Review
Immunology
Yilin Li, Rui Guo, Patrick Kwabena Oduro, Tongke Sun, Hao Chen, Yating Yi, Weiqian Zeng, Qilong Wang, Ling Leng, Long Yang, Jun Zhang
Summary: This study conducted a meta-analysis to investigate the relationship between Porphyromonas gingivalis (P. gingivalis) exposure and the prevalence of rheumatoid arthritis (RA). The results showed a significant association between P. gingivalis exposure and an increased risk of developing RA, especially in European and North American populations.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Tan Wan Jiun, Haslina Taib, Wan Majdiah Wan Mohamad, Suharni Mohamad, Wan Syamimee Wan Ghazali
Summary: This study found no significant association between the bacterial load of Porphyromonas gingivalis (P. gingivalis), a primary periodontal pathogen, and the levels of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with rheumatoid arthritis (RA) and periodontitis. Despite the prevalence of periodontitis among RA patients, the bacterial load does not have an impact on the production of anti-CCP antibodies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jacqueline Rodriguez, Gloria Ines Lafaurie, Wilson Bautista-Molano, Lorena Chila-Moreno, Juan Manuel Bello-Gualtero, Consuelo Romero-Sanchez
Summary: The study demonstrated an association between overweight or obesity and the diagnosis of eRA, with individuals with eRA exhibiting higher levels of leptin and vaspin. The presence of periodontitis and related markers only affected leptin levels in individuals with eRA.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Immunology
Parisa Ahmadi, Mahmoud Mahmoudi, Ramiar Kamal Kheder, Tola Abdulsattar Faraj, Samaneh Mollazadeh, Hadi Sajid Abdulabbas, Seyed-Alireza Esmaeili
Summary: In patients with rheumatoid arthritis (RA), certain citrullinated proteins can be targeted by ACCPAs in the synovial sites. Extra-articular sites may be the origin of primary auto-immunization against these proteins. There is a significant association between P. gingivalis periodontitis, anti-P. gingivalis antibodies, and RA. P. gingivalis can degrade proteins such as fibrin and alpha-enolase into citrullinated peptides, and induce inflammation and immune cell attraction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Anna Svard, Alf Kastbom, Karin Roos Ljungberg, Barbara Potempa, Jan Potempa, G. Rutger Persson, Stefan Renvert, Johan Sanmartin Berglund, Maria K. Soderlin
Summary: A Swedish study found that patients with rheumatoid arthritis (RA) had higher levels of saliva antibodies to Porphyromonas gingivalis (P. gingivalis) and these antibodies were associated with RA disease activity, but not with periodontitis or serum antibodies to citrullinated proteins (ACPA).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Gabriel D. Roman-Melendez, Daniel R. Monaco, Janelle M. Montagne, Rachel S. Quizon, Maximilian F. Konig, Mekbib Astatke, Erika Darrah, H. Benjamin Larman
Summary: The study successfully utilized phage display technology to profile antibody reactivities in rheumatoid arthritis patients and quantify differences among patients, identifying specific antibody profiles. This provides a powerful tool for research on autoimmune diseases.
Article
Immunology
Aleksandra Wielento, Grzegorz P. Bereta, Katarzyna B. Lagosz-Cwik, Sigrun Eick, Richard J. Lamont, Aleksander M. Grabiec, Jan Potempa
Summary: PPAD and fimbriae from P. gingivalis are important for TLR2-dependent host cell responses, contributing to the generation of inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Joyce A. Lee, Ted R. Mikuls, Kevin D. Deane, Harlan R. Sayles, Geoffrey M. Thiele, Jess D. Edison, Brandie D. Wagner, Marie L. Feser, Laura K. Moss, Lindsay B. Kelmenson, William H. Robinson, Jeffrey B. Payne
Summary: The objective of this study was to quantify the association between anti-P. gingivalis serum antibody concentrations and the risk of developing rheumatoid arthritis (RA), and to quantify the associations among RA cases between anti-P. gingivalis serum antibody concentrations and RA-specific autoantibodies. The results showed no longitudinal elevations of anti-bacterial serum antibody concentrations in RA patients prior to RA diagnosis compared to controls, but anti-P. intermedia displayed significant associations with RA autoantibody concentrations prior to RA diagnosis.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Multidisciplinary Sciences
Gina R. Lewin, Kendall S. Stocke, Richard J. Lamont, Marvin Whiteley
Summary: This study characterizes the behavior and virulence of the periodontal pathogen Porphyromonas gingivalis during human infection. It reveals that P. gingivalis is highly expressed in diseased samples, with genes related to virulence factors and growth/matabolism being actively expressed. The study also shows that the gene expression of P. gingivalis during periodontitis is highly conserved with logarithmic laboratory growth, suggesting that simple test tube growth can be used as a model for studying P. gingivalis biology.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Dentistry, Oral Surgery & Medicine
Aleksandra Wielento, Grzegorz P. Bereta, Katarzyna Szczesniak, Anna Jacula, Marina Terekhova, Maxim N. Artyomov, Yoshiaki Hasegawa, Aleksander M. Grabiec, Jan Potempa
Summary: Porphyromonas gingivalis, an oral pathogen, promotes dysbiosis by suppressing the bactericidal activity of the host immune system and maintaining chronic inflammation. It activates Toll-like receptor 2 (TLR2) through the secretion of virulence factors such as P. gingivalis peptidyl arginine deiminase (PPAD) and major fimbriae (FimA). PPAD-modified fimbriae trigger the host cell response, and accessory fimbrial subunits are modified by PPAD and stimulate the response to P. gingivalis infection in a TLR2-dependent manner.
