Article
Multidisciplinary Sciences
Sean R. Millar, Deirdre Mongan, Claire O'Dwyer, Bobby P. Smyth, Ivan J. Perry, Brian Galvin
Summary: There is a relationship between patterns and frequency of cannabis use and recent use of stimulants, with individuals with cannabis use disorder being more likely to use cocaine or ecstasy.
Article
Substance Abuse
Pravesh Sharma, Kira E. Riehm, Andrea S. Young, Maureen D. Reynolds, Ralph E. Tarter, Michelle S. Horner, Christopher J. Hammond
Summary: Adolescent cannabis use and family history of SUD were found to significantly impact the development of paranoid and schizotypal personality traits, while the transmissible liability index did not. The interactive effect between TLI and cannabis use was also not significant, and paranoid and schizotypal symptoms showed different dose-dependent sensitivities to cannabis exposure at age 16.
SUBSTANCE USE & MISUSE
(2021)
Article
Psychiatry
Carlos Blanco, Melanie M. Wall, Tianshu Feng, Mark Olfson
Summary: The study found that SUDs were more likely to precede mood disorders, rather than the other way around. Simultaneous onset of mood and anxiety disorders within the same year supports the idea of shared underlying vulnerabilities across disorder groups.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Medicine, General & Internal
Jason P. Connor, Daniel Stjepanovic, Bernard Le Foll, Eva Hoch, Alan J. Budney, Wayne D. Hall
Summary: Cannabis use disorder affects approximately 10% of global cannabis users, and while there are treatment methods available, enduring abstinence is not common. Legalization of non-medical cannabis use may increase the prevalence of CUD.
NATURE REVIEWS DISEASE PRIMERS
(2021)
Article
Multidisciplinary Sciences
Jill A. Rabinowitz, Jin Jin, Sally I-Chun Kuo, Adrian Campos, Miguel E. Renteria, Andrew S. Huhn, Johannes Thrul, Beth A. Reboussin, Kelly Benke, Benjamin Domingue, Nicholas S. Ialongo, Brion S. Maher, Darlene Kertes, Vanessa Troiani, George Uhl
Summary: This study examined the association between polygenic risk scores (PRS) for lifetime cannabis and alcohol use and the misuse of opioids among an urban, African-American sample. The findings suggest that higher PRS for lifetime cannabis use, heavy drinking, and alcohol consumption are associated with an increased risk for opioid misuse. Additionally, there are significant sex differences in these associations.
Article
Public, Environmental & Occupational Health
Da Huang, Roubing Xu, Rong Na
Summary: The impact of cannabis use on COVID-19 infection and survival outcomes was investigated. The study found that cannabis users were more likely to contract COVID-19, but cannabis use was also a protective factor against infection. However, regular cannabis users had poorer COVID-19-related survival compared to non-users.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Agronomy
Richard F. Lee, Manjunath L. Keremane, Chandrika Ramadugu
Summary: This study introduced a procedure for biological indexing using very young indicator plants and compared it with traditional biological indexing. The results showed that the two methods had similar sensitivity of detection. The use of mini-plant biological indexing could provide an efficient alternative with limited resources.
Article
Psychology, Clinical
Joshua A. Weller, Andrew M. Parker, Maureen Reynolds, Levent Kirisci
Summary: Adolescence and emerging adulthood are associated with increased risk-taking behaviors, and this study found that lower psychological regulation early in life was linked to lower decision-making competence later on. The research identified three distinct developmental trajectory classes of psychological dysregulation, showing that early patterns of psychological dysregulation development can impact later decision-making tendencies. Individual differences in intra-individual change across adolescence were also highlighted.
ADDICTIVE BEHAVIORS
(2021)
Article
Biochemistry & Molecular Biology
Fang Fang, Bryan Quach, Kaitlyn G. Lawrence, Jenny van Dongen, Jesse A. Marks, Sara Lundgren, Mingkuan Lin, Veronika V. Odintsova, Ricardo Costeira, Zongli Xu, Linran Zhou, Meisha Mandal, Yujing Xia, Jacqueline M. Vink, Laura J. Bierut, Miina Ollikainen, Jack A. Taylor, Jordana T. Bell, Jaakko Kaprio, Dorret I. Boomsma, Ke Xu, Dale P. Sandler, Dana B. Hancock, Eric O. Johnson
Summary: This study investigated the association between genome-wide DNA methylation and lifetime cannabis use. The results showed that there were four CpG sites significantly associated with lifetime cannabis use, and one CpG site was also associated with participants who never smoked cigarettes. The study also identified the best model that can explain the variation in lifetime cannabis use, and revealed potential DNA methylation changes related to the health impact of cannabis.
