Article
Oncology
Fan Zou, Wu Chen, Tianbao Song, Ji Xing, Yunlong Zhang, Kang Chen, Weimin Hu, Linzhi Li, Jinzhuo Ning, Chenglong Li, Weimin Yu, Fan Cheng
Summary: Bladder cancer is a common malignancy worldwide, but the lack of accurate targeted drugs is a major challenge in its clinical treatment. SQLE, a key enzyme in cholesterol biosynthesis, has been found to be involved in cancer development. High expression of SQLE is associated with poor prognosis in bladder cancer patients. Inhibition of SQLE through the PTEN/AKT/GSK3β signaling pathway has been shown to suppress tumor cell proliferation and metastasis. The findings suggest that SQLE may serve as a therapeutic target for bladder cancer.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
XiaoJuan Xie, HuiJin Li, JingJing Pan, Xi Han
Summary: TRIM26 is upregulated in bladder cancer tissues and its absence inhibits cellular behaviors, while overexpression promotes cell proliferation, migration and invasion. TRIM26 regulates cell proliferation, migration, and invasion in bladder cancer through the Akt/GSK3 beta/beta-catenin pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Cell Biology
Jutao Feng, Yanmin Liu, Tianling Fang, Jinrong Zhu, Guoying Wang, Jun Li
Summary: HN1 is identified as a novel regulatory factor in hepatocellular carcinoma (HCC), which promotes the progression of HCC by sustaining the activation of MYC. The interaction between HN1 and GSK3 beta plays a role in stabilizing MYC and promoting its activity. HN1 serves as a potential therapeutic target for HCC due to its tumor-promoting effects.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Ezgi Oner, Mustafa Kotmakci, Anne-Marie Baird, Steven G. Gray, Bilge Debelec Butuner, Emir Bozkurt, Ayse Gulten Kantarci, Stephen P. Finn
Summary: Researchers successfully developed novel cationic solid lipid nanoparticles carrying siRNA targeting EphA2 receptor, which showed enhanced gene silencing when co-administered with a histone lysine demethylase inhibitor, JIB-04. The delivery system demonstrated high transfection efficiency and holds promise for targeting other genes and cancer types in further in vitro and in vivo studies.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Cell Biology
Lokman Varisli, Aadil Javed, Bilge Esin Ozturk, Gencer Kaan Akyuz, Gulevin Takir, Fani-Marlen Roumelioti, Sarantis Gagos, Kutsal Yorukoglu, Kemal Sami Korkmaz
Summary: Prostate cancer is often associated with alterations in the HN1 gene, which plays a critical role in cell proliferation and cycle regulation. Overexpression of HN1 can lead to differential responses in prostate cancer cells, affecting centrosome clustering and potentially contributing to carcinogenesis.
Article
Pharmacology & Pharmacy
Bilge Debelec-Butuner, Ezgi Oner, Mustafa Kotmakci, Ayse Gulten Kantarci
Summary: Inhibition of SIRT1 can enhance the activity of doxorubicin on prostate cancer cell lines by improving DNA damage recognition and promoting cancer cell death.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Oncology
U. Schagdarsurengin, C. Luo, H. Slanina, D. Sheridan, S. Fuessel, N. Boeguercue-Seidel, S. Gattenloehner, G. B. Baretton, L. C. Hofbauer, F. Wagenlehner, T. Dansranjav
Summary: TET1 expression in basal cells of normal prostate and tumor cell clusters in aggressive prostate cancer, correlates with genes encoding chromatin remodeling and mitotic factors. Additionally, signaling pathways related to antiviral processes and stem cell pluripotency are activated. Promoter hypomethylation of a significant proportion of genes and presence of transcription factors with binding sites in TET1 and its coactivated genes suggest potential oncogenic role of TET1-expressing cells in PCa.
