In silico augmentation of the drug development pipeline: examples from the study of acute inflammation

From proteomics toward systems biology: integration of different types of proteomics data into network models

(2011) Sang-Chul Rho et al.   BMB Reports

Two-Dimensional (2D) In Silico Models for Absorption, Distribution, Metabolism, Excretion and Toxicity (ADME/T) in Drug Discovery

(2010) Prashant Kharkar   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The challenges ofin silicocontributions to drug metabolism in lead optimization

(2010) Roy J Vaz et al.   Expert Opinion on Drug Metabolism & Toxicology

Translational Systems Approaches to the Biology of Inflammation and Healing

(2010) Yoram Vodovotz et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Translational systems biology of inflammation: potential applications to personalized medicine

(2010) Qi Mi et al.   Personalized Medicine

Agent-Based Modeling of Endotoxin-Induced Acute Inflammatory Response in Human Blood Leukocytes

(2010) Xu Dong et al.   PLoS One

Using a Mathematical Model to Analyze the Role of Probiotics and Inflammation in Necrotizing Enterocolitis

(2010) Julia C. Arciero et al.   PLoS One

Closing the Scientific Loop: Bridging Correlation and Causality in the Petaflop Age

(2010) G. An   Science Translational Medicine

Translational systems biology of inflammation and healing

(2010) Yoram Vodovotz   WOUND REPAIR AND REGENERATION

Improving Compound Quality throughin vitroandin silicoPhysicochemical Profiling

(2009) Han van de Waterbeemd   CHEMISTRY & BIODIVERSITY

Scientific and Clinical Challenges in Sepsis

(2009) Luis Ulloa et al.   CURRENT PHARMACEUTICAL DESIGN

Rational drug design

(2009) Soma Mandal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Analytical strategies for the screening and evaluation of chemically reactive drug metabolites

(2009) Bo Wen et al.   Expert Opinion on Drug Metabolism & Toxicology

Translational Systems Biology: Introduction of an Engineering Approach to the Pathophysiology of the Burn Patient

(2009) Gary An et al.   Journal of Burn Care & Research

Docking, virtual high throughput screening and in silico fragment-based drug design

(2009) Vincent Zoete et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

In Silico Simulation of Corticosteroids Effect on an NFkB- Dependent Physicochemical Model of Systemic Inflammation

(2009) Panagiota T. Foteinou et al.   PLoS One

MATHEMATICAL MODELING OF POSTHEMORRHAGE INFLAMMATION IN MICE

(2009) Andres Torres et al.   SHOCK

The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways

(2009) Xavier Rovira et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Inflammatory Markers at Hospital Discharge Predict Subsequent Mortality after Pneumonia and Sepsis

(2008) Sachin Yende et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Understanding biological functions through molecular networks

(2008) Jing-Dong Jackie Han   CELL RESEARCH

In Silico and In Vitro: Identifying New Drugs

(2008) Ivani Pauli et al.   CURRENT DRUG TARGETS

Enhancing Drug Discovery Through In Silico Screening: Strategies to Increase True Positives Retrieval Rates

(2008) J. Kirchmair et al.   CURRENT MEDICINAL CHEMISTRY

A Genomic “Roadmap” to “Better” Drugs

(2008) Guochun Liao et al.   DRUG METABOLISM REVIEWS

An ensemble of models of the acute inflammatory response to bacterial lipopolysaccharide in rats: Results from parameter space reduction

(2008) Silvia Daun et al.   JOURNAL OF THEORETICAL BIOLOGY

A simple mathematical model of signaling resulting from the binding of lipopolysaccharide with Toll-like receptor 4 demonstrates inherent preconditioning behavior

(2008) Beatrice Rivière et al.   MATHEMATICAL BIOSCIENCES

Detailed qualitative dynamic knowledge representation using a BioNetGen model of TLR-4 signaling and preconditioning

(2008) Gary C. An et al.   MATHEMATICAL BIOSCIENCES

A model of TLR4 signaling and tolerance using a qualitative, particle–event-based method: Introduction of spatially configured stochastic reaction chambers (SCSRC)

(2008) Gary An   MATHEMATICAL BIOSCIENCES

Mechanistic simulations of inflammation: Current state and future prospects

(2008) Yoram Vodovotz et al.   MATHEMATICAL BIOSCIENCES

Modeling endotoxin-induced systemic inflammation using an indirect response approach

(2008) P.T. Foteinou et al.   MATHEMATICAL BIOSCIENCES

Unknown

(2008) John Klune et al.   MOLECULAR MEDICINE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

A Patient-Specific in silico Model of Inflammation and Healing Tested in Acute Vocal Fold Injury

(2008) Nicole Y. K. Li et al.   PLoS One

Introduction of an agent-based multi-scale modular architecture for dynamic knowledge representation of acute inflammation

(2008) Gary An   Theoretical Biology and Medical Modelling

Novel paradigms for drug discovery: computational multitarget screening

(2008) E JENWITHEESUK et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Translational Systems Biology of Inflammation

(2008) Yoram Vodovotz et al.   PLoS Computational Biology

Inferring regulatory networks

(2007) Huai Li   Frontiers in Bioscience-Landmark