Article
Biochemistry & Molecular Biology
Kaushik Mukherjee, Sukanta Roy, Tapan Kumar Giri
Summary: This research developed semi-interpenetrating network hydrogel matrix tablets for sustained gastrointestinal delivery of highly water soluble tramadol hydrochloride. The study investigated the effect of different assembly methods and cross-linking ions on the swelling, erosion, and release characteristics of the hydrogel matrices. The optimized formulation exhibited sustained release of tramadol hydrochloride in the gastrointestinal environment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biotechnology & Applied Microbiology
Lin Liu, Wendong Yao, Xiaowei Xie, Jianqing Gao, Xiaoyang Lu
Summary: A novel dual drug delivery system was designed to achieve synergistic analgesia between najanajaatra venom protein and resveratrol. The Janus nanoparticles were able to pass through intestinal epithelial cells and showed significant synergistic analgesic effects in animal models. This study provides new insights into the oral administration and analgesic treatment of dual drug delivery systems containing peptide drugs.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Polymer Science
Moises Bustamante-Torres, Victor H. Pino-Ramos, David Romero-Fierro, Sandra P. Hidalgo-Bonilla, Hector Magana, Emilio Bucio
Summary: The design of a new pH-sensitive hydrogel for localized prophylactic release of ciprofloxacin and silver nanoparticles was presented in this study. The hydrogel was copolymerized using gamma rays and characterized using various analytical techniques. The antimicrobial activity of the hydrogel against E. coli and MRSA was evaluated in vitro.
Article
Nanoscience & Nanotechnology
Rui-Chian Tang, Tzu-Chien Chen, Feng-Huei Lin
Summary: The study successfully lowered immediate blood glucose response by preparing a pH-responsive hydrogel, and significantly reduced weight gain, fat accumulation, and hepatic lipid deposition in rodent models, providing a novel strategy for managing metabolism disorders.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Hafiz Rashid Hussain, Sajid Bashir, Asif Mahmood, Rai Muhammad Sarfraz, Misbah Kanwal, Nadeem Ahmad, Hamid Saeed Shah, Imran Nazir
Summary: This study successfully developed a pH-responsive hydrogel system based on Fenugreek seed mucilage to improve the oral bioavailability of MTX. The experimental results suggest that this hydrogel system could be a promising tool for controlled release of MTX.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Bianca Andrade de Campos, Natalia Cristina Borges da Silva, Lucas Szmgel Moda, Pedro Vidinha, Ligia Passos Maia-Obi
Summary: pH-sensitive degradable hydrogels are smart materials that degrade upon pH variation. This study focused on the development of a hydrogel using HPG and OA, and investigated its formation process, as well as drug release for oral administration.
Article
Nanoscience & Nanotechnology
Zhiqiang Li, Weiqi Liu, Chenbo Sun, Xinyi Wei, Shiyuan Liu, Yanbin Jiang
Summary: This study proposed a strategy to prepare pH-responsive Pickering emulsions for improving the oral bioaccessibility of hydrophobic nutraceuticals. The Pickering emulsions fabricated by zein/TA/GA nanoparticles exhibited excellent stability at acid conditions while slowly demulsifying at neutral conditions and can be further used as an intestine-targeted delivery system. The presence of GA coating remarkably facilitated the encapsulation of curcumin, and the emulsions provided protection for the encapsulated curcumin from pepsin hydrolysis and exhibited higher bioaccessibility during simulated intestine digestion.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Yue Xin, Jionghong Liang, Lantu Ren, Wenshuo Gao, Weicheng Qiu, Zhenhan Li, Baoliu Qu, Aijian Peng, Zhixin Ye, Jun Fu, Guang Zeng, Xin He
Summary: In this study, a strong, stretchable, self-healing and antifreezing ion conductive hydrogel was developed by designing a multiphysically cross-linked network structure. The hydrogel exhibited high tensile strain, tensile strength, conductivity and freezing resistance, making it suitable for applications in wearable electronics.
Article
Pharmacology & Pharmacy
Mohamed Mohamady Ghobashy, Ahmed M. Elbarbary, Dalia E. Hegazy, Nabila A. Maziad
Summary: The popularity of hydrogel membrane as wound dressing is due to its elastic physical properties and the ability to encapsulate drug particles. The combination of ZnS nanoparticles with (DMAEM/PEO) hydrogel enhances the antimicrobial activities. The drug release rate experiments show differential release of the three drugs based on pH. The antimicrobial experiments demonstrate enhanced antimicrobial activity of the drugs loaded in (DMAEM/PEO)/ZnS hydrogel.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
S. Moraes, A. Marinho, S. Lima, A. Granja, J. P. Araujo, S. Reis, C. T. Sousa, C. Nunes
Summary: This study developed folic acid conjugated nanostructured lipid carriers (NLCs) as an effective doxorubicin delivery method targeted to breast cancer cells, with enhanced cellular uptake and targeting potential. In vitro studies showed good release performance and storage stability of the NLCs, indicating the potential for oral administration and targeted doxorubicin delivery to breast cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Jiaqi Zhang, Christopher Hurren, Zhentan Lu, Dong Wang
Summary: This study developed a pH-sensitive sodium alginate hydrogel for combating bacterial infection caused by tissue damage. The hydrogel showed fast drug release rate and effective antibacterial activity under weak acid conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Jiufang Duan, Yirong Huang, Shiyu Zong, Jianxin Jiang
Summary: This study introduces a high-strength galactomannan (GA)-based hydrogel with thermal and pH response properties. By adjusting the composition and content of raw materials, the structure and properties of the hydrogel can be controlled, showing potential as a drug carrier for colon delivery.
