Article
Microbiology
Karina M. S. Herrera, Gabriela F. M. Lopes, Michael E. Oliveira, Jaqueline F. Sousa, William G. Lima, Fernanda K. Silva, Julio C. M. Brito, Ana Julia P. S. Gomes, Gustavo H. R. Viana, Adriana C. Soares, Jaqueline M. S. Ferreira
Summary: This study evaluated the antibacterial activity of five 3-alkyl-pyridinic analogs against MRSA. Compound 6 showed promising antibacterial activity, exhibited a rapid bactericidal action, and had low resistance induction potential. It also showed an additive effect when combined with other antibiotics.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Infectious Diseases
Fatimah Muhammad Ballah, Md. Saiful Islam, Md. Liton Rana, Md. Ashek Ullah, Farhana Binte Ferdous, Fahim Haque Neloy, Samina Ievy, Md. Abdus Sobur, A. M. M. Taufiquer Rahman, Mst. Minara Khatun, Marzia Rahman, Md. Tanvir Rahman
Summary: This study aimed to investigate the virulence factors and methicillin resistance in biofilm-forming Staphylococcus aureus isolates from different foods and food handlers in Bangladesh. The results showed that these isolates carried various resistance genes and virulence factors, and exhibited resistance to multiple antibiotics. These findings suggest a potential threat to public health from biofilm-forming S. aureus in Bangladesh.
Article
Microbiology
Hui-Hui Yeo, Chung-Wei Shiau, Yu-Hsuan Jao, Tsai-Wen Wan, Hao-Chieh Chiu
Summary: This study found that oleic acid enhances the activity of the antibacterial agent SC5005 against Staphylococcus aureus and MRSA strains. Specifically, cis-form unsaturated fatty acids, such as docosahexaenoic acid (DHA), synergistically increase the potency of SC5005. The combination of SC5005 and DHA can effectively eradicate MRSA planktonic and persister cells, as well as biofilms.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Viktoria Rungelrath, Frank R. DeLeo
Summary: Staphylococcus aureus is a major cause of bacterial infections worldwide, with resistance to antibiotics and the ability to evade host defenses. Research has identified certain virulence molecules of S. aureus as therapeutic targets. Treatment options for methicillin-resistant S. aureus are limited, highlighting the need for further research to develop new therapies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Immunology
Syong H. Nam-Cha, Elena Dominguez-Jurado, Selena L. Tinoco-Valencia, Ramon Perez-Tanoira, Noelia Morata-Moreno, Rocio Alfaro-Ruiza, Agustin Lara-Sanchez, Jaime Esteban, Rafael Lujan, Carlos Alonso-Moreno, Pedro Segui, Alberto Ocana, Angel Lopez Gonzalez, John J. Aguilera-Correa, Francisco C. Perez-Martinez, Milagros Molina Alarcon
Summary: This study aimed to translate clinical research outcomes based on metallodrugs into clinical practice for the treatment of MRSA. The novel metallodrug 2P-Pt showed antibacterial effect against MRSA and inhibited biofilm formation. These findings suggest that 2P-Pt may be a promising therapeutic alternative for MRSA infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Nikki N. Tran, Taylor Morrisette, Sarah C. J. Jorgensen, Jose M. Orench-Benvenutti, Razieh Kebriaei
Summary: Staphylococcus aureus is a significant cause of healthcare-associated and community-acquired infections, especially when associated with medical devices and in biofilm form. Biofilm structure allows for the enrichment of resistant and persistent phenotypes, leading to relapse and recurrence of infection. Minimal diffusion of antibiotics within biofilms leads to heterogeneity and distinct physiological activity. Horizontal gene transfer between cells in proximity adds to the challenges of eradicating biofilms. This review focuses on biofilm-associated infections caused by S. aureus, the impact of environmental conditions on biofilm formation, interactions within biofilm communities, and the clinical challenges they pose. Potential solutions, novel treatment strategies, combination therapies, and reported alternatives are also discussed.
