Article
Multidisciplinary Sciences
Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Mika Takeuchi, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
Summary: Limited expandability of subcutaneous adipose tissue may be a characteristic of first-degree relatives of type 2 diabetes. This study found an association between family history of type 2 diabetes (FHD) and reduced subcutaneous fat mass in young Japanese women, suggesting impaired adipose tissue expandability.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Ruping Pan, Jiadai Liu, Yong Chen
Summary: Diabetes mellitus is classified into four types, with type 2 diabetes mellitus (T2DM) having the highest incidence rate and being most associated with obesity. T2DM is characterized by high blood glucose due to insulin resistance and insufficient insulin secretion. Obesity causes insulin resistance, but it can potentially be treated by activating thermogenic adipose tissues.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Margarete Milek, Yusef Moulla, Matthias Kern, Christine Stroh, Arne Dietrich, Michael R. Schoen, Daniel Gaertner, Tobias Lohmann, Miriam Dressler, Peter Kovacs, Michael Stumvoll, Matthias Blueher, Esther Guiu-Jurado
Summary: This study found that serum adipsin concentrations are strongly related to obesity and age, but not to parameters of glucose or lipid metabolism in patients with obesity with or without T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Tina Okdahl, Anne-Marie Wegeberg, Flemming Pociot, Birgitte Brock, Joachim Storling, Christina Brock
Summary: The level of low-grade inflammation in type 2 diabetes is associated with obesity, glycaemic regulation, therapeutical management, sex, and complications. Our results underline the importance of addressing inflammatory issues in type 2 diabetes, as these may predispose for crippling comorbidities.
Review
Physiology
Aneesh Dhore-patil, Tariq Thannoun, Rohan Samson, Thierry H. Le Jemtel
Summary: This article discusses the pathophysiology and therapeutic advances in the obese-diabetic phenotype of heart failure with preserved ejection fraction.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Dae-Seok Kim, Philipp E. Scherer
Summary: High rates of obesity and diabetes are associated with increased risk of multiple types of cancers, influenced by various factors. Metabolic abnormalities caused by obesity and diabetes may significantly contribute to the development and progression of cancer through the regulation of distinct signaling pathways.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Endocrinology & Metabolism
Agne Kulyte, Alisha Aman, Rona J. Strawbridge, Peter Arner, Ingrid A. Dahlman
Summary: Interindividual differences in the generation of new fat cells are associated with body fat and type 2 diabetes risk. This study identified several genetic loci and candidate genes, including SPATS2L, KCTD18, RPL8, HSD17B12, and PEPD, that are potentially important in controlling fat cell numbers, body fat size, and diabetes risk.
Article
Biochemistry & Molecular Biology
Tiago Morais, Alexandre L. Seabra, Barbara G. Patricio, Marta Guimaraes, Mario Nora, Pedro F. Oliveira, Marco G. Alves, Mariana P. Monteiro
Summary: The study revealed that there are differences in VAT metabolic fingerprint between obesity and different glycemic statuses, characterized by higher isoleucine consumption, lower acetate production, and lower pyruvate and pyroglutamate consumption in pre-diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Takaaki Murakami, Nobuya Inagaki, Hiroshi Kondoh
Summary: Increased insulin resistance and impaired insulin secretion are significant characteristics of type 2 diabetes mellitus (T2DM). Accumulation of senescent cells in adipose tissues and pancreatic beta-cells contribute to these dysfunctions. Removing senescent cells shows promise in preventing or improving diabetes-related diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Benedikt Dietz, Juergen Machann, Vaibhav Agrawal, Martin Heni, Patrick Schwab, Julia Dienes, Steffen Reichert, Andreas L. Birkenfeld, Hans-Ulrich Haering, Fritz Schick, Norbert Stefan, Andreas Fritsche, Hubert Preissl, Bernhard Schoelkopf, Stefan Bauer, Robert Wagner
Summary: The study indicated that diabetes can be detected through whole-body MRI without additional data, with visceral fat playing a crucial role in diabetes classification. The model identified a high-risk group with increased risk for future diabetes and microalbuminuria.
Article
Nutrition & Dietetics
Masayasu Horibe, Naoki Takahashi, Alexander D. Weston, Kenneth Philbrick, Satoshi Yamamoto, Hiroaki Takahashi, Santhi Swaroop Vege
Summary: In patients with acute pancreatitis, skeletal muscle and subcutaneous adipose tissue are associated with disease severity, while visceral adipose tissue is not.
