Journal
DNA REPAIR
Volume 7, Issue 1, Pages 1-9Publisher
ELSEVIER
DOI: 10.1016/j.dnarep.2007.07.004
Keywords
Swi5-Sfr1; Rad51; Dmc1; homologous recombination; recombination mediator; Schizosaccharomyces pombe
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The Schizosaccharomyces pombe Swi5 protein forms two distinct protein complexes, SwiS-Sfr1 and Swi5-Swi2, each of which plays an important role in the related but functionally distinct processes of homologous recombination and mating-type switching, respectively. The Swi5-Sfr1 mediator complex has been shown to associate with the two RecA-like recombinases, Rhp51 (spRad51) and Dmc1, and to stimulate in vitro DNA strand exchange reactions mediated by these proteins. Genetic analysis indicates that Swi5-Sfr1 works independently of another mediator complex, Rhp55-Rhp57, during Rhp51-dependent recombinational repair. In addition, mutations affecting the two mediators generate distinct repair spectra of HO endonuclease-induced DNA double strand breaks, suggesting that these recombination mediators differently regulate recombination outcomes in an independent manner. (C) 2007 Elsevier B.V. All rights reserved.
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