Article
Biochemistry & Molecular Biology
Emily E. Selig, Roberta J. Lynn, Courtney O. Zlatic, Yee-Foong Mok, Heath Ecroyd, Paul R. Gooley, Michael D. W. Griffin
Summary: The crystallin domain of human sHSPs interacts with amyloid fibrils to inhibit their elongation and joining. This interaction is sensitive to fibril concentration, suggesting a regulatory role in fibril dynamics.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Florence Franconi, Laurent Lemaire, Jean-Christophe Gimel, Samuel Bonnet, Patrick Saulnier
Summary: NMR-based diffusion methods are valuable tools for nanomedicine characterization and understanding interactions with the biological environment. They provide insights into diffusion phenomena and measurement of self-diffusion and mutual diffusion coefficients. NMR diffusometry spectroscopic and imaging methods have broad applications in nanomedicine, aiding in elucidating important issues.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Physics, Multidisciplinary
Ainitze Biteri-Uribarren, Pol Alsina-Bolivar, Carlos Munuera-Javaloy, Ricardo Puebla, Jorge Casanova
Summary: This study tackles the detection of individual molecules by combining a hybrid sensor-a nitrogen vacancy center (NV) and a dangling bond on the diamond surface-with a multi-tone dynamical decoupling sequence. Via numerical simulations, the authors prove that the sequence minimizes the impact of decoherence, which allows using the dangling-bond as a signal amplifier.
COMMUNICATIONS PHYSICS
(2023)
Article
Nutrition & Dietetics
Erwin Garcia, Irina Shalaurova, Steven P. Matyus, Joelle C. Schutten, Stephan J. L. Bakker, Robin P. F. Dullaart, Margery A. Connelly
Summary: The study found that ionized magnesium levels measured by an optimized nuclear magnetic resonance method were associated with type 2 diabetes. In IRAS participants, ionized magnesium levels were significantly lower in prediabetes and type 2 diabetes patients, possibly influenced by gender, and predicted the development of future type 2 diabetes.
Article
Quantum Science & Technology
Soham Pal, Priya Batra, Tanjung Krisnanda, Tomasz Paterek, T. S. Mahesh
Summary: Quantum entanglement is a unique form of correlation between quantum particles that cannot be increased through local operations and classical communication. The presence of entanglement gain between detectors interacting through a classical mediator suggests non-classical characteristics of the mediator. Research indicates the significance of the initial state in determining the entanglement gain between detectors.
Article
Physics, Multidisciplinary
Wentian Zheng, Ke Bian, Xiakun Chen, Yang Shen, Shichen Zhang, Rainer Stohr, Andrej Denisenko, Jorg Wrachtrup, Sen Yang, Ying Jiang
Summary: An efficient method was developed to engineer the electrostatic environment of near-surface nitrogen vacancy center qubits, increasing their coherence and sensitivity.
Article
Chemistry, Analytical
Lihua Xu, Biling Huang, Zhiying Hou, Shaohua Huang, Yufen Zhao
Summary: This study demonstrates the simultaneous analysis of a complex mixture using solvent effects by F-19 NMR spectroscopy, which enables the identification and quantification of multiple amino acids. This method has important implications for human health and disease diagnosis.
ANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Hsueh-Ying Chen, C. Blake Wilson, Robert Tycko
Summary: The spatial resolution of MRI is limited by signal detection sensitivity, but can be improved by performing measurements at low temperature and using dynamic nuclear polarization (DNP) technique. This allows for higher resolution and shorter data acquisition times, offering a promising direction for high-resolution MRI studies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Kathryn E. Anderssen, Geir Wing Gabrielsen, Mathias Kranz, France Collard
Summary: Monitoring plastic ingestion by marine wildlife is crucial for understanding the extent of plastic pollution and its impact on species and ecosystems. Current detection methods are slow and invasive, limiting the number of animals that can be screened. This study explores the use of MRI as a rapid and non-invasive method to detect plastic ingestion. The results show that MRI and NMR can directly or indirectly detect plastic in the digestive system of animals, with distinctive NMR signal characteristics for each type of plastic. While commercial MRI technology is not suitable for field use, existing single-sided MRI research systems could be adapted for monitoring wildlife outside the laboratory.
