Article
Multidisciplinary Sciences
Chinock Cheong, Jeonghyun Kang, Byung Soh Min, Nam Kyu Kim, Joong Bae Ahn, Kang Young Lee
Summary: This study investigated the impact of neoadjuvant imatinib on rectal GIST. The results showed that imatinib treatment can reduce tumor size, increase resectability, and help preserve the sphincter. The neoadjuvant group had a higher rate of levator ani muscle displacement and larger radiologic tumor size compared to the control group. However, there was no significant difference between the two groups in terms of postoperative complications, hospital stay, local recurrence, and disease-free survival.
Article
Gastroenterology & Hepatology
Krzysztof Dabkowski, Karolina Michalska, Natalia Rusiniak-Rosinska, Elzbieta Urasinska, Dariusz Bielicki, Teresa Starzynska
Summary: This study retrospectively analyzed rectal neuroendocrine tumors (rNETs) detected in the Polish colonoscopy screening program (PCSP). The results showed that, despite not being suspected by endoscopists during colonoscopy, the tumors were diagnosed through histopathological examinations after removal. This emphasizes the need for education of endoscopists in recognizing and treating rNETs.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Shahed A. Dawara, Sameera Naureen, Tasnim R. Keloth
Summary: Rectal gastrointestinal stromal tumors (GISTs) are a rare type of tumor. Neoadjuvant imatinib therapy has allowed for tumor size reduction and anus-preserving surgery, leading to improved quality of life. We present a case of successful trans-anal resection and long-term follow-up without recurrence.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Oncology
Wenjun Luo, Chunyu Liu, Luyin Han, Haidong Zhang, Chaoyong Shen, Xiaonan Yin, Zhou Zhao, Mingchun Mu, Tianxiang Jiang, Zhaolun Cai, Bo Zhang
Summary: This study protocol outlines a systematic review and meta-analysis comparing the surgical and oncological outcomes of local excision (LE) and radical excision (RE) for rectal gastrointestinal stromal tumors (GISTs). The study will include randomized controlled trials and non-randomized studies, evaluating primary outcomes such as R0 resection rate and disease-free survival, as well as secondary outcomes including overall survival, length of stay, tumor rupture rate, and complications. Preplanned subgroup analyses and sensitivity analyses will be conducted, and the strength of evidence will be assessed using GRADE.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Emanuele Tumino, Pierfrancesco Visaggi, Valeria Bolognesi, Linda Ceccarelli, Christian Lambiase, Sergio Coda, Purushothaman Premchand, Massimo Bellini, Nicola de Bortoli, Emanuele Marciano
Summary: Lower gastrointestinal endoscopy is the gold standard for diagnosing and removing colonic polyps. However, some patients refuse conventional colonoscopy due to fear of risks and discomfort. Robotic colonoscopy offers a promising alternative, allowing for a painless examination of the colon. Barium enema, computed tomographic colonography, and colon capsule endoscopy are also possible alternatives.
