Article
Pharmacology & Pharmacy
Heba E. Salem, Rasha M. Kharshoum, Heba A. Abou-Taleb, Hanan Osman Farouk, Randa Mohammed Zaki
Summary: Transdermal application of SIM-loaded niosomal gel successfully addressed the low bioavailability issue of simvastatin and achieved higher drug release and transdermal penetration. Experimental validation showed great potential for the topical delivery of simvastatin using this method.
Article
Chemistry, Multidisciplinary
Faiz Ullah, Muhammad Farhan Ali Khan, Nazeer Hussain Khan, Muhammad Fayyaz Rehman, Syed Sakhawat Shah, Muhammad Mustaqeem, Sami Ullah, Qidi Zhang, Hongchao Shi
Summary: A biodegradable nanocarrier was designed to enhance the effectiveness of simvastatin in treating hyperlipidemia and bypass its metabolism in the gastrointestinal tract. The optimized formulation showed favorable properties, and the transdermal hydrogel exhibited sustained release.
Article
Engineering, Biomedical
Ashish Kumar Garg, Balaji Maddiboyina, Mohammed Hamed Saeed Alqarni, Aftab Alam, Hibah M. Aldawsari, Pinki Rawat, Sima Singh, Prashant Kesharwani
Summary: The study formulated a niosomal gel of Luliconazole to improve its bioavailability, which showed stable release profiles and good biocompatibility.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Biotechnology & Applied Microbiology
Yuanyuan Jin, Da Liu, Zhen Lu, Lubing Yang, Jiangli Chen, Xuyan Zhou, Zhidong Qiu, Ye Jin
Summary: Ginsenosides, the bioactive compounds of ginseng, were formulated into GSLs and GSNs to enhance transdermal absorption efficiency. Results showed that GSL-7 exhibited higher anti-photoaging effects compared to GSN-4 and GS, indicating its potential for skin tissue repair and reduction of UV-induced skin aging.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Syed Sarim Imam, Sultan Alshehri, Mohammad A. Altamimi, Afzal Hussain, Khaled Hamad Alyahya, Wael A. Mahdi, Wajhul Qamar
Summary: Luteolin-loaded nanovesicles were successfully prepared using the solvent evaporation method, showing nanometric size, optimum polydispersibility index, and negative zeta potential. These nanovesicles exhibited enhanced drug release and permeation properties, with significant variations in encapsulation efficiency depending on the composition. The antioxidant activity of LT-NVs was superior to pure luteolin, and cytotoxicity studies showed a lower IC50 value, suggesting their potential as a natural alternative for lung cancer treatment.
Article
Pharmacology & Pharmacy
Kevin Ita, Monica Ukaoma
Summary: Most antimigraine drugs are administered orally, but this has limitations including low bioavailability. Transdermal drug delivery provides an alternative method, but obstacles exist. Chemical and physical techniques are being explored to enhance skin permeability and improve the delivery of antimigraine drugs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Multidisciplinary
Mohammad Javed Ansari, Mohammed F. Aldawsari, Ameeduzzafar Zafar, Alireza Soltani, Mohd Yasir, Mohammed Asadullah Jahangir, Mohamad Taleuzzaman, Vahid Erfani-Moghadam, Leila Daneshmandi, Nosrat O. Mahmoodi, Asieh Yahyazadeh, Md Lutfor Rahman, Mohd Sani Sarjadi
Summary: Two different nanoformulations, LTSP micellar/liposomal and TSP micellar/niosomal, were prepared using the thin-film hydration method. These nanoformulations showed potential for delivering SSZ, improving its bioavailability, and exhibited increased cell toxicity.
