Article
Pathology
Lina Yu, Yunlong Li, Hui Wang, Dong Wang, Huiting Hao, DongWei Zhang, Xiao Liang, Mengdi Cai, Rongwei Guan, Jing Bai, Jingcui Yu
Summary: In this study, the association between six single nucleotide polymorphisms (SNPs) of the OVCA1 gene and the risk of gastric cancer in the Han population of northeast China was evaluated. The study found that the AA + AG genotype of rs2273981 was significantly associated with an increased risk of gastric cancer in smokers, while the AG + GG genotype of rs1131600 and the CT + TT genotype of rs2236375 were significantly associated with increased gastric tumor volume. Furthermore, the rs2273981 GG genotype increased the transcription activity of OVCA1, potentially contributing to gastric cancer development.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Chao Liu, Wenhui Gao, Yijun Shi, Lu Lv, Weifeng Tang
Summary: This study investigated the relationship between miRNA rs2910164, rs11614913, and rs3746444 polymorphisms and the susceptibility to esophageal squamous cell cancer (ESCC) in the Chinese Han nationality. The results suggest that the rs3746444 GG genotype is associated with an increased risk of ESCC, while rs11614913 and rs2910164 polymorphisms are not associated with ESCC.
Article
Immunology
Shuyuan Liu, Nannan Liu, Hui Wang, Xinwen Zhang, Yufeng Yao, Shuqiong Zhang, Li Shi
Summary: The study found an association between CCR5 promoter polymorphisms and pulmonary TB and TB progression in the Chinese Han population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Yisen Cheng, Qiqi Tang, Yu Li, Xusan Xu, Xiangfan Zhen, Ning Chang, Si Huang, Jieqing Zeng, Fei Luo, Qianqian Ouyang, Liuquan Peng, Guoda Ma, Yajun Wang
Summary: miR-146a SNPs are associated with asthma susceptibility and clinical features in Southern Chinese Han population. rs2910164 C/G genotype increases asthma risk in females, while rs57095329 G/G genotype affects clinical characteristics of males with asthma. Furthermore, these SNPs affect miR-146a levels and structure in asthma patients.
Article
Cardiac & Cardiovascular Systems
Qing Zhang, Huan Yu, Zhenzhen Yang, Lijuan Li, Yan He, Shaohua Zhu, Chengtao Li, Suhua Zhang, Bin Luo, Yuzhen Gao
Summary: This study identified a 4-bp insertion/deletion variant in the miR-155 host gene associated with susceptibility to sudden cardiac death in a Chinese population. The homozygote deletion genotype was found to significantly decrease the risk of SCD. Further analysis revealed that the deletion allele was linked to lower expression levels of MIR155HG and mature miR155, indicating a potential biological mechanism for the decreased risk of SCD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Clinical Neurology
Xiao-Dong Deng, Jian-Lin Ke, Tai-Yu Chen, Qin Gao, Zhuo-Lin Zhao, Wei Zhang, Huan Liu, Ming-Liang Xiang, Li-Zhen Wang, Ying Ma, Yun Liu
Summary: In this study, the ERCC1 rs3212986 polymorphism was found to be associated with susceptibility to ischemic stroke in a Chinese Han population. The A allele of rs3212986 was found to be related to increased risk of ischemic stroke. The altered expression of the ERCC1 gene caused by the rs3212986 polymorphism may be involved in the pathophysiological process of ischemic stroke.
FRONTIERS IN NEUROLOGY
(2023)
Article
Oncology
Xiang Ma, Younan Wang, Hao Fan, Chuming Zhu, Wangwang Chen, Zengliang Li, Jian Xiao, Peidong Ni, Zekuan Xu, Li Yang
Summary: This study investigated the correlation of CTSB-related polymorphisms with gastric cancer (GC) risk and prognosis, finding that certain variants were associated with decreased risks of GC, earlier T stage, and better overall prognosis. The results suggest the importance of CTSB-related polymorphisms in predicting GC risk and prognosis.
Article
Biochemistry & Molecular Biology
Chrysostomos Avgeros, Aikaterini Patsatsi, Dimitrios Dimitriadis, Andigoni Malousi, Triantafyllia Koletsa, Despoina Papathemeli, Antonia Syrnioti, Paraskevi Avgerou, Elizabeth Lazaridou, Georgios Tzimagiorgis, Elisavet Georgiou
Summary: This study evaluates the plasma levels of miR-146a and miR-155 in Mycosis Fungoides (MF) patients and investigates their association with SNPs of their genes. The results show that the plasma levels of miR-146a and miR-155 are significantly higher in MF patients compared to controls, especially in early and advanced stages. miR-155 levels are significantly higher in patients with skin tumors or erythroderma. The presence of specific SNPs is associated with the expression of miRs and potentially with disease susceptibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yi Shen, Yi Shao, Xiaoli Ruan, Lingyan Zhu, Zhaoping Zang, Tong Wei, Rena Nakyeyune, Wenqiang Wei, Fen Liu
Summary: This study found that the rs1804506 polymorphism located in miR-17-92 cluster binding sites is associated with the susceptibility of ESCC, especially in older individuals, females, or non-smokers. The rs1804506 T allele reduces the binding of miR-19a-3p and TGFBR3, suggesting its potential role in ESCC development.
