Article
Biochemistry & Molecular Biology
Florian Alonso, Ling Li, Isabelle Fremaux, Dieter Peter Reinhardt, Elisabeth Genot
Summary: The study indicates that mutations in the fibrillin-1 gene disrupt arteriolar integrity and losartan can prevent or partially rescue these defects in Marfan syndrome.
Article
Cell Biology
Ilenia Agliarulo, Seetharaman Parashuraman
Summary: This article discusses the central role of the Golgi apparatus in the mammalian secretory pathway and its regulation of plasma membrane biosynthesis through three distinct processes. It also explores the importance of the molecules involved in these processes in physiology and development, as well as how mutations in these molecules can lead to genetic diseases and cancer.
Article
Cell Biology
Kai Liu, Lingjia Kong, Daniel B. Graham, Kimberly L. Carey, Ramnik J. Xavier
Summary: Phosphoinositides play a crucial role in regulating host innate defense response to intracellular bacterial replication. SAC1, a phosphoinositide phosphatase, is identified as an essential regulator of xenophagy. Loss of SAC1 leads to increased bacterial replication by impairing fusion between autophagosomes and lysosomes.
Review
Biology
Dustin A. Ammendolia, William M. Bement, John H. Brumell
Summary: Plasma membrane integrity is crucial for cellular homeostasis, and cells have repair pathways to restore membrane integrity when damaged. Tissue-specific stressors and membrane repair pathways play important roles in health and disease. Genetic and environmental factors impact plasma membrane integrity and contribute to disease pathogenesis in various tissues.
Article
Physiology
Michael Thompson, Masahide Sakabe, Mark Verba, Jiukuan Hao, Stryder M. Meadows, Q. Richard Lu, Mei Xin
Summary: Proper vascular formation is regulated by multiple signaling pathways. The expression of PRDM16 in arterial endothelial cells (ECs) but not venous ECs plays a crucial role in maintaining arterial characteristics. Deletion of Prdm16 in ECs leads to abnormal venous marker expression in the artery and reduced recruitment of vascular smooth muscle cells. The ectopic expression of ANGIOPOIETIN2 in Prdm16 knockout ECs further suggests the role of PRDM16 in suppressing venous characteristics.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Chemistry, Physical
R. T. Coones, R. J. Green, R. A. Frazier
Summary: The study explored the variability in lipid composition of epithelial membranes in the human gastrointestinal tract, highlighting that phosphatidylcholine dominates, while phosphatidylethanolamines and cholesterol have similar abundances. The research provides insights into the roles of lipid headgroups in various membrane types and the differences between major bilayer-forming lipids and peripheral lipids.
Article
Microbiology
Marta Lourenco, Lorenzo Chaffringeon, Quentin Lamy-Besnier, Marie Titecat, Thierry Pedron, Odile Sismeiro, Rachel Legendre, Hugo Varet, Jean-Yves Coppee, Marion Berard, Luisa De Sordi, Laurent Debarbieux
Summary: This study found that the regulation of bacterial gene expression in the digestive tract affects the interactions between bacteria and phages, influencing their coexistence in the intestines.
CELL HOST & MICROBE
(2022)
Article
Biochemistry & Molecular Biology
Andrea E. Toth, Hans C. Helms, Andras Harazin, Kasper B. Johnsen, Charlotte Goldeman, Annette Burkhart, Maj S. Thomsen, Paul J. Kempen, Adrian Klepe, Dora V. Lipka, Peter L. Moller, Thomas L. Andresen, Mette Nyegaard, Torben Moos, Birger Brodin, Morten S. Nielsen
Summary: Sortilin acts as a crucial regulatory protein for maintaining the tightness of the blood-brain barrier (BBB). Lack of sortilin results in BBB leakage, potentially due to alterations in signalling pathways, leading to compromised connections between brain endothelial cells.
