Article
Oncology
Hui-Shan Chen, Ching-Hsiung Lin, Shiao-Chi Wu, Bing-Yen Wang
Summary: This study compared the survival outcomes of neoadjuvant chemoradiotherapy followed by operation, definitive chemoradiotherapy, and esophagectomy alone in patients with locoregional esophageal squamous cell carcinoma. It found that neoadjuvant chemoradiotherapy followed by operation and esophagectomy alone were associated with better overall survival compared to definitive chemoradiotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Ronald Chow, Kyle Murdy, Marcus Vaska, Sangjune Laurence Lee
Summary: Patients with esophageal carcinoma receiving neoadjuvant chemoradiotherapy and esophagectomy have better overall survival compared to those receiving definitive chemoradiotherapy. However, further studies are needed due to limited data and inconsistent reporting of endpoints.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Eisuke Booka, Ryoma Haneda, Kenjiro Ishii, Takahiro Tsushima, Hirofumi Yasui, Yasuhiro Tsubosa
Summary: The study found that preoperative chemotherapy was ineffective for elderly patients aged 75-80 with cStage 2 or 3 esophageal cancer and performance status (PS) 0, and significantly negatively impacted the overall survival (OS) of patients with PS 1. Therefore, it is recommended that preoperative chemotherapy should not be administered to patients 75 years of age or older with cStage 2 or 3 esophageal cancer.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Ying-Jian Wang, Tao Bao, Kun-Kun Li, Xian-Feng Xie, Xian-Dong He, Xiao-Long Zhao, Wei Guo
Summary: This study evaluated the effectiveness of concurrent radiotherapy in esophageal cancer patients receiving neoadjuvant therapy. A retrospective analysis was conducted on 1026 patients who underwent minimally invasive esophagectomy. The results showed that neoadjuvant chemotherapy had advantages in terms of shorter operation time, less blood loss, and higher number of lymph nodes retrieved compared to neoadjuvant chemoradiotherapy, without compromising the surgical outcomes and long-term survival.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
H. Tang, H. Wang, Y. Fang, J. Y. Zhu, J. Yin, Y. X. Shen, Z. C. Zeng, D. X. Xiang, Y. Y. Hou, M. Du, C. H. Lian, Q. Zhao, H. J. Jiang, L. Gong, Z. G. Li, J. Liu, D. Y. Xie, W. F. Li, C. Chen, B. Zheng, K. N. Chen, L. Dai, Y. D. Liao, K. Li, H. C. Li, N. Q. Zhao, L. J. Tan
Summary: This study aimed to evaluate the safety and efficacy of neoadjuvant chemoradiotherapy (nCRT) versus neoadjuvant chemotherapy (nCT) followed by minimally invasive esophagectomy (MIE) for locally advanced esophageal squamous cell carcinoma (ESCC). The results showed that nCRT did not significantly improve overall survival compared to nCT.
ANNALS OF ONCOLOGY
(2023)
Article
Surgery
Sivesh K. Kamarajah, Alexander W. Phillips, George B. Hanna, Donald Low, Sheraz R. Markar
Summary: This cohort study analyzed data from the National Cancer Database to evaluate the treatment strategies for esophageal cancer. The study found that neoadjuvant chemoradiotherapy followed by planned esophagectomy was the optimum curative treatment regime for patients with locoregional esophageal cancer. Salvage esophagectomy did not have an impact on overall survival.
Article
Surgery
Ryoma Haneda, Eisuke Booka, Kenjiro Ishii, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Kinji Kamiya, Hirofumi Ogawa, Hirofumi Yasui, Hiroya Takeuchi, Yasuhiro Tsubosa
Summary: Definitive chemoradiotherapy may be a promising alternative therapy comparable with radical esophagectomy in patients with clinical T1bN0M0 esophageal squamous cell carcinoma. Early detection of recurrence by frequent follow-up after definitive chemoradiotherapy is crucial for controlling disease within local recurrence, and salvage therapy for local lesions could contribute to long-term survival.
