4.7 Article

A novel polymethylmethacrylate hydrophilic adhesive matrix intended for transdermal patch formulations

Journal

DRUG DELIVERY
Volume 17, Issue 3, Pages 171-177

Publisher

TAYLOR & FRANCIS INC
DOI: 10.3109/10717541003667772

Keywords

Poly(sodium methacrylate; methylmethacrylate) (PMM); pressure sensitive adhesive (PSA); texture analysis; lidocaine; full factorial design

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A novel poly(sodium methacrylate, methylmethacrylate) hydrophilic pressure sensitive adhesive (PSA) containing a large amount of water was designed. The effects of PEG400, glycerin, sorbitol, and/or NaCl on the in vitro and in vivo adhesive properties were investigated by means of a 2

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