Article
Environmental Sciences
Bin Yang, Haiyan Cui, Jie Gao, Jing Cao, Goran Klobucar, Mei Li
Summary: Bioassays were conducted to evaluate the toxic effects of pollutants in water, in addition to physico-chemical water quality evaluation. The study assessed the environmental health risks of industrial wastewater along the Yangtze River in China using a battery of bioassays. The results showed effective wastewater treatment processes in reducing various toxicities, and identified polycyclic aromatic hydrocarbons as potential major toxic chemicals of concern.
Article
Environmental Sciences
Tuukka Ihantola, Maija-Riitta Hirvonen, Mika Ihalainen, Henri Hakkarainen, Olli Sippula, Jarkko Tissari, Stefanie Bauer, Sebastiano Di Bucchianico, Narges Rastak, Anni Hartikainen, Jani Leskinen, Pasi Yli-Pirila, Maria-Viola Martikainen, Mirella Miettinen, Heikki Suhonen, Teemu J. Ronkko, Miika Kortelainen, Heikki Lamberg, Hendryk Czech, Patrick Martens, Juergen Orasche, Bernhard Michalke, Ali Oender Yildirim, Jorma Jokiniemi, Ralf Zimmermann, Pasi Jalava
Summary: The study compared the toxicological responses of spruce and brown coal combustion aerosols on human alveolar epithelial cells, showing both aerosols causing cytotoxic and genotoxic effects on the cells.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Environmental Sciences
Gabriel Souza-Silva, Clessius Ribeiro de Souza, Cintia Aparecida de Jesus Pereira, Walter Dos Santos Lima, Marcos Paulo Gomes Mol, Micheline Rosa Silveira
Summary: This study conducted a systematic review of the use of Biomphalaria glabrata as a biological model for ecotoxicological studies in aquatic environments contaminated with human pollutants. Several assays were performed to assess the toxicity, embryotoxicity, cytotoxicity, genotoxicity, and bioaccumulation of various substances using B. glabrata. The findings highlight the importance of using this species as a representative model for tropical environmental monitoring and call for further standardization of the model.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yulin Sun, Hongjuan Wang, Huan Chen, Sen Zhang, Jun Li, Jingni Zhang, Jianlu Tian, Youyu Zhang, Hongwei Hou, Qingyuan Hu
Summary: This study investigated the effects of nicotine on the cytotoxicity and genotoxicity of NNK using BEAS-2B cells expressing CYP2A13. The results showed that CYP2A13 caused cytotoxicity and genotoxicity of NNK in BEAS-2B cells, and the addition of nicotine could inhibit the toxicity of NNK.
Article
Biochemistry & Molecular Biology
Asiye Beytur, Cigdem Tekin, Eray Caliskan, Suat Tekin, Kenan Koran, Ahmet Orhan Gorgulu, Suleyman Sandal
Summary: In this study, hetero ring hexasubstituted cyclotriphosphazes were synthesized and investigated for their in vitro cytotoxicity and genotoxicity. The results showed that these compounds have cytotoxic effects against cancer cells and suggested that these effects have occurred through genotoxicity.
BIOORGANIC CHEMISTRY
(2022)
Article
Engineering, Environmental
Qian-Yuan Wu, Lu-Lin Yang, Ye Du, Zi-Fan Liang, Wen-Long Wang, Zhi-Min Song, De-Xiu Wu
Summary: This study found that ozonation of wastewater generates various toxic byproducts, with formaldehyde contributing the most to cytotoxicity and genotoxicity in the absence of bromide. However, ozonation generally increases the overall toxicity of wastewater, especially when bromide is present.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Review
Engineering, Environmental
Ashiq Ahamed, Lili Liang, Ming Yang Lee, Johan Bobacka, Grzegorz Lisak
Summary: Engineered nanomaterials (ENMs) are a novel class of materials with superior physicochemical properties compared to conventional materials, but can potentially release into the environment and pose toxic effects. Research focuses on the transformations and potential risks of ENMs in consumer products, aiming to ensure their safe application.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Yin Lu, Qin Ma, Xiaolu Xu, Zhefu Yu, Tianjiao Guo, Yangkai Wu
Summary: The study showed that exposure to poly styrene microplastics (PS-MPs) can lead to increased apoptosis and cell death, higher micronucleus rate, and reduced mitotic index in V. faba root cells. Additionally, it causes significant oxidative stress by altering the expression of antioxidant enzymes and genes related to cell cycle and DNA repair.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Anjali Vijeata, Savita Chaudhary, Ganga Ram Chaudhary, Ahmad Umar, Sotirios Baskoutas
