Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 111, Issue -, Pages 344-350Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2014.12.038
Keywords
Counterfeit medicines; Insulin; Micellar electroldnetic chromatography; Quality control; Stability
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A simple and efficient MEKC method was developed to simultaneously determine human insulin, its five analogues, the main degradation products and the excipients usually present in injection formulations. A very fast method with a total analysis time of 3 min was then successfully validated for the analysis of human insulin and the quality control of commercial formulations was carried out. (C) 2015 Elsevier B.V. All rights reserved.
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