, Qian Yu, Wenbiao Zheng, Fangda Fu
Summary: Osteoporosis is a systemic metabolic skeletal disorder that mainly affects the elderly, particularly postmenopausal women, causing a substantial burden to patients and society. Kidney-tonifying Traditional Chinese medicine (TCM) plays an important role in the prevention and treatment of osteoporosis, offering advantages such as minimal side effects, low toxicity, excellent tolerability, and suitability for long-term use. Cornus officinalis and its bioactive constituents have shown significant efficacy in osteoporosis treatment.
FRONTIERS IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Dawei Deng, Chen Pan, Zeming Wu, Yujiao Sun, Chang Liu, Hong Xiang, Peiyuan Yin, Dong Shang
Summary: Osteoporosis is increasingly common among the global elderly population, and serum metabolite markers are crucial for its treatment and prevention. Metabolomics and lipidomics analysis revealed that lipids metabolism, including glycerol phospholipids, sphingolipids, fatty acids, and bile acids, is deregulated in osteoporosis. Bile acids, particularly hyocholic acids, were found to play essential roles and may serve as potential markers for diagnosis and treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
R. P. Parameswari, Thangavelu Lakshmi
Summary: Microalgae are unicellular organisms that are highly photosynthetic and have diverse species. They are widely utilized in various industries due to their bioactive compounds, which possess antioxidant, anti-inflammatory, and anti-cancer properties.
JOURNAL OF BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Alexander T. H. Wu, Bashir Lawal, Li Wei, Ya-Ting Wen, David T. W. Tzeng, Wen-Cheng Lo
Summary: Alzheimer's disease is a common cause of neurodegenerative dementia, affecting nearly 50 million people worldwide. Despite challenges in early diagnosis and effective treatment, identifying essential genes and molecular pathways associated with the disease's pathogenesis may lead to potential treatments. Integrating differentially expressed genes from AD datasets has allowed for the identification of upregulated DEGs common in multiple datasets, offering insight into the molecular pathogenesis of AD.
Article
Engineering, Biomedical
Silvia Stella Ramirez Caballero, Daniel Ferri-Angulo, Romain Debret, Fabien Granier, Sebastien Marie, Francois-Xavier Lefevre, Jean-Michel Bouler, Christelle Despas, Jerome Sohier, Bruno Bujoli
Summary: The study explores combining CPC with organic monomers to form a continuous biocompatible 3D polymeric subnetwork, increasing CPC permeability and accelerating its in vivo degradation. By forming polymers in the CPC microstructure, the size, density, and arrangement of apatite crystals can be manipulated, offering a new route to modulate the microstructure and porosity of apatitic cements.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Chemistry, Physical
Paul De Bonfils, Elise Verron, Pierrick Nun, Vincent Coeffard
Summary: The study found that singlet oxygen release can be achieved through a thermolysis reaction, forming the 1,2-dihydropyridine compound.
Article
Engineering, Biomedical
Lun Jing, Solene Rota, Florian Olivier, David Momier, Jean-Marie Guigonis, Sebastien Schaub, Michel Samson, Jean-Michel Bouler, Jean-Claude Scimeca, Nathalie Rochet, Patricia Lagadec
Summary: Blood proteins adhering to bone substitute surface play a crucial role in affecting both biomaterial bioactivity and bone healing. The presence of 80-200 μm biphasic calcium phosphate particles in a blood clot is associated with higher expression of fibrinogen, which activates blood cells through the Myd88- and NF-κB-dependent TLR4 signaling pathway.
ACTA BIOMATERIALIA
(2021)
Review
Pharmacology & Pharmacy
Karan Gulati, Jean-Claude Scimeca, Saso Ivanovski, Elise Verron
Summary: Metal-doped orthopedic/dental implants can enhance local therapy and bioactivity through the intentional or unintentional release of metal ions/nanoparticles, but the potential adverse reactions must be carefully controlled to minimize cytotoxicity concerns.
