Article
Endocrinology & Metabolism
Dexian Kong, Ya Duan, Jinli Wang, Yabin Liu
Summary: This study suggests that the CC genotype of rs4705342 may be a risk factor for developing T2DM in the northern Chinese Han population by increasing the expression levels of miR-143.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Qing Zhang, Huan Yu, Zhenzhen Yang, Lijuan Li, Yan He, Shaohua Zhu, Chengtao Li, Suhua Zhang, Bin Luo, Yuzhen Gao
Summary: This study identified a 4-bp insertion/deletion variant in the miR-155 host gene associated with susceptibility to sudden cardiac death in a Chinese population. The homozygote deletion genotype was found to significantly decrease the risk of SCD. Further analysis revealed that the deletion allele was linked to lower expression levels of MIR155HG and mature miR155, indicating a potential biological mechanism for the decreased risk of SCD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Fuming Deng, Jinglu Zhao, Wei Jia, Kai Fu, Xiaoyu Zuo, Lihua Huang, Ning Wang, Huiming Xia, Yan Zhang, Wen Fu, Guochang Liu
Summary: GREM1 risk allele rs3743104[G] significantly increases the risk of mild/moderate and severe hypospadias in the Southern Han population, by altering the binding affinity of miR-182 to its gene locus for regulating GREM1 expression. This study provides new evidence for the association of GREM1 rs3743104 with hypospadias susceptibility, and suggests potential for a promising biomarker and further exploration.
Article
Cell Biology
Zhicheng Yang, Weixi Liu, Ting Yan, Ruiping Liu
Summary: The study revealed that HLA-DPB1 rs9277535 polymorphism is associated with a decreased risk of rheumatoid arthritis in the Chinese population, particularly among women and those at least 55 years old. Additionally, certain genotypes were linked to inflammatory markers and levels of HLA-DPB1 plasma and mRNA in RA patients.
Article
Biochemistry & Molecular Biology
Maria Radanova, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, Ivan Donev
Summary: There is a growing interest in studying single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, as they may be associated with susceptibility, prognosis, and treatment response in colorectal cancer (CRC). These miRNA-SNPs could serve as non-invasive biomarkers for early detection of CRC. However, contradictory findings have been reported when different research groups investigated the same SNP in a gene for a specific miRNA, highlighting the need for more case-control studies involving participants from different ethnic backgrounds. According to our review, three miRNA-SNPs - miR-146a rs2910164, miR-27a rs895819, and miR-608 rs4919510 - appear to be promising prognostic, diagnostic, and predictive biomarkers for CRC.
Article
Clinical Neurology
Yin-Hua Weng, Wen-Tao Yu, Yan-Ping Luo, Chao Liu, Xi-Xi Gu, Huo-Ying Chen, Hong-Bo Liu
Summary: The miR-365 rs30230 polymorphism may be associated with susceptibility to IS in the Chinese population. The TC/TT genotypes of rs30230 may be protective factors against IS.
FRONTIERS IN NEUROLOGY
(2023)
Article
Immunology
Shuyuan Liu, Nannan Liu, Hui Wang, Xinwen Zhang, Yufeng Yao, Shuqiong Zhang, Li Shi
Summary: The study found an association between CCR5 promoter polymorphisms and pulmonary TB and TB progression in the Chinese Han population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Natalia Landeros, Alejandro H. Corvalan, Maher Musleh, Luis A. Quinones, Nelson M. Varela, Patricio Gonzalez-Hormazabal
Summary: This study identified seven novel associations and replicated one previously described in Caucasian population, providing insights into the understanding of miRNA genetic polymorphisms in gastric cancer pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Jun Zhang, Jian Qi, Jia Shu, Guannan Su, Qingfeng Cao, Chunjiang Zhou, Yao Wang, Peizeng Yang
Summary: This study investigated the effects of lncRNA-related SNPs on Behcet's disease susceptibility in Chinese populations. The results showed a significantly decreased frequency of the rs7130280 A allele in BD patients, with functional experiments demonstrating its impact on NONHSAT159216.1 secondary structure and expression, as well as cell proliferation inhibition.
Article
Pathology
Lina Yu, Yunlong Li, Hui Wang, Dong Wang, Huiting Hao, DongWei Zhang, Xiao Liang, Mengdi Cai, Rongwei Guan, Jing Bai, Jingcui Yu
Summary: In this study, the association between six single nucleotide polymorphisms (SNPs) of the OVCA1 gene and the risk of gastric cancer in the Han population of northeast China was evaluated. The study found that the AA + AG genotype of rs2273981 was significantly associated with an increased risk of gastric cancer in smokers, while the AG + GG genotype of rs1131600 and the CT + TT genotype of rs2236375 were significantly associated with increased gastric tumor volume. Furthermore, the rs2273981 GG genotype increased the transcription activity of OVCA1, potentially contributing to gastric cancer development.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Jie Shen, Yiling Wu, Miao Mo, Xiaoshuang Feng, Changming Zhou, Zezhou Wang, Guoxiang Cai, Ying Zheng
Summary: This study found that sex, body mass index (BMI), and family history of CRC were associated with early-onset colorectal neoplasm. The RCS model showed a positive dose-response and linear association between BMI and risk of early-onset colorectal neoplasm among young participants. Further research is needed to explore the underlying causes of early-onset CRC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Yuqing Liu, Ling Mei, Yueyue Chen, Xiaoli Zhang, Dongmei Wei, Tao Cui, Yueting Zhang, Tao Wang, Xiaoyu Niu
Summary: Cervical cancer is a complex disease affected by the interaction of multiple SNPs, and rs59661306, rs257847, and rs637442 are potential susceptibility loci for cervical cancer.
REPRODUCTIVE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bayram Bayramov, Nuru Bayramov, Hazi Aslanov, Nigar Karimova, Karim Gasimov, Ilham Shahmuradov, Christoph Reissfelder, Vugar Yagublu
Summary: The study investigated the relationship between miR-149 and miR-196a2 small non-coding RNA polymorphisms and the risk of developing colorectal cancer in the Azerbaijani population. The findings suggest that the miR-149 gene mutation may have a protective role in female colorectal cancer, while the miR-196a2 gene polymorphism is associated with an increased risk of colorectal cancer in women.
Article
Pathology
Yuchen Jin, Linghan Meng, Haoyi Yang, Sirui Cheng, Yiting Xiao, Xingru Wang, Xianhong Feng, Qiantao Xiong, Bifeng Chen
Summary: The rs2227478 T > C polymorphism in the promoter region of the IL-22 gene is significantly associated with colorectal cancer risk, with the C allele showing a reduced risk compared to the T allele. Individuals with the CT+CC genotypes of rs2227478 have lower levels of IL22 mRNA in CRC tissue samples, and the C allele exhibits higher binding affinity to the transcription repressor Sp1.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Virology
Zepei Feng, Peng Huang, Jinwei Zhang, Xueshan Xia, A-mei Zhang, Tian Zeng, Qiong Chen, Chuanlong Zhu, Weilong Tan, Yun Zhang, Ming Yue
Summary: The genetic variants of KIR2DL4 and HLA-G are associated with susceptibility to hepatitis C virus infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