Summary: This study evaluates the uptake, translocation, and phytotoxicity of CQDs on Allium sativum plant and finds that CQDs accumulate more in Allium sativum. The study also suggests that CQDs derived from Aegle marmelos fruit can be used as growth regulators in other food plants.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Ghanya Al-Naqeb, Viktoryia Sidarovich, Donato Scrinzi, Ilaria Mazzeo, Sergio Robbiati, Michael Pancher, Luca Fiori, Valentina Adami
Summary: This study investigated the in vitro genotoxicity and cytotoxicity of hydrochar co-compost (HCO) and its precursors. The results showed that the cytotoxicity of HCO is similar to standard compost, and composting hydrochar from OFMSW digestate is an effective method to eliminate the cytotoxicity of hydrochar.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Environmental Sciences
Iteb Boughattas, Nesrine Zitouni, Marouane Mkhinini, Omayma Missawi, Sondes Helaoui, Sabrine Hattab, Moncef Mokni, Noureddine Bousserrhine, Mohamed Banni
Summary: This study investigated the effects of biochar on earthworms in soil remediation. The results showed that in the presence of biochar, the bioavailability of Cd and 2,4-D increased in earthworms, along with an increase in micronuclei frequency and a decrease in lysosomal membrane stability. Histopathological examination revealed numerous alterations in animals exposed to contaminants without any amelioration when biochar was added. The biochemical response of earthworms demonstrated that in the presence of biochar, animals tended to alleviate the toxicity of Cd and 2,4-D.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Carina Quintanilha da Silva, Andreia da Silva Fernandes, Gabriela Felix Teixeira, Rodrigo Jose Franca, Monica Regina da Costa Marques, Israel Felzenszwalb, Deborah Quintanilha Falca, Elisa Raquel Anastacio Ferraz
Summary: This study evaluated the influence of coffee bean quality and roasting degree on mutagenicity, cytotoxicity and genotoxicity. The results showed that the formation of polycyclic aromatic hydrocarbons during the roasting process can have toxic effects on cells, and different qualities and roast degrees of coffee beans can lead to varying levels of toxicity on cells.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Victor M. Rodrigues, Wogenes N. Oliveira, Daniel T. Pereira, Everton N. Alencar, Dayanne L. Porto, Cicero F. S. Aragao, Susana M. G. Moreira, Hugo A. O. Rocha, Lucas Amaral-Machado, Eryvaldo S. T. Egito
Summary: The aim of this study was to produce and characterize copaiba oil nanocapsules (CopNc) and to evaluate their hemocompatibility, cytotoxicity, and genotoxicity. The results showed that CopNc exhibited suitable stability and physicochemical properties, along with a remarkable safety profile on lung cells. These findings provide a foundation for further utilizing CopNc for the development of phytotherapeutic medicine intended for pulmonary delivery of copaiba oil.
Article
Medicine, Research & Experimental
B. Marciniak, R. Kontek, J. Zuchowski, A. Stochmal
Summary: Low-polarity fractions from sea-buckthorn exhibit strong cytotoxicity against cancer cells, potentially eliminating them through promoting apoptosis and moderate genotoxicity. Triterpenoids play a key role in this process.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Xiaolong Zhan, Zhengbo Wen, Xi Chen, Qi Lei, Yuxin Chen, Liang Zhou, Guansheng Zheng, Fanhui Kong, Jimin Guo, Yuyou Duan, Yuyan Lai, Panchao Yin, C. Jeffrey Brinker, Honglin Chen, Wei Zhu
Summary: In this study, a strategy for dynamic control of nano-scale mineralization processes is proposed, and an all-in-one healing agent is constructed using reversible metal-polyphenol coordination. The strategy promotes various physiological processes in wound healing, such as antibacterial effects, anti-inflammatory effects, angiogenesis, collagen deposition, and hair follicle regeneration.
CELL REPORTS PHYSICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Martha Patricia Gallegos-Arreola, Guillermo Moises Zuniga-Gonzalez, Josefina Yoaly Sanchez-Lopez, Alondra Yeraldi Naranjo Cruz, Valeria Peralta-Leal, Luis Eduardo Figuera, Ana Maria Puebla-Perez, Carlos Alberto Ronquillo-Carreon, Ana Graciela Puebla-Mora
ACTA BIOCHIMICA POLONICA
(2018)
Article
Dentistry, Oral Surgery & Medicine
Jose Francisco Del Real Garcia, Fausto Ruben Saldana-Velasco, Susana Vanessa Sanchez-de la Rosa, Yveth Marlene Ortiz-Garcia, Gabriela Morales-Velazquez, Belinda Claudia Gomez-Meda, Guillermo Moises Zuniga-Gonzalez, Maria Guadalupe Sanchez-Parada, Ana Lourdes Zamora-Perez
