Article
Immunology
Laura Barbieri, Pedro Velica, Paulo A. Gameiro, Pedro P. Cunha, Iosifina P. Foskolou, Eric Rullman, David Bargiela, Randall S. Johnson, Helene Rundqvist
Summary: CD8+ T cells can tolerate lactate anion at neutral pH and use it as an alternative energy source to glucose. The presence of lactate alters the transcriptome of CD8+ T cells and affects their differentiation and activity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Nisreen Faizo, Chandrakala Aluganti Narasimhulu, Anna Forsman, Shibu Yooseph, Sampath Parthasarathy
Summary: The study utilized RNA sequencing to investigate the impact of exposure to peroxidized linoleic acid on cellular processes, uncovering alterations in lipid metabolic pathways, detoxification mechanisms, and suppression of oxidative phosphorylation. These findings provide insights into the effects of 13-HPODE on cellular processes and propose potential therapeutic strategies for LOOH-related pathologies.
Article
Biochemistry & Molecular Biology
Martin Beaumont, Corinne Lencina, Katia Feve, Celine Barilly, Laurence Le-Normand, Sylvie Combes, Guillaume Devailly, Gaelle Boudry
Summary: The disruption of the primocolonizing gut microbiota alters epithelial innate immunity in the colon and imprints stem cells, which could have long-term consequences for gut health. Colistin, an antibiotic, was used in a newborn piglet model to deplete specific gram-negative bacteria in the neonatal gut microbiota. The depletion of these bacteria resulted in altered gene expression in the colon epithelium, decreased toll-like receptor 4 (TLR4) and lysozyme (LYZ) levels, and an increased concentration of succinate in the colon.
Article
Engineering, Environmental
Yankai Xia, Xu Wang, Mingzhi Zhang, Xu Yang, Yuqing Zhang, Tianyu Dong, Francis Manyori Bigambo, Danrong Chen, Heidi Aase
Summary: This study investigated the relationship between maternal exposure to PM2.5 and fetal immune system development. The results showed both negative and positive associations between maternal PM2.5 exposure and neonatal cytokines. The findings suggest that gestational exposure to PM2.5 could alter neonatal cytokine levels and highlight the importance of certain components.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Article
Reproductive Biology
Sriti Pandey, H. Lakshmi Devi, Irfan Ahmad Bhat, B. Indu, Mukesh Kumar Bharti, Uffaq Shabir, Bilal Ahmad Peer, Vikash Chandra, G. Taru Sharma
Summary: In this study, it was found that P4 supplementation is important for the modulation of adhesion molecules, and co-culturing blastocysts with UECs together affects the expression of adhesion molecules in both blastocysts and UECs.
Article
Biochemistry & Molecular Biology
Elizabeth Padilla-Banks, Wendy N. Jefferson, Brian N. Papas, Alisa A. Suen, Xin Xu, Diana V. Carreon, Cynthia J. Willson, Erin M. Quist, Carmen J. Williams
Summary: Research reveals that exposure to non-mutagenic environmental factors during development can contribute to an increased risk of cancer, but the mechanisms are not well understood. Using a mouse model and transcriptomics analysis, this study demonstrates how the endocrine-disrupting chemical diethylstilbestrol (DES) alters endometrial cell differentiation and leads to changes in stem and progenitor cell characteristics, eventually resulting in cancer development.
