Article
Neurosciences
Xue Jin, Payam Gharibani, Jieyun Yin, Jiande D. Z. Chen
Summary: Sacral nerve stimulation can improve visceral hypersensitivity in rats by reducing mast cell overactivation, thus alleviating pain symptoms in the rodents.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Gastroenterology & Hepatology
Charlotte Desprez, Audrey Grange, Guillaume Gourcerol, Alexis Deperrois, Oriane Garconnet, Clemence Leroux, Gregory Mosni, Laurence Poux, Justine Breemeersch, Cecile Goblot, Sebastien Kepka, Julie Ruillon, Margot Vannier, Valerie Bridoux, Anne-Marie Leroi
Summary: Regular follow-up and reprogramming of stimulation parameters in patients with implanted SNM devices can optimize the efficacy of treatment for fecal incontinence.
COLORECTAL DISEASE
(2022)
Article
Urology & Nephrology
Mathieu Fourel, Samy Hafez, Nassima Ramdane, Marie-Aimee Perrouin-Verbe, Stefan De Wachter, Patrick Vermersch, Xavier Biardeau
Summary: This study assessed the correlation between the response to TTNS and subsequent response to SNM in the treatment of overactive bladder. The results showed that the response to TTNS does not predict the response to SNM. Therefore, TTNS and SNM should be considered as separate therapies in the treatment of overactive bladder.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Urology & Nephrology
Konstantinos Kapriniotis, Julie Jenks, Bogdan Toia, Mahreen Pakzad, Helena Gresty, Ross Stephens, Sachin Malde, Arun Sahai, Tamsin Greenwell, Jeremy Ockrim
Summary: This study assessed the reliability of percutaneous tibial nerve stimulation (PTNS) response as an indicator for subsequent sacral nerve stimulation (SNS) trials. The results showed that a poor response to PTNS does not predict the response to SNS. Therefore, a negative PTNS trial should not preclude a trial of sacral nerve implantation.
NEUROUROLOGY AND URODYNAMICS
(2022)
Article
Neurosciences
J. R. Nadeau, B. M. Arnold, J. M. Johnston, G. D. Muir, V. M. K. Verge
Summary: Brief electrical stimulation (ES) or acute intermittent hypoxia (AIH) treatment during surgical repair can enhance the regeneration of injured peripheral nerves by influencing the expression of regeneration-associated genes (RAG). These treatments lead to significant improvements in growth indicators and functional recovery, showing promising potential for non-invasive therapies in nerve regeneration.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemical Research Methods
Qianru He, Fanhui Yu, Meng Cong, Yuhua Ji, Qi Zhang, Fei Ding
Summary: Peripheral nerve repair and functional recovery depend on the rate of nerve regeneration and the quality of target reinnervation. A quantitative proteomic technique was used to analyze the protein expression pattern between injured motor and sensory nerves, revealing 176 proteins with differential expressions. Functional categorization indicated that these differentially expressed proteins are linked to various molecular functions, which might play a crucial role in peripheral nerve regeneration.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Neurosciences
Basil C. Preisig, Alexis Hervais-Adelman
Summary: There is individual variability in the effectiveness of non-invasive brain stimulation. This study found evidence for a dose-response relationship between individual differences in electric fields and tACS-induced activity and connectivity changes, particularly in the right hemisphere.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Fei Jin, Tong Li, Zhidong Wei, Ruiying Xiong, Lili Qian, Juan Ma, Tao Yuan, Qi Wu, Chengteng Lai, Xiying Ma, Fuyi Wang, Ying Zhao, Fengyu Sun, Ting Wang, Zhang-Qi Feng
Summary: Researchers have developed a wearable neural invasive electrical stimulation (iES) system that can eliminate neural stimulus-inertia and achieve nerve regeneration and functional recovery. This system provides a promising avenue for personalized treatment of nerve injuries and neurodegenerative diseases.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Jessica Borges Kroth, Benjamim Handfas, Glaucia Rodrigues, Francisco Zepeda, Marco Aurelio Oliveira, Danny J. J. Wang, Raymundo Machado de Azevedo Neto, Gisele Sampaio Silva, Edson Amaro, Isaac Olubunmi Sorinola, Adriana Bastos Conforto
Summary: This study aims to compare the effects of RPSS on upper limb motor performance and learning in stroke patients at different stages, as well as investigate its impact on brain perfusion, functional imaging activation, and GABA levels. The results will inform future clinical trials on tailoring RPSS for patients who are more likely to benefit from this intervention.
