Article
Cell Biology
Jiahui Zhou, Wene Wei, Hu Hou, Shufang Ning, Jilin Li, Baoyue Huang, Kaisheng Liu, Litu Zhang
Summary: The study found that CRP, GPS, and CAR have independent prognostic values in patients with CRC. Survival nomograms based on these markers can provide more valuable clinical significance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Tomoki Nakamura, Kunihiro Asanuma, Tomohito Hagi, Akihiro Sudo
Summary: High-sensitivity modified Glasgow prognostic score (HS-mGPS) and mGPS were compared in predicting oncological outcomes in patients with soft tissue sarcomas (STSs) who underwent primary surgical tumour resection. The study found that patients with HS-mGPS and mGPS scores of 1 or 2 had a poorer survival rate, and tumor size and mGPS score were significant prognostic factors.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Oncology
Nora-Medea Messerich, Narasimha Rao Uda, Thomas Volken, Sergio Cogliatti, Thomas Lehmann, Andreas Holbro, Rudolf Benz, Lukas Graf, Vikas Gupta, Wolfram Jochum, Izadora Demmer, Tata Nageswara Rao, Tobias Silzle
Summary: In myelofibrosis, the C-reactive protein (CRP)/albumin ratio (CAR) and the Glasgow Prognostic Score (GPS) add independent prognostic information. Assessing CRP and albumin helps to identify a vulnerable population of MF patients, which eludes current prognostic models, even if the presence of high-risk mutations is considered. Further evaluation of albumin and CRP as prognostic markers in MF is warranted.
Article
Oncology
Kelechi Njoku, Neal C. Ramchander, Y. Louise Wan, Chloe E. Barr, Emma J. Crosbie
Summary: This study found that pretreatment systemic inflammation markers, such as CRP levels, are associated with survival outcomes in endometrial cancer patients. CRP may serve as a simple, low-cost predictive biomarker to guide personalized care in endometrial cancer. Further studies are needed to confirm the utility of CRP in other populations as most participants in this study were of White British ethnicity.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Medicine, General & Internal
Guangzhen Qu, Dong Wang, Weiyu Xu, Kai Wu, Wei Guo
Summary: This study retrospectively analyzed the clinical data of patients undergoing pancreaticoduodenectomy in Beijing Friendship Hospital, showing that preoperative mGPS and postoperative CRP were associated with postoperative complications. Interestingly, CAR on POD3 performed the best in predicting complications.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Oncology
Keiko Tanimura, Takayuki Takeda, Akihiro Yoshimura, Ryoichi Honda, Shiho Goda, Shinsuke Shiotsu, Mototaka Fukui, Yusuke Chihara, Kiyoaki Uryu, Shota Takei, Yuki Katayama, Makoto Hibino, Tadaaki Yamada, Koichi Takayama
Summary: A prognostic risk classification combining pre-chemoradiotherapy (CRT) modified Glasgow Prognostic Score (mGPS) and post-CRT C-reactive protein (CRP) level helps predict progression-free survival (PFS) and overall survival (OS) of durvalumab consolidation after CRT in locally advanced non-small cell lung cancer (NSCLC) patients.
