Article
Oncology
S. P. Somashekhar, Avanish Saklani, Jagannath Dixit, Jagdish Kothari, Sandeep Nayak, O. V. Sudheer, Surender Dabas, Jagadishwar Goud, Venkatesh Munikrishnan, Pavan Sugoor, Prasanth Penumadu, C. Ramachandra, Shilpa Mehendale, Akhil Dahiya
Summary: This study describes the method of personalizing international guidelines for rectal cancer management to the Indian context. The expert group reached a consensus through literature review and expert opinions, and classified the consensus statements as strong or weak. Disseminating these research findings to a wider medical community is of great importance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Jeremy Meyer, George van der Schelling, Jan Wijsman, Frederic Ris, Rogier Crolla
Summary: The study investigates the use of splenic flexure mobilization (SFM) during anterior resection and proposes a radiological index for identifying patients who may benefit from SFM based on pre-operative CT.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Zhi-Hang Liu, Zi-Wei Zeng, Hai-Qing Jie, Liang Huang, Shuang-Ling Luo, Wen-Feng Liang, Xing-Wei Zhang, Liang Kang
Summary: This study compared the perioperative results, long-term oncologic outcomes, and anorectal functions of patients with low rectal cancer undergoing laparoscopic abdominoperineal resection (laAPR) or transanal total mesorectal excision (taTME) combined with intersphincteric resection (ISR). The study found similar rates of local recurrence and overall survival for both surgical approaches, while patients receiving taTME combined with ISR had fewer intraoperative blood loss, lower rates of post-operative complications, and acceptable post-operative anorectal function.
GASTROENTEROLOGY REPORT
(2022)
Review
Health Care Sciences & Services
Simona Giuratrabocchetta, Giampaolo Formisano, Adelona Salaj, Enrico Opocher, Luca Ferraro, Francesco Toti, Paolo Pietro Bianchi
Summary: Minimally invasive treatment of rectal cancer with Total Mesorectal Excision is complex and challenging, with robotic surgery offering advantages in dexterity but cost and benefits still need further evaluation.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Surgery
Julia K. Grass, Chien-Chih Chen, Nathaniel Melling, Bharathi Lingala, Marius Kemper, Pasquale Scognamiglio, Roberto Persiani, Flavio Tirelli, Marco Caricato, Gabriella T. Capolupo, Jakob R. Izbicki, Daniel R. Perez
Summary: Robotic TME leads to better recovery of anorectal function compared to laparoscopic, open, and transanal techniques. Further high-quality studies are needed to confirm the benefits of robotic surgery.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2021)
Article
Multidisciplinary Sciences
Jung Kyong Shin, Hee Cheol Kim, Woo Yong Lee, Seong Hyeon Yun, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park
Summary: Intersphincteric resection (ISR) for low-lying rectal cancer aims to avoid abdominoperineal resection (APR). This study compared open and minimally invasive ISR, finding similar 5-year disease-free survival rates. Minimally invasive ISR showed advantages in postoperative outcomes like reduced surgical site infection and shorter hospital stay.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Yihui Liu, Min Liu, Yang Lei, Hao Zhang, Jingmao Xie, Shaihong Zhu, Juan Jiang, Jianmin Li, Bo Yi
Summary: This study evaluated the impact of robotic technology on postoperative genitourinary function in patients undergoing TME for rectal cancer. The results showed that robotic-assisted TME had superior outcomes in the early postoperative period, contributing to the early recovery of postoperative genitourinary function.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Surgery
L. J. X. Giesen, J. W. T. Dekker, M. Verseveld, R. M. P. H. Crolla, G. P. van der Schelling, C. Verhoef, P. B. Olthof
Summary: A study conducted in the Netherlands shows that the use of robot-assisted surgery for rectal cancer resections is increasing. While the conversion rate is lower in the robot-assisted surgery group, the proportion of defunctioning ileostomies is higher, and overall outcomes are comparable to laparoscopic surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Francesco Marchegiani, Valeria Palatucci, Giulia Capelli, Mario Guerrieri, Claudio Belluco, Daniela Rega, Emilio Morpurgo, Claudio Coco, Angelo Restivo, Silvia De Franciscis, Carlo Aschele, Alessandro Perin, Michele Bonomo, Andrea Muratore, Antonino Spinelli, Salvatore Ramuscello, Francesca Bergamo, Giampaolo Montesi, Gaya Spolverato, Paola Del Bianco, Maria Antonietta Gambacorta, Paolo Delrio, Salvatore Pucciarelli
Summary: The short-term outcomes of rectum-preservation for locally advanced rectal cancer patients achieving major clinical response or complete clinical response after neoadjuvant therapy were reported in the study. Transanal local excision for patients achieving cCR or mCR is safe, with an increased cCR rate seen when there is a 12-week interval from chemoradiotherapy completion to LE. Performing LE after achieving cCR reduces the risk of ypT >.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Klas Holmgren, Jenny Haggstrom, Markku M. Haapamaki, Peter Matthiessen, Jorgen Rutegard, Martin Rutegard
Summary: In anterior resection for rectal cancer, defunctioning stomas may decrease the likelihood of a stoma-free outcome. While the benefits of reducing leakage support routine diversion in TME, its necessity in PME remains questionable.