Article
Chemistry, Multidisciplinary
Saeed Nazemidashtarjandi, Vishva M. Sharma, Vishwajeet Puri, Amir M. Farnoud, Monica M. Burdick
Summary: Understanding the role of membrane lipid chemistry in regulating the uptake of engineered nanomaterials (ENMs) by cells is essential in biomedical and occupational health research. Altering the lipid composition of the plasma membrane outer leaflet affects ENM endocytosis and the intracellular fate of ENMs by influencing nonspecific ENM diffusion into the cell, changing membrane fluidity, and altering the activity of scavenger receptors (SRs).
Article
Biochemical Research Methods
Babak Beikzadeh
Summary: This study developed a multi-epitope vaccine against the prevalent serovars of NTS by targeting OmpA, OmpD, and enterotoxin (Stn) using an immunoinformatics approach. The vaccine was able to stimulate T and B cell immune responses and produced in the prokaryotic system. In-silico validation was conducted before in vitro and in vivo studies.
BMC BIOINFORMATICS
(2023)
Article
Multidisciplinary Sciences
Emiliano Maiani, Giacomo Milletti, Francesca Nazio, Sos Gronbaek Holdgaard, Jirina Bartkova, Salvatore Rizza, Valentina Cianfanelli, Mar Lorente, Daniele Simoneschi, Miriam Di Marco, Pasquale D'Acunzo, Luca Di Leo, Rikke Rasmussen, Costanza Montagna, Marilena Raciti, Cristiano De Stefanis, Estibaliz Gabicagogeascoa, Gergely Rona, Nelida Salvador, Emanuela Pupo, Joanna Maria Merchut-Maya, Colin J. Daniel, Marianna Carinci, Valeriana Cesarini, Alfie O'sullivan, Yeon-Tae Jeong, Matteo Bordi, Francesco Russo, Silvia Campello, Angela Gallo, Giuseppe Filomeni, Letizia Lanzetti, Rosalie C. Sears, Petra Hamerlik, Armando Bartolazzi, Robert E. Hynds, David R. Pearce, Charles Swanton, Michele Pagano, Guillermo Velasco, Elena Papaleo, Daniela De Zio, Apolinar Maya-Mendoza, Franco Locatelli, Jiri Bartek, Francesco Cecconi
Summary: AMBRA1 has been identified as a key regulator in cell cycle control, playing a crucial role in maintaining genomic integrity by regulating the abundance of D-type cyclins and facilitating the transition from G1 to S phase, thereby preventing replication stress. The findings suggest that CHK1 kinase could be a potential therapeutic target in AMBRA1-deficient tumors, highlighting the importance of the AMBRA1-cyclin D pathway in regulating cell cycle and genomic stability in embryonic development and tumorigenesis.
Article
Plant Sciences
Malgorzata Lichocka, Magdalena Krzymowska, Magdalena Gorecka, Jacek Hennig
Summary: Studies investigated the role of plant annexin 5 (ANN5) in maintaining membrane integrity in pollen grains, showing that ANN5 is involved in repairing cell membrane damage, especially under osmotic or ionic imbalances.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Immunology
John Santelices, Mark Ou, Gustavo H. B. Maegawa, Kamil Hercik, Mariola. J. J. Edelmann
Summary: This study identified several deubiquitinases that are regulated in human macrophages during bacterial infection. One of the deubiquitinases, USP8, was found to be downregulated during Salmonella infection and played a role in regulating autophagy, ultimately limiting the survival of intracellular bacteria.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Cell Biology
Cameron Howard Lee, Sue Biggins
Summary: During mitosis, proper regulation of gene expression programs is crucial for accurate cellular division. Disruption of microtubules can lead to coordinated translational and transcriptional repression of certain genes involved in cell wall biology processes. This study uncovers a previously unknown link between microtubule function and the regulation of mitotic gene expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Alex J. Vecchio, Sewwandi S. Rathnayake, Robert M. Stroud
Summary: The study reveals the molecular and structural basis of how CpE targets susceptible claudins, as well as differences in the primary CpE receptors in mice and humans due to sequence changes in the target motif.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)