ALEXANDRIA ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Ahmed Al Saqr, Manjusha Annaji, Ishwor Poudel, Shivani Rangari, Sai H. S. Boddu, Amit K. Tiwari, R. Jayachandra Babu
Summary: Hydroxytyrosol (HT), a natural polyphenol from the olive plant, has various beneficial properties such as antioxidant, cardioprotective, neuroprotective, and anti-inflammatory effects. This study aimed to enhance the skin permeation of HT through the use of a niosome gel formulation. The niosome formulations showed controlled release of HT and increased skin retention compared to HT solutions, with the presence of lecithin further enhancing the retention.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Yuehong Ren, Linghui Nie, Shiping Zhu, Xingwang Zhang
Summary: This article explores the significance of oral drug delivery and the role of nanovesicles in enhancing bioavailability. The study discusses the classification, preparative processes, intestinal transport mechanisms, in vivo fate, and design rationale of nanovesicles. By encapsulating drugs in nanoscale vesicles, the efficiency of oral drug delivery can be greatly improved.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Engineering, Biomedical
Ahlam Zaid Alkilani, Batool Musleh, Rania Hamed, Lubna Swellmeen, Haneen A. Basheer
Summary: This study aimed to design transdermal patch-embedded niosomes loaded with clarithromycin (CLR) to overcome its gastrointestinal tract side effects and bitter taste. The niosomal patch showed higher permeability coefficient and better antibacterial activity compared to conventional patch, indicating its potential as a promising method for transdermal drug delivery.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Pharmacology & Pharmacy
Ahlam Zaid Alkilani, Jehad Nasereddin, Rania Hamed, Sukaina Nimrawi, Ghaid Hussein, Hadeel Abo-Zour, Ryan F. Donnelly
Summary: Transdermal drug delivery (TDD) is a non-invasive approach that is convenient and easy to use, especially for vulnerable age groups. However, its applicability is limited to drugs with specific physicochemical properties due to the barrier posed by the skin. Various techniques, including chemical and passive methods, have been investigated to enhance drug permeability across the skin. Hybrid approaches combining chemical penetration enhancement technologies with physical technologies are also being intensely researched.
Review
Biochemistry & Molecular Biology
Bwalya A. Witika, Kokoette E. Bassey, Patrick H. Demana, Xavier Siwe-Noundou, Madan S. Poka
Summary: This review provides a comprehensive summary of the research on niosomes, including their preparation methods, characteristics, and applications in drug delivery. Niosomes, as a type of nanocarrier, have shown great potential for effective drug delivery and offer advantages over liposomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Sirikwan Sangboonruang, Natthawat Semakul, Sureeporn Suriyaprom, Kuntida Kitidee, Jiaranai Khantipongse, Sorasak Intorasoot, Chayada Sitthidet Tharinjaroen, Usanee Wattananandkul, Bordin Butr-Indr, Ponrut Phunpae, Khajornsak Tragoolpua
Summary: This study developed a niosome-based drug delivery platform for ethanolic extract of propolis (EEP) to target Mycobacterium tuberculosis (Mtb). The platform showed antimycobacterial activity and no toxicity on alveolar macrophages.
Article
Pharmacology & Pharmacy
Ali M. Nasr, Fayrouz Moftah, Mohammed A. S. Abourehab, Shadeed Gad
Summary: This study successfully formulated valsartan ethosomes for sustained release transdermal gel dosage form. The optimized VLT-ETHs showed nanometric size, negative surface charge, and high drug encapsulation, resulting in enhanced bioavailability. In vivo studies demonstrated sustained release of VLT from the ethosomal gel in rats.
Review
Biochemistry & Molecular Biology
Parthasarathi Subramanian
Summary: It is important to utilize lipid-based nanocarriers for improved absorption and stability of nutraceuticals. Enhancing bioavailability and stability through the use of lipid nanoparticles is essential for maximizing the benefits of nutraceuticals.
Article
Pharmacology & Pharmacy
Mohammed W. Al-Rabia, Nabil A. Alhakamy, Waleed Y. Rizg, Adel F. Alghaith, Osama A. A. Ahmed, Usama A. Fahmy
Summary: This study fabricated SV-conjugated CUR phytosomes and demonstrated their effective anti-cancer properties against human prostatic cancer PC3 cells. CUR-PL-SV induced cell cycle arrest, apoptosis, and necrosis, while also regulating gene expression and reducing mitochondrial permeability, highlighting its potential as a novel treatment approach for prostate cancer.
