Journal
DRUG DELIVERY
Volume 15, Issue 7, Pages 409-416Publisher
INFORMA HEALTHCARE
DOI: 10.1080/10717540802321727
Keywords
drug delivery system; nanoparticle; polycaprolactone/poly(ethylene glycol)/polycaprolactone; protein drug
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Biodegradable polyetherester copolymer (PCL/PEG/PCL, PCEC) was synthesized by ring-opening polymerization of -caprolactone initiated by poly(ethylene glycol) (PEG). The PCEC nanoparticles were prepared by solvent diffusion method or w/o/w double emulsion method. The obtained particles' morphology was observed on scanning electron microscopy, and the particle size distribution was determined using Malvern laser particle sizer. Bovine serum albumin was used as the model water-soluble protein drug, which was successfully encapsulated in PCEC nanoparticles, the drug release behavior was studied in detail. The hydrolytic degradation behavior of the PCEC nanoparticles was also studied.
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