Article
Chemistry, Physical
David M. Klein, Albert Poortinga, Frank M. Verhoeven, Daniel Bonn, Sylvestre Bonnet, Cees J. M. van Rijn
Summary: The study found that vibrating mesh nebulizers cause model liposomes to release over ten times more encapsulated material than continuous jet nebulizers. This highlights the importance of using a gentle nebulization technology when administering shear-sensitive lipid nanoparticle drugs to the lungs.
Article
Pharmacology & Pharmacy
Katarzyna Dobrowolska, Andrzej Emeryk, Kamil Janeczek, Radoslaw Krzosa, Michal Pirozynski, Tomasz R. Sosnowski
Summary: The physicochemical properties of micronized steroid suspensions have a weak influence on droplet size distribution and aerosol deposition, but affect the conversion of the drug to inhalable aerosol. The maximum inhaled dose of budesonide is below 80-90% of the label dose, depending on the formulation. This study highlights the sensitivity of nebulization in vibrating mesh nebulizers to minor dissimilarities among generic pharmaceuticals and discusses their potential clinical relevance.
Article
Pharmacology & Pharmacy
Lucila Garcia-Contreras, Vasu Sethuraman, Masha Kazantseva, Anthony Hickey
Summary: The study found that the combination of rifampicin liposomes (RLs) and rifampicin microparticles (RMs) with liposomes can enhance the permeation of rifampicin into granulomas. RLs delivered via the pulmonary route showed more significant reduction in lung bacterial burden and spleen weight in TB-infected guinea pigs compared to other treatment groups.
Article
Biotechnology & Applied Microbiology
Sadegh Niazi, Lisa K. Philp, Kirsten Spann, Graham R. Johnson
Summary: Laboratory-generated bioaerosols are widely used in studying virus transmission. In this study, we compared the performance of different nebulizers in aerosol production and virus survival. The results showed that while the hydraulic spray atomizer had the least impact on influenza viruses, the vibrating mesh nebulizer had the least impact on human rhinovirus.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nehal E. E. Sayed, Mona A. Abdelrahman, Mohamed E. A. Abdelrahim
Summary: This study evaluated the effect of functional principle, delivery technique, and connection on aerosol delivered from nebulizers. The results showed that vibrating mesh nebulizers are significantly better than jet nebulizers, and intermittent delivery has a better total emitted dose compared to continuous delivery. Holding chamber with both vibrating mesh nebulizers and jet nebulizers improved aerosol delivery compared to standard T-piece.
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Andrew Arnott, Robert Hart, Scott McQueen, Malcolm Watson, Malcolm Sim
Summary: This study aims to compare the viscosity of respiratory secretions after treatment with nebulised normal saline administered via vibrating mesh nebuliser or jet nebuliser. Sixty mechanically ventilated adult critical care patients with high secretion loads will be enrolled and randomised into three groups to receive different treatment modalities. The results will provide information for a definitive clinical study.
Article
Instruments & Instrumentation
Shruti S. Sawant, Suyash M. Patil, Snehal K. Shukla, Nishant S. Kulkarni, Vivek Gupta, Nitesh K. Kunda
Summary: Inhalable OB liposomes were developed to limit systemic toxicity and locally accumulate at tumor sites. Active loading of OB into liposomes resulted in higher cytotoxicity and potential for inhibiting lung cancer growth compared to passive loading methods.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Medicine, General & Internal
Haijia Hou, Dongyang Xu, Bing Dai, Hongwen Zhao, Wei Wang, Jian Kang, Wei Tan
Summary: This study investigated the effect of different types and positions of nebulizers on aerosol delivery efficiency during adult mechanical ventilation. The results showed that the type and position of the nebulizer had an impact on aerosol delivery efficiency, but there were no significant differences between different ventilators.
FRONTIERS IN MEDICINE
(2022)
Article
Instruments & Instrumentation
Annalisa Bianchera, Viviana Vilardo, Roberta Giaccari, Annalisa Michielon, Gianluca Bazzoli, Francesca Buttini, Marina Aiello, Alfredo Chetta, Stefano Bruno, Ruggero Bettini
Summary: Two nebulizers, a jet and a mesh vibrating system, were compared in terms of performance and effectiveness for delivering alpha-1 antitrypsin (AAT) to the lungs. The mesh nebulizer demonstrated higher efficiency in drug delivery, with preserved protein activity and conformation. Nebulization of AAT is a suitable administration strategy for AATD patients, either as a support therapy or for preventive purposes.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Ramy Said-Elbahr, Maha Nasr, Mohamed A. Alhnan, Ismail Taha, Omaima Sammour
Summary: This study demonstrates that nanoemulsion is a promising nebulizable system, which can be used for the treatment of lung diseases other than lung cancer.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Pharmacology & Pharmacy
Luciana Alcoforado, Dulciane Nunes Paiva, Arzu Ari, Jacqueline de Melo Barcelar, Simone Cristina Soares Brandao, James B. Fink, Armele Dornelas de Andrade
Summary: This study compared the pulmonary deposition of a jet nebulizer (JN) and a mesh nebulizer (MN) with and without a valved holding chamber (VHC) in a randomized cross-over trial. The results showed that using a VHC significantly increased pulmonary deposition for the JN, while the MN with VHC had the highest pulmonary deposition. However, the addition of a VHC did not substantially improve the efficiency of aerosol lung deposition for the JN alone.
