Article
Gastroenterology & Hepatology
Guillaume Meurette, Laurent Siproudhis, Anne-Marie Leroi, Henri Damon, David Urs Josef Keller, Jean-Luc Faucheron
Summary: This study confirms the clinical effectiveness, safety, and positive effect of sacral neuromodulation with the InterStim(TM) system for the treatment of faecal incontinence, showing significant improvements in quality of life and symptoms with high patient satisfaction. Main device-related adverse events include the need for reprogramming, infection, and surgical revision.
COLORECTAL DISEASE
(2021)
Article
Neurosciences
Gerrit E. Gmel, Paul F. Vollebregt, Marjolein E. G. Thijssen, Rosana Santos Escapa, Eleanor McAlees, Dave Mugan, John L. Parker, Charles H. Knowles
Summary: This study aimed to determine if electrophysiological responses can be recorded directly from the S3 sacral nerve during therapeutic SNM in patients with fecal incontinence, and to characterize such responses in order to better understand the mechanism of action (MOA) and changes in stimulation with posture. The findings show both neural and myoelectric responses, highlighting the heterogeneity of these responses and confirming that electrode lead position can change with posture.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Pediatrics
Stephen Trinidad, Amanda Jensen, Monica Holder, Allison Elsner, Nelson Rosen, Aaron Garrison, Beth Rymeski, Jason S. Frischer
Summary: This study evaluated the outcomes of sacral nerve stimulation (SNS) in patients with medically refractory fecal incontinence or severe constipation. A retrospective cohort study was conducted on patients who underwent SNS placement after failed medical management at a single center. The rates of involuntary bowel movements were compared pre- and post-SNS using a bowel severity score questionnaire.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Urology & Nephrology
Emmanuel Chartier-Kastler, Loic Le Normand, Alain Ruffion, Christian Saussine, Raissa Braguet, Bertrand Rabut, Evelyne Ragni, Marie-Aimee Perrouin-Verbe, Jean Pierrevelcin, Thierry Rousseau, Xavier Game, Yves Tanneau, Francois Dargent, Xavier Biardeau, Jean Pierre Graziana, Gabriel Stoica, Elena Brassart, Marc Fourmarier, Najdat Yaghi, Gregoire Capon, Jerome Ferchaud, Nathalie Berrogain, Laurence Peyrat, Francois Pecoux, Pierre-Emmanuel Bryckaert, Alice Melotti, Abdallah Abouihia, David Urs Josef Keller, Jean-Nicolas Cornu
Summary: This study confirms the safety and effectiveness of sacral neuromodulation (SNM) for overactive bladder (OAB) through real-world data. The study showed that SNM with the InterStim system significantly reduced voids and leaks, improved quality of life (QoL), and decreased symptom bother for up to 3 years after implantation.
EUROPEAN UROLOGY FOCUS
(2022)
Review
Medicine, General & Internal
Alfonso Javier Ibanez-Vera, Rosa Maria Mondejar-Ros, Vanessa Franco-Bernal, Guadalupe Molina-Torres, Esther Diaz-Mohedo
Summary: This review aims to determine the effectiveness of posterior tibial nerve stimulation (PTNS) in reducing episodes of fecal incontinence in adults. However, the results are inconclusive and more research is needed to support its recommendation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Satish S. C. Rao, Xuelian Xiang, Amol Sharma, Tanisa Patcharatrakul, Yun Yan, Rachael Parr, Deepak Ayyala, Shaheen Hamdy
Summary: The study found that TNT treatment can significantly improve symptoms in patients with FI, with the 1 Hz frequency showing better results than 5 and 15 Hz. Additionally, both anal neuropathy and physiology significantly improved, demonstrating mechanistic improvement.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Binit Katuwal, Jasneet Bhullar
Summary: Fecal incontinence is a common and debilitating condition caused by various factors. Conservative/medical management is the first-line treatment, and sacral nerve stimulation has emerged as an effective option for those suitable for surgical intervention.
