Article
Engineering, Biomedical
Ziv Azoulay, Polina Aibinder, Ayala Gancz, Jacob Moran-Gilad, Shiri Navon-Venezia, Hanna Rapaport
Summary: FKF, a tripeptide with potential antimicrobial activity, forms a pure peptide hydrogel phase made of natural amino acids. The hydrogel exhibits bactericidal activity against E. coli and P. aeruginosa, and reduces P. aeruginosa contamination in a rat skin lesion model.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Kirstie M. Rawson, Melissa M. Lacey, Peter N. Strong, Keith Miller
Summary: Antimicrobial peptides (AMPs) are potential alternatives to traditional antibiotics due to their rapid killing mechanism and low resistance potential. However, off-target toxicity limits their further development. This study aimed to improve the AMP Smp24 by performing single amino acid substitutions, enhancing its antimicrobial activity and reducing mammalian cytotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Sanhu Gou, Beibei Li, Xu Ouyang, Zufang Ba, Chao Zhong, Jingman Ni
Summary: The research involved modifying anoplin by dendrimerization on the C-terminal and lipidation on the N-terminal to improve antibacterial activity, but with an increase in hemolytic activity. Ultimately, a simple lipopeptide A-C8 with a high therapeutic index was obtained, showing potential as an antibiotic.
Article
Fisheries
Xiaowan Ma, Yuan Jin, Ying Qiao, Shengping Zhong, Yongze Xing, Xuyang Chen
Summary: Two antimicrobial peptides derived from histone 1 (LcH1-1 and LcH1-2) were described in this study, and they showed a broad antimicrobial spectrum. The results suggested that LcH1 may play a role in the immune response of L. crocea against Cryptocaryon irritans infection, and LcH1-derived antimicrobial peptides may be a potential strategy for controlling parasitic and bacterial diseases.
Article
Biochemistry & Molecular Biology
Min Ji Hong, Min Kyung Kim, Yoonkyung Park
Summary: The analog peptides derived from Hp1404 exhibit antimicrobial activity against multidrug-resistant Acinetobacter baumannii with lower cytotoxicity. They effectively permeate bacterial membranes and inhibit biofilm formation, showing potential as therapeutic agents for A. baumannii infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Jingjing Zhou, Ruitao Cha, Zhiyu Wu, Chunliang Zhang, Yuhang He, Hanru Zhang, Kexin Liu, Muhammad Subaan Fareed, Zhaopeng Wang, Changyan Yang, Yifan Zhang, Wenjin Yan, Kairong Wang
Summary: In this study, a peptide hydrogel formed by natural antimicrobial peptide Jelleine-1 was reported and its potential use for MRSA-infected wounds was investigated. The results showed that the Jelleine-1 hydrogel exhibited broad spectrum of antimicrobial activity, excellent biocompatibility, and great potential in promoting wound healing in a mouse model with MRSA-infected burn wound.
Review
Infectious Diseases
Gabriela Silva Cruz, Ariane Teixeira dos Santos, Erika Helena Salles de Brito, Gandhi Radis-Baptista
Summary: This review presents the antibacterial, antiparasitic, and antiviral effects of cell-penetrating antimicrobial peptides and highlights their potential for treating intracellular infections.
Article
Fisheries
Yanqi Zhang, Xun Xiao, Zhensheng Wang, Wentao Zhu, Zhiwei Liao, Xingchen Huo, Jianguo Su
Summary: This study found that truncated peptides from CiCXCL20a have strong antimicrobial and anti-inflammatory activities, killing bacteria and suppressing inflammation in vivo. These findings provide evidence for the close functional and evolutionary relationships between chemokines and antimicrobial peptides.
Article
Microbiology
Raja Aadil Hussain Bhat, Victoria C. Khangembam, Dimpal Thakuria, Vinita Pant, Ritesh Shantilal Tandel, Gayatri Tripathi, Debajit Sarma
Summary: In this study, a peptide called KK16 was designed with potent antibacterial and antifungal activity and low toxicity to host cells. The peptide showed strong efficacy against various pathogenic bacteria and remained stable under different environmental conditions.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Reiner Noschka, Fanny Wondany, Gonul Kizilsavas, Tanja Weil, Gilbert Weidinger, Paul Walther, Jens Michaelis, Steffen Stenger
Summary: Gran1, a synthetic fragment of Granulysin, demonstrates efficient antimicrobial activity against Mycobacterium tuberculosis and clinically relevant non-tuberculous mycobacteria. It interacts with the surface of Mtb, causing lethal distortions of the cell wall, while showing no off-target effects in primary human cells or zebrafish embryos. Gran1 is selectively internalized by macrophages, restricting the proliferation of the pathogen, and its hypothesis-driven design serves as a powerful approach for identifying small bioactive compounds with specific antimicrobial activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Miray Tonk, James J. Valdes, Alejandro Cabezas-Cruz, Andreas Vilcinskas
Summary: Arthropod antimicrobial peptides (AMPs) provide a potential source for new antibiotics with potent activity against multidrug-resistant bacterial pathogens. Synergistic effects can be achieved by combining AMPs from different sources. Hybrid peptides linked by glycine spacers show enhanced antibacterial activity, but can also exhibit increased cytotoxic activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Acoustics
Shen Yang, Zijin Yuan, Jude Juventus Aweya, Shiying Huang, Shanggui Deng, Linfan Shi, Mingjing Zheng, Yueling Zhang, Guangming Liu
Summary: This study found that the in silico predicted antimicrobial peptide TGH2 combined with low-intensity ultrasound significantly reduced the minimum inhibitory concentration of Escherichia coli and enhanced bactericidal effect, as shown by transmission electron microscopy and circular dichroism for structural analysis.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Infectious Diseases
Krzesimir Ciura, Natalia Ptaszynska, Hanna Kapica, Monika Pastewska, Anna Legowska, Krzysztof Rolka, Wojciech Kamysz, Wieslaw Sawicki, Katarzyna E. Greber
Summary: This study discusses the chromatographic experiments of three groups of related peptide substances to support the characterization of antimicrobial peptides. The results obtained through immobilized artificial membrane chromatography shed light on the mechanisms of action of these compounds. Despite efforts, commercial availability of peptide-based antimicrobials remains limited.
Article
Biochemistry & Molecular Biology
Hang Xu, Zihao Yuan, Li Sun
Summary: This study identified a non-canonical NK-lysin protein in Japanese flounder, which plays an important role in immune defense against bacterial infection. A peptide derived from this protein, P35, exhibits antimicrobial effects by targeting both bacteria and fish cells through multiple mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Byeong Jun Jeon, Nayeon Yoo, Jeong Do Kim, Jaeyoung Choi
Summary: This study identified highly conserved protein sequence profiles within the genus Streptomyces and discovered a highly conserved sequence with antimicrobial activity against bacterial and fungal plant pathogens. This sequence could be a potential antimicrobial agent for controlling plant diseases.
FRONTIERS IN PLANT SCIENCE
(2023)