Use of a Physiologically Based Pharmacokinetic Model for Quantitative Prediction of Drug–Drug Interactions via CYP3A4 and Estimation of the Intestinal Availability of CYP3A4 Substrates

Published 2015 View Full Article

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Title
Use of a Physiologically Based Pharmacokinetic Model for Quantitative Prediction of Drug–Drug Interactions via CYP3A4 and Estimation of the Intestinal Availability of CYP3A4 Substrates
Authors
Keywords
clinical trial simulations, cytochrome P450, drug interactions, intestinal metabolism, pharmacokinetics, physiologically based pharmacokinetic modeling
Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 104, Issue 9, Pages 3183-3193
Publisher
Elsevier BV
Online
2015-06-05
DOI
10.1002/jps.24495

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