CLINICS IN COLON AND RECTAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Assia Daikh, Fabienne Reymond, Dorothee Lombardo, Caroline Thuillier, Pierrick Bedouch, Jean-Luc Faucheron
Summary: Sacral nerve neuromodulation (SNM) is a safe and effective therapy for managing fecal and/or urinary incontinence. This study evaluated the lifespan of InterStim(TM) and InterStim(TM) II generators and the long-term hospital costs associated with SNM therapy. The results showed that the lifespan of InterStim(TM) II is shorter than the first-generation device, leading to increased hospital costs over time.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Judith Evers, P. Ronan O'Connell, James F. X. Jones
Summary: This study investigated the changes in the transmission of sensory anorectal stimuli in a rodent model of fecal incontinence and the effects of sacral nerve stimulation on defecation behavior. The results showed that chronic sacral nerve stimulation using miniature telemetric devices is feasible in rats and can improve fecal incontinence symptoms. The amplitude of anorectal evoked potentials was found to be negatively correlated with the behavioral signs of fecal incontinence.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Surgery
Luigi Brusciano, Antonio Brillantino, Gianluca Pellino, Franco Marinello, Coen I. M. Baeten, Alex Digesu, Gabriele Naldini, Claudio Gambardella, Francesco Saverio Lucido, Alessandro Sturiale, Giorgia Gualtieri, Stefan Riss, Ludovico Docimo
Summary: Sacral nerve modulation is a safe and effective treatment for fecal and double incontinence, improving symptoms, quality of life, and sexual function in the long term.
UPDATES IN SURGERY
(2023)
Article
Neurosciences
Liyun Wang, Payam Gharibani, Yi Yang, Yu Guo, Jieyun Yin
Summary: This study investigated the effects of sacral nerve stimulation (SNS) on Loperamide-induced constipation in rats. The results showed that SNS with appropriate parameters improved whole colon transit time, resolved constipation, reversed the detrimental effects of Loperamide on enteric neurons, and increased the expressions of GDNF and p-AKT in colon tissue. The findings suggest that SNS may be a potential treatment for opioid-induced constipation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Urology & Nephrology
Emmanuel Chartier-Kastler, Loic Le Normand, Alain Ruffion, Francois Dargent, Raissa Braguet, Christian Saussine, Yves Tanneau, Jean Pierre Graziana, Evelyne Ragni, Bertrand Rabut, Thierry Rousseau, Xavier Biardeau, Xavier Game, Jean Pierrevelcin, Elena Brassart, Marc Fourmarier, Gabriel Stoica, Nathalie Berrogain, Najdat Yaghi, Francois Pecoux, Gregoire Capon, Jerome Ferchaud, Laurence Peyrat, Pierre Emmanuel Bryckaert, Gilles Karsenty, Alice Melotti, Abdallah Abouihia, David Urs Josef Keller, Jean-Nicolas Cornu
Summary: This study evaluated the real-life effectiveness, quality of life, and safety of SNM with the InterStim system in patients with lower urinary tract dysfunctions. The results showed significant improvements in symptoms and quality of life for OAB patients, but also highlighted the risk of revisions.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Gastroenterology & Hepatology
Anthony Y. Lin, Chris Varghese, Niranchan Paskaranandavadivel, Sean Seo, Peng Du, Phil Dinning, Ian P. Bissett, Greg O'Grady
Summary: The rectosigmoid brake was suppressed in patients with faecal incontinence, and sacral neuromodulation (SNM) may exert a therapeutic effect by modulating this rectosigmoid brake.
COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Aaron J. Dawes, Juan O. Mariscal, Peter J. White, Emily F. Midura, Anne E. Sirany, Ann C. Lowry, Christine C. Jensen, Amy J. Thorsen
Summary: This study aimed to determine whether patients with rectoanal intussusception achieve similar benefits from device implantation to patients without rectoanal intussusception. The results showed that rectoanal intussusception does not affect the clinical outcomes or quality of life after sacral nerve stimulation for fecal incontinence. Therefore, patients with fecal incontinence and rectoanal intussusception can be considered for sacral nerve stimulation placement.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Gastroenterology & Hepatology
K. Ong, L. Bordeianou, M. Brunner, S. Buntzen, M. H. S. Collie, A. Hanly, C. W. Hunt, K. E. Matzel, P. R. O'Connell, M. Rydningen, L. Savitt, A. Totaro, C. J. Vaizey, Y. Maeda
Summary: This study aimed to determine whether the paradigm of surgical intervention for faecal incontinence has changed between 2000 and 2013. The results showed an increasing use of sacral neuromodulation over time, indicating a shift in the surgical intervention paradigm for faecal incontinence.
COLORECTAL DISEASE
(2021)