COLORECTAL DISEASE
(2021)
Article
Oncology
Pietro Achilli, Tyler S. Radtke, Jenna K. Lovely, Kevin T. Behm, Kellie L. Mathis, Scott R. Kelley, Amit Merchea, Dorin T. Colibaseanu, David W. Larson
Summary: Threatened or involved mesorectal fascia and T3 tumors with greater than 5 mm extension were identified as preoperative predictors of pathological CRM involvement, according to a retrospective study on robotic rectal cancer surgery outcomes. The predictive model based on preoperative radiological features showed good discrimination and could estimate the risk of CRM positivity for each patient.
Article
Surgery
Hiroshi Takeyama, Katsuki Danno, Takahiko Nishigaki, Masafumi Yamashita, Yoshio Oka
Summary: A novel simple switching technique (SST) was introduced to address the challenges of performing tumor-specific mesorectal excision in a narrow pelvic cavity, potentially reducing operation time without significant differences in short-term outcomes.
UPDATES IN SURGERY
(2021)
Article
Surgery
Swapnil Patel, Mufaddal Kazi, Ashwin L. Desouza, Vivek Sukumar, Jayesh Gori, Munita Bal, Avanish Saklani
Summary: Patients with positive pCRM have high rates of local and distal relapse, with systemic relapse often being detected through follow-up surveillance, while peritoneal or local relapse is more often symptomatic.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Surgery
Rebecca Svensson Neufert, Fredrik Jorgren, Pamela Buchwald
Summary: This study found that rectal washout during anterior resection for rectal cancer does not impact the oncological outcome at 3 years, but a reduction in local recurrence risk was observed after 5 years.
Article
Gastroenterology & Hepatology
Jan Scheele, Johannes Lemke, Mathias Wittau, Silvia Sander, Doris Henne-Bruns, Marko Kornmann
Summary: This study compared the quality of life (QoL) after low anterior resection (AR) and abdominoperineal resection (APR) for rectal cancer (RC), with a special analysis of AR patients with a stoma. The results showed that AR patients had higher overall health status, fewer symptoms, and better functionality compared to APR and AR patients with a stoma. Radiotherapy also had a significant impact on reducing QoL in all patients.
Article
Gastroenterology & Hepatology
DISEASES OF THE COLON & RECTUM
(2020)
Article
Gastroenterology & Hepatology
S. Tou, M. Gomez Ruiz, A. G. Gallagher, K. E. Matzel
COLORECTAL DISEASE
(2020)
Letter
Gastroenterology & Hepatology
M. Zawadzki, M. Gomez Ruiz, S. Tou, A. Jeffels, K. E. Matzel
COLORECTAL DISEASE
(2020)
Article
Medicine, General & Internal
Iwona Bednarz-Misa, Mariusz G. Fleszar, Marek Zawadzki, Bartosz Kapturkiewicz, Agnieszka Kubiak, Katarzyna Neubauer, Wojciech Witkiewicz, Malgorzata Krzystek-Korpacka
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Oncology
Malgorzata Krzystek-Korpacka, Berenika Szczesniak-Siega, Izabela Szczuka, Paulina Fortuna, Marek Zawadzki, Agnieszka Kubiak, Magdalena Mierzchala-Pasierb, Mariusz G. Fleszar, Lukasz Lewandowski, Pawel Serek, Natalia Jamrozik, Katarzyna Neubauer, Jerzy Wisniewski, Radoslaw Kempinski, Wojciech Witkiewicz, Iwona Bednarz-Misa
Article
Biochemistry & Molecular Biology
Paulina Lewandowska, Jaroslaw Wierzbicki, Marek Zawadzki, Anil Agrawal, Malgorzata Krzystek-Korpacka
Summary: The study found differential expression of ACKR2 and ACKR4 in colorectal polyps and adenocarcinomas, with ACKR2 primarily downregulated in adenomas and cancers, while ACKR4 mainly downregulated in adenocarcinomas. These expression changes have already occurred in precancerous lesions, emphasizing the potential for chemoprevention by manipulating ACKRs' expression.
