Article
Oncology
Yusuke Horiuchi, Toshiaki Hirasawa, Naoki Ishizuka, Hiroyuki Hatamori, Yohei Ikenoyama, Junki Tokura, Mitsuaki Ishioka, Yoshitaka Tokai, Ken Namikawa, Shoichi Yoshimizu, Akiyoshi Ishiyama, Toshiyuki Yoshio, Tomohiro Tsuchida, Junko Fujisaki
Summary: The study demonstrated that the diagnostic performance of endocytoscopy with narrow-band imaging was superior to magnifying endoscopy with narrow-band imaging in diagnosing gastric cancer. These results may potentially impact the choice of diagnostic techniques for gastric cancer.
Review
Medicine, General & Internal
Hiroki Kurumi, Kouichi Nonaka, Yuichiro Ikebuchi, Akira Yoshida, Koichiro Kawaguchi, Kazuo Yashima, Hajime Isomoto
Summary: The development of image-enhanced endoscopy, particularly narrow band imaging (NBI), has greatly improved the qualitative and quantitative diagnosis of gastrointestinal tumors. Various diagnostic algorithms based on NBI, such as vessel plus surface (VS) classification and magnifying endoscopy simple diagnostic algorithm for early gastric cancer (MESDA-G), have been proposed to aid in the diagnosis of early gastric cancer. Additionally, the usefulness of NBI in differentiating gastric cancer from gastritis, determining lesion extent, inferring histopathological type, and diagnosing depth has been investigated.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Dehua Tang, Muhan Ni, Chang Zheng, Xiwei Ding, Nina Zhang, Tian Yang, Qiang Zhan, Yiwei Fu, Wenjia Liu, Duanming Zhuang, Ying Lv, Guifang Xu, Lei Wang, Xiaoping Zou
Summary: This study aimed to investigate whether an artificial intelligence (AI) system could diagnose early gastric cancer (EGC) under narrow band imaging endoscopy (NBI) and evaluate its diagnostic assistance to endoscopists. The results showed that the AI system outperformed the endoscopists in diagnosing EGC and significantly enhanced their diagnostic performance.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Medicine, General & Internal
Tsuyoshi Suda, Yukihiro Shirota, Yuji Hodo, Katsuaki Sato, Tokio Wakabayashi
Summary: This study used narrow-band imaging to examine the range of beige colored mucosa in patients with esophageal eosinophilic infiltration. The results showed that all cases of esophageal eosinophilic infiltration had beige colored mucosa. There were significant differences in RGB values between bright and dark beige colored mucosa, suggesting that assessing the tone of beige colored mucosa may be a novel diagnostic method for esophageal eosinophilic infiltration.
Article
Oncology
Kai-Yao Yang, Yu-Jen Fang, Riya Karmakar, Arvind Mukundan, Yu-Ming Tsao, Chien-Wei Huang, Hsiang-Chen Wang
Summary: Video capsule endoscopy (VCE) is a small, patient-friendly tool used for medical imaging, but lacks narrow band imaging (NBI) functionality. This study successfully developed a method to convert white light images (WLI) from VCE into NBI-like images, offering a promising solution for better cancer detection.
Article
Oncology
Tsung-Jung Tsai, Arvind Mukundan, Yu-Sheng Chi, Yu-Ming Tsao, Yao-Kuang Wang, Tsung-Hsien Chen, I-Chen Wu, Chien-Wei Huang, Hsiang-Chen Wang
Summary: This research successfully categorized and identified esophageal cancer using a novel approach that integrates hyperspectral imaging and a deep learning diagnostic model. The results showed that hyperspectral imaging has more spectral features and improves diagnostic accuracy.
Article
Gastroenterology & Hepatology
Takao Kanemitsu, Noriya Uedo, Takahiro Ono, Satoshi Nimura, Rino Hasegawa, Kentaro Imamura, Kensei Ohtsu, Yoichiro Ono, Masaki Miyaoka, Toshiharu Ueki, Hiroshi Tanabe, Atsuko Ohta, Akinori Iwashita, Kenshi Yao
Summary: This study found that the micromucosal pattern observed through M-NBI technology is not useful for the diagnosis of incomplete GIM. However, the white opaque substance (WOS) is a promising endoscopic indicator for the presence of incomplete GIM.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Lixin Gong, Min Wang, Lei Shu, Jie He, Bin Qin, Jiacheng Xu, Wei Su, Di Dong, Hao Hu, Jie Tian, Pinghong Zhou
Summary: This study developed an EGC captioning model (EGCCap) to assist in the diagnosis of early gastric cancer (EGC) by automatically describing visual features. In the experiments, EGCCap exhibited satisfactory performance, achieving high scores in various evaluation metrics, and demonstrated good generalization, robustness, and interpretability. The diagnostic ability of endoscopists improved with the assistance of EGCCap, especially for junior endoscopists. Overall, EGCCap showed potential value in improving and assisting in the diagnosis of EGC.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Shingo Ono, Akira Dobashi, Hiroto Furuhashi, Akio Koizumi, Hiroaki Matsui, Yuko Hara, Kazuki Sumiyama
Summary: This study found that lesions of SESCC that were undetectable using NBI were mostly macroscopic flat type, with numerous irregularly shaped LVLs present, and were more common if located at the anterior wall of the esophagus.
