Article
Instruments & Instrumentation
Yao Liu, Yong Zhang, Qiuli Yan, Xueping Zhong, Chunhui Hu
Summary: By using solid dispersion technology, the triblock copolymer PEO-PPO-PEO P188 can make the poorly water-soluble drug paclitaxel exist in an amorphous state, significantly improving its release rate and enhancing its oral bioavailability.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Tuangrat Praphawatvet, Zhengrong Cui, Robert O. Williams III
Summary: This paper provides a comprehensive review of the pharmaceutical applications of thin-film freeze-drying (TFF) powders of small molecule drugs. The unique physical properties of TFF powders facilitate efficient pulmonary delivery and improve dissolution and bioavailability after oral administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Phuong Tran, Jeong-Sook Park
Summary: Dexibuprofen-loaded solid dispersion (SD) was formulated to improve solubility and bioavailability, with results demonstrating excellent potential for the SD formulation as a solution for poorly soluble drug Dexibuprofen.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Phuong Tran, Thu Nhan Nguyen, Jeong-Sook Park
Summary: This study aimed to improve the dissolution and oral bioavailability of celecoxib (CXB) by preparing a co-carrier-based solid dispersion (SD). The CXB-loaded SD formulation consisted of CXB, pol407, Aerosil 200, and Eudragit L100 at a specific weight ratio. The results showed that the optimized CXB-SD had significantly higher dissolution efficiency compared to raw CXB, and its bioavailability was also improved. In conclusion, SDs can enhance the dissolution and oral bioavailability of poorly water-soluble CXB.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Eetu Valkama, Ondrej Haluska, Vesa-Pekka Lehto, Ossi Korhonen, Katja Pajula
Summary: The study demonstrates the feasibility of producing stable amorphous solid dispersions from practically water insoluble drug compounds using freeze-drying method with DMSO solutions. The developed method results in amorphous binary solid dispersions that remain stable at room temperature, suitable for further research purposes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Plant Sciences
Mariana Colombo, Luana Roberta Michels, Helder Ferreira Teixeira, Leticia Scherer Koester
Summary: The poor water solubility of flavonoids is a challenge, but can be improved through the use of solid dispersions (SD). Studies commonly use the solvent evaporation method with polyvinylpyrrolidone as a carrier, and have shown that SD is an excellent alternative to enhance solubility, dissolution, and oral bioavailability of flavonoids.
PHYTOCHEMISTRY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Vishwas P. Pardhi, Keerti Jain
Summary: The study demonstrates that the preparation of BDQN solid dispersions can significantly enhance saturation solubility and in vitro dissolution performance, with TSD showing better stability under accelerated conditions and potential benefits for the treatment of patients with multidrug-resistant tuberculosis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sathish Dharani, Eman M. Mohamed, Tahir Khuroo, Ziyaur Rahman, Mansoor A. Khan
Summary: This study aimed to improve the physicochemical properties and oral bioavailability of dasatinib by using the amorphous solid dispersion approach. The results showed that the ASD formulation significantly increased dissolution and oral bioavailability compared to the physical mixture.
Article
Chemistry, Applied
Peuli Ghosh, Ake Rasmuson, Sarah P. Hudson
Summary: This study investigated the impact of single or combinations of additives on the generation and drying process of nanosuspensions of two poorly water-soluble pharmaceutical ingredients. It was found that using combinations of additives could stabilize the particle size distribution and improve the purity of the dried powder. However, the addition of additives did not significantly affect the dissolution profiles of the powders after freeze-drying.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Article
Food Science & Technology
Tomochika Sogabe, Koichi Ohira, Kiyoshi Kawai
Summary: The study on the effect of polymers on freeze-dried soup found that gelatin enhanced physical strength due to its gel network, and 1% gelatin was identified as a useful physical stabilizer for freeze-dried soup.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2022)
Article
Pharmacology & Pharmacy
Chenhui Wang, Xiaowei Liu, Ruihan Zhao, Meiqing Yang, Wenqian Liu, Qiuyang Dai, Xiaofeng Bao, Yong Chen, Jun Ma
Summary: This study aimed to improve the dissolution and oral bioavailability of chrysin by developing a stable solid dispersion formulation. The optimized solid dispersion showed enhanced dissolution rates and had acceptable stability. In rat models, the solid dispersion of chrysin exhibited stronger antihyperlipidemic effects compared to chrysin raw material.
Article
Biochemistry & Molecular Biology
Eun-Sol Ha, Du Hyung Choi, In-hwan Baek, Heejun Park, Min-Soo Kim
Summary: In this study, amorphous solid dispersions based on Eudragit E/HCl were designed to enhance the dissolution of trans-resveratrol. Experimental results showed that Eudragit E/HCl was the most effective polymer for enhancing the solubility of trans-resveratrol, demonstrating a promising formulation strategy for high-quality health supplements and pharmaceutical products with high oral bioavailability.
Review
Pharmacology & Pharmacy
Aman Gupta, Gourav Paudwal, Rigzin Dolkar, Shaila Lewis, Prem N. Gupta
Summary: The oral route is the preferred method of drug administration due to its advantages such as cost-effectiveness and improved patient compliance. However, poor solubility and low bioavailability are common problems for new molecules in the drug discovery process. Solid dispersion (SD) has been widely used to address these issues and improve drug performance. Various polymers are currently used to prepare SDs for immediate or controlled release, and the choice of polymer and preparation method greatly affects the biological behavior of the SDs.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Review
Polymer Science
Arif Budiman, Annisa Luthfiyah Handini, Mutia Nur Muslimah, Neng Vera Nurani, Eli Laelasari, Insan Sunan Kurniawansyah, Diah Lia Aulifa
Summary: Improving the solubility of anticancer drugs for oral administration is crucial for enhancing their efficacy and safety. Amorphous solid dispersion (ASD) is a promising approach to increase the aqueous solubility and bioavailability of poorly water-soluble drugs. This study summarizes and elucidates the mechanisms and impact of the ASD system on cancer therapy, providing a comprehensive overview and discussion of related issues.
Article
Pharmacology & Pharmacy
Joris Lammens, Niloofar Moazami Goudarzi, Laurens Leys, Gust Nuytten, Pieter-Jan Van Bockstal, Chris Vervaet, Matthieu N. Boone, Thomas De Beer
Summary: The research showed that the spin-freezing rate affects the dried product layer characteristics, with slow spin-freezing resulting in high mass transfer resistance structures, and fast spin-freezing leading to low mass transfer resistance structures.