Review
Rheumatology
Daniel Ennis, Zareen Ahmad, Melanie A. Anderson, Sindhu R. Johnson
Summary: This article reviews the effectiveness of botulinum toxin injections in treating Raynaud's phenomenon and discusses formulations, dosages, administration sites, and adverse effects. The evidence for botulinum toxin in the treatment of Raynaud's phenomenon is promising, but further research is needed to ensure consistency in treatment outcomes across different patient populations and treatment options.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2021)
Review
Medicine, General & Internal
Peter Klein-Weigel, Oliver Sander, Simone Reinhold, Jessica Nielitz, Julia Steindl, Jutta Richter
Summary: Raynaud's phenomenon (RP) is characterized by vasospasm of the fingers or toes triggered by cold or emotional stressors. The most important diagnostic steps include demonstrating a tendency towards vasospasm, excluding occlusions, nail-fold capillaroscopy, and determining autoantibody status. The main treatment options are protection against cold and administration of calcium antagonists.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2021)
Article
Rheumatology
Michael Hughes, Suiyuan Huang, John D. Pauling, Maya Sabbagh, Dinesh Khanna
Summary: This study explores patient priorities and ranking of factors influencing decision-making regarding treatment escalation in Raynaud's phenomenon secondary to systemic sclerosis. The results show that patients prioritize factors such as inability to use fingers properly, new digital ulcers, worsening pain or discomfort, more severe attacks, and potential internal problems when considering treatment escalation. Patients also express concerns about potential treatment side effects and show a preference for nonpharmacologic management of SSc-RP.
ARTHRITIS CARE & RESEARCH
(2021)
Review
Medicine, General & Internal
Kevin Y. C. Su, Meghna Sharma, Hyunjun Jonathan Kim, Elizabeth Kaganov, Ian Hughes, Mohamed Hashim Abdeen, Jennifer Hwee Kwoon Ng
Summary: This study updated a review on pharmacological treatments for primary Raynaud's phenomenon first published in 2008. The evidence of vasodilators' efficacy is limited, with insufficient support for their use and suggestions that they may even worsen the disease.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Rheumatology
Susan L. Murphy, Alain Lescoat, Mary Alore, Michael Hughes, John D. Pauling, Maya Sabbagh, Dinesh Khanna
Summary: There are differences in how people with primary and secondary RP define RP, with primary RP patients more likely to focus on the impact on quality of life and pain, while secondary RP patients tend to emphasize specific body parts and management of attacks. These findings have implications for assessing RP outcomes in different patient populations.
CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Greta Pacini, Andrea Pogna, Monica Pendolino, Carmen Pizzorni, Luca Carmisciano, Emanuele Gotelli, Alberto Sulli, Sabrina Paolino, Carlotta Schenone, Vanessa Smith, Maurizio Cutolo
Summary: This study describes an NVC 'prescleroderma signature' to potentially identify RP patients later developing a 'scleroderma pattern'.
