Review
Biochemistry & Molecular Biology
Pelin Ergun, Sezgi Kipcak, Serhat Bor
Summary: Barrett's esophagus (BE) is a condition resulting from chronic gastroesophageal reflux disease, which may progress to esophageal adenocarcinoma (EAC). The histological dysplasia grade is commonly used as a biomarker, but its effectiveness is limited due to cost and lack of progression in many BE patients. Clinicians require multiple or more quantitative biomarkers for early diagnosis of EAC, which has high mortality. Epigenetic factors in the early stages of neoplastic transformation show promise as predictive biomarkers. This review summarizes current research on DNA methylations, histone modifications, and noncoding RNAs (miRNAs) during the progression from BE dysplasia to EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Tarek Sawas, Saam Dilmaghani, Lovekirat Dhaliwal, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka
Summary: The study found that compared to BE patients, EAC patients had significantly lower rates of heartburn, diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome. Therefore, optimal strategies for screening for prevalent EAC may need to be adjusted.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Nan Yi, Hailiang Zhao, Juan He, Xike Xie, Liexin Liang, Guowen Zuo, Mingyue Xiong, Yunxiao Liang, Tingzhuang Yi
Summary: Almost 50% of esophageal adenocarcinoma (EAC) patients are progressed from Barrett's esophagus (BE). However, effective stratification and therapy methods for BE and EAC are still lacking. Differentially expressed genes (DEGs) between BE and EAC were identified through the analysis of two public datasets (GSE26886 and GSE37200), followed by bioinformatics analyses to explore potential biomarkers associated with BE-EAC. The results revealed a number of up- and down-regulated genes, which were highly involved in tumorigenesis according to the GO and KEGG enrichment analysis. In addition, the study identified several potential diagnostic and prognostic biomarkers in BE-EAC.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Ksenia Maslenkina, Liudmila Mikhaleva, Maxim Naumenko, Rositsa Vandysheva, Michail Gushchin, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann
Summary: Barrett's esophagus (BE) is a premalignant lesion that can develop into esophageal adenocarcinoma (EAC). The development of BE is caused by biliary reflux and involves various stem cell origins. The concept of healing has been replaced by the cytokine storm and inflammatory microenvironment, leading to intestinal metaplasia. This review discusses the roles of molecular pathways in the pathogenesis of BE and EAC, including NOTCH, hedgehog, NF-?B, and IL6/STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Franz Ludwig Dumoulin, Fabian Dario Rodriguez-Monaco, Alanna Ebigbo, Ingo Steinbruck
Summary: Esophageal adenocarcinoma is the most common subtype of esophageal cancer in Western societies and its incidence is increasing. The development and validation of artificial intelligence systems in the field of gastroenterology may help address unresolved issues in the prevention and surveillance of this cancer.
Review
Gastroenterology & Hepatology
Motasem Alkhayyat, Prabhat Kumar, Krishna O. Sanaka, Prashanthi N. Thota
Summary: The incidence of Barrett's esophagus and esophageal adenocarcinoma has been increasing, leading to a search for chemoprevention strategies. Proton-pump inhibitors and Aspirin have shown effectiveness in reducing cancer incidence in Barrett's patients. Other agents lack sufficient evidence for chemoprevention in these patients.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Chunyang Bao, Richard W. Tourdot, Gregory J. Brunette, Chip Stewart, Lili Sun, Hideo Baba, Masayuki Watanabe, Agoston T. Agoston, Kunal Jajoo, Jon M. Davison, Katie S. Nason, Gad Getz, Kenneth K. Wang, Yu Imamura, Robert Odze, Adam J. Bass, Matthew D. Stachler, Cheng-Zhong Zhang
Summary: By analyzing chromosomal copy-number evolution in early cancers and precancerous lesions of the esophagus, the authors reveal signatures of ongoing chromosomal instability and its role in promoting tumor progression.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Lei Chen, Farah Ballout, Heng Lu, Tianling Hu, Shoumin Zhu, Zheng Chen, Dunfa Peng
Summary: In this study, the gene expression of NEK family members in esophageal adenocarcinoma and its precancerous condition was analyzed. The findings suggest that upregulation of certain NEKs may be important in the development of esophageal adenocarcinoma.