WORLD JOURNAL OF SURGERY
(2021)
Article
Oncology
Satoru Matsuda, Tomoyuki Irino, Hirofumi Kawakubo, Masashi Takeuchi, Erika Nishimura, Kazuhiko Hisaoka, Junichi Sano, Ryota Kobayashi, Kazumasa Fukuda, Rieko Nakamura, Hiroya Takeuchi, Yuko Kitagawa
Summary: In this study, an AI-guided endoscopic response evaluation using a deep neural network was developed to discriminate endoscopic responders in patients with ESCC after NAC. The AI method showed high sensitivity, specificity, PPV, and NPV, suggesting its accuracy and feasibility.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Smita Sihag, Samuel C. Nussenzweig, Henry S. Walch, Meier Hsu, Kay See Tan, Sergio De La Torre, Yelena Y. Janjigian, Steven B. Maron, Geoffrey Y. Ku, Laura H. Tang, Pari M. Shah, Abraham Wu, David R. Jones, David B. Solit, Nikolaus Schultz, Karuna Ganesh, Michael F. Berger, Daniela Molena
Summary: MDM2 amplification and TP53 status are associated with response to therapy in patients with esophageal adenocarcinoma. Worsening TP53 dysfunction is directly correlated with worse treatment outcomes.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
I. L. Defize, S. van der Horst, M. Bulbul, N. Haj Mohammad, S. Mook, G. J. Meijer, L. A. A. Brosens, J. P. Ruurda, R. van Hillegersberg
Summary: In patients with cT4b esophageal cancer treated with dCRT followed by a salvage RAMIE, a radical resection rate of 92% was achieved, with acceptable complications and promising survival rates. These results demonstrate the feasibility of a curative surgical treatment for patients with initially irresectable esophageal cancer but underscore the importance of proper preoperative patient selection.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Zhichao Liu, Jie Zhang, Yuchen Su, Jie Pan, Yang Yang, Binhao Huang, Jianqiang Zhao, Zhigang Li
Summary: This study aimed to analyze the outcomes of surgery management after ER and evaluate risk factors for residual disease. Additional esophagectomy allowed the resection of residual tumor and nodal metastasis, with favorable outcomes. Close follow-up may be feasible for certain patients, while intensive treatment should be considered for others, especially when combined with specific factors.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Han Tang, Dongxian Jiang, Shumin Zhang, Zhaochong Zeng, Lijie Tan, Yingyong Hou, Qun Wang, Hao Wang, Jiangyi Zhu, Yaxing Shen, Jun Yin, Di Ge
Summary: The study found that residual tumors in esophageal squamous cell carcinoma are primarily located in the mucosa and submucosa, making them difficult to detect with current techniques. Additionally, there is a low rate of pathological complete response in lymph nodes, and diverse regression patterns further complicate the identification of residual tumors.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Mohamad K. Abou Chaar, Anny Godin, William S. Harmsen, Camryn Wzientek, Sahar A. Saddoughi, Christopher L. Hallemeier, Stephen D. Cassivi, Francis C. Nichols, Janani S. Reisenauer, K. Robert Shen, Luis F. Tapias, Dennis A. Wigle, Shanda H. Blackmon
Summary: This study found that long-term survival in patients with esophageal cancer after esophagectomy is low. Unmodifiable variables such as age, sex, smoking history, history of coronary artery disease, and disease stage are associated with decreased overall survival. Modifiable variables such as the use of neoadjuvant therapy, pathologic stage, surgical reintervention, and blood transfusion requirement are also associated with decreased overall survival. The study highlights the importance of high-volume centers using multidisciplinary care teams adhering to national guidelines in improving long-term survival in esophageal cancer patients.
ANNALS OF THORACIC SURGERY
(2023)
Editorial Material
Medicine, General & Internal
Jing Wen, Shuogui Fang, Yi Hu, Mian Xi, Zelin Weng, Chuqing Pan, Kongjia Luo, Yihong Ling, Renchun Lai, Xiuying Xie, Xiaodan Lin, Ting Lin, Jiyang Chen, Qianwen Liu, Jianhua Fu, Hong Yang
Summary: This study used single-cell RNA sequencing to examine the cellular and molecular dynamics in esophageal squamous cell carcinoma (ESCC) patients before and after neoadjuvant chemoradiotherapy (neoCRT). The findings revealed that neoCRT increased the infiltration of CD8(+) T cells in the tumor microenvironment but also promoted their exhaustion. Additionally, neoCRT influenced the differentiation and abundance of other immune cell types, including Th cells, Treg cells, cDC1s, and macrophages.