Review
Biochemistry & Molecular Biology
Ho Ying Low, Chang-Tong Yang, Bin Xia, Tao He, Winnie Wing Chuen Lam, David Chee Eng Ng
Summary: Quantitative nuclear imaging techniques are in high demand for disease diagnostics and cancer theranostics. Liposomal radiotracers have been rapidly developing as novel nuclear imaging probes, with their physicochemical properties and structural characteristics addressed for stability and specific targeting. Various radionuclide labeling methods have been summarized to obtain radiolabeled liposomes for in vivo biodistribution and targeting studies.
Article
Multidisciplinary Sciences
Yoann Montigaud, Quentin Georges, Lara Leclerc, Anthony Clotagatide, Aurore Louf-Durier, Jeremie Pourchez, Nathalie Prevot, Sophie Perinel-Ragey
Summary: The success of aerosol therapy in mechanically ventilated patients relies on various factors, including the position of the nebulizer in the ventilator circuit and the humidification of inhaled gases. A preclinical study was conducted to evaluate the impact of gas humidification and nebulizer position on aerosol deposition and losses in the lungs during invasive mechanical ventilation. The study found that the optimal nebulizer position is proximal before the Y-piece adapter, resulting in a higher lung dose compared to positions next to the ventilator. Dry conditions are more likely to cause peripheral deposition of aerosols in the lungs. However, interrupting gas humidification efficiently and safely in clinical use is challenging.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Dorde Cvjetinovic, Zeljko Prijovic, Drina Jankovic, Magdalena Radovic, Marija Mirkovic, Zorana Milanovic, Milos Mojovic, Sani Skalamera, Sanja Vranjes-Duric
Summary: The use of glucose-modified liposomes (GML) enhances the delivery of drugs to tumor cells through glucose transporters, resulting in significantly better accumulation in tumor tissues compared to non-glucose liposomes (NGL). This study demonstrates the potential for GML in targeted cancer therapy using radiotracking for biodistribution studies.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Alexie Mayor, Beatrice Thibert, Sylvain Huille, Fethi Bensaid, Renaud Respaud, Heloise Audat, Nathalie Heuze-Vourc'h
Summary: In the past decade, oral inhalation has been a popular research topic for direct treatment of respiratory diseases. The formulation of inhaled antibodies plays a crucial role in their stability and lung safety. This study reveals the significant impact of the buffering system on the stability of monoclonal antibodies during nebulization.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Sandra Sherif Amer, Wael Mamdouh, Maha Nasr, Amr ElShaer, Elena Polycarpou, Rasha T. A. Abdel-Aziz, Omaima A. Sammour
Summary: This study successfully developed composite nanofibers of polyvinyl alcohol/quercetin/essential oils with significant antibacterial efficacy against Propionibacterium acne, showing promising results in reducing acne lesions in patients.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Dalia O. Saleh, Maha Nasr, Azza Hassan, Sally A. El-Awdan, Gehad A. Abdel Jaleel
Summary: The aim of this study was to investigate the therapeutic effects of curcumin nanoemulsion (NC) on cerebral damage in diabetic rats. The results showed that NC treatment reduced neurological deficit and redox imbalance, decreased inflammation and apoptosis, and restored glucose transporter 1 expression in the brain.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Maha Nasr, Hend Abd-Allah, Omar A. H. Ahmed-Farid, Rofanda M. Bakeer, Nabila S. Hassan, Rania F. Ahmed
Summary: Curcumin nanoemulsion can effectively mitigate the adverse effects of a high-fat high-fructose diet on spermatogenesis, improving sperm production and regulating blood, oxidative, and nitrosative parameters.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Robert M. Frederickson, Thomas Ritter, Kevin Morris, Marcin Kortylewski, Maha Nasr, Roland W. Herzog
Article
Chemistry, Medicinal
Sara Zaher, Mahmoud E. Soliman, Mahmoud Elsabahy, Rania M. Hathout
Summary: In this study, sesamol-loaded albumin nanoparticles showed a better protective effect against oxidative stress induced by anthracyclines. The nanoparticles were prepared using the desolvation technique and freeze-dried with trehalose as a cryoprotectant. The optimized nanoparticles had a spherical shape, smaller particle diameter, longer half-life, and mean residence time compared to the free drug. In vivo experiments demonstrated that the sesamol-loaded albumin nanoparticles significantly ameliorated biochemical markers and histopathological changes.
