Article
Medicine, General & Internal
Elena Mirela Ionescu, Andrei Ovidiu Olteanu, Cristian George Tieranu, Luis Ovidiu Popa, Silvia Ioana Andrei, Carmen Monica Preda, Monica Irina Dutescu, Mihai Bojinca, Ioana Tieranu, Olivia Mihaela Popa
Summary: This study evaluated the role of two IL-4 gene single nucleotide polymorphisms (SNPs) in disease susceptibility and phenotypic expression in inflammatory bowel diseases (IBD). The study found a significantly reduced frequency of the minor allele T of both SNPs in CD patients and the entire IBD group. Haplotype analysis identified a high-risk haplotype associated with IBD development.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Nutrition & Dietetics
Yan Jiang, Karolin Jarr, Cosima Layton, Christopher D. Gardner, Judith E. Ashouri, Maria T. Abreu, Sidhartha R. Sinha
Summary: Despite being an important issue for patients, the impact of diet on adult inflammatory bowel disease (IBD) is not well explored, with limited guidance. Current evidence on various diets used in the treatment of IBD is summarized, with potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs) to inform providers. Multiple diets, including Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets, have shown positive results in other inflammatory diseases, suggesting potential applicability to IBD, but further well-designed clinical trials are needed for guidance.
Article
Gastroenterology & Hepatology
Gavin W. Sewell, Arthur Kaser
Summary: The cytokine interleukin-23 (IL-23), mainly produced by macrophages and dendritic cells in response to microbial stimulation, plays a critical role in chronic intestinal inflammation. IL-23 has been found to be associated with disease protection through genetic variations, and therapeutic targeting of the shared p40 subunit of IL-12/IL-23 has shown success in treating inflammatory bowel disease (IBD). Recent phase 2 studies have shown promise in targeting the specific p19 subunit of IL-23. However, the exact pathways downstream of IL-23 in mucosal inflammation in the gut are still debated.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Immunology
Susanna Esposito, Giulia Antoniol, Marialuisa Labate, Lucrezia Passadore, Patrizia Alvisi, Valeria Dacco, Chiara Ghizzi, Carla Colombo, Nicola Principi
Summary: The incidence of inflammatory bowel diseases (IBDs) is rising globally, leading to a higher risk of infections in children with dysfunctional immune systems. Vaccines are essential for preventing these infections, and should be administered according to specific immunization guidelines for IBD patients. Compliance with vaccination recommendations is generally low, highlighting the need for multidisciplinary educational programs to improve vaccination coverage and protect children with IBD from vaccine-preventable diseases.
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Review
Biochemistry & Molecular Biology
Maria Jose Sanchez-Quintero, Cristina Rodriguez-Diaz, Francisco J. Rodriguez-Gonzalez, Alejandra Fernandez-Castaner, Eduardo Garcia-Fuentes, Carlos Lopez-Gomez
Summary: Mitochondria play a crucial role in maintaining cellular functions and are involved in various cellular processes. Dysfunction of mitochondria has been linked to complex disorders, including inflammatory bowel diseases (IBD). The impact of mitochondrial dysfunction on IBD, including its role in intestinal mucosa, immune cell populations, mucosal repair, microbiota-brain-gut axes, and the development of colitis-associated colorectal cancer, is discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Flavia Baccini, Federica Micheli, Giovanni Di Nardo, Caterina Lombardo
Summary: This study found that patients with inflammatory bowel disease have poorer subjective sleep quality compared to controls, with even worse sleep quality in those with active IBD. However, there were no differences within IBD subtypes. These results highlight the importance of considering sleep quality as a relevant comorbidity in IBD.
SLEEP MEDICINE REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Anna Krystyna Zielinska, Maciej Salaga, Pawel Siwinski, Marcin Wlodarczyk, Adam Dziki, Jakub Fichna
Summary: The study found that IBD patients had significantly decreased SOD activity, GSH and GSSG levels, and GPX activity was significantly diminished only in CD patients. CAT and COX-1 activity was increased, while COX-2 was significantly decreased in IBD patients. TBARS were significantly higher in CD patients compared to the control group. There was no correlation between pain scores, inflammatory status, disease activity, disease duration, or dietary habits and OS markers.
Review
Gastroenterology & Hepatology
Alexa N. Sasson, Ashwin N. Ananthakrishnan, Maitreyi Raman
Summary: The global incidence of inflammatory bowel diseases (IBDs) has increased significantly in the past few decades, with genetic and environmental factors playing a role in the pathogenesis. Diet is a potentially modifiable environmental risk factor for IBD, as it can promote intestinal inflammation through various mechanisms such as dysregulating the immune system and altering intestinal permeability. Dietary changes may be integrated into therapeutic strategies for IBD treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Medicine, General & Internal
Eduard Brunet Mas, Xavier Calvet Calvo
Summary: Combination of two biological therapies (CoT) appears to be a safe and effective treatment option for refractory and severely ill patients with inflammatory bowel disease (IBD). Ustekinumab plus vedolizumab and vedolizumab plus anti-TNF are the most commonly used CoTs for Crohn's disease. For ulcerative colitis, vedolizumab plus anti-TNF and vedolizumab plus tofacitinib are the most commonly used CoTs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Tien-En Chang, Jiing-Chyuan Luo, Ueng-Cheng Yang, Yi-Hsiang Huang, Ming-Chih Hou, Fa-Yauh Lee
Summary: The study found that patients with IBD had decreased richness and diversity in their gut microbiota compared to healthy controls. There was no significant difference in the composition of fecal microbiota between different types of inflammatory bowel disease.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Review
Biochemistry & Molecular Biology
Rita Lauro, Federica Mannino, Natasha Irrera, Francesco Squadrito, Domenica Altavilla, Giovanni Squadrito, Giovanni Pallio, Alessandra Bitto
Summary: Inflammatory Bowel Disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC) and is primarily treated with anti-inflammatory drugs, with a recent increase in the use of biological drugs. This review focuses on summarizing the pharmacogenetics of biological drugs approved for IBD, highlighting the association between certain polymorphisms and drug response in patients.