Review
Biochemistry & Molecular Biology
Nehme El-Hachem, Manal M. Fardoun, Hasan Slika, Elias Baydoun, Ali H. Eid
Summary: Raynaud's Phenomenon is caused by exaggerated cold-induced vasoconstriction, leading to compromised digital blood perfusion and potential tissue damage. Various drugs have been used to alleviate symptoms, but there is currently no FDA-approved drug for treating RP. One potential option being explored is the repurposing of cilostazol, which acts as a selective inhibitor of phosphodiesterase-III with antiplatelet and vasodilating properties.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Dermatology
Jason Britton
Summary: The objective of this study was to establish the repeatability of baseline diagnostic images of the dorsum of the hands in patients with Raynaud's phenomenon secondary to systemic sclerosis (SSc) using high-resolution laser Doppler imaging. The repeatability of the technique was assessed using methods described by Bland and Altman, as well as by plotting the results from two visits and calculating the line of best fit. The results suggest that the technique is probably repeatable, but a larger study with more patients is needed for conclusive evidence.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2023)
Article
Immunology
Edilburga Reyes-Jimenez, Alma Aurora Ramirez-Hernandez, Jovito Cesar Santos-Alvarez, Juan Manuel Velazquez-Enriquez, Karina Gonzalez-Garcia, Gabriela Carrasco-Torres, Saul Villa-Trevino, Rafael Baltierrez-Hoyos, Veronica Rocio Vasquez-Garzon
Summary: This study investigated the effects of coadministration of AD and Q on the development and maintenance of pulmonary fibrosis in a BLM-induced SSc mouse model. The combination therapy led to attenuated histological alterations and pulmonary fibrosis, achieved by decreasing the expression of proliferation, inflammation, and oxidative stress markers.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Margarita Barriga, Raquel Benitez, Gema Robledo, Marta Caro, Francisco O'Valle, Jenny Campos-Salinas, Mario Delgado
Summary: This study investigates the role of the neuropeptide cortistatin in scleroderma. The findings suggest that cortistatin acts as an endogenous regulator of skin inflammation and fibrosis. Deficiency in cortistatin may indicate a poor prognosis for scleroderma and its associated complications. Cortistatin-based therapies may be potential treatments for severe systemic sclerosis and for managing fibrosis-related side effects in oncology patients receiving bleomycin chemotherapy.
NEUROENDOCRINOLOGY
(2022)
Article
Rheumatology
Kathleen Morrisroe, Dylan Hansen, Wendy Stevens, Laura Ross, Joanne Sahhar, Gene-Siew Ngian, Catherine L. Hill, Lauren Host, Jennifer Walker, Susanna Proudman, Mandana Nikpour
Summary: This study aimed to describe the frequency of progressive pulmonary fibrosis (PPF) in an incident cohort of systemic sclerosis (SSc)-related interstitial lung disease (ILD) and its impact on survival. The results showed that about one-third of the patients experienced PPF, and the presence of PPF was significantly associated with mortality. This suggests that some patients may benefit from earlier introduction of immunosuppressive and/or antifibrotic therapy.
Article
Surgery
Diego Herrera Vegas, Mario Alejandro Fabiani, Mauricio Gonzalez-Urquijo, Agustin Bignotti, Ignacio Sere, Pablo Salvadores
Summary: A novel treatment approach involving a modified distal sympathectomy and injection of A botulinum toxin into digital neuromuscular bundles has shown efficacy in treating severe Raynaud's Phenomenon (RP). Immediate pain relief and complete healing of digital wounds with full hand mobility were achieved post-surgery.
VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Pharmacology & Pharmacy
Manal Fardoun, Stefania Mondello, Firas Kobeissy, Ali H. Eid
Summary: Exaggerated cold-induced vasoconstriction can lead to the development of Raynaud's phenomenon. This disease is more prevalent in females and the hormone 17 beta-estradiol may play a role in its etio-pathogenesis. Our research suggests that 17 beta-estradiol stimulates the expression of vascular alpha 2C-adrenoceptors through the G-protein coupled estrogen receptor.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Rheumatology
Matthieu Roustit, Ariane Jullien, Clement Jambon-Barbara, Hugo Goudon, Sophie Blaise, Jean-Luc Cracowski, Charles Khouri
Summary: This study aimed to explore and quantify the placebo response in Raynaud's Phenomenon (RP) and evaluate the contribution of regression towards the mean (RTM). The findings showed a large and significant placebo response in RP trials, which is likely due to RTM rather than a true placebo effect. This highlights the importance of considering this phenomenon when designing future trials.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Review
Medicine, General & Internal
Magdalena Maciejewska, Mariusz Sikora, Cezary Maciejewski, Rosanna Alda-Malicka, Joanna Czuwara, Lidia Rudnicka
Summary: Raynaud's phenomenon is a vascular condition that can be primary or secondary to other medical conditions. Systemic sclerosis is a common cause of secondary Raynaud's phenomenon.
JOURNAL OF CLINICAL MEDICINE
(2022)