Article
Surgery
Shirou Kuwabara, Kazuaki Kobayashi, Natsuru Sudo
Summary: This study investigated the short- and long-term outcomes of thoracoscopic esophagectomy (TE) in older patients and found that the overall survival and relapse-free survival were worse in the elderly group compared to the non-elderly group, especially when pulmonary complications occurred. Therefore, perioperative management to prevent pulmonary complications is crucial for improving the long-term outcomes of older patients receiving TE.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Surgery
Yassin Eddahchouri, Frans van Workum, Frits J. H. van den Wildenberg, Mark I. van Berge Henegouwen, Fatih Polat, Harry van Goor, M. Asif Chaudry, E. Cheong, F. Daams, M. J. van Det, C. Gutschow, J. Heisterkamp, R. Van Hillegersberg, A. Holscher, E. A. Kouwenhoven, M. D. P. Luyer, I. S. Martijnse, P. Nafteux, G. A. P. Nieuwenhuijzen, M. Nilsson, P. Pattyn, D. L. van der Peet, J. V. Rasanen, J. P. Ruurda, P. Schneider, W. Schroder, H. van Veer, B. P. L. Wijnhoven, Jean-Pierre E. N. Pierie, Bastiaan R. Klarenbeek, Suzanne S. Gisbertz, Camiel Rosman
Summary: Through Delphi methodology, consensus among European experts was achieved on essential surgical steps for both Ivor Lewis and McKeown minimally invasive esophagectomy, with a total of 106 essential steps identified and consensus reached in two rounds of surveys.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Anouk Overwater, Bas L. A. M. Weusten, Jelle P. Ruurda, Richard van Hillegersberg, Roel J. Bennink, Bart de Keizer, Sybren L. Meijer, Lodewijk A. A. Brosens, Roos E. Pouw, Jacques J. G. H. M. Bergman, Mark I. van Berge Henegouwen, Suzanne S. Gisbertz
Summary: This study evaluated the feasibility and safety of SNNS using a hybrid tracer in patients with high-risk T1b EAC, showing that all patients could identify and resect SNs, with high concordance between preoperative and intraoperative detection. Indocyanine green fluorescence appears to be valuable for detecting peritumoral SNs.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Biology
Sanne M. Jansen, Daniel M. de Bruin, Leah S. Wilk, Mark I. van Berge Henegouwen, Simon D. Strackee, Suzanne S. Gisbertz, Ed T. van Bavel, Ton G. van Leeuwen
Summary: This study investigates the use of fluorescence imaging to evaluate perfusion in the gastric tube during surgery and its correlation with patient outcomes in terms of anastomotic leakage. The study found that poor fundus perfusion is a major factor for the development of anastomotic leakage. Parameters for the quantification of fluorescence signal were tested and compared with patient outcomes. The study concludes that quantitative perfusion imaging can provide early risk stratification of necrosis.
Article
Oncology
Paul M. Jeene, Steven C. Kuijper, Hector G. van den Boorn, Sherif Y. El Sharouni, Petra M. Braam, Vera Oppedijk, Rob H. A. Verhoeven, Maarten C. C. M. Hulshof, Hanneke W. M. van Laarhoven
Summary: This study investigated the use of prediction models to improve the estimation of patient survival in dysphagia caused by incurable esophageal cancer. The results showed that the SOURCE model was a more useful decision aid than the Steyerberg model, with higher accuracy and specificity.
Article
Oncology
Sofie P. G. Henckens, Eliza R. C. Hagens, Mark I. van Berge Henegouwen, Sybren L. Meijer, Wietse J. Eshuis, Suzanne S. Gisbertz
Summary: This study investigates the impact of lymph node yield after transthoracic esophagectomy on lymph node metastasis, complications, and survival in patients with esophageal adenocarcinoma. The results demonstrate that a lymph node yield of 31 or higher is associated with an increased number of positive lymph nodes, improved disease-free survival, and overall survival, without increasing morbidity.
Article
Oncology
Sanne J. M. Hoefnagel, Willem J. Koemans, Hina N. Khan, Jan Koster, Sybren L. Meijer, Jolanda M. van Dieren, Liudmila L. Kodach, Johanna W. van Sandick, Silvia Calpe, Carmen M. del Sancho-Serra, Ana C. P. Correia, Mark I. Van Berge Henegouwen, Suzanne S. Gisbertz, Maarten C. C. M. Hulshof, Sandro Mattioli, Manon C. W. Spaander, Kausilia K. Krishnadath
Summary: This study identified and validated three distinct biological subgroups of esophageal adenocarcinoma (EAC) and found immune signatures associated with treatment response.
Article
Nutrition & Dietetics
Maurits R. Visser, Jennifer Straatman, Daan M. Voeten, Suzanne S. Gisbertz, Jelle P. Ruurda, Misha D. P. Luyer, Pieter C. van der Sluis, Donald L. van der Peet, Mark I. van Berge Henegouwen, Richard van Hillegersberg
Summary: The study investigated the variation in the placement, surgical techniques, and safety of feeding jejunostomies (FJ) during minimally invasive esophagectomy (MIE) in the Netherlands. Data from the Dutch Upper Gastrointestinal Cancer Audit (DUCA) were analyzed, and hospital variation in FJ placement rates and short-term outcomes were examined. The study found a wide range of FJ placement rates among hospitals and identified higher complication rates in hospitals that did not routinely perform FJ placement. The study concludes that FJs can be safely placed, with lower complication rates, in centers that perform routine placement.