CLINICAL NUTRITION
(2022)
Article
Integrative & Complementary Medicine
Xiaoling Zhou, Xin Li, Tingting Wei, Ying Xu, Yunyuan Mao, Chen Lei
Summary: Establishing gestational diabetes mouse model through high-fat and high-sugar diet intervention revealed significant reduction of UCP1 protein in brown fat of GDM mice, which is correlated with obesity tendency and evident insulin resistance.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Bianca-Margareta Salmen, Valeria-Anca Pietrosel, Cristiana-Elena Durdu, Teodor Salmen, Cosmina Theodora Diaconu, Ioana-Cristina Bica, Claudia Gabriela Potcovaru, Florentina Gherghiceanu, Roxana-Adriana Stoica, Anca Pantea Stoian
Summary: The prevalence of gestational diabetes mellitus (GDM) has increased, calling for non-invasive and precise techniques to assess the risk factors such as visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). A systematic review identified 11 relevant articles that favored using US-determined VAT in predicting GDM. VAT may be more valuable than body mass index or SAT in GDM prediction, and can be utilized in conjunction with other parameters or risk factors. However, US measurements are heterogeneous and the lack of a gold standard for GDM identification poses a limitation.
Article
Biochemistry & Molecular Biology
Kosuke Otani, Hiroshi Funada, Risa Teranishi, Muneyoshi Okada, Hideyuki Yamawaki
Summary: This study investigated changes in cardiovascular dynamics, adipose tissue, and kidney pathology associated with obesity and T2D in ZFDM rats. The results showed that heart rate and plasma adrenaline concentration decrease with the progression of obesity and T2D in ZFDM rats. In addition, inflammation occurs in perirenal white adipose tissue, while degeneration and whitening occur in interscapular brown adipose tissue. Furthermore, renal function is impaired. ZFDM rats will be useful for studying metabolic changes associated with obesity and T2D progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Anna-Claire Pilkington, Henry A. Paz, Umesh D. Wankhade
Summary: Adipose tissue is classified based on its characteristics, but differentiating beige adipose tissue (BeAT) remains a challenge. Recent research focuses on identifying different types of adipose tissue through transcript markers to advance understanding of their biology. The development of concrete strategies to distinguish types of adipose tissue may be crucial for improving metabolic health and preventing excessive weight gain.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Lukasz Grzeskowiak, Eva-Maria Saliu, Anna Grete Wessels, Beatriz Martinez-Vallespin, Klaus Maenner, Jose Joaquin Ceron, Wilfried Vahjen, Juergen Zentek
Summary: Maternal dietary factors have no significant influence on the colonization of Clostridioides difficile in the neonatal piglets' intestines, regardless of whether the sows were fed diets supplemented with high-fermentable sugar beet pulp or low-fermentable lignocellulose. This study provides insights into the relationship between maternal diet and neonatal piglet gut microbiota colonization.
Article
Immunology
Marinela Contreras, Joaquin Vicente, Jose Joaquin Ceron, Silvia Martinez Subiela, Jose Miguel Urra, Francisco J. Rodriguez-del-Rio, Elisa Ferreras-Colino, Rita Vaz-Rodrigues, Isabel G. de Fernandez G. de Mera, Sandra Antunes, Ana Domingos, Christian Gortazar, Jose de la Fuente
Summary: This study identified potential diagnostic, prognostic, and protective antibody binding epitopes for SARS-CoV-2. The results provide new tools for COVID-19 surveillance and risk evaluation in hospitalized patients, as well as potential insights for the development of new vaccines.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Veterinary Sciences
Ana Huertas-Lopez, Gema Alvarez-Garcia, Roberto Sanchez-Sanchez, Ana Cantos-Barreda, Francisco Javier Ibanez-Lopez, Silvia Martinez-Subiela, Jose Joaquin Ceron, Carlos Martinez-Carrasco
Summary: In this study, a systematic review and meta-analysis were conducted to analyze and compare the transdisciplinary and integrative research under the One Health approach for the diagnosis of T. gondii infection. The results showed that further integration among scientific disciplines is needed in the serodiagnosis of T. gondii under the One Health approach.
RESEARCH IN VETERINARY SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Maria Botia, Damian Escribano, Silvia Martinez-Subiela, Asta Tvarijonaviciute, Fernando Tecles, Marina Lopez-Arjona, Jose J. Ceron
Summary: The main glucocorticoids involved in the stress response, such as cortisol, cortisone, and corticosterone, are widely used as biomarkers for evaluating physiological response to stress. Measurement of total glucocorticoids, which encompasses various types of glucocorticoids, is commonly performed using immunoassays. This review explores the characteristics of these glucocorticoids, techniques for their quantification, and the importance of measuring multiple types of glucocorticoids in assessing welfare.