GASTROENTEROLOGY REPORT
(2021)
Article
Medicine, General & Internal
Yi-Wen Chen, Cheng-Yen Chuang, Shyh-Sheng Yang, Sen-Ei Shai, Ming-Ching Lee, Hao-Yun Chen, Chih-Hung Lin
Summary: This study reviewed the outcomes of narrow gastric conduit compared to wide gastric conduit reconstruction for esophageal cancer patients. The results showed that the narrow gastric conduit had lower anastomotic leakage rate and shorter hospital stay compared to the wide gastric conduit. The narrow gastric conduit can be considered as an alternative option for gastric conduit preparation.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Shunsuke Okumura, Misa Goudo, Satoru Hiwa, Takeshi Yasuda, Hiroaki Kitae, Yuriko Yasuda, Akira Tomie, Tatsushi Omatsu, Hiroshi Ichikawa, Nobuaki Yagi, Tomoyuki Hiroyasu
Summary: An accurate demarcation line between cancerous lesions and background mucosa is important in magnifying narrow-band imaging (M-NBI)-based diagnosis. This study aimed to automatically determine the accurate demarcation line using a machine learning method. The proposed system can support the training of inexperienced doctors and enrich the knowledge of experienced doctors in endoscopy.
Article
Gastroenterology & Hepatology
Takashi Kanesaka, Ryu Ishihara, Masayasu Ohmori, Kenshi Matsuno, Noriko Matsuura, Hiroko Nakahira, Satoki Shichijo, Akira Maekawa, Sachiko Yamamoto, Yoji Takeuchi, Koji Higashino, Noriya Uedo
Summary: The study investigated the use of an endoscopic diagnostic algorithm for gastric adenocarcinoma in esophageal or EGJ adenocarcinoma cases. The findings suggest that this algorithm may not be effective for esophageal or EGJ adenocarcinomas, particularly in Siewert type 1 adenocarcinoma where demarcation lines are difficult to visualize.
DIGESTIVE DISEASES
(2021)
Article
Oncology
Juanjuan Zhu, Rui Liu, Xiancheng Wu, Qin Li, Beilei Gong, Yuanbing Shen, Yurong Ou, Wei Li
Summary: This study aimed to investigate the value of narrow-band imaging (NBI) in diagnosing central lung cancer. The results showed that NBI had high accuracy in diagnosing central lung cancer and different histological types had different vascular patterns. Patient smoking status, NBI vascular patterns, and age partially influenced the histological types of lung cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Hisanori Utsunomiya, Yoichi Akazawa, Hiroya Ueyama, Tomoyo Iwano, Momoko Yamamoto, Ryota Uchida, Shotaro Oki, Nobuyuki Suzuki, Daiki Abe, Atsushi Ikeda, Tsutomu Takeda, Kumiko Ueda, Mariko Hojo, Yukinori Yube, Sanae Kaji, Soh Okano, Sho Tsuyama, Hidetaka Eguchi, Yasushi Okazaki, Masami Arai, Tetsu Fukunaga, Takashi Yao, Akihito Nagahara
Summary: Although gastric juvenile polyposis (GJP) often coexists with gastric cancer, preoperative accurate diagnosis is difficult. This study reports a case of a 70-year-old woman who was diagnosed with intramucosal adenocarcinoma in gastric juvenile polyposis through target biopsy using magnifying endoscopy with narrow-band imaging (M-NBI) and endoscopic resection.
Article
Medicine, General & Internal
Masashi Kawamura, Tomoyuki Koike, Yohei Ogata, Ryotaro Matsumoto, Kota Yano, Takashi Hiratsuka, Hideaki Ohyama, Isao Sato, Kimiko Kayada, Suguo Suzuki, Satsuki Hiratsuka, Yumiko Watanabe
Summary: Magnifying and nonmagnifying image-enhanced endoscopy (IEE) show comparable effectiveness in diagnosing gastric intestinal metaplasia (IM). Nonmagnifying IEE demonstrates similar performance as magnifying IEE in evaluating light-blue crest (LBC), white opaque substance (WOS), and endoscopic grading of gastric IM (EGGIM). The presence of high EGGIM score is correlated with gastric cancer (GC) in patients.