MARINE POLLUTION BULLETIN
(2022)
Review
Chemistry, Multidisciplinary
Thomas Allam, Dominick E. Balderston, Mandeep K. Chahal, Kira L. F. Hilton, Charlotte K. Hind, Olivia B. Keers, Rebecca J. Lilley, Chandni Manwani, Alix Overton, Precious I. A. Popoola, Lisa R. Thompson, Lisa J. White, Jennifer R. Hiscock
Summary: This tutorial review focuses on the characterization of supramolecular amphiphiles and their aggregates, covering various techniques such as nuclear magnetic resonance spectroscopy and mass spectrometry. The review also provides guidance for applying these techniques in vitro and in vivo, as well as using accessible software programs. It offers valuable insights and future directions in the field of supramolecular amphiphiles.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Engineering, Electrical & Electronic
Feifei Ge, Bing Chen, Yangpeng Wang, Feifei Zhou, Renfei Zheng, Xiaofan Yang, Peng Qian, Nanyang Xu
Summary: We present a wideband balun-based microwave device for quantum manipulation of nitrogen-vacancy centers in diamond. The device has a large bandwidth and excellent magnetic field homogeneity, making it suitable for solid-state quantum information processing.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zoe L. Sinclair, Nicola L. Bell, Jessica. R. R. Bame, De-Liang Long, Leroy Cronin
Summary: Polyoxopalladates (POPs) are a class of self-assembling palladium-oxide clusters that have different sizes, shapes, and compositions. The largest compound in this family, {Pd-84}(Ac), is an ideal molecule for exploring supramolecular behavior in aqueous media. Through molecular visualization and nuclear magnetic resonance studies, it has been found that {Pd-84}(Ac) forms a 1:7 host-guest complex with benzyl viologen (BV2+) in aqueous solution.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Medical Laboratory Technology
Erwin Garcia, Irina Shalaurova, Steven P. Matyus, Justyna Wolak-Dinsmore, David N. Oskardmay, Margery A. Connelly
Summary: A high-throughput nuclear magnetic resonance (NMR)-based assay has been developed for measuring choline in serum and plasma. The assay exhibits good performance characteristics and can be used for clinical purposes.
CLINICA CHIMICA ACTA
(2022)
Article
Quantum Science & Technology
Johannes Jakob Meyer, Johannes Borregaard, Jens Eisert
Summary: This research demonstrates the feasibility of variational quantum algorithms on noisy and intermediate-scale quantum devices to address the core challenge of multi-parameter estimation problems. A general framework is introduced and practical functionality is shown through numerical simulations. By utilizing quantum technology, more optimal quantum metrology protocols have been developed.
NPJ QUANTUM INFORMATION
(2021)
Article
Quantum Science & Technology
Nicolas Staudenmaier, Anjusha Vijayakumar-Sreeja, Santiago Oviedo-Casado, Genko Genov, Daniel Cohen, Daniel Dulog, Thomas Unden, Nico Striegler, Alastair Marshall, Jochen Scheuer, Christoph Findler, Johannes Lang, Ilai Schwartz, Philipp Neumann, Alex Retzker, Fedor Jelezko
Summary: Diffusion noise is the main cause of spectral line broadening in liquid-state nano-scale nuclear magnetic resonance with shallow nitrogen-vacancy centers, resulting in limited resolution. However, a more accurate analysis of diffusion reveals that correlations persist for a longer time at the nano-scale, allowing for improved resolution and challenging our understanding of diffusion. Through experiments using different setups and measurement techniques, we provide overwhelming evidence of power-law decay of correlations, leading to sharp-peaked spectral lines where diffusion broadening is no longer a limitation to resolution.
