Odanacatib, A Cathepsin K-Specific Inhibitor, Inhibits Inflammation and Bone Loss Caused by Periodontal Diseases

TLR2 Promoter Hypermethylation Creates Innate Immune Dysbiosis

(2014) M. Benakanakere et al.   JOURNAL OF DENTAL RESEARCH

T Cell Response Mediated by Myeloid Cell-Derived IL-12 Is Responsible for Porphyromonas gingivalis -Induced Periodontitis in IL-10-Deficient Mice

(2014) Hajime Sasaki et al.   JOURNAL OF IMMUNOLOGY

Expression of cathepsin K in periodontitis and in gingival fibroblasts

(2014) A Beklen et al.   ORAL DISEASES

Cbf  deletion in mice recapitulates cleidocranial dysplasia and reveals multiple functions of Cbf  required for skeletal development

(2014) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Periodontitis-activated monocytes/macrophages cause aortic inflammation

(2014) Shin-ichi Miyajima et al.   Scientific Reports

Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone Destruction

(2014) Sen Yang et al.   Bone Research

Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants

(2013) Lee S. Jacobson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Invariant NK T Cells in Periodontitis Lesions

(2013) M. Nowak et al.   JOURNAL OF IMMUNOLOGY

RNAi-Mediated Silencing of Atp6i and Atp6i Haploinsufficiency Prevents Both Bone Loss and Inflammation in a Mouse Model of Periodontal Disease

(2013) Hongbing Jiang et al.   PLoS One

C/EBP  regulates osteoclast lineage commitment

(2013) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Interference-Mediated Silencing ofAtp6iPrevents Both Periapical Bone Erosion and Inflammation in the Mouse Model of Endodontic Disease

(2012) Junqing Ma et al.   INFECTION AND IMMUNITY

Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery

(2012) Christian E Jacome-Galarza et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function

(2012) Julia F. Charles et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibiting Periapical Lesions through AAV-RNAi Silencing of Cathepsin K

(2012) B. Gao et al.   JOURNAL OF DENTAL RESEARCH

Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

(2012) A. Garcia-Cattaneo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey

(2011) Tara Cusick et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

(2011) Sarah E. Ewald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comparison of microRNA profiles of human periodontal diseased and healthy gingival tissues

(2011) Yu‐feng Xie et al.   International Journal of Oral Science

The role of bacterial biofilm in persistent infections and control strategies

(2011) Li Chen et al.   International Journal of Oral Science

Toll-like receptors and their dual role in periodontitis: a review

(2011) Mayank Hans et al.   Journal of Oral Science

Bisphosphonates Cause Osteonecrosis of the Jaw-Like Disease in Mice

(2010) Yanming Bi et al.   AMERICAN JOURNAL OF PATHOLOGY

Odanacatib in the treatment of postmenopausal women with low bone mineral density: Three-year continued therapy and resolution of effect

(2010) John A Eisman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

T-Helper Cell Type 17/Regulatory T-Cell Immunoregulatory Balance in Human Radicular Cysts and Periapical Granulomas

(2010) Juliana R.B. Marçal et al.   JOURNAL OF ENDODONTICS

Effect of the Cathepsin K Inhibitor Odanacatib on Bone Resorption Biomarkers in Healthy Postmenopausal Women: Two Double-Blind, Randomized, Placebo-Controlled Phase I Studies

(2009) S A Stoch et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Progression of chronic periodontitis can be predicted by the levels ofPorphyromonas gingivalisandTreponema denticolain subgingival plaque

(2009) S. J. Byrne et al.   Oral microbiology and immunology

Taking a Toll on the bones: Regulation of bone metabolism by innate immune regulators

(2008) Zvi Bar-Shavit   AUTOIMMUNITY

Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts

(2008) Shengmei Feng et al.   BIOCHEMICAL JOURNAL

The Toll of Cathepsin K Deficiency

(2008) A. M. Krieg et al.   SCIENCE

Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis

(2008) M. Asagiri et al.   SCIENCE

Immunohistochemical localization of Toll-like receptors 1-10 in periodontitis

(2008) A. Beklen et al.   Oral microbiology and immunology