Article
Environmental Sciences
Long Miao, Boshen Wang, Juan Zhang, Lihong Yin, Yuepu Pu
Summary: This study investigated the association between SNPs in the AKT2 gene and susceptibility to NIHL, finding that the rs2304186 genotype increases the risk of NIHL, especially in male subgroups and certain age categories. Additionally, a specific haplotype involving rs2304186-rs41275750-rs76524493 was significantly associated with a higher risk of NIHL. Functional experiments revealed that the rs2304186 G allele alters the binding affinity of hsa-miR-625-5p to the mutation region in an allele-specific manner, suggesting its potential role as a biomarker for NIHL susceptibility.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Medicine, General & Internal
Wei Li, Haidong Jiang, Xu Chen, Kevin Yang, Xindan Deng, Zheng Tang, Zhihui Hu, Xiaodan Zhang, Shihan Lin, Yuanlin Zou, Hui Wu
Summary: A case series study and case-control study were conducted on patients with Graves' disease (GD), revealing several gene variants associated with familial GD, including PTPRB, TRAF3IP3, and DISC1. More variants of these genes were found in GD patients, suggesting their susceptibility to GD.
Article
Biology
Yifeng Yang, Wenwen Lu, Mei Ning, Xianhao Zhou, Xinyao Wan, Qianglong Mi, Xiaoyan Yang, Di Zhang, Yuanyuan Zhang, Biao Jiang, Lin He, Jia Liu, Yan Zou
Summary: A T/C variant in miR-27a is associated with bipolar disorder by reducing its ability to target important neurodevelopmental genes. This study reveals the relationship between genetic variations of miRNA and schizophrenia or bipolar disorder, emphasizing the importance of miR-27a and its polymorphism in bipolar disorder.
COMMUNICATIONS BIOLOGY
(2022)
Article
Genetics & Heredity
Baoping Hu, Yuhe Wang, Zhongtao Wang, Xue He, Li Wang, Dongya Yuan, Yongjun He, Tianbo Jin, Shumei He
Summary: By studying the northwest Chinese Han population, this research identified the relationships between polymorphisms in or near the SLC11A1 gene and age- and sex-specific tuberculosis risk.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Guiyi Ji, Miaomiao Zhang, Qianqian Liu, Shouquan Wu, Yu Wang, Guo Chen, Andrew J. Sandford, Jian-Qing He
Summary: The study found that single nucleotide polymorphisms of the NFE2L2 gene are associated with susceptibility to tuberculosis, potentially impacting the occurrence of tuberculosis through regulation of NFE2L2's transcriptional activity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Silvia Jimenez-Morales, Juan Carlos Nunez-Enriquez, Jazmin Cruz-Islas, Vilma Carolina Bekker-Mendez, Elva Jimenez-Hernandez, Aurora Medina-Sanson, Irma Olarte-Carrillo, Adolfo Martinez-Tovar, Janet Flores-Lujano, Julian Ramirez-Bello, Maria Luisa Perez-Saldivar, Jorge Alfonso Martin-Trejo, Hector Perez-Lorenzana, Raquel Amador-Sanchez, Felix Gustavo Mora-Rios, Jose Gabriel Penaloza-Gonzalez, David Aldebaran Duarte-Rodriguez, Jose Refugio Torres-Nava, Juan Eduardo Flores-Bautista, Rosa Martha Espinosa-Elizondo, Pedro Francisco Roman-Zepeda, Luz Victoria Flores-Villegas, Edna Liliana Tamez-Gomez, Victor Hugo Lopez-Garcia, Jose Ramon Lara-Ramos, Juana Esther Gonzalez-Ulivarri, Sofia Irene Martinez-Silva, Gilberto Espinoza-Anrubio, Carolina Almeida-Hernandez, Rosario Ramirez-Colorado, Luis Hernandez-Mora, Luis Ramiro Garcia-Lopez, Gabriela Adriana Cruz-Ojeda, Arturo Emilio Godoy-Esquivel, Iris Contreras-Hernandez, Abraham Medina-Hernandez, Maria Guadalupe Lopez-Caballero, Norma Angelica Hernandez-Pineda, Jorge Granados-Kraulles, Maria Adriana Rodriguez-Vazquez, Delfino Torres-Valle, Carlos Cortes-Reyes, Francisco Medrano-Lopez, Jessica Arleet Perez-Gomez, Annel Martinez-Rios, Antonio Aguilar-De-los-Santos, Berenice Serafin-Diaz, Maria de Lourdes Gutierrez-Rivera, Laura Elizabeth Merino-Pasaye, Gilberto Vargas-Alarcon, Minerva Mata-Rocha, Omar Alejandro Sepulveda-Robles, Haydee Rosas-Vargas, Alfredo Hidalgo-Miranda, Juan Manuel Mejia-Arangure
Summary: The study found that the SNP in the miR-499a gene (rs3746444) showed significant differences between ALL patients and the control group, with the GG genotype posing a higher risk for ALL, especially in males. There was also a gender-dependent association between SNPs in the miR-146a and miR-196a-2 genes and susceptibility to ALL in Mexican children.
FRONTIERS IN ONCOLOGY
(2021)