Article
Oncology
Kensuke Kudou, Yuichiro Nakashima, Yasuhiro Haruta, Sho Nambara, Yasuo Tsuda, Eiji Kusumoto, Koji Ando, Yasue Kimura, Kenkichi Hashimoto, Keiji Yoshinaga, Hiroshi Saeki, Eiji Oki, Yoshihisa Sakaguchi, Tetsuya Kusumoto, Koji Ikejiri, Mototsugu Shimokawa, Masaki Mori
Summary: This study found that inflammation-based prognostic scores, specifically PI and PNI, were more strongly associated with poor prognosis in patients who underwent surgery for adenocarcinoma of the esophagogastric junction and upper gastric cancer.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Maciej W. Socha, Bartosz Malinowski, Oskar Puk, Mateusz Wartega, Piotr Bernard, Monika Nowaczyk, Bartlomiej Wolski, Michal Wicinski
Summary: C-reactive protein shows potential as a diagnostic and prognostic factor for endometrial cancer, with correlations to EC incidence and the ability to distinguish between different diseases. Perioperational CRP and its changes can independently predict the prognosis of EC. Additionally, CRP-to-albumin ratio and Glasgow Prognostic Score have greater prognostic value for EC than CRP alone.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Immunology
Xin-Ying Li, Shuang Yao, Yang-Ting He, Song-Qing Ke, Yi-Fei Ma, Ping Lu, Shao-Fa Nie, Shao-Zhong Wei, Xin-Jun Liang, Li Liu
Summary: This study demonstrates that high Inflammation-Immunity-Nutrition score is associated with poorer survival outcomes in patients with resectable colorectal cancer, particularly in those with wild type KRAS. Compared to traditional prognostic indicators, Inflammation-Immunity-Nutrition score showed better predictive performance for overall survival.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Surgery
Mushegh A. Sahakyan, Kristoffer Watten Brudvik, Jon-Helge Angelsen, Rachel G. Dille-Amdam, Oddvar M. Sandvik, Bjorn Edwin, Linn S. Nymo, Kristoffer Lassen
Summary: This study aimed to investigate the association between selected preoperative inflammatory markers and outcomes of liver resection for colorectal liver metastases (CRLM). It was found that Glasgow prognostic score (GPS), modified Glasgow prognostic score (mGPS), and C-reactive protein to albumin ratio (CAR) had no impact on postoperative complications, but CAR was a better predictor of overall survival, especially after open liver resections.
WORLD JOURNAL OF SURGERY
(2023)
Article
Surgery
Petter Fruhling, Jozef Urdzik, Cecilia Stromberg, Bengt Isaksson
Summary: A clinically relevant preoperative prognostic model for colorectal liver metastases patients was constructed and validated, with prognostic factors and Composite Score effectively categorizing patients into low, medium, and high-risk groups.
Article
Oncology
Kenta Kasahara, Masanobu Enomoto, Ryutaro Udo, Tomoya Tago, Junichi Mazaki, Tetsuo Ishizaki, Tesshi Yamada, Yuichi Nagakawa, Kenji Katsumata, Akihiko Tsuchida
Summary: This study investigated the prognostic value of preoperative high-sensitivity mGPS (HS-GPS) in patients with colon cancer. It found that HS-GPS is useful for predicting the prognosis of resectable advanced colon cancer. However, GPS may be more effective than HS-GPS as a prognostic model for advanced colon cancer.
Article
Oncology
Kohei Yasui, Dai Shida, Yuya Nakamura, Yuka Ahiko, Shunsuke Tsukamoto, Yukihide Kanemitsu
Summary: This study suggests that postoperative changes in inflammation-based prognostic markers are more accurate in predicting overall survival and recurrence-free survival in patients with stage III CRC. The study found that patients with a normalised inflammatory state had better prognosis compared to those with persistently elevated inflammatory state.
BRITISH JOURNAL OF CANCER
(2021)
Article
Immunology
Blanca Molins, Marc Figueras-Roca, Oliver Valero, Victor Llorenc, Sara Romero-Vazquez, Oriol Sibila, Alfredo Adan, Carolina Garcia-Vidal, Alex Soriano
Summary: In COVID-19 patients, monomeric CRP levels are associated with disease severity, and levels higher than 4000 ng/mL independently predict disease severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medical Laboratory Technology
Marta Kramer Mikkelsen, Nana Aviaja Frederikke Lindblom, Anne Dyhl-Polk, Carsten Bogh Juhl, Julia Sidenius Johansen, Dorte Nielsen
Summary: Inflammation is an important characteristic of cancer, and circulating inflammatory biomarkers, such as C-reactive protein (CRP), have been explored for their clinical value in prognosis, prediction, and monitoring of therapeutic response in breast cancer patients. However, the results regarding the use of serum CRP as a biomarker in breast cancer appear inconsistent, particularly in non-metastatic and general breast cancer populations. Meta-analyses suggest limited value in these settings, but consistent findings support an association between high serum CRP and poor prognosis in metastatic breast cancer patients. Further research is needed to assess the role of serum CRP in prediction and monitoring of treatment response.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2022)