Article
Engineering, Environmental
Wenxu Zhang, Xuyang Mu, Yan Xu, Sijie Li, Xiaoming Liu, Ziqiang Lei
Summary: In this study, a temperature/pH-responsive core-shell hydrogel was prepared by static template polymerization. The hydrogel exhibited good temperature responsiveness in the range of 25-55 degrees C and pH responsiveness from pH= 4 to pH= 13, with a short response time. The design of the core-shell structure enhanced the stability performance of the shell temperature-sensitive hydrogel, making it suitable for agricultural and pharmaceutical applications.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Hui Zhi, Xiaobo Zhang, Fengya Wang, Liang Feng
Summary: In this study, a pH-sensitive, stretchable, antibacterial, and stable ionogel artificial tongue was fabricated through dual cross-linking. The ionogel exhibited excellent water-locking properties, mechanical stretchability, stability, and demonstrated good results in artificial simulated saliva testing, indicating its potential for clinical applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Seungoh Jung, Jungkyu Kim, Junsik Bang, Minjung Jung, Sangwoo Park, Heecheol Yun, Hyo Won Kwak
Summary: In this study, a pH-sensitive smart hydrogel was prepared using biopolymeric nanofibrils. The hydrogel showed excellent structural stability and the ability to remove ionic contaminants in water. It also exhibited a high contaminant removal efficiency even after repeated reuse. The eco-friendly biopolymeric nanofibrillar pH-sensitive hydrogel has potential applications in complex wastewater treatment and long-term use.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Physical
Naglaa Salem El-Sayed, Ahmed Salama, Vincenzo Guarino
Summary: A novel anionic nanostructured cellulose derivate was prepared by coupling TEMPO-oxidized cellulose nanofibers with 3-aminopropyl sulfonic acid (3-APSA). The surface morphology of the cellulose nanofibers was improved after the 3-APSA coupling, resulting in enhanced adsorption capacity for methylene blue. The study suggests that chemical grafting via 3-APSA is a reliable method to design high-performance adsorbent materials for water pollutant remediation.
Article
Engineering, Biomedical
Ahmed Salama, Ahmed K. Saleh, Iriczalli Cruz-Maya, Vincenzo Guarino
Summary: A novel technique for preparing cationic bacterial cellulose hydrogel through in situ incorporation of cationic water-soluble cellulose derivative was proposed in this article. The cationic functionalization was deeply examined, and the results showed good cytocompatibility and antimicrobial properties of the cationic bacterial cellulose. This suggests a promising use of cationic hybrid materials in biomedical and bio-sustainable applications.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Chemistry, Medicinal
Yasmine Radwan, Kholoud K. Arafa, Monira G. Ghoniem, Eida S. Al-Farraj, Ibrahim M. El-Sherbiny
Summary: This study aimed to investigate the synergistic therapeutic effect of the novel combination of capsaicin and 5-fluorouracil encapsulated in lipid nanocapsules. The results showed that the developed nanoformulations had good physical stability and exhibited superior antiproliferative effect compared to the free drugs.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Materials Science, Textiles
Ahmed Salama
Summary: In this study, cellulose/silica microspheres containing amino groups were successfully prepared and applied for the capture of anionic pollutants. The fabricated microspheres exhibited excellent adsorption capacity for methyl orange. Therefore, these cellulose/silica microspheres offer a promising platform for sustainable water purification systems.
FIBERS AND POLYMERS
(2023)
Article
Pharmacology & Pharmacy
Mohamed El -Far, Alaa Essam, Fardous F. El-Senduny, Amira O. Abd El-Azim, Sarah Yahia, Ibrahim M. El-Sherbiny
Summary: In this study, the anticancer effect of a novel drug combination using nanoformulations of Quercetin and Ascorbyl palmitate was investigated in Ehrlich ascites carcinoma (EAC)-bearing mice. The combination treatment significantly reduced tumor growth, increased antioxidant status, and reduced lipid peroxidation. The combination also downregulated the expression of p-STAT3 and HIF-1 alpha, induced cell cycle arrest and apoptosis in EAC cells, and caused DNA damage. The combination was also superior in the destruction of the mitochondrial membrane.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mohamed Fawzi Kabil, Osama A. Badary, Frank Bier, Shaker A. Mousa, Ibrahim M. El-Sherbiny
Summary: Cancer is a major cause of death worldwide, and chemotherapy is the most commonly used treatment. However, current chemotherapeutic treatments have limitations, including lack of specificity and adverse effects. Lipid nanoparticles (LNPs) offer a promising nanocarrier system to improve drug delivery and reduce side effects, potentially leading to better therapeutic outcomes.
