Review
Pharmacology & Pharmacy
Gerallt Williams, Julie D. Suman
Summary: Nasal drug delivery has been used for locally acting diseases for decades. It is also a gateway to the systemic circulation and central nervous system. With the increase in nasal sprays for vaccination and respiratory disease prevention, targeted regional deposition in the nose has become important in nasal drug development. In vitro tools such as nasal casts have been used to facilitate formulation and product development, and to study nasal deposition and its impact on pharmacokinetics.
Article
Pharmacology & Pharmacy
Laura Nizic Nodilo, Mirna Perkusic, Ivo Ugrina, Drago Spoljaric, Cvijeta Jakobusic Brala, Daniela Amidzic Klaric, Jasmina Lovric, Vesna Sarson, Masa Safundzic Kucuk, Dijana Zadravec, Livije Kalogjera, Ivan Pepic
Summary: This study presents the development of an in situ gelling nanosuspension as an advanced form for delivering fluticasone propionate to the nasal cavity. Drug nanocrystals were prepared using a wet milling technique and incorporated into a polymeric in situ gelling system. The drug nanonization improved release profile and mucoadhesive properties. By optimizing formulation and administration parameters, the nasal deposition profile was optimized, with a significant portion of the dose deposited in the critical region for treating rhinosinusitis and nasal polyposis.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Polymer Science
Sandra Aulia Mardikasari, Gabor Katona, Bence Sipos, Rita Ambrus, Ildiko Csoka
Summary: This study focuses on the optimization of bovine serum albumin (BSA) nanoparticles as a carrier system for nasal drug delivery. The ratio of BSA and ethanol is found to play a critical role in the nanoparticle characteristics of BSA nanogel matrices (BSA-NGs). The BSA-NGs exhibit moderate mucoadhesive properties and viscosity suitable for nasal liquid preparations. The in vitro release studies show high drug release within 4 hours. BSA nanoparticle gelling matrices have the potential to improve nasal drug administration.
Review
Biochemistry & Molecular Biology
Maria Bialik, Marzena Kuras, Marcin Sobczak, Ewa Oledzka
Summary: Rectal drug delivery offers a viable option for both local and systemic medication. Recent developments in thermosensitive liquid suppositories have shown promise, despite current limitations. Further research and development are necessary to fully uncover the potential of rectal drug delivery systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Theodore Ebenezer Leonard, Alvaro Filbert Liko, Marsia Gustiananda, Agus Budiawan Naro Putra, Ario Betha Juanssilfero, Pietradewi Hartrianti
Summary: Mucoadhesive drug delivery systems (DDS) can enhance localized drug distribution and retention, promoting safer chemotherapy for colorectal cancer (CRC). Carbohydrate polymers, such as pectin (P) and chitosan (CS), are potential biomaterials for CRC-targeted DDS due to their gelling ability, mucoadhesive property, colonic digestibility, and anticancer activity. Thiolation can augment polymer mucoadhesion, while the P-CS polyelectrolyte complex improves structural stability. TP-CS composites show superior mucoadhesive properties compared to single- or dual-crosslinked counterparts, making them promising biomaterials for CRC-targeted DDS.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Elisa Corazza, Massimiliano Pio di Cagno, Annette Bauer-Brandl, Angela Abruzzo, Teresa Cerchiara, Federica Bigucci, Barbara Luppi
Summary: The objective of this study was to optimize a thermosensitive in situ gelling formulation to improve the intranasal and nose-to-brain delivery of the antiepileptic drug carbamazepine (CBZ). The formulation consisted of poloxamer 407 (P407), poloxamer 188 (P188), and hydroxypropylmethylcellulose (HPMC) and exhibited suitable properties for nasal delivery. The mucoadhesive properties of the formulation were enhanced by adding different grades of HPMC, and the formulation showed promising mucoadhesive potential. Furthermore, the formulation was able to increase drug solubility, control drug release, and promote drug permeation across barrier membranes.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Engineering, Environmental
Jirapornchai Suksaeree, Pattwat Maneewattanapinyo, Kamon Panrat, Wiwat Pichayakorn, Chaowalit Monton
Summary: The solvent-cast polymeric films containing ionic liquid lidocaine/aspirin developed in this study are suitable for transdermal patches, demonstrating good physicomechanical properties and drug release characteristics.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
Article
Engineering, Chemical
Sana Hosseini, Ali Alfaifi, Amir Reza Esmaeili, David Edwards, Theodore Schuman, Worth Longest, Michael Hindle, Laleh Golshahi
Summary: This study investigated the relationship between nasal anatomical characteristics and drug deposition. The results showed no clear correlation between nasal anatomical characteristics and drug deposition, but a combination of specific variables can predict the range of drug deposition.