Article
Veterinary Sciences
Laura Miguel-Pastor, Katy Satue, Deborah Chicharro, Pau Pelaez, Marta Torres-Torrillas, Jose M. Carrillo, Jose J. Ceron, Joaquin J. Sopena, Monica Rubio
Summary: Feline leukemia virus (FeLV) is a chronic disease that weakens a cat's immune system. Platelet-rich plasma (PRP) and growth factors (GFs) determination offer potential alternative treatment for improving quality of life in FeLV cats. This study aimed to determine the concentration of platelets, red blood cells, white blood cells, and growth factors in whole blood, PRP, and platelet-poor plasma fractions using a standardized protocol.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
M. Botia, M. Lopez-Arjona, D. Escribano, M. D. Contreras-Aguilar, P. J. Vallejo-Mateo, J. J. Ceron, S. Martinez-Subiela
Summary: In recent years, saliva has been increasingly used as a non-invasive matrix for measuring biomarkers of health and welfare. This study aimed to develop and validate an assay based on luminescent amplification for measuring Hp in bovine saliva, and to examine the changes in inflammatory situations such as the peripartum period and lameness.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Alba Ortin-Bustillo, Damian Escribano, Silvia Martinez-Subiela, Asta Tvarijonaviciute, Alberto Munoz-Prieto, Marina Lopez-Arjona, Jose J. Ceron, Fernando Tecles
Summary: The objective of this study was to evaluate the changes of zinc, copper, iron, and ferritin in pigs during the fattening cycle and at different sampling times. The presence of pen contaminants and storage stability were also assessed. The analytes showed variation throughout the cycle, with higher values in the initial phases. The measurements of zinc and copper also varied at different sampling times. The addition of feces or feed increased the values of all analytes, especially at higher concentrations.
Article
Biochemistry & Molecular Biology
Vitoldo Antonio Kozlowski Neto, Elizabeth Moreira dos Santos Schmidt, Camila Peres Rubio, Naiara Mirelly Marinho da Silva, Renata Tardivo, Ciniro Costa, Paulo Roberto de Lima Meirelles, Jose Joaquin Ceron, Asta Tvarijonaviciute, Alessandro Francisco Talamini do Amarante
Summary: The trial aimed to evaluate the levels of oxidative stress biomarkers and biochemical analytes in crossbred lambs during the rearing phase in an integrated crop-livestock system (ICLS) for controlling gastrointestinal parasites. 36 crossbred lambs were divided into two groups, with one group supplemented with whole cottonseed (WCS) and the other serving as controls. The results showed that the inclusion of WCS was beneficial in controlling infection and increasing antioxidants while reducing oxidants in lambs naturally infected by gastrointestinal parasites. The combination of WCS and ICLS could effectively control gastrointestinal parasite infection without affecting production performance.
Review
Biology
Jose Joaquin Ceron, Alba Ortin-Bustillo, Maria Jose Lopez-Martinez, Silvia Martinez-Subiela, Peter David Eckersall, Fernando Tecles, Asta Tvarijonaviciute, Alberto Munoz-Prieto
Summary: S100 proteins are a group of calcium-binding proteins with similar molecular mass and amino acid sequence, which have diverse biological functions. The calgranulins family, including S100A8, S100A9, and S100A12, have potential value as biomarkers in veterinary science. The heterodimer calprotectin can be formed by SA100A8 and SA100A9 proteins. This review will enhance understanding of S100 proteins and their potential use as biomarkers in the veterinary field.
Article
Food Science & Technology
Jose Enrique de la Rubia Orti, Jose Luis Platero Armero, Maria Cuerda-Ballester, Claudia Emmanuela Sanchis-Sanchis, Esther Navarro-Illana, Jose Maria Lajara-Romance, Maria Benlloch, Jose Joaquin Ceron, Asta Tvarijonaviciute, Belen Proano
Summary: Dyslipidemia in multiple sclerosis (MS) patients is not associated with dietary habits. Administration of epigallocatechin gallate (EGCG) and coconut oil can lower blood triglyceride (TG) levels and potentially improve functional disability.
Article
Veterinary Sciences
Lorena Franco-Martinez, Luis Pardo-Marin, Laura Sanchez-Mateos, Alberto Munoz-Prieto, Juan Diego Garcia-Martinez, Jose J. Ceron, Silvia Martinez-Subiela, Camila P. Rubio, Asta Tvarijonaviciute
Summary: The study found higher levels of ferritin in overweight/obese dogs compared to lean/normal weight dogs, which may indicate tissue hypoxia. Additionally, obese dogs exhibited higher haematocrit and erythrocyte mean corpuscular volume. These findings contribute to our understanding of the mechanisms causing complications in obese dogs.