CLINICAL ORAL INVESTIGATIONS
(2019)
Article
Biotechnology & Applied Microbiology
Yveth Marlene Ortiz-Garcia, Trinidad Garcia-Iglesias, Gabriela Morales-Velazquez, Blanca Patricia Lazalde-Ramos, Guillermo Moises Zuniga-Gonzalez, Ramon Guillermo Ortiz-Garcia, Ana Lourdes Zamora-Perez
BIOMED RESEARCH INTERNATIONAL
(2019)
Article
Integrative & Complementary Medicine
Gabriela Morales-Velazquez, Blanca Patricia Lazalde-Ramos, Belinda Claudia Gomez-Meda, Guillermo Moises Zuniga-Gonzalez, Yveth Marlene Ortiz-Garcia, Rosalinda Gutierrez-Hernandez, Celia Guerrero-Velazquez, Susana Vanessa Sanchez de la Rosa, Ana Lourdes Zamora-Perez
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Agriculture, Dairy & Animal Science
Eduardo Naranjo-Vazquez, Maria Guadalupe Sanchez-Parada, Belinda Claudia Gomez-Meda, Ana Lourdes Zamora-Perez, Martha Patricia Gallegos-Arreola, Ana Elizabeth Gonzalez-Santiago, Guillermo Moises Zuniga-Gonzalez
Article
Environmental Sciences
Alejandro Solorzano-Melendez, Rodolfo Rodrigo-Alarcoen, Belinda C. Gomez-Meda, Ana L. Zamora-Perez, Ramon G. Ortiz-Garcia, Luis H. Bayardo-Lopez, Roberto Gonzalez-Virgen, Martha P. Gallegos-Arreola, Guillermo M. Zuniga-Gonzalez
Summary: The study showed that lactating rat pups had increased micronucleated erythrocytes in their blood when mothers were irradiated with X-rays, possibly due to the formation of long-lived reactive species in the breast milk. The addition of vitamin C provided some protection in both mother rats and pups exposed to radiation.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2021)
Article
Biotechnology & Applied Microbiology
Ana Elizabeth Gonzalez-Santiago, Guillermo Moises Zuniga-Gonzalez, Belinda Claudia Gomez-Meda, Francisco Javier Gutierrez-Corral, Ana Lourdes Zamora-Perez, Maria Guadalupe Sanchez-Parada
Summary: This study evaluated the cytotoxic and genotoxic effects in healthy young adults exposed to different levels of air pollution using the buccal micronucleus cytome (BMC) assay. Results showed that individuals exposed to higher concentrations of pollutants exhibited increased frequencies of nuclear abnormalities, with significant cytotoxic and genotoxic damage observed in highly contaminated areas compared to less polluted areas.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Juan Ernesto Gutierrez-Sevilla, Jhonathan Cardenas-Bedoya, Martha Escoto-Delgadillo, Guillermo Moises Zuniga-Gonzalez, Alma Minerva Perez-Rios, Belinda Claudia Gomez-Meda, Gracia Viviana Gonzalez-Enriquez, Izchel Figarola-Centurion, Efrain Chavarria-Avila, Blanca Miriam Torres-Mendoza
Summary: The study revealed that individuals living with HIV who receive antiretroviral treatment show increased genomic instability, with the CD4/CD8 ratio affecting the numbers of nuclear buds and binucleated cells. These findings are relevant for understanding mechanisms of damage and potential strategies to reduce carcinogenesis in PLWH.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2021)
Article
Pharmacology & Pharmacy
M. P. Gallegos-Arreola, C. J. Briseno-Zuno, L. E. Figuera, J. Y. Sanchez-Lopez, G. M. Zuniga-Gonzalez, A. M. Puebla-Perez, B. C. Gomez-Meda, H. Montoya-Fuentes, J. I. Delgado-Saucedo
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2020)
Article
Pharmacology & Pharmacy
M. P. Gallegos-Arreola, M. A. Ramirez-Hernandez, L. E. Figuera, G. M. Zuniga-Gonzalez, A. M. Puebla-Perez
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2020)
Article
Oncology
Martha Patricia Gallegos-Arreola, Carlos Jovany Briseno-Zunoi, Luis Eduardo Figuera, Guillermo Moises Zuniga-Gonzalez, Carlos Ivan Perales-Mederos, Ana Maria Puebla-Perez, Monica Alejandra Rosales-Reynoso
Article
Oncology
Martha Patricia Gallegos-Arreola, Guillermo Moises Zuniga-Gonzalez, Luis Eduardo Figuera, Ana Maria Puebla-Perez, Jorge Ivan Delgado-Saucedo
Article
Oncology
Dalia Ivette Carrillo-Moreno, Luis Eduardo Figuera, Guillermo M. Zuniga-Gonzalez, Ana Maria Puebla-Perez, Andres de Jesus Moran-Mendoza, Martha Patricia Gallegos-Arreola
Article
Medicine, Research & Experimental
Martha Patricia Gallegos-Arreola, Guillermo Moises Zuniga-Gonzalez, Karen Gomez-Mariscal, Monica Alejandra Rosales-Reynoso, Luis E. Figuera, Ana Maria Puebla-Perez, Tomas Pineda-Razo
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2019)
Article
Medical Laboratory Technology
Karen Gomez-Mariscal, Belinda C. Gomez-Meda, Ana L. Zamora-Perez, Maria G. Sanchez-Parada, Martha P. Gallegos-Arreola, Guillermo M. Zuniga-Gonzalez
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2018)