Article
Gastroenterology & Hepatology
Gianluca Pellino, Alejandro Solis-Pena, Miquel Kraft, Bernat Miguel Huguet, Eloy Espin-Basany
Summary: This study aims to assess the impact of a combined regimen of oral antibiotics and mechanical bowel preparation on surgical site infections after colonic surgery. A randomized controlled trial will be conducted with the primary outcome of 30-day SSI and additional endpoints, with planned interim analyses.
COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
Martin Rutegard, Alethea Tang, Darren James Gregoire, Christopher Stewart, Libor Hurt, Susan Chandler, Matthew David Hitchings, Brendan Healy, Dean Harris
Summary: The study aims to evaluate the impact of oral antibiotics on the incidence of surgical site infections in colorectal surgery. The results show that the use of oral antibiotics in colorectal surgery may reduce the risk of infection and alter the structure of the intestinal microbiome. However, further research is needed on the application methods of different oral antibiotics and the mechanism of the gut microbiome.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Review
Gastroenterology & Hepatology
Chee Hoe Koo, Aik Yong Chok, Ian Jun Yan Wee, Isaac Seow-En, Yun Zhao, Emile John Kwong Wei Tan
Summary: This study investigates the efficacy of oral antibiotics and mechanical bowel preparation in preventing surgical site infection after elective colorectal surgery. The findings suggest that the combination of oral antibiotics and mechanical bowel preparation reduces the risk of surgical site infection. Certain oral antibiotic regimens show greater effectiveness than others.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Surgery
Purun Lei, Guiru Jia, Xiaofeng Yang, Ying Ruan, Bo Wei, Tufeng Chen
Summary: The study found that preoperative use of OA+MBP significantly reduces the incidence of SSIs in colorectal surgery, particularly in left-sided resections.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Jun Ho Lee, Byung Kyu Ahn, Jiin Ryu, Kang Hong Lee
Summary: The study found that in colorectal cancer surgery, mechanical bowel preparation combined with oral antibiotics can reduce the rate of surgical site infection, shorten hospital stay, and decrease medical costs.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
Evgeny Rybakov, Marat Nagudov, Marina Sukhina, Yuri Shelygin
Summary: The study found that oral combined with intravenous antibiotic prophylaxis significantly reduced the risk of surgical site infection after rectal surgery, with bacterial contamination of the pelvic cavity and oral antimicrobial prophylaxis identified as independent risk factors for infection.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Simran Grewal, J. Reinder D. Reuvers, Gabor S. A. Abis, Rene H. J. Otten, Geert Kazemier, Hein B. A. C. Stockmann, Marjolein van Egmond, Steven J. Oosterling
Summary: Prophylactic oral antibiotics combined with mechanical bowel preparation can reduce the rates of surgical-site infection and anastomotic leakage in patients undergoing elective colorectal carcinoma surgery, with selective decontamination of the digestive tract showing greater effectiveness in reducing anastomotic leakage compared to broad-spectrum antibiotics.
Article
Infectious Diseases
Marco Lollobrigida, Gianluca Pingitore, Luca Lamazza, Giulia Mazzucchi, Giorgio Serafini, Alberto De Biase
Summary: The benefit of antibiotic prophylaxis for most oral surgical procedures is controversial, with substantial agreement found in some clinical scenarios but discordant responses in others. Specific guidelines on antibiotics in dentistry, particularly on antibiotic prophylaxis in oral surgery, are needed to avoid unnecessary prescriptions, as indicated by the heterogeneous responses collected from the survey sample.