FRONTIERS IN NEUROLOGY
(2022)
Review
Geriatrics & Gerontology
Melike Kahya, Dawn Hackman, Laura Jacobs, Daniel Nilsson, Yvonne Rumsey, Lars I. E. Oddsson
Summary: This narrative review provides an overview of wearable technologies/devices that use noninvasive peripheral neuromodulation to improve mobility and gait function in adults over the age of 65. The study identifies three main categories of technologies: sensory substitution, sensory augmentation (open loop, closed loop), and motor stimulation. The results indicate that these technologies can address various aspects of mobility, such as gait function, fall risk, foot drop, navigating environment, and postural control. Overall, wearable peripheral neuromodulation technologies show promise in improving mobility for older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Immunology
Yu He, Ding Xia, Yonghua Tong, Haojie Shang, Xiao Liu, Ejun Peng, Qiu Huang, Kun Tang, Zhiqiang Chen
Summary: This study evaluated the risk factors for postoperative systemic inflammatory response syndrome (SIRS) after percutaneous nephrolithotomy (PCNL), including cytokines and lymphocyte subsets. The results showed that long operation time, positive urine culture, high interleukin 2 receptor, high white blood cell counts, and low percentages of CD3(+) cells were independent risk factors for post-PCNL SIRS. It is important to carefully evaluate and provide appropriate treatment strategies for patients with these risk factors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Chia-En Wong, Chia-Ying Hu, Po-Hsuan Lee, Chi-Chen Huang, Han-Wei Huang, Chih-Yuan Huang, Hsin-Tien Lo, Wentai Liu, Jung-Shun Lee
Summary: This study investigated the therapeutic effect of sciatic nerve stimulation (SNS) on acute neuropathic pain (NP) and its underlying mechanism. The results showed that both 2 Hz and 20 Hz SNS could alleviate pain behavior and hyperactivation of pain conducting pathways, reduce neuroinflammation and inflammatory protein expression, suppress astrocytic gliosis and microglia activation, and enhance the activity of the descending pain modulation pathway.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Medicine, General & Internal
Ding-Yuan Yang, Liu-Ni Zhao, Ming-Xing Qiu
Summary: Transcutaneous tibial nerve stimulation (TTNS) and percutaneous tibial nerve stimulation (PTNS) showed similar efficacy in treating overactive bladder, with no significant differences in voiding frequency, urgency episodes, incontinence episodes, nocturia frequency, HRQL scores, and incontinence quality of life scores between the two groups. The total complication rate was low, and no adverse events were reported in the TTNS group.
Article
Engineering, Biomedical
Yanjuan Geng, Liuni Qin, Yongcheng Li, Zhebin Yu, Linling Li, Mojisola Grace Asogbon, Yang Zhan, Nan Yan, Xin Guo, Guanglin Li
Summary: This study demonstrates the feasibility of identifying multi-site and multi-intensity tactile stimulation using electroencephalography (EEG) and shows that high-level PNI patients and non-PNI subjects can be accurately classified based on these stimuli.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Anesthesiology
Kai-kai Guo, Long Wang, Fang Liu, Jie-jie Niu, Chao Wang, Shao-hua You, Ze-guo Feng, Gui-jun Lu
Summary: SNS can effectively alleviate pain severity, improve quality of life, and prolong sleep duration in patients with refractory PN.