Article
Biology
Qiaosen Su, Fengsheng Wang, Dong Chen, Gang Chen, Chao Li, Leyi Wei
Summary: Gastrointestinal (GI) diseases are a serious threat to human health, and the detection and treatment of gastrointestinal diseases burden medical institutions. This study proposes a novel method using convolutional neural networks to detect gastrointestinal diseases from wireless capsule endoscopy images, achieving better results than existing methods and demonstrating the potential of using deep learning models for effective GI disease screening.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Neil Sengupta, Joseph D. D. Feuerstein, Vipul Jairath, Amandeep K. K. Shergill, Lisa L. L. Strate, Robert J. J. Wong, David Wan
Summary: Acute lower gastrointestinal bleeding (LGIB) is a common and serious condition that requires hospitalization. These revised guidelines provide recommendations for risk stratification, diagnostic testing, therapeutic options, and management of antithrombotic medications for LGIB patients. Important changes include the use of risk stratification tools, the role of reversal agents for anticoagulant patients, the increasing use of computed tomography angiography (CTA), and updated recommendations for resuming medication after LGIB.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Letter
Gastroenterology & Hepatology
Henriette C. Jodal, Magnus Loberg
Summary: This article is linked to papers by Jodal et al. To view these articles, please visit the provided link.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Neal Shahidi, Sergei Vosko, Sunil Gupta, Anthony Whitfield, Oliver Cronin, Timothy O'Sullivan, W. Arnout van Hattem, Mayenaaz Sidhu, David J. Tate, Eric Y. T. Lee, Nicholas Burgess, Stephen J. Williams, Michael J. Bourke
Summary: A selective resection algorithm (SRA) for large rectal polyps improves oncologic outcomes and reduces the risk of piecemeal resection of cancers.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Takahiro Shigaki, Yuichiro Tsukada, Koichi Teramura, Hiro Hasegawa, Koji Ikeda, Yuji Nishizawa, Takeshi Sasaki, Masaaki Ito
Summary: This study evaluated the feasibility of trans-anal surgery with the taTME technique for rectal GISTs. The results showed that the technique is feasible and two-team surgery may have advantages in terms of operation time and blood loss.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Review
Medicine, General & Internal
Tingting Wu, Xiaobin Cheng, Wenbin Chen
Summary: Surgery remains the mainstay of treatment for rectal GIST patients who achieve clinical complete response (cCR) after imatinib therapy, while close follow-up and continuous imatinib treatment are necessary for patients who cannot undergo surgery.
Article
Medicine, General & Internal
Ranbir Singh, Harsh Patel, Bhavin M. Patel, Franklin E. Kasmin
Summary: Dieulafoy lesions are characterized by vessels that erode the epithelium without forming ulcers. While most commonly found in the stomach, they can also occur in other parts of the gastrointestinal tract. Bleeding from these lesions can be self-limited, but may also be recurrent and prolonged.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Sang-Hyun Kim, Hyuk-Soon Choi, Bora Keum, Hoon-Jai Chun
Summary: Recent advancements in endoscopic technology have revolutionized the treatment of gastrointestinal diseases, improving patient outcomes and quality of life. While robotics have enhanced maneuverability and treatment capability for endoscopists, further developments are needed to address technical limitations and create more sophisticated instruments. Innovative robotic systems are being developed to eventually facilitate minimally invasive robotic surgery across various clinical fields for lower patient risk.
APPLIED SCIENCES-BASEL
(2021)
Article
Pharmacology & Pharmacy
Weihao Li, Xinyue Li, Kun Yu, Binyi Xiao, Jianhong Peng, Rongxin Zhang, Lingfang Zhang, Kun Wang, Zhizhong Pan, Cong Li, Xiaojun Wu
Summary: This study retrospectively analyzed the clinicopathological characteristics of 58 patients with rectal GIST who received neoadjuvant imatinib therapy. The results showed that neoadjuvant imatinib therapy is an effective and safe treatment for locally advanced rectal GISTs. Further studies are needed to validate its long-term prognostic benefit.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Arun Rajendran, Siwan Thomas-Gibson, Paul Bassett, Paul Dunckley, Rajaratnam Rameshshanker, Nick Sevdalis, Adam Haycock
Summary: Polypectomy training and assessment show significant variability internationally. Using DOPyS as an assessment tool, this study in the UK found that higher procedure intensity at baseline DOPyS assessment was associated with a higher likelihood of obtaining certification sooner.
Article
Surgery
Charles T. Harris, Sharven Taghavi, Emily Bird, Juan Duchesne, Tomas Jacome, Danielle Tatum
Summary: This study retrospectively reviewed adult trauma patients who received prehospital simple thoracostomy (ST) or needle thoracostomy (NT). The results showed that ST did not improve the success rates of return of spontaneous circulation (ROSC) and was associated with longer on-scene times in the prehospital setting.