NPJ QUANTUM INFORMATION
(2022)
Article
Substance Abuse
Rong Guo, Steve M. Simasko, Heiko T. Jansen
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2016)
Article
Physiology
K. S. Rigano, J. L. Gehring, B. D. Evans Hutzenbiler, A. V. Chen, O. L. Nelson, C. A. Vella, C. T. Robbins, H. T. Jansen
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2017)
Article
Ecology
Jasmine V. Ware, Karyn D. Rode, Jeffrey F. Bromaghin, David C. Douglas, Ryan R. Wilson, Eric V. Regehr, Steven C. Amstrup, George M. Durner, Anthony M. Pagano, Jay Olson, Charles T. Robbins, Heiko T. Jansen
Article
Biodiversity Conservation
Marc Cattet, Gordon B. Stenhouse, David M. Janz, Luciene Kapronczai, Joy Anne Erlenbach, Heiko T. Jansen, O. Lynne Nelson, Charles T. Robbins, John Boulanger
CONSERVATION PHYSIOLOGY
(2017)
Article
Veterinary Sciences
Hilary L. Wright, Annie Chen, Heiko T. Jansen
JOURNAL OF ZOO AND WILDLIFE MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Chantal A. Vella, O. Lynne Nelson, Heiko T. Jansen, Charles T. Robbins, Andrew E. Jensen, Silvana Constantinescu, Marcia J. Abbott, Lorraine P. Turcotte
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2020)
Article
Biology
Jasmine V. Ware, Karyn D. Rode, Charles T. Robbins, Tanya Leise, Colby R. Weil, Heiko T. Jansen
JOURNAL OF BIOLOGICAL RHYTHMS
(2020)
Correction
Biology
Heiko T. Jansen, Shawn Trojahn, Michael W. Saxton, Corey R. Quackenbush, Brandon D. Evans Hutzenbiler, O. Lynne Nelson, Omar E. Cornejo, Charles T. Robbins, Joanna L. Kelley
COMMUNICATIONS BIOLOGY
(2020)
Article
Biology
Heiko T. Jansen, Brandon Evans Hutzenbiler, Hannah R. Hapner, Madeline L. McPhee, Anthony M. Carnahan, Joanna L. Kelley, Michael W. Saxton, Charles T. Robbins
Summary: Feeding glucose to hibernating bears partially restores metabolic parameters to active season levels, with some indicators remaining incomplete due to the suppression of circulating free fatty acids. The study provides a controlled model to examine the relationship between nutrient availability and metabolism on the hibernation phenotype in bears.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Veterinary Sciences
Marc Cattet, David M. Janz, Luciene Kapronczai, Joy A. Erlenbach, Heiko T. Jansen, O. Lynne Nelson, Charles T. Robbins, Gordon B. Stenhouse
Summary: The study showed that injecting cosyntropin into captive grizzly bears caused a significant increase in blood cortisol levels within a short period, but did not have a noticeable effect on hair cortisol concentration. This suggests that the spike in cortisol induced by cosyntropin may not be sufficient to explain the stress response of free-ranging bears when captured. Further research with a larger sample of captive bears is recommended to better simulate the adrenocortical response in these animals.
VETERINARY MEDICINE AND SCIENCE
(2021)
Article
Evolutionary Biology
Richard J. Wang, Yadira Pena-Garcia, Madeleine G. Bibby, Muthuswamy Raveendran, R. Alan Harris, Heiko T. Jansen, Charles T. Robbins, Jeffrey Rogers, Joanna L. Kelley, Matthew W. Hahn
Summary: This study examines the per-generation mutation rate in a brown bear pedigree and finds that both male bias and per-generation mutation rates are similar to that of non-hibernating species, contradicting previous theories. These findings provide new evidence for the determinants of mutation rates and mutation biases.
GENOME BIOLOGY AND EVOLUTION
(2022)
Article
Physiology
Ellery P. Vincent, Blair W. Perry, Joanna L. Kelley, Charles T. Robbins, Heiko T. Jansen
Summary: Hibernation and circadian rhythms play important roles in energy conservation for brown bears. The study shows that culturing cells at hibernation body temperature delays ATP production peak and alters the timing and amplitudes of mitochondrial gene transcription and circadian gene transcripts. Key metabolic genes linked to the circadian system and energy balance also show changes.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2023)
Article
Cell Biology
Blair W. Perry, Anna L. Mcdonald, Shawn Trojahn, Michael W. Saxton, Ellery P. Vincent, Courtney Lowry, Brandon D. Evans Hutzenbiler, Omar E. Cornejo, Charles T. Robbins, Heiko T. Jansen, Joanna L. Kelley
Summary: Hibernation in bears involves changes in gene expression in multiple tissues, including insulin resistance, and feeding bears glucose during hibernation can partially restore active season physiological phenotypes. This study analyzes gene expression in adipose, liver, and muscle tissues to identify genes that respond to midhibernation glucose feeding and drive metabolic and physiological shifts. The results suggest that peroxisome proliferator-activated receptor gamma (PPARG) and other regulators of insulin sensitivity play a role in shifting metabolic phenotypes between hibernation and active states.
