Article
Biochemistry & Molecular Biology
Chunling Wei, Peiwu Cui, Xiangqian Liu
Summary: Antibacterial resistance is a serious global health problem, and scientists are focusing on developing new antibacterial drugs from natural products. This study investigated the antibacterial activity and mechanism of madecassic acid (MA), a compound isolated from Chinese medicine. It was found that MA had inhibitory effects on eight pathogenic bacteria, with a minimum inhibitory concentration of 31.25μg/mL for Staphylococcus aureus.
Article
Chemistry, Multidisciplinary
Federica Dell'Annunziata, Veronica Folliero, Francesca Palma, Valeria Crudele, Emiliana Finamore, Giuseppina Sanna, Aldo Manzin, Anna De Filippis, Massimiliano Galdiero, Gianluigi Franci
Summary: The plant-derived compound Rhein has significant antibacterial activity against Staphylococcus aureus, inhibiting major virulence factors and biofilm formation.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Jinjin Pei, Yigang Huang, Ting Ren, Yaodong Guo, Jun Dang, Yanduo Tao, Yonggui Zhang, A. M. Abd El-Aty
Summary: This study aimed to evaluate the inhibitory effect and mechanism of plantaricin YKX on Staphylococcus aureus. The results showed that plantaricin YKX caused leakage of cellular content and damage to the cell membranes of S. aureus, and it also inhibited the formation of S. aureus biofilms. Furthermore, plantaricin YKX was found to affect the QS system of S. aureus.
Article
Microbiology
Edward J. A. Douglas, Abdulaziz H. H. Alkhzem, Toska Wonfor, Shuxian Li, Timothy J. J. Woodman, Ian S. S. Blagbrough, Maisem Laabei
Summary: This study demonstrates that polyamine derivatives based on spermine and norspermine possess potent anti-Staphylococcus aureus activity and low toxicity towards human cells. The study also identifies a gain of function mutation in the mprF gene as a mechanism of AHA-1394 resistance. Additionally, AHA-1394 shows the ability to potentiate the activity of certain antibiotics.
FRONTIERS IN MICROBIOLOGY
(2022)
Letter
Chemistry, Medicinal
Nadine Werler, Linda Guentas, Julien Colot, Edouard Hnawia, Mariko Matsui, Mohammed Nour
Summary: The antibacterial activity of Xylopia pancheri Baill. leaf extract was investigated against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), and extended-spectrum-beta-lactamase (ESBL)-producing Pseudomonas aeruginosa. The results showed that the leaf extract had antibacterial activity against S. aureus, with a higher inhibitory effect on MRSA compared to the control gentamycin antibiotic, and an IC50 value of 36.97 μg/mL [95%CI:29.59-46.18] against MRSA.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Thibaut Barbier, Cedric Badiou, Floriane Davy, Yves Queneau, Oana Dumitrescu, Gerard Lina, Laurent Soulere
Summary: In this study, five series of heterocyclic tripartite 2,6-difluorobenzamides were synthesized to investigate the influence of the nature of the heterocyclic central scaffold on the biological activity against Staphylococcus aureus. Among the compounds, II.c showed low minimum inhibitory concentration and exhibited no cytotoxicity against human cells.
Article
Food Science & Technology
Weijun Leng, Xiaoyun Wu, Tong Shi, Zhiyu Xiong, Li Yuan, Wengang Jin, Ruichang Gao
Summary: The skin mucus extract of Channa argus possesses strong inhibitory action against Staphylococcus aureus, disrupting cell membrane functions to induce intracellular metabolic imbalance and affecting the normal physiological functions and growth of the bacteria. The antimicrobial mechanism involves inhibiting primary metabolic pathways of the bacteria such as the tricarboxylic acid cycle and amino acid biosynthesis.
Article
Microbiology
Yanhui Hu, Yuyuan Xing, Peng Ye, Haikuan Yu, Xianglei Meng, Yuting Song, Gongying Wang, Yanyan Diao
Summary: Ionic liquids (ILs) have been gaining attention in the biomedical field due to their unique properties. However, there is still a lack of understanding of their potential applications and underlying principles. We evaluated the antibacterial activity and mechanism of imidazole chloride ILs on Staphylococcus aureus, finding that the length of the imidazolidinyl side chain positively correlated with ILs toxicity. C12MIMCl caused bacterial death by simultaneously affecting the internal and external parts of S. aureus, stimulating oxidative stress and destroying the cell membrane.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Chemistry, Medicinal
Dingyi Shen, Songpo Duan, Yuhan Hu, Jintong Liang, Youzhi Tang
Summary: This study found that the phloroglucinol derivative TPG and 2-nitrophloroglucinol exhibited potent synergistic antibacterial activity with penicillin or bacitracin against MRSA. The combination disrupted the MRSA cell membrane and inhibited the expression of related proteins, effectively inhibiting MRSA growth.