Article
Pharmacology & Pharmacy
Nabil A. Alhakamy, Giuseppe Caruso, Anna Privitera, Osama A. A. Ahmed, Usama A. Fahmy, Shadab Md, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Basma G. Eid, Ashraf B. Abdel-Naim, Filippo Caraci
Summary: Impaired diabetic wound healing is a global concern for healthcare professionals. This study developed a fluoxetine ecofriendly nanoemulsion (FLX-EFNE) and demonstrated its significant efficacy in promoting wound healing in diabetic rats.
Article
Pharmacology & Pharmacy
Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Nabil A. Alhakamy, Usama A. Fahmy, Osama A. A. Ahmed, Thikryat Neamatallah, Singkome Tima, Raghad H. Almaghrabi, Fayda M. Alkudsi, Asmaa A. Alamoudi, Amjad A. Alzahrani, Sabna Kotta, Omar D. Al-hejaili
Summary: This study optimized SMV-SPNs using a combined mixture-process variable design to minimize particle size and maximize zeta potential, leading to enhanced anticancer activity. The optimized spanlastics showed significantly improved cytotoxicity against three different cancer cell lines, indicating the potential of SMV-SPNs as an ideal strategy to combat cancer.
Review
Biochemistry & Molecular Biology
Omar Fahmy, Osama A. A. Ahmed, Mohd Ghani Khairul-Asri, Nabil A. Alhakamy, Waleed S. Alharbi, Usama A. Fahmy, Mohamed A. El-Moselhy, Claudia G. Fresta, Giuseppe Caruso, Filippo Caraci
Summary: The combination of durvalumab and tremelimumab has a higher risk of treatment discontinuation, mortality, fever, diarrhea, rash, pruritis, and reduced appetite compared to durvalumab monotherapy. This information is crucial for patients enrolled in clinical trials involving this combined therapy.
Article
Biology
Nabil Abdulhafiz Alhakamy, Gamal Abdallah Mohamed, Usama Ahmed Fahmy, Basma Ghazi Eid, Osama Abdelhakim Aly Ahmed, Mohammed Wanees Al-Rabia, Amgad Ibrahim Mansour Khedr, Mohammed Zahid Nasrullah, Sabrin Ragab Mohamed Ibrahim
Summary: Two new benzophenones were purified from the pericarps fraction of Garcinia mangostana and showed significant alpha-amylase inhibitory activity. Docking studies and molecular dynamics simulations further confirmed their potential as alpha-amylase inhibitors.
Article
Pharmacology & Pharmacy
Hussam Murad, Osama Ahmed, Thamer Alqurashi, Mostafa Hussien
Summary: The self-microemulsifying drug delivery system of olmesartan medoxomil (OMS) was found to have better anti-inflammatory, antioxidant, and anti-apoptotic effects in TNBS-induced acute colitis in rats compared to olmesartan medoxomil alone.
Article
Pharmacology & Pharmacy
Hani Z. Asfour, Nabil A. Alhakamy, Usama A. Fahmy, Osama A. A. Ahmed, Waleed Y. Rizg, Raed Felimban, Ashraf B. Abdel-Naim, Mohammad A. S. Abourehab, Rasha A. Mansouri, Ulfat M. Omar, Shaimaa M. Badr-Eldin
Summary: This study developed a nanosphere formula to improve the bioavailability of Icariin (ICA) using nanotechnology. By optimizing the formulation of the nanospheres, the desired particle size, zeta potential, and drug entrapment efficiency were achieved. Animal experiments showed that the optimized nanospheres significantly enhanced sexual behavior. The results suggest that ICA-tocozeinolate nanospheres have the potential to improve drug delivery and efficacy.