CLINICAL EPIGENETICS
(2021)
Review
Biochemistry & Molecular Biology
Aadil Javed, Mahdieh Yarmohammadi, Kemal Sami Korkmaz, Teresa Rubio-Tomas
Summary: Gastric cancer is characterized by uncontrolled growth and metastasis of gastric epithelial cells, which is predominantly in adenocarcinoma form. The regulation of gastric cell growth is influenced by key cell cycle regulators, including Cyclins and Cyclin-dependent kinases (CDKs). Dysregulation of these molecules can lead to disturbances in cell cycle dynamics and the development of gastric cancer. Numerous studies have examined the roles of Cyclins and CDKs in gastric cancer, and this review aims to compile evidence of upstream regulators that activate or inhibit Cyclins and CDKs. It serves as a comprehensive resource for future studies and hypothesis generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Lokman Varisli, Veysel Tolan
Summary: In this study, the researchers investigated the role of HN1L in various cancer cells. They found that HN1L is co-expressed with DNA replication and DNA damage response/repair associated genes. They also observed increased expression of HN1L in diverse cancer types, which promotes cell proliferation and migration. Therefore, HN1L may be a novel proto-oncogene.
PERIODICUM BIOLOGORUM
(2022)
Article
Biology
Aadil Javed, Guelseren Ozduman, Lokman Varisli, Bilge Esin Ozturk, Kemal Sami Korkmaz
Summary: HN1 is highly expressed in prostate cancer compared to normal prostate cells. It is involved in the regulation of cell cycle progression at the S-phase and mitotic exit. HN1 interacts with Cdh1 to stabilize and degrade Cyclin B1 through increased ubiquitination.
Review
Biochemistry & Molecular Biology
Garrett M. Dancik, Lokman Varisli, Spiros A. Vlahopoulos
Summary: The ALDH protein family has nineteen members, with ALDH1A1 emerging as a significant risk factor in acute myeloid leukemia. ALDH1A1 is overexpressed in the poor prognosis group at both the RNA and protein levels, protecting leukemia cells from lipid peroxidation byproducts. This protection is due to the enzyme's stability under oxidant stress, and it shields cells effectively in both in vitro and in vivo experiments. Despite normal cells often having higher ALDH activity, ALDH1A1 RNA expression is significantly associated with poor prognosis in acute myeloid leukemia patients, emphasizing the importance of targeting ALDH1A1 in this specific group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Oncology
Garrett M. Dancik, Lokman Varisli, Ioannis F. Voutsas, Spiros Vlahopoulos
FRONTIERS IN ONCOLOGY
(2023)
Article
Genetics & Heredity
Garrett M. Dancik, Lokman Varisli, Veysel Tolan, Spiros Vlahopoulos
Summary: ALDH1A1 and ALDH2 were found to have the strongest association with AML patient risk group classification, and the sum of their RNA expression values was more strongly associated with AML patient risk group classification and survival than each gene alone. This suggests that ALDH1A1 and ALDH2 may serve as important targets for the treatment of high-risk AML patients.
Review
Oncology
Lokman Varisli, Garrett M. Dancik, Veysel Tolan, Spiros Vlahopoulos
Summary: Breast cancer is one of the most commonly diagnosed malignancies in women, and estrogen signaling plays a critical role in its development and progression. SRC-3 is an important factor in breast cancer and has versatile effects in promoting malignant behavior of tumor cells and creating an immunosuppressive tumor microenvironment.
Article
Oncology
Lokman Varisli, Veysel Tolan, Jiyan H. Cen, Spiros Vlahopoulos, Osman Cen
Summary: Prostate cancer is a common malignancy in males, with increasing prevalence worldwide. Androgen deprivation therapy has been used for treating advanced prostate cancer, but some cells become resistant to this therapy and continue to metastasize. Recent evidence suggests that androgen deprivation therapy may induce cadherin switching, leading to the release of tumor cells into surrounding tissues and circulation.
Article
Medicine, General & Internal
Lokman Varisli, Veysel Tolan
Summary: This study investigated the effects of a sublethal dose of H2O2 on migrative behaviors and E-and N-cadherin levels in prostate cancer cells. The results showed that H2O2 treatment decreased E-cadherin levels, increased N-cadherin levels, and enhanced cell migration abilities. Furthermore, inhibition of ERK abolished the effects of H2O2.
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2022)
Article
Medical Laboratory Technology
Lokman Varisli
Summary: The study demonstrates that HN1 plays a vital role in chemotherapeutic resistance in prostate cancer cells by inhibiting Docetaxel and 2-Methoxyestradiol induced apoptosis through regulating Cyclin B1.
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2022)