PHYTOTHERAPY RESEARCH
(2023)
Article
Microbiology
Mohamad Hamad, Farah Al-Marzooq, Vunnam Srinivasulu, Hany A. Omar, Ashna Sulaiman, Dana M. Zaher, Gorka Orive, Taleb H. Al-Tel
Summary: We report the discovery of a new class of potent antimicrobial compounds effective against Gram-positive bacteria, including MRSA. These compounds exhibit low minimum inhibitory concentrations and rapid killing ability, without inducing bacterial resistance. Furthermore, they show minimal toxicity to human red blood cells. The study suggests that these small molecules hold promise as new antibacterial agents against MRSA infections.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yong Guo, Ruige Yang, Fangfang Chen, Tingting Yan, Tingyu Wen, Fang Li, Xiaoyu Su, Lei Wang, Juan Du, Jifeng Liu
Summary: In this study, three triphenyl-sesquineolignans were isolated and seven derivatives were prepared. Compound 6 showed the best antibacterial activity against Gram-positive bacteria and clinical MRSA strains, with low drug resistance development probability and hemolysis. Mechanism studies revealed that compound 6 kills bacterial strains by disrupting membranes, indicating its potential as a new antibacterial candidate for combating MRSA infections.
BIOORGANIC CHEMISTRY
(2021)
Article
Engineering, Environmental
Nuttaporn Chokesawatanakit, Pasakorn Jutakridsada, Sophon Boonlue, Jesper T. N. Knijnenburg, Phillip C. Wright, Mika Sillanpaa, Khanita Kamwilaisak
Summary: Hydrothermal reaction and photodeposition were used to transform TiO2 nanoparticles to TiO2 nanotubes loaded with Ag, showing increased surface area and antibacterial activity. Ag/TNTs exhibited antibacterial activity under UV light and could also reduce bacteria growth in the dark.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Plant Sciences
Sara Stumpf, Gregor Hostnik, Tomaz Langerholc, Masa Pintaric, Zala Kolenc, Urban Bren
Summary: The study aims to evaluate the antimicrobial activity of tannins from chestnut extract on Gram-positive Staphylococcus aureus bacteria. The results show that MIC values increase with higher growth medium strength and tannin concentrations, leading to longer lag phase and slower growth rates. Comparing with the results on E. coli, the antimicrobial effects of tannins on S. aureus are not as pronounced, suggesting a different mechanism of action for Gram-positive and Gram-negative bacteria.
Article
Food Science & Technology
Shen Yang, Mingyao Wang, Jialong Gao, Jiaxin Liu, Ritian Jin, Rong Lin, Wuyin Weng, Jude Juventus Aweya
Summary: The activity of antimicrobial peptides (AMPs) can be enhanced by low concentration of sodium chloride (NaCl), which can increase the antibacterial effect against Staphylococcus aureus. The enhancement is achieved through the destruction of bacterial structure, transformation of peptide structure, and increased binding and permeability to bacterial membranes.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Hang Sun, Mohammad Fawad Ansari, Bo Fang, Cheng-He Zhou
Summary: Berberine-hybridized benzimidazoles, such as the 2,4-dichlorobenzyl derivative 7d, showed potent antibacterial efficacy against Staphylococcus aureus, with the ability to eradicate bacterial biofilm and low toxicity towards mammalian cells. Combination with norfloxacin enhanced the antibacterial efficacy, while development of bacterial resistance was not observed. Mechanism studies indicated that the active molecule 7d damaged membrane integrity, stimulated ROS generation, and bound with DNA and S. aureus sortase A, exerting powerful antibacterial ability in treating S. aureus in the livestock industry.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Electrochemistry
V. Novak, B. Kostura, P. Raska, K. Peterek Dedkova, R. G. Mendes, T. Gemming, J. Lesko
Summary: This study investigates the formation of iron oxide nanolayers on the particle surface of blast furnace sludge after acid leaching during voltammetric cycling in 1 M NaOH. It shows that nanostructured magnetite and maghemite are the main oxidation products on the solid iron electrode surface, with similar redox processes affected by hydrogen. Additionally, the accumulation of maghemite during cycling influences the growth of the oxide layer and catalytically increases the hydrogen evolution reaction yield.