Letter
Surgery
Yuichiro Yokoyama, Rei Ishibashi, Mitsuhiro Fujishiro, Soichiro Ishihara
ASIAN JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Mitsuru Esaki, Masao Yoshida, Kohei Takizawa, Akifumi Notsu, Satoru Nonaka, Satoki Shichijo, Sho Suzuki, Chiko Sato, Hiroyuki Komori, Takeyoshi Minagawa, Ichiro Oda, Noriya Uedo, Kingo Hirasawa, Kenshi Matsumoto, Tetsuya Sumiyoshi, Seiichiro Abe, Takuji Gotoda, Hiroyuki Ono
Summary: Our study compared the treatment outcomes of endoscopic submucosal dissection (ESD) with an insulated-tip knife (ESD-IT) and a needle-type knife (ESD-N) for large superficial esophageal neoplasms. The results showed similar procedural outcomes between the two groups, but the handover rate was higher in ESD-N and the injection volume was higher in ESD-IT. Sub-analyses revealed that traction-assisted ESD (TA-ESD) significantly reduced the handover rate for ESD-N and decreased the injection volume for ESD-IT.
DISEASES OF THE ESOPHAGUS
(2023)
Editorial Material
Gastroenterology & Hepatology
Tatsuya Sato, Tomotaka Saito, Tsuyoshi Hamada, Yousuke Nakai, Mitsuhiro Fujishiro
Article
Oncology
Kazushi Fukagawa, Yu Takahashi, Nobutake Yamamichi, Natsuko Kageyama-Yahara, Yoshiki Sakaguchi, Miho Obata, Rina Cho, Nobuyuki Sakuma, Sayaka Nagao, Yuko Miura, Naoki Tamura, Daisuke Ohki, Hiroya Mizutani, Seiichi Yakabi, Chihiro Minatsuki, Keiko Niimi, Yosuke Tsuji, Mitsue Yamamichi, Narumi Shigi, Shuta Tomida, Hiroyuki Abe, Tetsuo Ushiku, Kazuhiko Koike, Mitsuhiro Fujishiro
Summary: In this study, the transcriptome analysis of GA-FG revealed significant expression of NKX2-1/TTF1 in GA-FG. Immunohistochemistry and cell biology experiments demonstrated ectopic expression and normal transactivation ability of NKX2-1/TTF-1, suggesting its essential role in GA-FG development.
Article
Gastroenterology & Hepatology
Junya Arai, Tomonori Aoki, Yoku Hayakawa, Ryota Niikura, Rei Ishibashi, Nobumi Suzuki, Yosuke Tsuji, Atsuo Yamada, Tetsuo Ushiku, Mitsuhiro Fujishiro
Summary: The incidence of early-onset colorectal neoplasms is increasing, and the risk factors differ between early-onset and late-onset neoplasms. For young male patients, especially those with a family history of colorectal cancer, colonoscopy is recommended.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Koichi Muroi, Naomi Kakushima, Kazuhiro Furukawa, Satoshi Furune, Nobuhito Ito, Takashi Hirose, Emiko Hida, Tomohiko Suzuki, Takahiro Suzuki, Keiko Hirai, Hiroyuki Shibata, Eri Ishikawa, Tsunaki Sawada, Keiko Maeda, Takeshi Yamamura, Eizaburo Ohno, Masanao Nakamura, Mitsuhiro Fujishiro, Hiroki Kawashima
Summary: This study demonstrated that adding endocytoscopy (ECS) to conventional white light imaging (WLI) improved the biopsy sensitivity and eosinophil detection in patients with eosinophilic esophagitis (EE). The sensitivity of a single biopsy specimen and the eosinophil count were significantly higher in the ECS group compared to the WLI group. ECS-based biopsy also had higher sensitivity for the diagnosis of edema and linear furrows compared to WLI.
Article
Oncology
Hiroyuki Kato, Keisuke Tateishi, Dosuke Iwadate, Keisuke Yamamoto, Hiroaki Fujiwara, Takuma Nakatsuka, Yotaro Kudo, Yoku Hayakawa, Hideaki Ijichi, Motoyuki Otsuka, Takahiro Kishikawa, Ryota Takahashi, Koji Miyabayashi, Yousuke Nakai, Yoshihiro Hirata, Atsushi Toyoda, Shinichi Morishita, Mitsuhiro Fujishiro
Summary: This study discovered the correlation between 3D genome structures and molecular subtypes of pancreatic cancer (PC) through Hi-C analysis. They found that HNF1B regulates the expression of related genes by influencing the 3D structures. These findings are significant for a better understanding of the molecular features of PC.