Article
Chemistry, Medicinal
Mohammed Z. Nasrullah, Khalid Eljaaly, Thikryat Neamatallah, Usama A. Fahmy, Abdulmohsin J. Alamoudi, Hussain T. Bakhsh, Ashraf B. Abdel-Naim
Summary: The concomitant administration of omeprazole significantly reduces colistin-induced nephrotoxicity in rats by preventing abnormal elevation of renal biomarkers, reducing histopathological changes, and inhibiting oxidative stress and inflammation. Omeprazole also prevents the toxic accumulation of colistin in kidneys.
Article
Biology
Abdullah A. Alamoudi, Awaad S. Alharbi, Ashraf B. Abdel-Naim, Shaimaa M. Badr-Eldin, Zuhier A. Awan, Solomon Z. Okbazghi, Osama A. A. Ahmed, Nabil A. Alhakamy, Usama A. Fahmy, Ahmed Esmat
Summary: Diabetic hyperglycemia delays wound healing, but the ion-paired CTX-APA nanocomplex can promote wound healing in diabetic rats.
Article
Biochemistry & Molecular Biology
Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Usama A. Fahmy, Osama A. A. Ahmed, Nabil A. Alhakamy, Omar D. Al-hejaili, Alhanoof A. Alhassan, Ghadeer A. Ammari, Shouq I. Alhazmi, Raghad M. Alawadi, Rana Bakhaidar, Abdulmohsen J. Alamoudi, Thikryat Neamatallah, Singkome Tima
Summary: Ellagic acid has been studied for its potential in preventing and treating cancer. In this study, APA-functionalized emulsomes were used to enhance the cytotoxic activity of ellagic acid against breast cancer cells, resulting in significant inhibition of cell growth and induction of apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Salwa D. Al-Qahtani, Hawazen H. Bin-Melaih, Eman M. Atiya, Usama A. Fahmy, Lenah S. Binmahfouz, Thikryat Neamatallah, Fahad A. Al-Abbasi, Ashraf B. Abdel-Naim
Summary: The optimized 2ME self-nanoemulsifying drug delivery system (2ME-SNEDDS) showed significant enhancement of cytotoxicity and pro-apoptotic activities in MCF-7 breast cancer cells, potentially mediated by the generation of reactive oxygen species (ROS).
Article
Biochemistry & Molecular Biology
Mohsen G. Alrashedi, Ahmed Shaker Ali, Osama Abdelhakim Ahmed, Ibrahim M. Ibrahim
Summary: Humanity has been severely affected by the COVID-19 pandemic, resulting in millions of deaths. Azithromycin, an antibiotic, has shown antiviral activity against various viruses, including SARS-CoV-2. The use of nanotechnology to deliver azithromycin directly to the lungs could improve its efficacy and reduce potential side effects.
Article
Multidisciplinary Sciences
Mohamed A. Alfaleh, Omar Fahmy, Mohammed W. Al-Rabia, Mohammed A. S. Abourehab, Osama A. A. Ahmed, Usama A. Fahmy, Helal H. Alsulimani, Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Bander M. Aldhabi, Awaad S. Alharbi, Nabil A. Alhakamy
Summary: This study aims to investigate the combination of FLV with MEL loaded hybrid formula of PL with ALA nanoparticles to enhance anticancer tendencies. The optimized formulation showed enhanced cytotoxic potential and inhibited colon cancer cells more significantly compared to other therapeutic treatments.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Waleed S. Alharbi, Rawan H. Hareeri, Mohammed Bazuhair, Mohamed A. Alfaleh, Nabil A. Alhakamy, Usama A. Fahmy, Abdullah A. Alamoudi, Shaimaa M. Badr-Eldin, Osama A. Ahmed, Shareefa A. AlGhamdi, Marianne J. Naguib
Summary: This study aimed to develop an intranasal formulation of flibanserin using nanotechnology to overcome the limitations of oral administration. The optimized formulation showed improved bioavailability and brain delivery compared to the raw drug.