DRUG DISCOVERY TODAY
(2021)
Article
Nanoscience & Nanotechnology
Mari C. Manas-Torres, Cristina Gila-Vilchez, Francisco J. Vazquez-Perez, Pavel Kuzhir, David Momier, Jean-Claude Scimeca, Arnaud Borderie, Marianne Goracci, Fanny Burel-Vandenbos, Cristina Blanco-Elices, Ismael A. Rodriguez, Miguel Alaminos, Luis Alvarez de Cienfuegos, Modesto T. Lopez-Lopez
Summary: The incorporation of magnetic nanoparticles in hydrogel matrices has expanded the materials' application in biomedical research by allowing remote modulation of physical properties, inducing anisotropy, and improving mechanical stability. The resulting magnetic short-peptide hydrogels exhibit enhanced mechanical properties, faster self-healing, good biocompatibility, and potential for minimally invasive biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Philippe Collery, Patricia Lagadec, Imene Krossa, Charlotte Cohen, Julie Antomarchi, Didier Varlet, Marianna Lucio, Jean-Marie Guigonis, Jean-Claude Scimeca, Heidy Schmid-Antomarchi, Annie Schmid-Alliana
Summary: The study aimed to investigate the anti-tumor effects of Re-diSe on mice bearing 4T1 breast tumors and correlate them with several biomarkers. The results showed that Re-diSe did not have anti-tumor activity in this experiment. However, the choice of the experimental model is crucial for further evaluation of the compound's effects.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Acoustics
M. Majnooni, P. Lasaygues, V Long, J-C Scimeca, D. Momier, F. Rico, N. Buzhinsky, C. Guivier-Curien, C. Baron
Summary: Ultrasound stimulation of living tissues is a promising technique for regenerative treatments, but the mechanotransduction mechanism is not well understood. In-vitro studies can provide insights into the interaction between ultrasound and cells, and monitoring the ultrasound intensity delivered to cells is crucial for reliable analysis.
Article
Materials Science, Multidisciplinary
J. C. Scimeca, E. Verron
Summary: Nanotechnologies have been widely applied in the field of tissue engineering, with significant advances in the design and production of nanomaterials. However, the clinical translation of these materials remains a challenge due to limited predictive capacity of traditional safety tests. New toxicity evaluation protocols are needed to address safety concerns associated with the nanoscale and ensure the robustness and reproducibility of risk assessment procedures.
MATERIALS TODAY ADVANCES
(2022)
Review
Pharmacology & Pharmacy
Tianqi Guo, Jean-Claude Scimeca, Saso Ivanovski, Elise Verron, Karan Gulati
Summary: Titanium is an ideal material for dental implants due to its favorable biocompatibility and biomechanics. However, chemical corrosions caused by interaction with oral tissues and fluids can compromise the integrity of titanium implants. Various nanoscale surface modifications, such as depositing nanowires/nanoparticles and refining grain size, have been explored to enhance the stability of titanium implants. Electrochemical anodization has emerged as a promising method to create controlled titanium dioxide nanostructures, improving corrosion resistance and bioactivity. This review focuses on anodized titanium implants with nanotubes/nanopores for local drug delivery, aiming to develop the next generation of therapeutic and corrosion-resistant dental implants.
Article
Oncology
P. H. I. L. I. P. P. E. Collery, B. E. R. N. H. A. R. D. Michalke, M. A. R. I. A. N. N. A. Lucio, D. I. D. I. E. R. Varlet, Jean -marie Guigonis, Jean-claude Scimeca, H. E. I. D. Y. Schmid-antomarchi, A. N. N. I. E. Schmid-alliana
Summary: This study aimed to investigate the tumor effects of a lower dose (0.1 mg/kg) of Re-diSe and assay the concentrations of Re and Se in plasma. The results showed that the 0.1 mg/kg dose of Re-diSe significantly increased the plasma Se concentrations, while the weight of tumors remained unchanged.
ANTICANCER RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Alaa Mansour, Maya Romani, Anirudh Balakrishna Acharya, Betul Rahman, Elise Verron, Zahi Badran
Summary: Modern drug discovery methods have led to the development of new drugs with significant potential, but properties like solubility and administration challenges may hinder their benefits. Biotechnology advances have also resulted in the development of molecules with short half-lives, requiring frequent administration. Controlled release systems are necessary to enhance treatment efficacy and improve patient compliance. This review provides an overview of different approaches used for drug delivery.
Article
Engineering, Biomedical
Maxence Limelette, Claire De Fourmestraux, Christelle Despas, Audrey Lafragette, Joelle Veziers, Yohan Le Guennec, Gwenola Touzot-Jourde, Lefevre Francois-Xavier, Elise Verron, Bouler Jean-Michel, Bruno Bujoli, Olivier Gauthier
Summary: The presence of blood delays the setting reaction of calcium phosphate cement. The composite material with blood requires around 10 hours to harden, but shows improved cohesion after injection. The addition of blood facilitates the replacement of the composite material by newly formed bone.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Acoustics
Meysam Majnooni, Elise Doveri, Jeanne Baldisser, Vincent Long, Julien Houles, Jean-Claude Scimeca, David Momier, Carine Guivier-Curien, Philippe Lasaygues, Cecile Baron
Summary: This article presents the application of low-intensity ultrasound stimulation in bone regeneration and the research on its underlying mechanisms. In vitro cell culture experiments were conducted to analyze the effects of ultrasound waves on cells. The development and experimental validation of an anti-reflection cover were proposed, which effectively avoids multiple reflections and allows for the replacement of culture medium with water. Additionally, an analytical study on the acoustic intensity delivered to the cells was performed.
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)