Letter
Gastroenterology & Hepatology
Takuma Nakatsuka, Ryosuke Tateishi, Masaya Sato, Mitsuhiro Fujishiro, Kazuhiko Koike
JOURNAL OF HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Satoru Mizutani, Yu Takahashi, Takeshi Shimamoto, Hideki Nakagawa, Hiroyuki Hisada, Kaori Oshio, Dai Kubota, Hiroya Mizutani, Daisuke Ohki, Yoshiki Sakaguchi, Seiichi Yakabi, Keiko Niimi, Naomi Kakushima, Yosuke Tsuji, Ryoichi Wada, Nobutake Yamamichi, Mitsuhiro Fujishiro
Summary: This study aimed to analyze whether performing the ABC screening twice in a lifetime is useful for stratifying the risk of gastric cancer. Retrospective analysis of data from individuals who participated in health checkups in 2010 and 2015 showed that performing the ABC method twice, 5 years apart, does not significantly improve gastric cancer risk stratification.
Article
Gastroenterology & Hepatology
Osamu Toyoshima, Toshihiro Nishizawa, Shuntaro Yoshida, Tatsuya Matsuno, Kotaro Miyoshi, Eri Naito, Chihiro Shiomi, Takeshi Uozumi, Mitsuhiro Fujishiro, Yutaka Saito
Summary: This study investigated the association between the presence and severity of hemorrhoids and the detection of precancerous colorectal polyps. The results showed that hemorrhoids were associated with a higher number of adenomas, especially severe ones. Therefore, complete colonoscopy should be performed in patients with hemorrhoids.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Article
Oncology
Kei Saito, Nobuaki Michihata, Tsuyoshi Hamada, Taisuke Jo, Hiroki Matsui, Kiyohide Fushimi, Yousuke Nakai, Hideo Yasunaga, Mitsuhiro Fujishiro
Summary: This study aimed to investigate the incidence and risk factors of interstitial lung disease (ILD) in patients with pancreatic cancer (PC) receiving gemcitabine plus nab-paclitaxel chemotherapy. The researchers found that ILD occurred in 2.7% of patients receiving this chemotherapy regimen and was associated with older age. Therefore, monitoring ILD-related symptoms is necessary when administering gemcitabine plus nab-paclitaxel to older patients with PC.
Article
Gastroenterology & Hepatology
Hidenori Tanaka, Shiro Oka, Akiko Shiotani, Mitsushige Sugimoto, Hidekazu Suzuki, Yuji Naito, Osamu Handa, Tadakazu Hisamatsu, Shin Fukudo, Mitsuhiro Fujishiro, Satoshi Motoya, Naohisa Yahagi, Satoru Yamaguchi, Francis K. L. Chan, Sun-Young Lee, Baiwen Li, Tiing Leong Ang, Murdani Abdullah, Maria Carla Tablante, Varayu Prachayakul, Shinji Tanaka
Summary: This study investigated the current status of diagnosis and treatment of early-stage colorectal cancer in Asian countries. The results showed disparities in the dissemination of advanced technologies and the prevalence of colorectal ESD in different countries. Therefore, the promotion of advanced technologies and education is necessary.
Editorial Material
Gastroenterology & Hepatology
Kohei Kurihara, Yousuke Nakai, Mitsuhiro Fujishiro
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Junya Arai, Ryota Niikura, Atsuo Yamada, Tomonori Aoki, Nobumi Suzuki, Yosuke Tsuji, Yoku Hayakawa, Takashi Kawai, Mitsuhiro Fujishiro
Summary: Colonic diverticular bleeding is a common cause of lower gastrointestinal bleeding. This study aimed to investigate the association between 24-h blood pressure and diverticular rebleeding. The findings suggest that lower blood pressure in the early morning and a higher pre-awakening surge are risk factors for diverticular rebleeding.
Article
Computer Science, Artificial Intelligence
Yu Tian, Fengbei Liu, Guansong Pang, Yuanhong Chen, Yuyuan Liu, Johan W. Verjans, Rajvinder Singh, Gustavo Carneiro
Summary: Unsupervised anomaly detection (UAD) is an important medical image analysis method for disease screening. However, training with only normal images may result in ineffective image representations that cannot detect unseen abnormal lesions. This paper proposes a new self-supervised pre-training method (PMSACL) that improves the accuracy of UAD methods by forming dense clusters for synthesized abnormal images.
MEDICAL IMAGE ANALYSIS
(2023)