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2021)
Article
Environmental Sciences
Tomasz Gonet, Barbara A. Maher, Jana Kukutschova
Summary: The study found that vehicle brake wear is the main source of airborne magnetite in the roadside environment in the UK, accounting for 68%-85%. In comparison, diesel and petrol engine emissions account for 7%-12% and 2%-4% respectively, while background dust contributes around 6%-10%. The high magnetite content in vehicle brake wear may pose potential risks to human cardiovascular and neurological health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Kristina Cabanova, Oldrich Motyka, Hana Bielnikova, Lenka Cabalova, Petr Handlos, Dominika Zabiegaj, Karol Zelenik, Jana Dvorackova, Pavel Kominek, Silvie Heviankova, Miroslav Havlicek, Jana Kukutschova
Summary: Solid metal-based particles may play a role in the pathogenesis of chronic hypertrophic rhinitis, as indicated by Raman microspectroscopy analysis revealing the presence of various compounds in the nasal mucosa of affected patients. This direct identification of compounds can provide insight into the health of individuals and potential causes of mucosal diseases.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Karel Frydrysek, Sarka Michenkova, Leopold Pleva, Jan Koutecky, Jiri Fries, Katerina Peterek Dedkova, Roman Madeja, Antonin Trefil, Pavel Krpec, Tomas Halo, Leopold Hrabovsky, Lubor Bialy, Roland Janco, Jiri Pokorny
Summary: This article discusses a new analytical solution for the deformation, force, and stress states in wood screw joints, up to the limit values of pulling out or breaking the screw. The wood-to-screw interaction is simplified by introducing physical model variants using a tangential elastic non-linear foundation. Experimental verification of the proposed models in lab conditions and in a biomechanical model confirms their validity beyond timber structures.
APPLIED SCIENCES-BASEL
(2021)
Article
Environmental Sciences
Tomasz Gonet, Barbara A. Maher, Ilona Nyiro-Kosa, Mihaly Posfai, Miroslav Vaculik, Jana Kukutschova
Summary: Excessive amounts of iron-rich magnetic particles in brake-wear emissions from passenger cars may pose a threat to neurological and cardiovascular health.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Kristina Cabanova, Kristina Strbova, Oldrich Motyka, Karol Zelenik, Jana Dvorackova, Dominika Zabiegaj, Miroslav Havlicek, Jana Kukutschova
Summary: The study investigates the origin of metal elements in the tonsillar tissues of children patients and establishes a link between environmental pollution and tonsillitis diagnosis. The results show no significant association between the elemental composition and region, but an association with the distance to the closest main road.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Veronika Krbeckova, Zuzana Simonova, Petr Langer, Pavlina Peikertova, Katerina Mamulova Kutlakova, Barbora Thomasova, Daniela Placha
Summary: Pharmaceutical products are significant pollutants in the environment, and this study demonstrates the successful use of waste material for the preparation of nanogold-composite catalysts in paracetamol removal.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Construction & Building Technology
Jonas Tokarsky, Jiri Scucka, Petr Martinec, Katerina Mamulova Kutlakova, Pavlina Peikertova, Pavel Lipina
Summary: Hydrophobic poly(alkyl siloxane) coatings (pure and containing nano-ZnO) were sprayed on sandstone and compared with uncoated samples. The coatings effectively prevented water penetration and minimized color changes. The color changes were correlated with meteorological conditions including relative air humidity, precipitation, and particulate matter concentration.
JOURNAL OF BUILDING ENGINEERING
(2022)
Article
Chemistry, Physical
Monika Michalska, Jiri Pavlovsky, Pavlina Peikertova, Sylva Holesova, Krishnan Shanmugam Anuratha, Jeng-Yu Lin
Summary: A modified sol-gel method was used to synthesize a nanocrystalline composite as an efficient anode material for lithium-ion batteries. The composite exhibited a mesoporous/microporous microstructure and showed improved electrochemical performance, especially at high C rates.
SOLID STATE IONICS
(2022)
Article
Chemistry, Physical
Katerina Karaskova, Katerina Pacultova, Tereza Bilkova, Dagmar Fridrichova, Martin Kostejn, Pavlina Peikertova, Pawel Stelmachowski, Pavel Kukula, Lucie Obalova
Summary: Co4-iZniAlOx mixed oxides were prepared and modified with potassium for catalytic NO decomposition. The catalyst showed high activity and stability.
Article
Chemistry, Physical
Anna Klegova, Katerina Pacultova, Tomas Kiska, Pavlina Peikertova, Anna Rokicinska, Piotr Kustrowski, Lucie Obalova
Summary: By investigating the interactions between Cs-Co3O4 and different washcoats, it was found that SiO2 and TiO2 washcoats had the largest surface areas, and SiO2 did not interact with the active phase. The catalytic activity was closely related to the surface Cs/Co molar ratio and the surface Co3+/Co2+ molar ratio.