Article
Medicine, Research & Experimental
Eman A. Bseiso, Sarah A. Abd El-Aal, Maha Nasr, Omaima A. Sammour, Nabaweya A. Abd El Gawad
Summary: This study successfully developed MEL-loaded polymeric nanocapsules (MEL-PNCs) and investigated their potential in neuroprotection in a rat model of cerebral ischemia reperfusion injury. The MEL-PNCs showed good drug release and permeation properties, and demonstrated a significant reduction in oxidative stress and inflammation caused by cerebral ischemia, leading to the restoration of hippocampal neurons.
Article
Pharmacology & Pharmacy
Rania F. Ahmed, Maha Nasr, Marawan Abd Elbaset, Alyaa Farouk Hessin, Omar A. H. Ahmed-Farid, Nermeen M. Shaffie, Marwa E. Shabana
Summary: The study indicated that branched chain amino acids loaded nanoliposomes could be a new strategy in preventing the adverse effects of cisplatin.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Maria B. Sokol, Margarita Chirkina, Nikita G. Yabbarov, Mariia R. Mollaeva, Tatyana A. Podrugina, Anna S. Pavlova, Viktor V. Temnov, Rania M. Hathout, Abdelkader A. Metwally, Elena D. Nikolskaya
Summary: In this study, a combination of molecular dynamics simulation and in vitro experiments was used to improve the design of polymer-based nanoparticles for cancer treatment. The results showed that nanoparticles loaded with novel carboplatin derivatives exhibited high antitumor activity and hemocompatibility, indicating the potential for optimizing encapsulation and antitumor efficacy in drug delivery system design.
Article
Pharmacology & Pharmacy
Abdullah El-Kholy, Maha Fadel, Maha Nasr, Ibrahim El-Sherbiny, Abeer Tawfik, Yasser O. Mosaad, Doaa Abdel Fadeel
Summary: This study introduces a new protocol for managing Hidradenitis Suppurativa using the synergistic photodynamic and photothermal effect of Eosin Yellow-Gold-Polypyrrole hybrid nanoparticles. The study shows promising results in improving the lesions and demonstrates good tolerance and safety.
Article
Pharmacology & Pharmacy
Mai Mansour, Maha Nasr, Omar A. H. Ahmed-Farid, Rania F. Ahmed
Summary: This study demonstrated that ondansetron microemulsion, administered via the nasal or oral route, can alleviate the adverse effects of cisplatin chemotherapy. The nasal administration of ondansetron microemulsion showed superior effects compared to oral administration.
PHARMACOLOGICAL REPORTS
(2023)
Article
Psychology, Clinical
Ryan Ahmed, Brian D. Boyd, Damian Elson, Kimberly Albert, Patrick Begnoche, Hakmook Kang, Bennett A. Landman, Sarah M. Szymkowicz, Patricia Andrews, Jennifer Vega, Warren D. Taylor
Summary: This study found that clinical improvement in late-life depression is associated with functional connectivity in intrinsic brain networks, particularly in the default mode, cognitive control, and limbic networks. Future research should focus on clinical markers of network connectivity informing prognosis.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Rania M. Hathout, Eman M. El-Marakby
Summary: The intranasal route is a highly promising route for drug delivery to the brain, but also one of the most difficult and complex. Scientists are continuously searching for new drug delivery vehicles, and in this study, the superiority of nanocarriers, with lipid nanoparticles in particular, was confirmed.
BIOENGINEERING-BASEL
(2022)
Article
Pharmacology & Pharmacy
Merna H. Emam, Reham S. Elezaby, Shady A. Swidan, Samah A. Loutfy, Rania M. Hathout
Summary: In this study, cerium oxide nanoparticles were successfully incorporated into polyacrylonitrile nanofibers for the fabrication of antiviral filters. These nanofibers showed excellent bacterial filtration efficiency and were non-toxic to cells. Furthermore, the cerium oxide nanoparticles exhibited antiviral activity. Therefore, this nanofiber can effectively reduce virus transmission.
Article
Pharmacology & Pharmacy
Dina Mahmoud Abd-Alaziz, Mai Mansour, Maha Nasr, Omaima A. Sammour
Summary: A novel vesicular system, spanethosomes, was developed by introducing ethanol into spanlastics, showing improved drug encapsulation efficiency, drug release, and cellular uptake compared to spanlastics.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Medicinal
Sara Barakat, Maha Nasr, Rania F. Ahmed, Sabry Badawy, Nahed Mortada
Summary: Nutraceuticals have shown valuable contributions in disease treatment, but their efficacy is limited by poor solubility. Delivery carriers can overcome these limitations and improve their pharmacological effects.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)