MOLECULAR PSYCHIATRY
(2023)
Article
Substance Abuse
Laurel P. Gibson, Charleen J. Gust, Jarrod M. Ellingson, Sophie L. YorkWilliams, Cristina Sempio, Jost Klawitter, Angela D. Bryan, Kent E. Hutchison, L. Cinnamon Bidwell
Summary: This study investigated sex differences in subjective drug effects and verbal memory errors after ad libitum use of high potency THC concentrate. Men were found to have higher levels of THC and CBD in their plasma immediately after cannabis concentrate use compared to women. However, no significant sex differences were observed in subjective effects and verbal memory errors, suggesting similar acute drug effects across genders. Further research is needed to understand the mechanisms behind these findings.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Review
Medicine, General & Internal
Deborah Hasin, Claire Walsh
Summary: This narrative review provides a comprehensive overview of the comorbidity between cannabis use and CUD with other substance use and psychiatric disorders. Evidence shows a potential causal relationship between cannabis use and psychotic disorders, while the relationship with mood and anxiety disorders is inconsistent. Limited understanding exists regarding the impact of CUD on individuals with personality disorders.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Substance Abuse
Zoe E. Reed, Robyn E. Wootton, Marcus R. Munafo
Summary: Bidirectional Mendelian randomization testing of the gateway hypothesis reveals that smoking initiation may lead to increased alcohol consumption, cannabis use, and cannabis dependence. Cannabis use may also lead to smoking initiation, and opioid dependence may lead to increased alcohol consumption.
Article
Psychology, Clinical
Angel Garcia-Perez, Gema Aonso-Diego, Sara Weidberg, Roberto Secades-Villa
Summary: This study confirms the gateway hypothesis of cannabis and finds different results compared to other countries. The findings can support the development of preventive strategies for substance use in Spanish adolescents.
ADDICTIVE BEHAVIORS
(2023)
Article
Medicine, General & Internal
Amanda Doggett, Kyla Belisario, Andre J. Mcdonald, Mark A. Ferro, James G. Murphy, James Mackillop
Summary: A longitudinal observational cohort study in Canada found that there were decreases in cannabis use frequency and related consequences among high-risk young adults after recreational cannabis legalization.
Article
Medicine, General & Internal
Ruoyan Sun, David Mendez, Kenneth E. Warner
Summary: The study found a strong association between adolescent e-cigarette use and subsequent cannabis use. However, at the population level, there seems to be minimal impact of e-cigarette use on the prevalence of youth cannabis use.
Article
Genetics & Heredity
Emily Shelkowitz, Marie G. Gantz, Ty A. Ridenour, Ann O. Scheimann, Theresa Strong, Jessica Bohonowych, Jessica Duis
Summary: Prader-Willi syndrome is a genetic disorder with various characteristics and symptoms, including hypotonia, feeding difficulties, developmental delays, behavioral and psychiatric issues, endocrine disorders, etc. This study used data from the Global PWS Registry to explore the onset and severity of neuropsychiatric features in PWS individuals over time, and its associations with sleep disorders, seizures, and psychiatric symptoms. The study found that seizures are more common in the deletion subtype, while narcolepsy and cataplexy are more common in individuals with sleep-related seizures. The study also showed that anxiety and compulsive behaviors are persistent features of PWS and are associated with a higher frequency of comorbid psychiatric diagnoses.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
Article
Neurosciences
Giorgia Picci, Diana H. Fishbein, John W. VanMeter, Emma J. Rose
Summary: Genetic variants in the OPRM1 and DRD2 genes are associated with substance use disorders, affecting structural differences in key reward-related brain regions. The study also found that these genetic risk factors interact with future substance use, leading to structural variability in regions commonly implicated in risk for substance use disorders.
PSYCHOPHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Ty A. Ridenour, Gracelyn Cruden, Yang Yang, Erin E. Bonar, Anthony Rodriguez, Lissette M. Saavedra, Andrea M. Hussong, Maureen A. Walton, Bethany Deeds, Jodi L. Ford, Danica K. Knight, Kevin P. Haggerty, Elizabeth Stormshak, Terrence K. Kominsky, Kym R. Ahrens, Diana Woodward, Xin Feng, Lynn E. Fiellin, Timothy E. Wilens, David J. Klein, Claudia-Santi Fernandes
Summary: The paper introduces the development of evidence-based interventions for preventing opioid misuse and disorder by the Helping to End Addiction Long-Term (HEAL) Prevention Cooperative (HPC). It focuses on comparing the impacts of different interventions on opioid misuse initiation, escalation, severity, and disorder, while also providing an opportunity to harmonize measures across distinct outcome studies. The paper describes a strategy to measure opioid use and discusses the limitations and opportunities of data harmonization, as well as the implications for future research cooperatives and the broader HEAL data ecosystem.
PREVENTION SCIENCE
(2023)
Article
Psychology, Clinical
Chardee A. Galan, Daniel S. Shaw, Flannery O'Rourke, Maureen D. Reynolds, Anne Gill, Debra L. Bogen, Ty A. Ridenour
Summary: This study evaluated the acceptability, engagement, and efficacy of a primary care screening and prevention program aiming to reduce substance use in early adolescence. The results showed that the screening tools and prevention measures were well accepted by parents and youths, and families actively engaged in the preventive intervention. The study also found that higher-risk youth benefited more from the prevention measures.
RESEARCH ON CHILD AND ADOLESCENT PSYCHOPATHOLOGY
(2023)
Article
Psychology, Applied
Desiree W. Murray, Ty A. Ridenour, Margaret M. Swingler, Anna Morgan, Meghan Hegarty-Craver
Summary: Adolescent stress is complex and impairing, and novel measures are needed to understand stress variability within individuals. This study tested the feasibility of using ecological momentary assessment (EMA) and wearable biosensors to assess adolescent stress. The results showed that biobehavioral methods can help in understanding day-to-day stress in adolescents, but there is variability in stress experiences and technological limitations, especially for youth of color.
Article
Public, Environmental & Occupational Health
Susan L. Andersen, Diana H. Fishbein
Summary: The HEAL Prevention Collaborative aims to develop interventions for preventing opioid misuse and addiction in young people. This collaborative effort includes ten outcome studies and emphasizes the importance of innovative designs, advanced methodologies, and real-time data analysis. However, there is a need for stronger effect sizes and a better understanding of underlying mechanisms.
PREVENTION SCIENCE
(2023)
Article
Psychology, Clinical
Diana H. Fishbein, Zili Sloboda
Summary: The National Drug Control Strategy (2022) emphasizes a comprehensive plan to enhance treatment access, increase harm reduction strategies, and implement evidence-based prevention programming at the community level. However, there are missing components and a lack of structure to support a national comprehensive service delivery system. This paper provides recommendations for establishing a structure focused on prevention.
CLINICAL CHILD AND FAMILY PSYCHOLOGY REVIEW
(2023)
Article
Psychology, Clinical
Jacinda K. Dariotis, Keren Mabisi, Rachel Jackson-Gordon, Emma Jane Rose, Diana H. Fishbein, Tamar Mendelson
Summary: In the context of adverse social conditions, adolescents may lack the emotional and behavioral skills needed to navigate life challenges effectively. Mindfulness and health education programs were explored in this qualitative study, and both were found to have positive impacts on adolescents' development and decision-making.
Article
Public, Environmental & Occupational Health
J. D. Cance, E. T. Adams, E. J. D'Amico, A. Palimaru, C. S. F. Fernandes, L. E. Fiellin, E. E. Bonar, M. A. Walton, K. A. Komro, D. Knight, K. Knight, V. Rao, S. Youn, L. Saavedra, T. A. Ridenour, B. Deeds
Summary: Substance use disorder prevention programs should be tailored to the specific risk profiles of different populations, as individuals who misuse opioids have different risk factors compared to those who use other substances. However, most prevention programs are designed for broad audiences and fail to address important points of intervention. The HEAL Prevention Cooperative (HPC) is a unique research initiative that covers a continuum of care, targeting both universal prevention strategies and specific interventions for older adolescents and young adults currently misusing opioids or other substances. This paper outlines the theoretical foundation of addressing opioid misuse and use disorder across the prevention continuum using examples from HPC research projects.