JOURNAL OF LIPOSOME RESEARCH
(2023)
Correction
Pharmacology & Pharmacy
Amira Mansour, Mohamed Y. Mahmoud, Alaa F. Bakr, Monira G. Ghoniem, Fatima A. Adam, Ibrahim M. El-Sherbiny
Article
Chemistry, Multidisciplinary
Mostafa Fytory, Amira Mansour, Waleed M. A. El Rouby, Ahmed A. Farghali, Xiaorong Zhang, Frank Bier, Mahmoud Abdel-Hafiez, Ibrahim M. El-Sherbiny
Summary: By grafting glycyrrhetinic acid to polyethyleneimine, a biocompatible Zr-based metal-organic framework was designed for efficient controlled drug release and selective targeting against hepatic cancer cells. The improved core-shell structure enhanced the drug loading capacity and selectivity towards tumor cells, while exhibiting minimal toxicity to normal cells. This study provides a new approach for active drug delivery and efficient cancer therapy applications.
Article
Chemistry, Multidisciplinary
Ahmed Salama, Ragab Abouzeid, Benedicte Prelot, Mohamed Diab, Marwa Assaf, Peter Hesemann
Summary: Wastewater containing organic pollutants is a major concern due to its harmful effects on human health and the environment. This article presents the development of a promising material, TEMPO-cellulose/silica/calcium carbonate composite, for efficient adsorption of water pollutants. The composite demonstrated high adsorption performance for methylene blue compared to cellulose/silica composite, making it a cost-effective and environmentally friendly alternative for water remediation.
CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Sarah Yahia, Islam A. Khalil, Monira G. Ghoniem, Ibrahim M. El-Sherbiny
Summary: This work aimed to develop a functional spine unit (FSU) replacement using different technologies to mimic the structure and function of the vertebral body (VB) and intervertebral disc (IVD) and treat spinal tuberculosis (TB). 3D-printed scaffolds with different porous patterns were fabricated to replace damaged VB and IVD. The results showed excellent mechanical strength and biocompatibility of the custom-designed replacements, along with the expected prolonged release of antibiotics. These findings suggest that this drug-eluting scaffold system could be used for treating various spinal problems.
Article
Pharmacology & Pharmacy
Amira Mansour, Mostafa Fytory, Osama M. Ahmed, Fatema El-Zahraa S. Abdel Rahman, Ibrahim M. El-Sherbiny
Summary: This study developed a novel nanostructure for breast cancer treatment by loading Methotrexate (MTX) and 5-fluorouracil (Fu) into a core-shell nanocarrier. The nanostructure showed high drugs' entrapment efficiency and a pH-responsive drug release pattern. In vitro and in vivo experiments demonstrated the enhanced anticancer effect of the developed nanostructure and its ability to maintain the normal functions of vital organs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Ahmed S. Abo Dena, Mariam Dhaou, Ibrahim M. El-Sherbiny
Summary: In this study, a fluorescent molecularly imprinted polymer (FMIP) was developed for the solid-phase extraction (SPE) and fluorimetric determination of hydrochlorothiazide (HCTZ) in water. The FMIP exhibited high adsorption capacity and selectivity for HCTZ, making it suitable for easy and fast SPE of HCTZ.
Article
Nanoscience & Nanotechnology
Amany A. Aboomeirah, Wessam A. Sarhan, Eman A. Khalil, Ahmed Abdellatif, Ahmed S. Abo Dena, Ibrahim M. El-Sherbiny
Summary: We developed a well-designed single-dose extracellular matrix (ECM)-mimicking nanofibers (NFs)-reinforced hydrogel (HG)-based skin substitute for wound healing. The skin substitute exhibited adjustable mechanical characteristics, outstanding physical properties, and an excellent porous microstructure. In vivo application of the skin substitute demonstrated excellent wound-healing activity and improvement in the quality of the regenerated skin.
ACS APPLIED BIO MATERIALS
(2022)
Article
Materials Science, Biomaterials
Sarah Yahia, Ahmed S. Abo Dena, Rasha M. El Nashar, Ibrahim M. El-Sherbiny
Summary: This study reports the fabrication of a new transdermal patch for delivering varenicline tartrate, a smoking cessation drug. The patch is composed of nanomicelles-in-coaxial nanofibers structure, which exhibits good release properties and low cytotoxicity.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Said F. Hamed, Ayat F. Hashim, Hoda Abdel Hay, Kamel A. Abd-Elsalam, Ibrahim M. El-Sherbiny
Summary: Omega-3 fatty acids are potential therapeutic agents with antioxidant, nutritional, and health benefits. However, their unsaturated nature makes them susceptible to oxidation, requiring protection in food products. This review discusses the chemistry, natural sources, health benefits, and antimicrobial activity of omega-3 fatty acids. It also highlights the challenges of incorporating omega-3 fatty acids into foods, particularly regarding oxidation, and explores the use of natural polyphenols and different wall materials for microencapsulation. Various encapsulation techniques are also discussed.
EGYPTIAN JOURNAL OF CHEMISTRY
(2022)