Article
Medicine, General & Internal
Mariusz G. Fleszar, Paulina Fortuna, Marek Zawadzki, Pawel Hodurek, Iwona Bednarz-Misa, Wojciech Witkiewicz, Malgorzata Krzystek-Korpacka
Summary: This study aimed to investigate cortisol levels and changes in colorectal cancer patients undergoing open or robot-assisted surgery. The results showed that surgery type, estimated blood loss, and length of surgery significantly affected the cortisol time profile, and cortisol co-examined with C-reactive protein may be predictive of surgical site infections.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Krzystek-Korpacka, Magdalena Mierzchala-Pasierb, Marek Zawadzki, Dorota Diakowska, Wojciech Witkiewicz
Summary: This study aims to understand the changes in antioxidant capacity, including TAC, FRAP, SOD, and GPx, in patients undergoing surgery, especially in older, obese, and comorbid patients. The time frame between 8 and 24 h post-incision is crucial for antioxidant-based interventions, as seen in the transient increase in FRAP and TAC, and the significant changes in SOD and GPx activities.
Article
Biochemistry & Molecular Biology
Paulina Lewandowska, Izabela Szczuka, Iwona Bednarz-Misa, Berenika M. Szczesniak-Siega, Katarzyna Neubauer, Magdalena Mierzchala-Pasierb, Marek Zawadzki, Wojciech Witkiewicz, Malgorzata Krzystek-Korpacka
Summary: The antineoplastic effects of oxicams are not fully understood. The study found that novel oxicams can effectively modulate chemokine expression, upregulate NAG1, and interfere with NF-kappa B signaling pathway.
Article
Surgery
Kryspin Mitura, Piotr Mysliwiec, Wojciech Rogula, Michal Solecki, Jaroslaw Piotr Furtak, Michal Kazanowski, Stanislaw Klek, Michal Nowakowski, Michal Pedziwiatr, Marek Zawadzki, Grzegorz Wallner, Jacek Sobocki
POLISH JOURNAL OF SURGERY
(2020)
Review
Surgery
Kryspin Mitura, Piotr Mysliwiec, Wojciech Rogula, Michal Solecki, Jaroslaw P. Furtak, Michal Kazanowski, Stanislaw Klek, Michal Nowakowski, Michal Pedziwiatr, Marek Zawadzki, Grzegorz Wallner, Jacek Sobocki
VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
(2020)
Article
Biochemistry & Molecular Biology
Mariusz G. Fleszar, Paulina Fortuna, Marek Zawadzki, Bogna Kosyk, Malgorzata Krzystek-Korpacka
Meeting Abstract
Rheumatology
R. Westhovens, D. Yoo, P. Wiland, M. Zawadzki, D. Ivanova, A. Berrocal, E. Chalouhi, E. Balazs, S. Shevchuk, S. J. Lee, S. H. Kim, J. Suh, C. Hwang, D. S. Choi
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Meeting Abstract
Rheumatology
D. Yoo, R. Westhovens, P. Wiland, M. Zawadzki, D. Ivanova, A. Berrocal, E. Chalouhi, E. Balazs, S. Shevchuk, S. J. Lee, S. H. Kim, N. Han, Y. Jung
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Meeting Abstract
Rheumatology
Rene Westhovens, Piotr Wiland, Marek Zawadzki, Delina Ivanova, Alfredo Berrocal, Elias Chalouhi, Eva Balazs, Sergii Shevchuk, Larisa Eliseeva, Mykola Stanislavchuk, Roman Yatsyshyn, Sangjoon Lee, Jeehye Suh, Seulgi Lee, Yunah Kim, Daehyun Yoo
ANNALS OF THE RHEUMATIC DISEASES
(2019)