VETERINARY SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Carlos E. Iglesias-Aguirre, Antonio Gonzalez-Sarrias, Adrian Cortes-Martin, Maria Romo-Vaquero, Leire Osuna-Galisteo, Jose Joaquin Ceron, Juan Carlos Espin, Maria Victoria Selma
Summary: The capacity to produce urolithin varies among individuals due to differences in gut bacterial ecology. In this study, two urolithin-producing bacterial consortia were administered to rats, successfully colonizing their guts and transferring the ability to produce urolithins. The bacterial strains were well-tolerated and did not have adverse effects on gut bacteria, blood parameters, or biochemical parameters, making them potential probiotics for individuals who cannot produce bioactive urolithins.
Article
Veterinary Sciences
Diana Rammal, Christos K. K. Koutinas, Labrini V. V. Athanasiou, Melpomeni Tangalidi, Camila P. P. Rubio, Jose J. Ceron, Androniki Tamvakis, Michael N. N. Patsikas, Zoe S. S. Polizopoulou
Summary: The study aimed to measure the concentration of Paraoxonase-1 (PON-1) and N-terminal-prohormone-B-type natriuretic peptide (NT-proBNP) in dogs with mitral valve disease and determine their association with clinical stage and specific clinico-pathologic and echocardiographic findings. The results showed that PON-1 was not correlated with clinical stage, gender, or concurrent conditions. NT-proBNP, on the other hand, was correlated with clinical stage and echocardiographic indices of cardiomegaly and heart failure. These findings suggest that PON-1 is an insensitive marker for the severity of mitral valve disease and its utility may be hindered by confounding factors.
VETERINARY SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Mehak Nisar, Shafayat Ahmad Beigh, Abdul Qayoom Mir, Syed Ashaq Hussain, Aijaz Ahmad Dar, Iqbal Yatoo, Adil Mehraj Khan
Summary: This study aimed to evaluate the role of vitamin D in redox balance, insulin resistance, and its predicting value for subclinical pregnancy toxemia (SPT) in pregnant ewes. The results showed that ewes with insufficient vitamin D had significantly lower total antioxidant capacity (TAC) compared to ewes with sufficient vitamin D, and there were significant differences in metabolite concentrations between the two groups. Additionally, vitamin D was positively correlated with fructosamine, calcium, and TAC, and negatively correlated with non-esterified fatty acid (NEFA) and total oxidant status (TOS). Ewes with insufficient vitamin D had a higher risk of developing SPT two weeks prior to lambing and at lambing.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
L. G. Gonzalez-Arostegui, A. Munoz-Prieto, C. P. Rubio, J. J. Ceron, L. Bernal, I. Rubic, V. Mrljak, J. C. Gonzalez-Sanchezc, A. Tvarijonaviciute
Summary: This study investigated changes in the saliva and serum proteome of dogs with hypothyroidism using TMT labelling and LC-MS/MS. The findings showed that this disease induces alterations in the saliva and serum proteome, reflecting physiological and pathological changes in the immune system, metabolism, skin, and coagulation. The downregulation of LDH in saliva may serve as a potential biomarker for canine hypothyroidism.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
Camila R. C. Brito, Agatha D. Cordeiro, Pricila Baldessar, Carolini Schultz, Monike Quirino, Rafael R. Ulguim, Paulo B. D. Goncalves, Thomaz Lucia Jr, Ivan Bianchi, Bernardo G. Gasperin
Summary: This study tested synchronization protocols without progestogens during the luteal phase in gilts. The results showed that the protocols based on PGF and hCG were effective in reducing the interval between estrus in gilts. Additionally, the hCG2 protocol had negative effects on the number of piglets born alive and total litter size.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
F. Frers, J. Delarocque, K. Feige, K. Huber, T. Warnken
Summary: This study aimed to investigate the relationship between insulin dysregulation and the expression and phosphorylation of key proteins in the insulin signaling cascade in different tissues of horses. The results showed enhanced phosphorylation of the insulin receptor and protein kinase B in response to stimulation, while phosphorylation of adenosine monophosphate protein kinase alpha decreased after glucose administration. Interestingly, horses with insulin dysregulation had significantly higher phosphorylation of mechanistic target of rapamycin in muscle tissue. These findings suggest that insulin signaling is maintained in horses, but post-receptor alterations may occur.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
Patrice Dufour, Vincent Frisee, Goulven Rigaux, Flore Brutinel, Sophie Egyptien, Philippe Bossaert, Jessica Deleersnyder, Stefan Deleuze, Stephanie Peeters, Caroline Le Goff, Jerome Ponthier, Etienne Cavalier
Summary: This report describes the method of measuring progesterone and estrone-sulfate using Liquid Chromatography coupled with Mass Spectrometry in American Bison feces. This method provides an alternative to serum assay for studying the pregnancy-related evolution of these hormones in American Bison.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)