Article
Surgery
Alison Smith, Max Shapiro, Rebecca Fabian, Hector Mejia Morales, Sharven Taghavi, Juan Duchesne, Rebecca Schroll, Patrick McGrew
Summary: The study found that the use of drains in operative liver trauma is associated with an increased risk of infectious complications. Drains were more commonly used in patients with more severe liver injury, intra-operative bile leaks, penetrating trauma, and increased blood transfusion requirements. Future studies should focus on developing specific guidelines for the use of drains in liver trauma.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Critical Care Medicine
Magnus Chun, Yichi Zhang, Chad Becnel, Tommy Brown, Mohamed Hussein, Eman Toraih, Sharven Taghavi, Chrissy Guidry, Juan Duchesne, Rebecca Schroll, Patrick McGrew
Summary: Trauma scores are important for predicting mortality and operative decision making in trauma patients. The New Trauma Injury Severity Score was found to be the most effective in predicting mortality for penetrating trauma, while the Trauma Injury Severity Score was the best predictor for specific types of injuries.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Critical Care Medicine
Sharven Taghavi, Zoe Maher, Amy J. Goldberg, Elliott R. Haut, Shariq Raza, Grace Chang, Leah C. Tatebe, Eman Toraih, Michelle Mendiola, Christofer Anderson, Scott Ninokawa, Patrick Maluso, Jane Keating, Sigrid Burruss, Matthew Reeves, Lauren E. Coleman, David Shatz, Anna Goldenberg-Sandau, Apoorva Bhupathi, M. Chance Spalding, Aimee LaRiccia, Emily Bird, Matthew R. Noorbakhsh, James Babowice, Marsha C. Nelson, Lewis E. Jacobson, Jamie Williams, Michael Vella, Kate Dellonte, Thomas Z. Hayward, Emma Holler, Mark J. Lieser, John D. Berne, Dalier R. Mederos, Reza Askari, Barbara Okafor, Eric Etchill, Raymond Fang, Samantha L. Roche, Laura Whittenburg, Andrew C. Bernard, James M. Haan, Kelly L. Lightwine, Scott H. Norwood, Jason Murry, Mark A. Gamber, Matthew M. Carrick, Nikolay Bugaev, Antony Tatar, Danielle Tatum
Summary: Police transport of penetrating trauma patients in urban locations results in similar outcomes compared with ALS. Immediate transport to definitive trauma care should be emphasized in this patient population.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Critical Care Medicine
Brian K. Yorkgitis, Danielle M. Tatum, Sharven Taghavi, Thomas J. Schroeppel, Matthew R. Noorbakhsh, Frances Hite Philps, Nikolay Bugaev, Kaushik Mukherjee, Mellody Bellora, Adrian W. Ong, Asanthi Ratnasekera, Kristen D. Nordham, Matthew M. Carrick, James M. Haan, Kelly L. Lightwine, Lawrence Lottenberg, Robert Borrego, Daniel C. Cullinane, John D. Berne, Dalier Rodriguez Mederos, Thomas Z. Hayward, Andy J. Kerwin, Marie Crandall
Summary: This study compared the effects of different antithrombotic medications on the severity of head injuries and found that reversal therapy does not improve mortality in patients with severe traumatic brain injury.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Critical Care Medicine
Sharven Taghavi, Sarah Abdullah, Eman Toraih, Jacob Packer, Robert H. Drury, Oguz A. Z. Aras, Emma M. Kosowski, Aaron Cotton-Betteridge, Mardeen Karim, Nicholas Bitonti, Farhana Shaheen, Juan Duchesne, Olan Jackson-Weaver
Summary: The study suggests that the use of dimethyl malonate (DMM) can prevent succinate accumulation and improve physiological recovery after severe hemorrhagic shock. DMM reduces the need for intravenous fluid and improves cardiac function.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Surgery
Walker Lyons, Ryan Lamm, Emily R. Duffner, Jason Shames, Alliric Willis, Melissa Lazar
Summary: This study aimed to explore the circumstances in which bracketed localization should be considered. The results showed that bracketed localization was most commonly used for patients with large lesion spans, multifocality, and a DCIS or invasive lobular component. Despite the typically higher rates of positive margins associated with these characteristics, our study found that the use of bracketed localization could be beneficial in reducing the rate of additional surgery.