JOURNAL OF AEROSOL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Keegan Mendez, William Whyte, Benjamin R. Freedman, Yiling Fan, Claudia E. Varela, Manisha Singh, Juan C. Cintron-Cruz, Sandra E. Rothenbucher, Jianyu Li, David J. Mooney, Ellen T. Roche
Summary: Soft robotic technologies for therapeutic biomedical applications require conformal and atraumatic tissue coupling for effective drug delivery or tissue stimulation. A new class of hybrid hydrogel actuator is introduced, which can facilitate enhanced drug delivery through tunable mechanoresponsive release. The actuator can adhere to tissue via a flexible, drug-permeable adhesive bond and achieve improved drug spatial delivery. Future integration with other soft robotic assistive technologies can enable a synergistic approach for disease treatment.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yong-Jin Kim, Eun-Soo Lee, Joonho Choi, Seunghan Park, Byungguen Chae, Eunmi Kim
Summary: A zein-induced polyelectrolyte (ZiP) complex was developed for delivering hydrolyzed ginseng saponin. The complex demonstrated stability and high encapsulation efficiency, making it an effective drug delivery system.
Article
Polymer Science
Andy Chai, Keagan Schmidt, Gregory Brewster, Lu Shi Peng Xiong, Benjamin Church, Timothy Wahl, Hamed Sadabadi, Subha Kumpaty, Wujie Zhang
Summary: This study aimed to develop a pectin-based microsphere system for encapsulating pulmonary drugs and facilitating their delivery to the deep lungs. Pectin-based hydrogel microspheres were produced using electrospray, and the stability and responsiveness of the microspheres were altered through coatings. The microsphere system exhibited high responsiveness and stability in simulated lung fluid.
Article
Polymer Science
Regina R. Vildanova, Svetlana F. Petrova, Sergey V. Kolesov, Vitaliy V. Khutoryanskiy
Summary: Preparation of stable hydrogels using charge-complementary polyelectrolyte chains offers practical advantages over the use of organic crosslinking agents. This study utilizes natural polyelectrolytes-chitosan and pectin-with their biocompatibility and biodegradability. Different molecular weights of pectin are used to prepare hydrogels with varying rheological characteristics and swelling kinetics. These polyelectrolyte hydrogels can release the cytostatic drug cisplatin over an extended period, potentially improving the effectiveness of cancer treatment.
Review
Polymer Science
Jovana Milutinov, Veljko Krstonosic, Dejan Cirin, Nebojsa Pavlovic
Summary: Novel delivery systems such as emulgels play an important role in incorporating and protecting active substances for cosmetics, drugs, and food ingredients. The selection of main constituents determines the stability and efficacy of emulgels, which are dual-controlled release systems. Emulsifiers and gelling agents are crucial in ensuring emulsion stability and improving sensory properties.
Article
Polymer Science
Xiang Chen, Haojie Yu, Li Wang, Nan Wang, Qian Zhang, Weibin Zhou, Md Alim Uddin
Summary: This study investigates the direct loading of insulin into polymerized glucose-responsive microneedle patch, demonstrating that insulin loading procedure was related to glucose concentration. The release of insulin on the surface of microneedles was uncontrolled by microneedles, while the release of insulin within microneedles depended on glucose concentration.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Avantika Dalvi, Punna Rao Ravi, Chandra Teja Uppuluri
Summary: A thermoresponsive nasal in situ gel loaded with Rufinamide (Rufi) nanocrystals was developed to improve nose-to-brain distribution. The optimized Rufi nanocrystals had reproducible and reliable manufacturing process with small particle size. The combination of nanometric size and in situ gelling properties of Rufi nanocrystals contributed to higher brain distribution and sustained drug concentrations.
FRONTIERS IN PHARMACOLOGY
(2022)