Article
Neurosciences
Liyun Wang, Payam Gharibani, Yi Yang, Yu Guo, Jieyun Yin
Summary: This study investigated the effects of sacral nerve stimulation (SNS) on Loperamide-induced constipation in rats. The results showed that SNS with appropriate parameters improved whole colon transit time, resolved constipation, reversed the detrimental effects of Loperamide on enteric neurons, and increased the expressions of GDNF and p-AKT in colon tissue. The findings suggest that SNS may be a potential treatment for opioid-induced constipation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pediatrics
Stephen Trinidad, Amanda Jensen, Monica Holder, Allison Elsner, Nelson Rosen, Aaron Garrison, Beth Rymeski, Jason S. Frischer
Summary: This study evaluated the outcomes of sacral nerve stimulation (SNS) in patients with medically refractory fecal incontinence or severe constipation. A retrospective cohort study was conducted on patients who underwent SNS placement after failed medical management at a single center. The rates of involuntary bowel movements were compared pre- and post-SNS using a bowel severity score questionnaire.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Multidisciplinary Sciences
Zakir Mridha, Jan Willem de Gee, Yanchen Shi, Rayan Alkashgari, Justin Williams, Aaron Suminski, Matthew P. Ward, Wenhao Zhang, Matthew James McGinley
Summary: The study demonstrates that pupil dilation is a reliable and noninvasive biosensor for titratable VNS-evoked cortical neuromodulation by acetylcholine in mice.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Ximeng Wang, Jiande D. Z. Chen
Summary: The systematic review aims to introduce the clinical applications and potential mechanisms of sacral nerve stimulation (SNS) for various gastrointestinal diseases. The results showed that SNS is highly effective in treating fecal incontinence, but it is ineffective for constipation. Further research is needed to explore the potential applications of SNS for irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD).
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Beniamina Mercante, Paolo Enrico, Franca Deriu
Summary: In recent years, there has been a significant scientific effort to find effective and safe treatments for cognitive decline. Non-invasive neuromodulation, particularly trigeminal nerve stimulation (TNS), has gained attention for its potential cognitive effects. However, the use of TNS for cognitive enhancement and treatment of cognitive decline still faces challenges due to the lack of standardization in stimulation protocols.
Article
Gastroenterology & Hepatology
D. F. Altomare, A. Picciariello, A. Di Ciaula, M. Rinaldi, M. De Fazio, P. Portincasa
Summary: Temporary sacral nerve stimulation (SNS) did not have any effect on upper/lower gastrointestinal motility and transit in patients with severe constipation.
TECHNIQUES IN COLOPROCTOLOGY
(2021)
Article
Multidisciplinary Sciences
Benjamin U. Hoffman, Yoshichika Baba, Stephen A. Lee, Chi-Kun Tong, Elisa E. Konofagou, Ellen A. Lumpkin
Summary: This study successfully modulated the activity of peripheral neurons using targeted ultrasound stimulation and electrophysiology in mouse ex vivo skin-saphenous nerve preparations. The findings showed that high-intensity, millisecond ultrasound pulses reliably evoked action potentials in peripheral neurons, and there was a discrete range of parameters capable of exciting different types of neurons. Additionally, ultrasound stimulation could be targeted to cutaneous receptive fields or peripheral nerves, expanding the therapeutic range of ultrasound-based peripheral neuromodulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Gastroenterology & Hepatology
Aylin Hande Gokce, Feridun Suat Gokce, Raim Iliaz, Nihat Gulaydin
Summary: The study evaluated the efficacy of bilateral transcutaneous tibial nerve stimulation as a noninvasive treatment method for functional constipation in 105 patients. Results showed a reduction in time spent in the toilet, decreased use of softeners, and improvement in various symptoms after the 6-week treatment period.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Biology
Ronny Rodrigues Correia, Luis Felipe Orsi Gameiro, Nathalia Grion Trevisane, Matheus Bertanha, Erika Veruska Paiva Ortolan, Pedro Luiz Toledo de Arruda Lourencao
Summary: This study conducted a systematic review of randomized clinical trials on the effects of transcutaneous neuromodulation in treating constipation and retentive fecal incontinence in children and adolescents. The analysis of three studies revealed that transcutaneous neuromodulation is an effective adjuvant treatment modality that improves children's constipation and retentive fecal incontinence. The included studies demonstrated a high methodological quality and a high degree of confidence based on the GRADE system.
Article
Urology & Nephrology
Konstantinos Kapriniotis, Julie Jenks, Bogdan Toia, Mahreen Pakzad, Helena Gresty, Ross Stephens, Sachin Malde, Arun Sahai, Tamsin Greenwell, Jeremy Ockrim
Summary: This study assessed the reliability of percutaneous tibial nerve stimulation (PTNS) response as an indicator for subsequent sacral nerve stimulation (SNS) trials. The results showed that a poor response to PTNS does not predict the response to SNS. Therefore, a negative PTNS trial should not preclude a trial of sacral nerve implantation.
NEUROUROLOGY AND URODYNAMICS
(2022)
Article
Surgery
Hiroya Enomoto, Yuji Nishizawa, Koji Inamori, Hiro Hasegawa, Koji Ikeda, Yuichiro Tsukada, Takeshi Sasaki, Masaaki Ito
Summary: A retrospective study investigated the efficacy of sacral neuromodulation (SNM) in 10 patients who underwent intersphincteric resection (ISR). Results showed that 40% of patients achieved a good response at the end of follow-up, while 3 patients required permanent stoma creation.
Review
Clinical Neurology
Adam G. Evans, Abigail N. Horrar, Maryo M. Ibrahim, Brady L. Burns, Christopher L. Kalmar, Patrick E. Assi, Krista N. Brooks-Horrar, Tigran Kesayan, Salam Al Kassis
Summary: The study found that transcutaneous nerve stimulators showed significant reductions in both headache frequency and severity, effectively reducing the number of headache days and pain scores.
JOURNAL OF NEUROLOGY
(2022)
Article
Obstetrics & Gynecology
Marco Agnello, Mario Vottero, Paola Bertapelle
Summary: This study aimed to evaluate the efficacy and safety of sacral neuromodulation (SNM) during pregnancy. A total of 14 pregnancies among 11 women who underwent SNM implantation were included in the study. The results showed that maintaining the SNM device on during pregnancy appeared to be safe, with no major urological complications reported among the majority of women. The study also suggested that the risks associated with switching the device off may outweigh the benefits, justifying the continuation of electrical stimulation throughout pregnancy.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Haocheng Zhou, Rui Han, Li Chen, Zhen Zhang, Xiaobo Zhang, Jianlong Wang, Zuoliang Liu, Dong Huang
Summary: This study found that both spinal cord stimulation (SCS) and peripheral nerve stimulation (PNS) can induce cortical alpha oscillation changes in patients with zoster-related pain, which may partly mediate the analgesic effect of implantable electrical nerve stimulation (ENS).
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Horn C. Charles, Mats Forssell, Michael Sciullo, Jonathan E. Harms, Stephanie Fulton, Chenchen Mou, Fan Sun, Tyler W. Simpson, Gutian Xiao, Lee E. Fisher, Christopher Bettinger, Gary K. Fedder
Summary: This study demonstrates the potential for selective cervical VNS as a therapeutic approach for modulating distal nerve branches while reducing off target effects, which could potentially be refined to treat gastrointestinal, metabolic, inflammatory, cardiovascular, and respiratory diseases amenable to vagal neuromodulatory control.
JOURNAL OF NEURAL ENGINEERING
(2021)