Article
Cardiac & Cardiovascular Systems
Pengsheng Li, Fan Li, Ling Tang, Wenjing Zhang, Yan Jin, Haiwei Gu, Wuqiang Zhu
Summary: The study revealed distinct differences in the metabolic profiles of pig hearts at different postnatal stages. P1 hearts showed active anabolism of nucleotide and proteins, while P28 hearts demonstrated active posttranslational protein modification, metabolic switch from glucose to fatty acids, and reduced collagen to total protein ratio.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Qiwei Yang, Mohamed Ali, Lindsey S. Trevino, Aymara Mas, Nahed Ismail, Ayman Al-Hendy
Summary: The developmental exposure to the endocrine-disrupting chemical, diethylstilbestrol (DES), activates inflammatory pathways in myometrial stem cells (MMSCs), which are the origin of uterine fibroids (UFs), leading to a hyper-inflammatory phenotype and an increased risk of hormone-dependent diseases. The epigenetic mechanisms involving mixed-lineage leukemia protein-1 (MLL1) and histone deacetylases (HDACs) play a key role in the reprogramming of MMSCs and the aberrant expression of inflammatory responsive genes (IRGs) induced by DES exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yitang Yan, Min Shi, Rick Fannin, Linda Yu, Jingli Liu, Lysandra Castro, Darlene Dixon
Summary: This study found that prolonged exposure to cadmium alters the morphological and mechanodynamic features of uterine fibroid cells, leading to changes in cell migration behavior, increased heterogeneity in nuclear size, increased speed and variation in motility, and altered migration patterns. Cadmium exposure also alters gene expression, enhancing cell movement and invasion.
Article
Microbiology
Rafal Sawicki, Jaroslaw Widelski, Piotr Okinczyc, Wieslaw Truszkiewicz, Joanna Glous, Elwira Sieniawska
Summary: Through metabolomic and transcriptomic analysis, it was found that the extract of Trigona sp. propolis from Nepal had an impact on bacterial cells. The lipid profile of the mycobacterial cell envelope remained unchanged, but fluctuations in the profile of amphipathic glycerophospholipids were observed. The influence of propolis could last for a long time, and early bacterial response showed increased energy demand and upregulation of molecules involved in cell membrane formation. Transcriptomic analysis confirmed that bacteria experienced oxidative stress after propolis treatment.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Food Science & Technology
Yi Kai, Yi Liu, Hongliang Li, Hongshun Yang
Summary: The development of high-quality nutritional noodles has become a new research hotspot in food science. This study explored the effects of extruded wakame flours on the texture and visco-elasticity of noodles through metabolite release, texture quality, and rheological properties. The addition of wakame was found to enhance the physiochemical properties of noodles and potentially reduce diet-related diabetes.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Miji Kim, Junho Park, Hojun Lee, Whasun Lim, Gwonhwa Song
Summary: As the use of herbicides in agriculture has increased worldwide, there is a need to identify the unexpected toxic effects of these chemicals on non-target organisms. This study focuses on the herbicide bensulide, which is widely used in agriculture and poses a high risk to non-target organisms. The study reveals that bensulide can disrupt the mechanisms of implantation in porcine trophectoderm and uterine luminal epithelial cells, leading to cell division cycle arrest and implantation failure. These findings suggest that bensulide may interrupt early pregnancy by disrupting maternal-fetal interaction.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Reproductive Biology
Guangzhu Dong, Rundong Sun, Rui Zhang, Yufeng Qin, Chuncheng Lu, Xinru Wang, Yankai Xia, Guizhen Du
Summary: Preimplantation triclosan exposure affects the receptivity of the endometrium by upregulating the expression of tight junction genes, thus reducing the rate of embryo implantation.
BIOLOGY OF REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Xun Chen, Sufang Kuang, Yi He, Hongyu Li, Chen Yi, Yiming Li, Chao Wang, Guanhui Chen, Shangwu Chen, Dongsheng Yu
Summary: Metabolic reprogramming in tumors plays a crucial role in tumor development, progression, and drug resistance. Early metabolic intervention may prevent the development of drug resistance. Comparative metabolomics analysis can identify metabolic targets and biomarkers for tumor therapy by examining differential metabolic responses between tumor cells and normal cells.
Article
Biochemistry & Molecular Biology
Ahmad Abd-El-Aziz, Angela Riveroll, Blanca Esparza-Gonsalez, Laurie McDuffee, Alejandro M. Cohen, Adam L. Fenech, William J. Montelpare
Summary: This research investigated the impact of heat stress on cell differentiation in an equine mesenchymal stem cell model. The results showed that heat stress led to specific responses in different cell types and temperatures, with differentially expressed proteins involved in cell-signaling pathways. Moreover, cytoskeletal proteins exhibited altered levels and the cells did not organize properly, suggesting long-term impacts on cellular development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)