Article
Gastroenterology & Hepatology
Ebram Salama, Faisal Al-Rashid, Allison Pang, Gabriela Ghitulescu, Carol-Ann Vasilevsky, Marylise Boutros
Summary: This retrospective study compared the perioperative morbidity between patients who received preoperative oral antibiotic bowel preparation (OABP) and those who did not before urgent colectomy. The results showed that OABP was associated with reduced rates of organ space surgical site infection (SSI) and ileus, but had no effect on leak rates and major morbidity.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Review
Gastroenterology & Hepatology
Mohamed Maatouk, Alaa Akid, Ghassen Hamdi Kbir, Aymen Mabrouk, Marwen Selmi, Anis Ben Dhaou, Sami Daldoul, Karim Haouet, Mounir Ben Moussa
Summary: This study aimed to assess the available evidence of mechanical and oral antibiotic bowel preparation in reducing the incidence of surgical site infection (SSI) and other complications following minimally invasive elective colorectal surgery. The study included 18 studies, and the results showed that the combination of mechanical bowel preparation and oral antibiotics significantly reduced the occurrence of SSI, anastomotic leakage, and overall morbidity compared to other options (no preparation, mechanical bowel preparation only, oral antibiotics only). Therefore, the combination of oral antibiotics and mechanical bowel preparation should be encouraged in this specific group of patients undergoing minimally invasive surgery.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Aleksandra Olkina, Aleksei Karachun, Sergey Bagnenko, Alexey Belyaev, Aleksei Petrov
Summary: This study aims to assess the clinical value of mechanical bowel preparation and oral antibiotics before rectal surgery and their impact on postoperative complications. The results of this study could potentially influence current preoperative practices and improve postoperative outcomes.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Surgery
L. Koskenvuo, T. Lehtonen, S. Koskensalo, S. Rasilainen, K. Klintrup, A. Ehrlich, T. Pinta, T. Scheinin, V. Sallinen
Summary: The study results showed that mechanical and oral antibiotic bowel preparation did not reduce the rate of surgical-site infections or complications in patients undergoing either right or left colectomy compared with no bowel preparation.
Article
Gastroenterology & Hepatology
Yumin Yue, Xi Chen, Hui Wang, Min Cheng, Bobo Zheng
Summary: A pooled analysis combined with trial sequential analysis demonstrated that mechanical bowel preparation (MBP) combined with oral antibiotic bowel decontamination (OAB) significantly reduces the incidence of anastomotic leak (AL) and surgical site infection (SSI) in patients after colorectal resection compared with MBP alone.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Javier Gomez Sanchez, Rocio Forneiro Perez, Marisol Zurita Saavedra, Paola de Castro Monedero, Cristina Gonzalez Puga, Carlos Garde Lecumberri, Benito Miron Pozo
Summary: This study demonstrated that mechanical bowel preparation combined with oral antibiotics reduces the risk of surgical wound infection and anastomotic leakage in patients undergoing colon and rectal cancer surgery.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Review
Infectious Diseases
Jiahui Yao, Li Chen, Xiaoli Liu, Jin Wang, Jinru Zeng, Yun Cai
Summary: This meta-analysis examined the efficacy and safety of different preoperative oral antibiotic preparations in comparison with intravenous antibiotic preparation and/or mechanical bowel preparation for intestinal surgery. The results showed that the combination of preoperative oral antibiotic preparation and preoperative/postoperative intravenous antibiotic preparation significantly reduced the incidence of surgical site infection.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)
Article
Gastroenterology & Hepatology
Drew J. Gunnells, Lauren N. Wood, Lauren Goss, Melanie S. Morris, Gregory D. Kennedy, Jamie A. Cannon, Daniel I. Chu