MOLECULAR ORAL MICROBIOLOGY
(2023)
Article
Cell Biology
Niu Zhou, Fagui Zou, Xiao Cheng, Yilian Huang, Hang Zou, Qingru Niu, Yi Qiu, Fen Shan, Aoxiang Luo, Wei Teng, Jianbo Sun
Summary: Periodontitis induced by P. gingivalis may exacerbate collagen-induced arthritis in mice and affect the differentiation of immune cells, leading to a decrease in B10 cells, which could be a key mechanism in promoting rheumatoid arthritis.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Chemistry, Analytical
Seonhwa Park, Kiryeon Park, Hee Sam Na, Jin Chung, Haesik Yang
Summary: An electrochemical biosensor for sensitive detection of Porphyromonas gingivalis in saliva was developed without the need for washing and separation steps. This biosensor can be used as an initial diagnosis method to distinguish between healthy people and patients with periodontal diseases.
ANALYTICAL CHEMISTRY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Jerian Gonzalez-Febles, Mariano Sanz
Summary: Rheumatoid arthritis and periodontitis are chronic inflammatory diseases characterized by the destruction of cartilage and periodontal tissues, with emerging evidence suggesting a possible link between specific bacterial periodontal pathogens and the development of autoantibodies in rheumatoid arthritis patients. Research is ongoing to explore the epidemiologic association and biological mechanisms between these two diseases, as well as the potential impact of periodontal treatment on the initiation and progression of rheumatoid arthritis.
PERIODONTOLOGY 2000
(2021)
Article
Biotechnology & Applied Microbiology
Rui Li, Mengjie Hou, Liying Yu, Wen Luo, Jie Kong, Renmei Yu, Ruihan Liu, Qian Li, Lisi Tan, Chunling Pan, Hongyan Wang
Summary: This study aimed to investigate the effects of salivary histatin 5 (Hst5) on Porphyromonas gingivalis (P. gingivalis) biofilms in vitro and in vivo and the possible mechanisms. The results showed that 25μg/mL Hst5 effectively inhibited biofilm formation and increased concentrations of Hst5 increased the inhibitive effect. Hst5 could regulate membrane function and metabolic processes in P. gingivalis, and RpoD and FeoB proteins might play important roles in this process. Moreover, 100μg/mL Hst5 inhibited periodontal inflammation and alveolar bone loss in rat periodontitis through its antibacterial and anti-inflammatory effects.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Immunology
Banndith Cheat, Coralie Torrens, Asmaa Foda, Brigitte Baroukh, Jeremy Sadoine, Lotfi Slimani, Veronique Witko-Sarsat, Olivier Huck, Marjolaine Gosset, Jerome Bouchet
Summary: Our study investigates the role of NLRP3 in periodontitis, demonstrating its ambiguous role in neutrophils and its interaction with Porphyromonas gingivalis. The study reveals that NLRP3 is involved in regulatory pathways that limit periodontitis in mouse models, but its protective effect is diminished in the presence of P. gingivalis. Overexpression of NLRP3 in connective tissue leads to increased production of mature IL-1 beta and mobilization of neutrophils, while NLRP3 deficiency results in lower IL-1 beta expression and almost no neutrophil mobilization.
FRONTIERS IN IMMUNOLOGY
(2022)