Article
Environmental Sciences
Shanhui Tao, Zhiang Yao, Huitao Li, Yiyan Wang, Xinyi Qiao, Yang Yu, Yang Li, Yangyang Ning, Ren-shan Ge, Shijun Li
Summary: This study demonstrates that exposure to 4-nonyl phenol compromises Leydig cell development through multiple mechanisms, including downregulation of key genes and proteins involved in Leydig cell steroidogenesis, induction of oxidative stress, and induction of apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Agriculture, Dairy & Animal Science
Mariana Di Lorenzo, Aldo Mileo, Vincenza Laforgia, Maria De Falco, Luigi Rosati
Summary: The continuous release of toxic substances poses a threat to wildlife survival. The study investigates the effects of Nonylphenol and Octylphenol on the testis of the lizard Podarcis siculus during the reproductive period, inhibiting steroidogenesis and interfering with reproductive capacity.
Article
Pharmacology & Pharmacy
Lin Wang, Mei Guo, Guoli Feng, Pan Wang, Jie Xu, Jie Yu
Summary: Chronic exposure to nonylphenol at environmental concentration may have toxic effects on thyroid function and induce thyroid hyperplasia disease in male rats.
Article
Environmental Sciences
Jialu Bao, Yan Zhang, Linchao Zhang, Xiaodan Wang
Summary: Exposure of pregnant mice to PFOA was found to have a damaging effect on testicular development in male offspring mice, leading to reduced testosterone content and increased apoptosis. Genes associated with snRNA and THOC were dysregulated after PFOA exposure, indicating potential mechanisms underlying the observed effects.
Article
Toxicology
Abhishek Venkatratnam, Christelle Douillet, Brent C. Topping, Qing Shi, Kezia A. Addo, Folami Y. Ideraabdullah, Rebecca C. Fry, Miroslav Styblo
Summary: Exposure to inorganic arsenic (iAs) can affect gene expression in parental germ cells and lead to the development of diabetic phenotypes in male offspring, possibly through germ cell-associated inheritance. However, paradoxically, preconception exposure may have a protective effect in female offspring, warranting further investigation.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hongyu Zhang, Chengguang Song, Rong Yan, Hongbo Cai, Yi Zhou, Xiaoyu Ke
Summary: The combination of NP and HFD had a significant impact on the birth weight, body weight, and liver organ coefficient of male rats in the first generation. HFD exacerbated abnormal lipid metabolism, liver function, and histopathological damage caused by NP in the first generation, and this effect could be passed on to the second generation.
BMC PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Endocrinology & Metabolism
Melanie C. Faure, Rita Khoueiry, Jusal Quanico, Herve Acloque, Marie-Justine Guerquin, Michael J. Bertoldo, Claire Chevaleyre, Christelle Rame, Isabelle Fournier, Michel Salzet, Joelle Dupont, Pascal Froment
Summary: The study found that fetal exposure to metformin may lead to reduced fertility in male offspring, manifested by lower sperm head quality and higher DNA damage. This could be attributed to hypermethylation of sperm genomic DNA and lower expression of the TET1 protein.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Maeve Ballantyne, Lorna Taylor, Tuanjun Hu, Dominique Meunier, Sunil Nandi, Adrian Sherman, Brenda Flack, John M. Henshall, Rachel J. Hawken, Mike J. McGrew
Summary: The study found that avian PGCs are not sexually restricted for functional gamete formation, as they can form functional gametes in both female and male hosts, providing new insights for the cryopreservation of poultry and other bird species using diploid stage germ cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Rong Xiang, Jiuming Yan, Shupin Cheng, Yi Yang, He Wang, Jinghua Xie, Lishi Zhang, Jinyao Chen
Summary: The aim of this study was to investigate the effects of perinatal exposure to 4-nonylphenol (4-NP) on developmental immunotoxicity (DIT) and its potential gender differences. The findings showed that high-dose 4-NP exposure during perinatal period caused growth retardation in male rats during infancy, but this effect was not evident in females. Additionally, perinatal exposure to 4-NP induced DIT, characterized by decreased weight of immune organs, suppressed immune function, and altered cellular ratios. The study also identified a signaling pathway involved in regulating the balance of immune cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cardiac & Cardiovascular Systems
Hasitha Chavva, Adam M. Belcher, Daniel A. Brazeau, Boyd R. Rorabaugh
Summary: Methamphetamine use during pregnancy can negatively impact offspring. This study found that prenatal exposure to methamphetamine alters vascular function in adult offspring, increasing the risk of developing vascular disorders.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Veronika Palenikova, Michaela Frolikova, Eliska Valaskova, Pavla Postlerova, Katerina Komrskova
Summary: Integrins play a crucial role in sperm maturation, with their gene expression and protein localization being essential for successful fertilization. Studying the membrane localization of alpha V integrin in sperm from different species and its relocation during sperm activation provides valuable insights for further investigations into infertility and related fertility issues in human medicine and veterinary science.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Pengfei Gong, Danielle Bailbe, Stefania Tolu, Gaelle Pommier, Junjun Liu, Jamileh Movassat
Summary: Since the restricted use of BPA due to its endocrine disruptor properties, BPS has been widely used as a substitute. However, BPS has similar effects on metabolic health as BPA. Previous studies have documented the effects of maternal exposure to BPA and BPS on offspring, but the impact of preconceptional paternal exposure to BPS remains unexplored. This study showed that preconceptional paternal exposure to BPS had non-monotonic and sex-specific effects on the metabolic health of offspring, suggesting that BPS is not a safe substitute for BPA regarding the inter-generational transmission of metabolic disorders through the paternal lineage.
Article
Engineering, Environmental
Haoxing Cai, Mingyue Chen, Yang Gao, Jinpeng Ruan, Chengyong He, Zhenghong Zuo
Summary: This study investigated the transgenerational effects of tributyltin exposure on rat neurodevelopment in male offspring. The results showed adverse effects on neurodevelopment in F1, F2, and F3 generations, including premature eye-opening, delayed visual positioning, anxiety, cognitive deficits, loose arrangement of neurons in the hippocampus, increased serotonin and dopamine levels, and altered gene expression and DNA methylation patterns. These findings suggest that tributyltin exposure can lead to transgenerational neurodevelopmental disorders in male offspring via epigenetic reprogramming.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chie-Pein Chen, Pei-Chun Chen, Yu-Ling Pan, Yi-Chao Hsu
Summary: The study shows that prenatal infection may contribute to the development of neuropsychiatric disorders in children. Exposure to lipopolysaccharide during prenatal development could lead to anxiety-like behavior and sensorineural hearing loss in offspring, as well as disruptions in neural differentiation. The abnormal differentiation of astrocytes and oligodendrocytes in the brain, potentially mediated by ApoB/E signaling pathways in response to inflammatory stimuli, may be responsible for the anxiety-like behavior observed in male offspring.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Cardiac & Cardiovascular Systems
Jiahui Lei, Meng Zhao, Fengying Deng, Ting Xu, Bingyu Ji, Xietong Wang, Meihua Zhang, Miao Sun, Qinqin Gao
Summary: This study demonstrates that prenatal administration of synthetic glucocorticoids (GCs) affects the reactivity of the middle cerebral artery (MCA) in postnatal offspring, increasing their sensitivity to angiotensin II and ultimately leading to increased MCA contractility, which may contribute to the development of cerebrovascular disease.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)