Article
Surgery
Ryan Lamm, Walker Lyons, Winnie So, Alliric Willis
Summary: The COVID-19 pandemic has led to changes in melanoma presentation and treatment timeline, with patients during the pandemic showing thicker lesions and more advanced-stage disease. This dangerous trend may impact the prognosis of melanoma and other rapidly growing cancers as the prolonged effects of the pandemic continue to affect patients' access to medical care.
WORLD JOURNAL OF SURGERY
(2022)
Editorial Material
Critical Care Medicine
Leah C. Tatebe, Elinore J. Kaufman, Tina Nappi, Andrew J. Dennis, Kathy J. Neely, Erin C. Hall, Michael Smith, Thomas Duncan
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2023)
Article
Surgery
Rebecca Wu, Alison Smith, Tommy Brown, John P. Hunt, Patrick Greiffenstein, Sharven Taghavi, Danielle Tatum, Olan Jackson-Weaver, Juan Duchesne
Summary: This study demonstrates the utility of DI scores in predicting decompensation risk in the trauma ICU population, which may otherwise go unnoticed in real time. The DI model can identify high-risk patients and increase surveillance to mitigate unplanned returns to the ICU and failure to rescue.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Surgery
Ayman Ali, Jacob M. Broome, Danielle Tatum, Youssef Abdullah, Jonathan Black, John Tyler Simpson, Ali Salim, Juan Duchesne, Sharven Taghavi
Summary: Universal screening was found to be the most cost-effective strategy for identifying blunt cerebrovascular injuries (BCVI) among patients with blunt trauma. It resulted in decreased stroke rate, mortality, and cost, while increasing quality-adjusted life-years. The implementation of universal screening in the US could prevent an estimated 3,506 strokes annually. Trauma centers should develop institutional protocols that consider individual BCVI rates.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2023)
Letter
Critical Care Medicine
Sharven Taghavi, Zoe Maher, Leah C. Tatebe, Amy Goldberg, Danielle Tatum
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2023)
Article
Surgery
Ayman Ali, John T. Simpson, Danielle Tatum, Jessica A. Sedhom, Jacob Broome, Patrick R. McGrew, Juan Duchesne, Sharven Taghavi
Summary: After acute trauma, pregnant women did not have increased mortality or complications compared to matched controls, although they were more likely to be victims of assault, directly go to the operating room, require mechanical ventilation or ICU admission, and have longer lengths of stay.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Critical Care Medicine
Sharven Taghavi, Sarah Abdullah, Farhana Shaheen, Jacob Packer, Juan Duchesne, Stephen E. Braun, Chad Steele, Derek Pociask, Jay K. Kolls, Olan Jackson-Weaver
Summary: Exosomes and microvesicles derived from adipose-derived mesenchymal stem cells (ASCs) can protect the endothelial glycocalyx from LPS injury, potentially through the action of a specific enzyme.
Article
Multidisciplinary Sciences
Sarah Abdullah, Michael Ghio, Aaron Cotton-Betteridge, Aditya Vinjamuri, Robert Drury, Jacob Packer, Oguz Aras, Jessica Friedman, Mardeen Karim, David Engelhardt, Emma Kosowski, Kelby Duong, Farhana Shaheen, Patrick R. McGrew, Charles T. Harris, Robert Reily, Mimi Sammarco, Partha K. Chandra, Derek Pociask, Jay Kolls, Prasad V. Katakam, Alison Smith, Sharven Taghavi, Juan Duchesne, Olan Jackson-Weaver
Summary: Acute hemorrhage can lead to coagulopathy and organ dysfunction. Recent evidence shows that damage to the endothelial glycocalyx contributes to these adverse outcomes. This study suggests that succinate accumulation in endothelial cells promotes glycocalyx degradation through a membrane reorganization-mediated mechanism involving lipid oxidation and phospholipase A2. Inhibiting succinate metabolism or membrane reorganization can prevent glycocalyx damage and coagulopathy in a rat hemorrhage model and trauma patients.