Article
Biotechnology & Applied Microbiology
Georgios Katsipis, Anastasia A. Pantazaki
Summary: In this study, the antimicrobial effects of SPT on Staphylococcus aureus biofilms were demonstrated. SPT reduced the content of cell wall components, altered the activity of alkaline phosphatases and proteins involved in phosphate metabolism, and weakened the resistance of bacteria to biofilm formation.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Infectious Diseases
Felipe Francisco Tuon, Paula Hansen Suss, Joao Paulo Telles, Leticia Ramos Dantas, Nicolas Henrique Borges, Victoria Stadler Tasca Ribeiro
Summary: Staphylococcus aureus is frequently associated with implant-related infections due to its ability to produce biofilms, which make these infections difficult to treat. The effectiveness of different drugs in inhibiting bacterial growth within the biofilm cannot always be accurately interpreted using routine sensitivity tests. This review provides a comprehensive discussion on the genes involved in biofilm formation, quorum sensing, and antimicrobial activity, aiming to benefit researchers working on optimizing the treatment of S. aureus biofilm-associated infections.
Review
Biotechnology & Applied Microbiology
J. Jayakumar, V. A. Kumar, L. Biswas, R. Biswas
Summary: Staphylococcus aureus causes various infections and the development of effective anti-staphylococcal agents, such as lysostaphin, is crucial. However, issues with immunogenicity and bio-availability hinder its clinical application.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Infectious Diseases
Arianna Pani, Valeria Lucini, Silvana Dugnani, Francesco Scaglione
Summary: This study evaluated the effects of erdosteine in combination with different antibiotics against Staphylococcus aureus biofilms. The results showed that erdosteine enhanced the activity of antibiotics and reduced biofilm mass and bacterial viability. This suggests that erdosteine has potential clinical value in treating biofilm-related infections.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Agriculture, Dairy & Animal Science
Pengfei Zhang, Xinyu Liu, Jie Zhang, Xueting Fu, Yangli Wan, Hu Pan, Congming Wu, Xin Wang
Summary: The study found that yak butter from Tibet, China, is contaminated with Staphylococcus aureus, including methicillin-resistant strains. The isolates carried various virulence genes, with blaZ being the most frequently detected resistance gene.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Microbiology
Elizabeth V. K. Ledger, Andrew M. Edwards
Summary: Most bactericidal drugs require bacterial replication and/or metabolic activity for their killing activity, but the lipopeptide antibiotic daptomycin has been reported to efficiently kill growth-arrested bacteria. However, a prolonged growth arrest can lead to daptomycin tolerance in Staphylococcus aureus, requiring glucose and increased production of certain cell wall polymers. This active cell wall remodelling sets daptomycin tolerance apart from other forms of antibiotic tolerance in nonreplicating bacteria.
Review
Immunology
Brittney D. Gimza, James E. Cassat
Summary: Staphylococcus aureus is a common etiologic agent in osteomyelitis, a prevalent invasive disease. Treatment of this infection is challenging due to antimicrobial resistant strains, antibiotic tolerance in staphylococci, and bone remodeling and destruction.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Jelle Vlaeminck, Qiang Lin, Basil Britto Xavier, Sarah De Backer, Matilda Berkell, Henri De Greve, Jean-Pierre Hernalsteens, Samir Kumar-Singh, Herman Goossens, Surbhi Malhotra-Kumar
Summary: There are striking differences in gene expression during biofilm formation by three important pandemic MRSA clones, USA300, HEMRSA-15, and ST239. The clfA gene is the only significantly upregulated gene across all three strains in 24-hour biofilm cultures and represents an important target for disrupting early biofilms. Furthermore, our data indicate the critical role of arginine catabolism pathways in early biofilm formation.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Josefien W. Hommes, Bas G. J. Surewaard
Summary: MRSA infections pose a global health threat and have a high mortality rate. In addition to being an extracellular pathogen, MRSA can also survive and replicate intracellularly, using the antimicrobial environment of phagocytes to evade immune cells and antibiotics. The intracellular niche of bacteria may contribute to the development of antibiotic tolerance, and there are various new antibacterial strategies targeting this intracellular bacterial niche.