4.7 Review

The value of the Semantic Web in the laboratory

Journal

DRUG DISCOVERY TODAY
Volume 14, Issue 11-12, Pages 552-561

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2009.03.007

Keywords

-

Funding

  1. EPSRC
  2. JISC
  3. EPSRC [EP/F05811X/1] Funding Source: UKRI
  4. Engineering and Physical Sciences Research Council [EP/C008863/1, EP/F05811X/1] Funding Source: researchfish

Ask authors/readers for more resources

The Semantic Web is beginning to impact on the wider chemical and physical sciences, beyond the earlier adopted bio-informatics. While useful in large-scale data driven science with automated processing, these technologies can also help integrate the work of smaller scale laboratories producing diverse data. The semantics aid the discovery, reliable re-use of data, provide improved provenance and facilitate automated processing by increased resilience to changes in presentation and reduced ambiguity. The Semantic Web, its tools and collections are not yet competitive with well-established solutions to current problems. It is in the reduced cost of instituting solutions to new problems that the versatility of Semantic Web-enabled data and resources will make their mark once the more general-purpose tools are more available.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Multidisciplinary Sciences

Canine mammary cancer tumour behaviour and patient survival time are associated with collagen fibre characteristics

Ana P. Garcia, Luana A. Reis, Fernanda C. Nunes, Francis G. J. Longford, Jeremy G. Frey, Ana M. de Paula, Geovanni D. Cassali

Summary: Changes in collagen fibers in different types of canine mammary gland carcinomas are directly associated with tumor behavior and survival time. These changes could serve as a useful tool in diagnosis.

SCIENTIFIC REPORTS (2021)

Review Chemistry, Physical

eScience Infrastructures in Physical Chemistry

Samantha Kanza, Cerys Willoughby, Colin Leonard Bird, Jeremy Graham Frey

Summary: As the volume of scientific research data has increased, the use of digital infrastructures has significantly improved the way physical chemistry research is conducted. This review highlights the various aspects of eScience infrastructures and their impact on enhancing physical chemistry research.

ANNUAL REVIEW OF PHYSICAL CHEMISTRY (2022)

Editorial Material Multidisciplinary Sciences

Stop squandering data: make units of measurement machine-readable

Robert Hanisch, Stuart Chalk, Romain Coulon, Simon Cox, Steven Emmerson, Francisco Javier Flamenco Sandoval, Alistair Forbes, Jeremy Frey, Blair Hall, Richard Hartshorn, Pascal Heus, Simon Hodson, Kazumoto Hosaka, Daniel Hutzschenreuter, Chu-Shik Kang, Susanne Picard, Ryan White

NATURE (2022)

Article Chemistry, Multidisciplinary

RSC CICAG Open Chemical Science meeting: integrating chemical data from two symposia and a series of workshops

Christopher J. Swain, Jeremy G. Frey, Jonathan M. Goodman

Summary: In November 2020, the Royal Society of Chemistry's Chemical Information and Computer Applications interest group held a five-day conference on Open Chemical Science, focusing on open data, open access publishing, and various open-source tools for chemistry. This online event was highly popular and attracted attendees from 45 different countries. The workshops, in particular, were well-received and led to a year-long series of further workshops.

PURE AND APPLIED CHEMISTRY (2022)

Article Food Science & Technology

Artificial intelligence and ethics within the food sector: Developing a common language for technology adoption across the supply chain

Louise Manning, Steve Brewer, Peter J. Craigon, Jeremy Frey, Anabel Gutierrez, Naomi Jacobs, Samantha Kanza, Samuel Munday, Justin Sacks, Simon Pearson

Summary: This review paper examines the ethical language used by stakeholders in adopting AI in food supply chains. It explores the ethical interaction of AI in food supply chains and proposes management activities to improve the applicability and performance benefits of AI technology.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2022)

Article Chemistry, Analytical

The units of rate constants in chemical kinetics

Jeremy Frey, Timothy J. Wallington, Richard Hartshorn, Martin Quack, Pascal Heus, Steven Emmerson

Summary: This article discusses the units of rate constants as used in chemical kinetics, particularly the aspect of non-integral powers of base units, which may be considered unusual in the SI system. While the units of rate constants can provide useful information about the order of reactions, having the same quantity with different units under different conditions is not ideal. Moreover, functions of rate constants, such as logarithms in the Arrhenius equation, require special attention.

ACCREDITATION AND QUALITY ASSURANCE (2023)

Article Chemistry, Multidisciplinary

Robustness under parameter and problem domain alterations of Bayesian optimization methods for chemical reactions

Rubaiyat Mohammad Khondaker, Stephen Gow, Samantha Kanza, Jeremy G. Frey, Mahesan Niranjan

Summary: The problems of chemical reaction optimization and reaction scope search can be solved by mathematical methods, such as Bayesian optimization. The Experimental Design for Bayesian optimization (EDBO) optimizer is a recent development in this area, which has shown promising results in various experiments and data sets.

JOURNAL OF CHEMINFORMATICS (2022)

Article Biochemical Research Methods

Prostate cancer tissue classification by multiphoton imaging, automated image analysis and machine learning

Egleidson F. A. Gomes, Eduardo Paulino Junior, Mario F. R. de Lima, Luana A. Reis, Giovanna Paranhos, Marcelo Mamede, Francis G. J. Longford, Jeremy G. Frey, Ana Maria de Paula

Summary: Prostate carcinoma, the second most common cancer among men worldwide, is often slow-growing and indolent. Prognosis relies heavily on the Gleason system, but new treatment and monitoring strategies require a more precise diagnosis. This study used multiphoton imaging to analyze prostate tumor samples from 120 patients, resulting in quantitative parameters that can indicate specific tumor aggressiveness signatures. The automated image analysis distinguished between non-neoplastic tissue and carcinoma areas with an accuracy of 89% +/- 3%, but only achieved 46% +/- 6% accuracy in differentiating between Gleason groups. However, the inclusion of stromal parameters improved the accuracy to 65% +/- 5%, highlighting the importance of considering these parameters for a more accurate diagnosis.