JOURNAL OF GASTROINTESTINAL SURGERY
(2018)
Article
Gastroenterology & Hepatology
Tyler S. Wahl, Fenil C. Patel, Lauren E. Goss, Daniel I. Chu, Jayleen Grams, Melanie S. Morris
DISEASES OF THE COLON & RECTUM
(2018)
Article
Public, Environmental & Occupational Health
Mini Kamboj, Teresa Childers, Jessica Sugalski, Donna Antonelli, Juliane Bingener-Casey, Jamie Cannon, Karie Cluff, Kimberly A. Davis, E. Patchen Dellinger, Sean C. Dowdy, Kim Duncan, Julie Fedderson, Robert Glasgow, Bruce Hall, Marilyn Hirsch, Matthew Hutter, Lisa Kimbro, Boris Kuvshinoff, Martin Makary, Melanie Morris, Sharon Nehring, Sonia Ramamoorthy, Rebekah Scott, Mindy Sovel, Vivian Strong, Ashley Webster, Elizabeth Wick, Julio Garcia Aguilar, Robert Carlson, Kent Sepkowitz
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2018)
Article
Education, Scientific Disciplines
Kevin D. Cofer, Robert H. Hollis, Lauren Goss, Melanie S. Morris, John R. Porterfield, Daniel Chu
JOURNAL OF SURGICAL EDUCATION
(2018)
Editorial Material
Surgery
Melanie S. Morris, Mary T. Hawn
JOURNAL OF SURGICAL RESEARCH
(2019)
Article
Health Care Sciences & Services
Ashley Titan, Laura Graham, Amy Rosen, Kamal Itani, Laurel A. Copeland, Hillary J. Mull, Edith Burns, Joshua Richman, Stefan Kertesz, Tyler Wahl, Melanie Morris, Jeffery Whittle, Gordon Telford, Mark Wilson, Mary Hawn
Article
Surgery
Hillary J. Mull, Laura A. Graham, Melanie S. Morris, Amy K. Rosen, Joshua S. Richman, Jeffery Whittle, Edith Burns, Todd H. Wagner, Laurel A. Copeland, Tyler Wahl, Caroline Jones, Robert H. Hollis, Kamal M. F. Itani, Mary T. Hawn
Article
Surgery
Tyler S. Wahl, Laura A. Graham, Melanie S. Morris, Joshua S. Richman, Robert H. Hollis, Caroline E. Jones, Kamal M. Itani, Todd H. Wagner, Hillary J. Mull, Jeffrey C. Whittle, Gordon L. Telford, Amy K. Rosen, Laurel A. Copeland, Edith A. Burns, Mary T. Hawn
Article
Gastroenterology & Hepatology
Evie Carchman, Daniel I. Chu, Gregory D. Kennedy, Melanie Morris, Marc Dakermandji, John R. T. Monson, Laura Melina Fernandez, Rodrigo Oliva Perez, Alessandro Fichera, Marco E. Allaix, David Liska
JOURNAL OF GASTROINTESTINAL SURGERY
(2019)
Article
Surgery
Tyler S. Wahl, Lauren E. Goss, Melanie S. Morris, Allison A. Gullick, Joshua S. Richman, Gregory D. Kennedy, Jamie A. Cannon, Selwyn M. Vickers, Sara J. Knight, Jeffrey W. Simmons, Daniel I. Chu
Editorial Material
Surgery
Melanie Morris, Albert Pierce, Brenda Carlisle, Brooke Vining, Jeffrey Dobyns
AMERICAN JOURNAL OF SURGERY
(2020)
Article
Surgery
Isabel C. Dos Santos Marques, Lauren M. Theiss, Lauren N. Wood, Drew J. Gunnells, Robert H. Hollis, Karin M. Hardiman, Jamie A. Cannon, Melanie S. Morris, Gregory D. Kennedy, Daniel Chu
Summary: A retrospective cohort study using the ACS-NSQIP database revealed racial disparities in surgical outcomes for Black, Hispanic, and Asian patients with IBD compared to White patients. Black patients had increased odds of complications, Hispanic patients had higher odds of readmission, and Asian patients had longer hospital stays. Future research is needed to understand the mechanisms behind these disparities.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Surgery
James A. Stewart, Lauren Wood, Jameson Wiener, Gregory D. Kennedy, Daniel Chu, Jeffrey R. Lancaster, Melanie S. Morris
Summary: The study found that using visual teaching aids during the informed consent process for colectomy can increase patient recall of potential complications, reduce anxiety levels, and improve understanding.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Rikki M. Tanner, Monika M. Safford, Keri L. Monda, Benjamin Taylor, Ronan O'Beirne, Melanie Morris, Lisandro D. Colantonio, Ricardo Dent, Paul Muntner, Robert S. Rosenson
CARDIOVASCULAR DRUGS AND THERAPY
(2017)
Review
Surgery
Brandon Singletary, Nisha Patel, Andrew Mims, Andrew Smedley, Jacob Swords, Ronan O'Bierne, Melanie S. Morris, Monika Safford, Martin Heslin