Article
Chemistry, Multidisciplinary
Johanna J. Joosten, Paul R. Bloemen, Richard M. van den Elzen, Jeffrey Dalli, Ronan A. Cahill, Mark I. van Berge Henegouwen, Roel Hompes, Daniel M. de Bruin
Summary: The aim of this study is to investigate light distribution and the center-periphery effect among five different NIR imaging devices. The results showed considerable variability in regard to light distribution among the five camera systems, especially toward the periphery of the field of view. NIR signal distribution varies between different systems and within the same displayed image, and the fluorescence intensity diminishes peripherally away from the center of the field of view.
APPLIED SCIENCES-BASEL
(2023)
Article
Oncology
N. Schuring, W. T. Stam, V. D. Plat, M. C. Kalff, M. C. C. M. Hulshof, H. W. M. van Laarhoven, S. Derks, D. L. van der Peet, M. I. van Berge Henegouwen, F. Daams, S. S. Gisbertz
Summary: This study investigated the recurrence patterns and survival after multimodal therapy for recurrent esophageal adenocarcinoma. It found that recurrent disease was most frequently located distantly with poor prognosis, but a subgroup of patients with loco-regional recurrence had prolonged survival when treated with curative intent. These findings suggest the need for intensive surveillance protocols and further research to identify high-risk patients.
Article
Oncology
Sergio Gaspar-Figueiredo, Pierre Allemann, Alexander B. J. Borgstein, Gaetan-Romain Joliat, Valentine Luzuy-Guarnero, Christophe Brunel, Christine Sempoux, Suzanne Sarah Gisbertz, Nicolas Demartines, Mark Ivo van Berge Henegouwen, Markus Schafer, Styliani Mantziari
Summary: This study aimed to assess the prognostic value of microscopically positive margins (R1) after gastrectomy on survival and tumor recurrence in diffuse-type gastric cancer (DTGC) patients. It showed that patients with R1 had poorer overall survival and disease-free survival, as well as higher early tumor recurrence rates. Therefore, achieving R0 resection should be pursued whenever possible.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Surgery
Nannet Schuring, Noel E. Donlon, Eliza R. C. Hagens, Didier Gootjes, Claire L. Donohoe, Mark I. van Berge Henegouwen, John V. Reynolds, Suzanne S. Gisbertz
Summary: This study externally validated the nomogram model for predicting 5-year overall survival in a cohort of esophageal cancer patients from another high-volume center. The model demonstrated moderate discrimination and accuracy in predicting conditional survival.
Article
Gastroenterology & Hepatology
Kammy Keywani, Alexander B. J. Borgstein, Djamila Boerma, Stijn van Esser, Wietse J. Eshuis, Mark van Berge I. Henegouwen, Johanna van Sandick, Suzanne S. Gisbertz
Summary: Curative therapy for gastric cancer usually includes perioperative chemotherapy and radical gastrectomy. The role of omentectomy in improving survival remains uncertain. This study presents the follow-up data of the OMEGA study.
Article
Surgery
Sander Ubels, Moniek H. P. Verstegen, Bastiaan R. Klarenbeek, Stefan Bouwense, Mark I. van Berge Henegouwen, Freek Daams, Marc J. van Det, Ewen A. Griffiths, Jan Willem Haveman, Joos Heisterkamp, Grard Nieuwenhuijzen, Fatih Polat, Jeroen Schouten, Peter D. Siersema, Pritam Singh, Bas Wijnhoven, Gerjon Hannink, Frans van Workum, Camiel Rosman
Summary: This retrospective cohort study aimed to assess the effectiveness of different treatment strategies for anastomotic leak after oesophagectomy. The study found that less invasive primary treatment resulted in fewer complications. Therefore, less invasive primary treatment may lead to better clinical outcomes, but further studies are needed to confirm these findings.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
B. Feike Kingma, Eliza R. C. Hagens, Mark. I. Van Berge I. Henegouwen, Alicia. S. S. Borggreve, Jelle. P. P. Ruurda, Suzanne. S. S. Gisbertz, R. Richard van Hillegersberg
Summary: This study investigated the impact of paratracheal lymphadenectomy on lymph node yield and short-term outcomes in patients undergoing esophagectomy for cancer in the Netherlands. The results showed that paratracheal lymphadenectomy increased lymph node yield, but also led to longer hospital stay and more re-interventions.
Letter
Surgery
Berend J. van der Wilk, Sjoerd M. Lagarde, Mark I. van Berge Henegouwen
BRITISH JOURNAL OF SURGERY
(2022)