PREVENTION SCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Amy M. Yule, Claudia-Santi F. Fernandes, Elizabeth A. Stormshak, Yang Yang, Lillyan Shelley, Lynn E. Fiellin, Kaitlin Larkin, Ty A. Ridenour, Lissette M. Saavedra, Kelly Kelleher, Xin Feng, Maureen A. Walton, Erin E. Bonar
Summary: We aim to review the association between childhood-onset mental health conditions and early substance use, specifically opioid misuse and opioid use disorders (OUD). The findings suggest that youth with mental health conditions may benefit from prevention efforts that address both mental health and opioid misuse. We will also discuss the challenges and opportunities of using mental health screening or substance use screening in high-risk settings. Additionally, we will review how the National Institutes of Health's Helping to End Addiction Long-term (HEAL) Prevention Cooperative is incorporating mental health in its interventions for youth regarding opioid misuse and OUD prevention.
PREVENTION SCIENCE
(2023)
Editorial Material
Public, Environmental & Occupational Health
Ty A. Ridenour, Lissette M. Saavedra, Claudia-Santi F. Fernandes, Jessica Duncan Cance, Phillip W. Graham, Barbara A. Oudekerk
Summary: This article describes the individual studies and collaborative efforts of the Helping to End Addiction Long-term Prevention Cooperative's (HPC's) innovative approaches to rapidly develop evidence-based prevention programs for widespread dissemination. The authors summarize the context, objectives, and collective efforts of the HPC research projects in advancing the prevention of opioid misuse. By harmonizing and coordinating efforts across 10 distinct outcomes studies, the HPC's efficacy and etiology evidence will surpass the additive contributions of 10 individual research projects.
PREVENTION SCIENCE
(2023)
Article
Health Care Sciences & Services
Natalie A. Blackburn, Stefany Ramos, Michele Dorsainvil, Camara Wooten, Ty A. Ridenour, Anna Yaros, Vicki Johnson-Lawrence, Dana Fields-Johnson, Nzinga Khalid, Phillip Graham
Summary: Community violence is a persistent problem that affects the well-being of individuals, families, and communities. Traditional law enforcement approaches have been detrimental, and community-centered solutions are needed. This study aims to understand the impact of community-level violence prevention interventions and explore the implementation strategies and barriers.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Psychology, Developmental
Chardee A. Galan, Jocelyn Meza, Ty A. Ridenour, Daniel S. Shaw
Summary: This study identified a developmental pathway from Black parents' experiences of racial discrimination to adolescent problem behaviors via parent-child conflict. The findings may inform interventions aimed at promoting resilience in parents and youth faced with pervasive racism.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Social Work
June-Yung Kim, Sonia Minnes, Ty A. A. Ridenour, Adam T. T. Perzynski, Meeyoung O. O. Min, Lynn T. T. Singer
Summary: Problem behavior theory suggests that adolescent attitudes towards deviance may precede health risk behaviors. This study identified three different ATD patterns among early adolescents with prenatal drug exposure, which were associated with subsequent risk behaviors. The findings also highlighted the distinct associations between adolescents' current developmental contexts and ATD patterns.
JOURNAL OF THE SOCIETY FOR SOCIAL WORK AND RESEARCH
(2022)
Article
Psychology, Mathematical
Stephen Tueller, Derek Ramirez, Jessica D. D. Cance, Ai Ye, Anne C. C. Wheeler, Zheng Fan, Christoph H. Hornik, Ty A. A. Ridenour
Summary: This study examines the impact of various factors on the statistical power to detect treatment outcomes in idiographic clinical trials. The factors that are under researchers' control, such as sample size and number of observations per participant, as well as factors that are largely outside of researchers' control, such as population size and treatment effect size, are tested. The study finds that larger treatment effect sizes have the greatest impact on power, followed by more observations per participant and larger samples.
BEHAVIOR RESEARCH METHODS
(2022)