PHYSIOLOGICAL GENOMICS
(2023)
Article
Biology
Heiko T. Janseng, Shawn Trojahn, Michael W. Saxton, Corey R. Quackenbush, Brandon D. Evans Hutzenbiler, O. Lynne Nelson, Omar E. Cornejo, Charles T. Robbins, Joanna L. Kelley
COMMUNICATIONS BIOLOGY
(2019)
Article
Zoology
D. R. Rivet, O. L. Nelson, C. A. Vella, H. T. Jansen, C. T. Robbins
CANADIAN JOURNAL OF ZOOLOGY
(2017)
Article
Agriculture, Dairy & Animal Science
Mehak Nisar, Shafayat Ahmad Beigh, Abdul Qayoom Mir, Syed Ashaq Hussain, Aijaz Ahmad Dar, Iqbal Yatoo, Adil Mehraj Khan
Summary: This study aimed to evaluate the role of vitamin D in redox balance, insulin resistance, and its predicting value for subclinical pregnancy toxemia (SPT) in pregnant ewes. The results showed that ewes with insufficient vitamin D had significantly lower total antioxidant capacity (TAC) compared to ewes with sufficient vitamin D, and there were significant differences in metabolite concentrations between the two groups. Additionally, vitamin D was positively correlated with fructosamine, calcium, and TAC, and negatively correlated with non-esterified fatty acid (NEFA) and total oxidant status (TOS). Ewes with insufficient vitamin D had a higher risk of developing SPT two weeks prior to lambing and at lambing.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
L. G. Gonzalez-Arostegui, A. Munoz-Prieto, C. P. Rubio, J. J. Ceron, L. Bernal, I. Rubic, V. Mrljak, J. C. Gonzalez-Sanchezc, A. Tvarijonaviciute
Summary: This study investigated changes in the saliva and serum proteome of dogs with hypothyroidism using TMT labelling and LC-MS/MS. The findings showed that this disease induces alterations in the saliva and serum proteome, reflecting physiological and pathological changes in the immune system, metabolism, skin, and coagulation. The downregulation of LDH in saliva may serve as a potential biomarker for canine hypothyroidism.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
Camila R. C. Brito, Agatha D. Cordeiro, Pricila Baldessar, Carolini Schultz, Monike Quirino, Rafael R. Ulguim, Paulo B. D. Goncalves, Thomaz Lucia Jr, Ivan Bianchi, Bernardo G. Gasperin
Summary: This study tested synchronization protocols without progestogens during the luteal phase in gilts. The results showed that the protocols based on PGF and hCG were effective in reducing the interval between estrus in gilts. Additionally, the hCG2 protocol had negative effects on the number of piglets born alive and total litter size.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
F. Frers, J. Delarocque, K. Feige, K. Huber, T. Warnken
Summary: This study aimed to investigate the relationship between insulin dysregulation and the expression and phosphorylation of key proteins in the insulin signaling cascade in different tissues of horses. The results showed enhanced phosphorylation of the insulin receptor and protein kinase B in response to stimulation, while phosphorylation of adenosine monophosphate protein kinase alpha decreased after glucose administration. Interestingly, horses with insulin dysregulation had significantly higher phosphorylation of mechanistic target of rapamycin in muscle tissue. These findings suggest that insulin signaling is maintained in horses, but post-receptor alterations may occur.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
Patrice Dufour, Vincent Frisee, Goulven Rigaux, Flore Brutinel, Sophie Egyptien, Philippe Bossaert, Jessica Deleersnyder, Stefan Deleuze, Stephanie Peeters, Caroline Le Goff, Jerome Ponthier, Etienne Cavalier
Summary: This report describes the method of measuring progesterone and estrone-sulfate using Liquid Chromatography coupled with Mass Spectrometry in American Bison feces. This method provides an alternative to serum assay for studying the pregnancy-related evolution of these hormones in American Bison.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