Article
Oncology
Anshuman Panda, Gyan Bhanot, Shridar Ganesan, Manisha Bajpai
Summary: Stable cell lines derived from primary tissues and tumors are commonly used in medical research. This study evaluated gene expression profiles of esophageal tissues and cell lines, finding discrepancies in the gene expression profiles of Barrett's esophagus (BE) cell lines compared to primary BE tissues and esophageal adenocarcinoma (EAC) tumors. Exposure to an acidic bile environment did not alter the squamous-like gene expression pattern of a BE cell line. The findings underscore the importance of carefully selecting appropriate in vitro tools for studying esophageal adenocarcinoma.
Review
Medicine, General & Internal
Kazumi Inokuchi, Takahiro Ochiya, Juntaro Matsuzaki
Summary: Esophageal adenocarcinoma (EAC) is the major histologic type of esophageal cancer in Western countries with a poor prognosis primarily due to late stage diagnosis. Barrett's esophagus (BE) is a precursor lesion of EAC. Extracellular microRNAs (miRNAs) may serve as non-invasive markers for the management of EAC in the future, with potential utility for diagnosis and treatment responses. Multiple studies have reported dysregulation of certain miRNAs in both EAC and BE, suggesting their potential as valuable biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Takuya Shijimaya, Tomomitsu Tahara, Jumpei Yamazaki, Yasushi Matsumoto, Naohiro Nakamura, Yu Takahashi, Takashi Tomiyama, Toshiro Fukui, Tomoyuki Shibata, Makoto Naganuma
Summary: The molecular mechanisms of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) in Japanese patients are still unclear. A study conducted on Japanese patients, mostly with short-segment BE (SSBE), found that methylation levels of the N33, DPYS, and SLC16A12 genes were higher in the ADJ and T groups compared to the N group.
MOLECULAR CARCINOGENESIS
(2023)
Article
Immunology
Cathryn M. Kolka, Julie Webster, Ailin Lepletier, Clay Winterford, Ian Brown, Renee S. Richards, Wioleta M. Zelek, Yilang Cao, Ramlah Khamis, Karthik B. Shanmugasundaram, Alain Wuethrich, Matt Trau, Sandra Brosda, Andrew Barbour, Alok K. Shah, Guy D. Eslick, Nicholas J. Clemons, B. Paul Morgan, Michelle M. Hill
Summary: This study confirms the increased formation of C5b-9 in esophageal adenocarcinoma (EAC) and demonstrates the capability and heterogeneity in C5b-9 formation and shedding in Barrett's Esophagus (BE) and EAC cell lines following sublytic C9 exposure.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Jitka Vaculova, Radek Kroupa, Zdenek Kala, Jiri Dolina, Tomas Grolich, Jakub Vlazny, David Said, Lydie Izakovicova Holla, Petra Borilova Linhartova, Vladimir Prochazka, Marek Joukal, Petr Jabandziev, Ondrej Slaby, Lumir Kunovsky
Summary: Confocal laser endomicroscopy (CLE) is a real-time microscopic imaging technique used mainly in gastroenterology, particularly in the diagnosis of Barrett's esophagus and esophageal adenocarcinoma. Although many studies have shown that CLE increases diagnostic accuracy in detecting neoplastic transformation of BE, it is still not widely used as a standard diagnostic tool in BE surveillance due to a lack of scientific evidence.
Article
Gastroenterology & Hepatology
Tarek Sawas, Shawn A. Zamani, Sarah Killcoyne, Andrew Dullea, Kenneth K. Wang, Prasad G. Iyer, Rebecca C. Fitzgerald, David A. Katzka
Summary: Existing Barrett's esophagus screening guidelines have limitations in detecting prevalent esophageal adenocarcinoma. An optimized approach is needed to identify individuals most suitable for esophageal adenocarcinoma screening, particularly one that does not rely on chronic reflux symptoms.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Surgery
Ronan J. Kelly, Amir M. Ansari, Tomoharu Miyashita, Marianna Zahurak, Frank Lay, A. Karim Ahmed, Louis J. Born, Maryam K. Pezhouh, Kevan J. Salimian, Christopher Ng, Aerielle E. Matsangos, Anne-Heloise Stricker-Krongrad, Ken-ichi Mukaisho, Guy P. Marti, Christine H. Chung, Marcia I. Canto, Michelle A. Rudek, Stephen J. Meltzer, John W. Harmon
Summary: Itraconazole significantly reduces the development of esophageal adenocarcinoma and SHH expression in a preclinical animal model of Barrett's Metaplasia. In humans, BE tissue expresses higher levels of SHH, Indian Hedgehog, and bone morphogenic protein compared to normal squamous esophageal epithelium.
