Journal
DRUG DELIVERY
Volume 17, Issue 3, Pages 103-113Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10717540903548447
Keywords
Plumbagin; chitosan; microspheres; pharmacokinetics; pharmacodynamics
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Funding
- Indian Council of Medical Research (ICMR), New Delhi, India [200500150]
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The present study was aimed to evaluate the anti-tumor efficacy and systemic toxicity of chitosan-based plumbagin microspheres in comparison to free plumbagin. The optimized formulation had a mean particle size of 106.35 mu m with an encapsulation efficiency of 80.12%. Pharmacokinetic studies showed a 22.2-fold increase in elimination half-life (t(1/2)) of plumbagin from chitosan microspheres as compared to free plumbagin. Administration of plumbagin microspheres resulted in a significant tumor growth inhibition and reduced systemic toxicity. These results suggest that chitosan-based microspheres could be a promising strategy for the systemic delivery of anti-cancer agents like plumbagin.
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