Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 115, Issue -, Pages 86-106Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2015.06.013
Keywords
Flavonoids; HPLC-DAD-ESI-IT-TOF-MS; Iridoid glycosides; Phenolic acids; Phenylethanoid glycosides; Shuang-huang-lian powder injection
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Funding
- Natural Science Foundation of Beijing, China [7142088]
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A high-performance liquid chromatography-diode array detector-electrospray ionization-ion trap-time of flight-mass spectrometry (HPLC-DAD-ESI-IT-TOF-MS) method was established for excellent separation and structural identification of constituents in Shuang-huang-lian powder injection (SHLPI). The typical ultraviolet absorptions, accurate empirical molecular formula and reasonable fragmentation mechanisms of these ingredients were used for their structural elucidation. In consequence, 125 constituents (33 phenolic acids, 29 flavonoids, 32 phenylethanoid glycosides, 15 iridoid glycosides, 8 lignans, 3 amino acids and 2 purines nucleosides, 2 quinoid glycosides and 1 alkylbenzene glycoside) were either unequivocally identified or tentatively characterized by comparing authentic standards or published data. The result showed that this study could provide valuable information for the quality control and further investigation of SHLPI formula. (C) 2015 Elsevier B.V. All rights reserved.
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