MOLECULAR CATALYSIS
(2022)
Article
Green & Sustainable Science & Technology
Richard Dvorsky, Jana Kukutschova, Marek Pagac, Ladislav Svoboda, Zuzana Simonova, Katerina Peterek Dedlkova, Jiri Bednar, Rafael Gregorio Mendes, Dalibor Matysek, Ondrej Malina, Jiri Tucek, Zuzana Vilamova, Sergei Kiselev, Thomas Gemming, Peter Filip
Summary: Despite the recent focus on eco-friendly additive manufacturing, the properties of nanoparticulate pollutants emitted during Laser Powder Bed Fusion have been overlooked. This study provides new insights into the production of distinct metal/oxide core-shell nanoparticles and suggests ways to remove these harmful by-products. Additionally, a kinetic model predicts the growth time of the metal core and confirms the theory of by-product formation.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Chemistry, Physical
Lenka Matejova, Ivana Troppova, Zuzana Jankovska, Hana Sezimova, Jan Endres, Pavlina Peikertova, Monica Marcela Gomez Leon
Summary: The ecotoxicological effects of manufactured TiO2, cerium doped TiO2, and zirconium doped TiO2 were evaluated. TiO2 prepared using titanyl sulphate as a precursor showed toxicity to plant species, while TiO2 prepared using titanium (IV) isopropoxide was non-toxic. Cerium doped TiO2 with a low amount of cerium (<5.5 wt.%) was non-toxic and zirconium doped TiO2 stimulated plant growth. The presence of SO42- was identified as the chemical cause of TiO2 toxicity, and high cerium content in TiO2 led to the formation of toxic CeO2 nuclei.
SURFACES AND INTERFACES
(2023)
Article
Chemistry, Physical
Michal Lesnak, Daniel Cvejn, Martin Petr, Pavlina Peikertova, Roman Gabor, Tibor Fordos, Pavel Czernek, Daniela Placha
Summary: A novel N-doped carbon material, named nano-mousse, was obtained by depositing medium-sized pyridine-based molecules on copper-based substrates. The resulting material is a system of interconnected multi-wall carbon nanospheres with substantial N-doping. The N-doped carbon nano-mousses exhibit metal-like properties in terms of optical conductivity and other optical properties, and their structure and chemical composition are highly dependent on the nature of the precursor and preparation conditions.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Engineering, Environmental
Jan Bednarek, Lenka Matejova, Zuzana Jankovska, Michal Vastyl, Barbora Sokolova, Pavlina Peikertova, Pavel Siler, Adam Verner, Jonas Tokarsky, Ivan Koutnik, Marek Svab, Martina Vrablova
Summary: Biochars prepared from agricultural biomass were tested as adsorbents for the removal of herbicide metazachlor from water. Banana waste-based biochar showed the best adsorption performance. Molecular modeling revealed the interaction between the biochar's polar functional groups and the herbicide.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Girgis Obaid, Menitte Eroy, Jie Zhao, Shazia Bano, Mari Mino-Kenudson, Tayyaba Hasan
Summary: The presence of desmoplasia in pancreatic ductal adenocarcinoma (PDAC) is associated with poor treatment outcomes and reduced drug delivery. By analyzing collagen subtypes in PDAC tumors following different treatment regimens, immunofluorescence profiling can predict long-term survival and tumor growth inhibition. This information can aid in personalized treatment and improve patient survival.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Fatemeh Malekpour, Rashin Bahrami, Mahshid Hodjat, Neda Hakimiha, Behnam Bolhari, Aidin Sooratgar, Soheil Niavarzi
Summary: This study investigated the effect of photobiomodulation (PBM) therapy using an 808 nm diode laser on cellular modulation mechanisms in regenerative endodontic procedures (REPs). The results showed that PBM treatment significantly increased cell viability and migration, and enhanced the release of TGF-131 from dentin.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Pranathi Tata, Ramakrishnan Ganesan, Jayati Ray Dutta
Summary: Thin film coatings with potent antibacterial properties are widely used in medical devices, frequently touched surfaces, and food packaging. However, achieving antibacterial performance under both light and dark conditions remains a challenge. In this study, we successfully prepared AgBr-coated ZnO nanorod thin film architecture using a unique surfactant-mediated solution-phase spin-coating approach. The resulting structures showed dual functionality as antimicrobial agents and photosensitizers, effectively enhancing the visible-light photodisinfection efficacy of ZnO nanorods. The concentration of the surfactant-based precursor solution could be modulated to control the AgBr content. Additionally, components like urea and lactic acid were found to enhance the photocatalytic efficiency of the structures.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