JOURNAL OF BIOPHOTONICS (2023)

Article Food Science & Technology

Reflexive governance architectures: Considering the ethical implications of autonomous technology adoption in food supply chains

Louise Manning, Steve Brewer, Peter J. Craigon, Jeremy Frey, Anabel Gutierrez, Naomi Jacobs, Samantha Kanza, Samuel Munday, Justin Sacks, Simon Pearson

Summary: This paper criticizes existing reflective food-related ethical assessment tools and proposes the structural elements required for reflexive governance architectures in the application of autonomous technology in food supply chains. The findings suggest that considering the ethical implications in real-life contexts is challenging, and a more holistic approach can inform ethical considerations and the need for mitigation at all lifecycle stages of technology and food product in the supply chain. This research is of interest to those engaged in ethical deliberation on data sharing, AI, and machine learning in food supply chains.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2023)

Article Microscopy

Characterisation of engineered defects in extreme ultraviolet mirror substrates using lab-scale extreme ultraviolet reflection ptychography

Haoyan Lu, Michal Odstrcil, Charles Pooley, Jan Biller, Mikheil Mebonia, Guanze He, Matthew Praeger, Larissa Juschkin, Jeremy Frey, William Brocklesby

Summary: Ptychography is an aberration-free lensless imaging technique that can image both amplitude and phase of reflected or transmitted radiation using iterative algorithms. It provides better resolution than conventional optical microscopy and deeper penetration than scanning electron microscopy. The use of high harmonic generation as a lab-scale EUV light source enables high coherence required for ptychography. This paper describes the application of reflection-mode ptychography with a lab-scale high harmonic generation based EUV light source to measure the amplitude and phase reflection from engineered substrate defects in EUV multilayer mirrors.

ULTRAMICROSCOPY (2023)

Article Chemistry, Multidisciplinary

Digital research environments: a requirements analysis

Samantha Kanza, Cerys Willoughby, Nicola J. Knight, Colin L. Bird, Jeremy G. Frey, Simon J. Coles

Summary: Physical science relies on historical records and new ideas, results, and opportunities. However, a significant amount of scientific data remains inaccessible and challenges persist in the creation and accessing of high quality reusable data in the increasingly digital era.

DIGITAL DISCOVERY (2023)

Article Chemistry, Multidisciplinary

Specification of International Chemical Identifier (InChI) QR codes for linking labels on containers of chemical samples to digital resources (IUPAC Recommendations 2021)

Jeremy G. G. Frey, Richard M. M. Hartshorn, Leah R. R. McEwen

Summary: This article discusses the methods of connecting physical objects to digital information relevant to chemical entities, specifically those described by the use of the IUPAC International Chemical Identifier (InChI). It provides recommendations on the format of computer readable labels for chemicals and materials used on product/sample containers and the accompanying documentation for container transportation. The focus is on the 2D Quick Response bar code content that describes the molecular content of the containers and links to digital resources. Additionally, the necessary technical and potential business infrastructure to support the use of InChI and InChIKey for quick retrieval of relevant information is considered, with suggestions provided.

PURE AND APPLIED CHEMISTRY (2022)

Article Computer Science, Artificial Intelligence

Considering the ethical implications of digital collaboration in the Food Sector

Naomi Jacobs, Steve Brewer, Peter J. Craigon, Jeremy Frey, Anabel Gutierrez, Samantha Kanza, Louise Manning, Samuel Munday, Simon Pearson, Justin Sacks

Summary: The Internet of Food Things Network (IoFT) and the Artificial Intelligence and Augmented Intelligence for Automated Investigation for Scientific Discovery Network (AI3SD) have collaborated to create an ethical framework for digital collaboration in the food industry. This article identifies areas for ethical consideration related to digital collaboration and the use of Industry 4.0 technologies in the food sector, highlighting interdisciplinary methodologies being used to develop this framework. The research questions and objectives addressed by the working group are outlined, with ongoing work being reported and recommendations provided for projects in this area.

PATTERNS (2021)

Article Food Science & Technology

A trust framework for digital food systems

Steve Brewer, Simon Pearson, Roger Maul, Phil Godsiff, Jeremy G. Frey, Andrea Zisman, Gerard Parr, Andrew McMillan, Sarah Cameron, Hannah Blackmore, Louise Manning, Luc Bidaut

Summary: The food system relies on data-driven technologies to connect global supply chains, improve governance of data exchange can drive sustainable business growth and secure wider public benefits.

NATURE FOOD (2021)

Article Computer Science, Artificial Intelligence

The AI for Scientific Discovery Network+

Samantha Kanza, Colin Leonard Bird, Mahesan Niranjan, William McNeill, Jeremy Graham Frey

Summary: The AI3SD Network was established to promote research in artificial intelligence for accelerating scientific discoveries, and the challenges highlighted in the first year activities in chemistry and AI space are shaping the future directions of the Network.

PATTERNS (2021)

Review Pharmacology & Pharmacy

Illuminating the druggable genome: Pathways to progress

Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley

Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.

DRUG DISCOVERY TODAY (2024)

Review Pharmacology & Pharmacy

Unravelling the potential of mitochondria-targeted liposomes for enhanced cancer treatment

Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani

Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.

DRUG DISCOVERY TODAY (2024)

Review Pharmacology & Pharmacy

Multiorgan locked-state model of chronic diseases and systems pharmacology opportunities

Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu

Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.

DRUG DISCOVERY TODAY (2024)