Article
Gastroenterology & Hepatology
Jennifer M. Yeh, Chin Hur, Zachary Ward, Deborah Schrag, Sue J. Goldie
Article
Gastroenterology & Hepatology
Kathleen E. Corey, Matthew J. Klebanoff, Angela C. Tramontano, Raymond T. Chung, Chin Hur
DIGESTIVE DISEASES AND SCIENCES
(2016)
Meeting Abstract
Gastroenterology & Hepatology
Mimi C. Tan, Timothy Quang, Kalpesh K. Patel, Richard A. Schwarz, Chin Hur, Fan Zhang, Yu Xinying, Jason K. Hou, Mohamed O. Othman, Lubin F. Arevalo, Sanford G. Dawsey, Daniel G. Rosen, Rebecca R. Richards-Kortum, Sharmila Anandasabapathy
Article
Oncology
Jennifer M. Yeh, Angela C. Tramontano, Chin Hur, Deborah Schrag
Article
Gastroenterology & Hepatology
Jagpreet Chhatwal, Sumeyye Samur, Brian Kues, Turgay Ayer, Mark S. Roberts, Fasiha Kanwal, Chin Hur, Drew Michael S. Donnell, Raymond T. Chung
Article
Gastroenterology & Hepatology
Matthew J. Klebanoff, Kathleen E. Corey, Jagpreet Chhatwal, Lee M. Kaplan, Raymond T. Chung, Chin Hur
Article
Gastroenterology & Hepatology
Sumeyye Samur, Matthew Klebanoff, Reiner Banken, Daniel S. Pratt, Rick Chapman, Daniel A. Ollendorf, Anne M. Loos, Kathleen Corey, Chin Hur, Jagpreet Chhatwal
Article
Multidisciplinary Sciences
Carrie Lubitz, Ayman Ali, Tiannan Zhan, Curtis Heberle, Craig White, Yasuhiro Ito, Akira Miyauchi, G. Scott Gazelle, Chung Yin Kong, Chin Hur
Article
Surgery
Matthew J. Klebanoff, Jagpreet Chhatwal, Jacob D. Nudel, Kathleen E. Corey, Lee M. Kaplan, Chin Hur
Article
Emergency Medicine
Christopher Kabrhel, Ayman Ali, Jin G. Choi, Chin Hur
ACADEMIC EMERGENCY MEDICINE
(2017)
Review
Gastroenterology & Hepatology
T. He, M. A. Lopez-Olivo, C. Hur, J. Chhatwal
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2017)
Letter
Gastroenterology & Hepatology
Sonja Kroep, Curtis R. Heberle, Kit Curtius, Chung Yin Kong, Iris Lansdorp-Vogelaar, Ayman Ali, W. Asher Wolf, Nicholas J. Shaheen, Stuart J. Spechler, Joel H. Rubenstein, Norman S. Nishioka, Stephen J. Meltzer, William D. Hazelton, Marjolein van Ballegooijen, Angela C. Tramontano, G. Scott Gazelle, E. Georg Luebeck, John M. Inadomi, Chin Hur
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2017)
Article
Gastroenterology & Hepatology
Curtis R. Heberle, Amir-Houshang Omidvari, Ayman Ali, Sonja Kroep, Chung Yin Kong, John M. Inadomi, Joel H. Rubenstein, Angela C. Tramontano, Emily C. Dowling, William D. Hazelton, E. Georg Luebeck, Iris Lansdorp-Vogelaar, Chin Hur
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2017)
Article
Gastroenterology & Hepatology
Angela C. Tramontano, Deirdre F. Sheehan, Jennifer M. Yeh, Chung Yin Kong, Emily C. Dowling, Joel H. Rubenstein, Julian A. Abrams, John M. Inadomi, Deborah Schrag, Chin Hur
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2017)
Review
Gastroenterology & Hepatology
Jagpreet Chhatwal, Tianhua He, Chin Hur, Maria A. Lopez-Olivo
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2017)