Journal
DRUG DELIVERY
Volume 17, Issue 2, Pages 83-91Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10717540903509019
Keywords
Sumatriptan; transdermal system; poliyvinyl alcohol; Azone (R); bioadhesion
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Funding
- Fondo de Investigaciones Sanitarias (Ministerio de Sanidad y Consumo) [PI 060108]
- Universidad CEU Cardenal Herrera
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The aim of the present study was to develop a sumatriptan succinate transdermal system for applying migraine treatments efficiently and easily. For this system polyvinyl alcohol was employed as a matrix and Azone (R) was added as a permeability enhancer. The physical characteristics, mechanical properties, and in vivo bioadhesion of the systems were evaluated, as was in vitro permeation across porcine skin. A uniform distribution of the drug in the matrix was observed, and moisture uptake values were constant. With regard to mechanical parameters, occlusive layer inclusion made the system more resistant, and no significant differences were detected with respect to other systems. Although Azone (R) reduced the bioadhesivity of the systems, adherence to skin was maintained 24 h after application. Permeation studies showed that the systems formulated with Azone (R) provided the highest permeability profiles for sumatriptan succinate.
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