Article
Gastroenterology & Hepatology
Matthias Zilbauer, Robert Heuschkel
Summary: Inflammatory bowel diseases like Crohn's disease and ulcerative colitis are complex conditions that require personalized treatment approaches. Developing biomarkers to predict disease course and treatment response is challenging.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Biochemistry & Molecular Biology
Shaghayegh Baradaran Ghavami, Hamid Asadzadeh Aghdaei, Dario Sorrentino, Shabnam Shahrokh, Maryam Farmani, Fatemeh Ashrafian, Maria Pina Dore, Shahrbanoo Keshavarz Azizi Raftar, Seyed Mobin Khoramjoo, Mohammad Reza Zali
Summary: Inflammatory bowel diseases (IBDs) are immune-mediated, chronic relapsing diseases with a rising prevalence worldwide. Probiotic bacteria may impact immunomodulation by regulating dendritic cells to produce tolerogenic DCs, which could play a role in the treatment of IBD and associated conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Sepideh Ebrahimi Meimand, Gholamreza Azizi, Reza Yazdani, Negin Sanadgol, Nima Rezaei
Summary: Glycogen storage disease type Ib (GSDIb) is an autosomal recessive disorder caused by mutations of the SLC37A4 gene, leading to various clinical manifestations such as hepatomegaly, renomegaly, neutropenia, hypoglycemia, and lactic acidosis. It may also result in severe long-term complications.
IMMUNOLOGIC RESEARCH
(2023)
Review
Clinical Neurology
Amirmohammad Khalaji, Amir Hossein Behnoush, Parnian Shobeiri, Behrad Saeedian, Antonio L. Teixeira, Nima Rezaei
Summary: The study found no significant difference in BDNF levels between patients with OSA and controls, as well as no statistically significant impact of CPAP treatment on BDNF levels. Therefore, BDNF peripheral levels are not significantly altered in OSA or by its related treatment, preventing its use as a biomarker.
SLEEP AND BREATHING
(2023)
Review
Neurosciences
Mobina Amanollahi, Melika Jameie, Arash Heidari, Nima Rezaei
Summary: Adult neurogenesis plays a critical role in various neurological disorders, and neuroinflammation is a key factor that can affect this process by regulating multiple steps of neurogenesis. Understanding the effects of immune components on adult neurogenesis can provide insights into potential therapeutic candidates for these disorders.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Virology
Amene Saghazadeh, Nima Rezaei
Summary: An immunocompromised status increases the risk of monkeypox virus infection and severe disease, highlighting the importance of immune competence for controlling and clearing the virus. Studies have shown various effects of monkeypox virus on the immune system, including stimulation, modulation, and memory, affecting immune cells and molecules such as natural killer cells, macrophages, neutrophils, lymphocytes, cytokines, interferons, chemokines, and complement.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Review
Pharmacology & Pharmacy
Mandana Azari, Farbod Bahreini, Vladimir N. Uversky, Nima Rezaei
Summary: Breast cancer is a malignancy that occurs in the mammary glands, with triple-negative breast cancer (TNBC) being the most aggressive subtype. TNBC is resistant to hormone therapy and targeted therapies, making chemotherapy the primary treatment. However, resistance to chemotherapy can lead to treatment failure, cancer recurrence, and distant metastasis. Targeting chemoresistant metastases-initiating cells with specific therapeutic agents is a promising approach in TNBC management. Peptides, with their specificity, low immunogenicity, and efficacy, can be used to design drugs that enhance the effectiveness of chemotherapy for targeting drug-tolerant TNBC cells.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Hematology
Hanieh Kolahi Azar, Aylar Imanpour, Hanieh Rezaee, Fatemeh Ezzatifar, Zeinab Zarei-Behjani, Mohammadreza Rostami, Mahmoud Azami, Nima Behestizadeh, Nima Rezaei
Summary: This article discusses the importance of two core elements, mesenchymal stromal cells (MSCs) and chimeric antigen receptor (CAR)-T cells, in cell therapy procedures. It analyzes multiple parameters that affect cell homing and the impact of several chemokines in the tumor microenvironment on the homing process. Emerging comprehensive mechanistic strategies and their significant role in cell therapy remodeling are reviewed, and the development of combination therapies incorporating MSCs and CAR-T cells for cancer treatment is discussed.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Parnian Shobeiri, Sanam Alilou, Mehran Jaberinezhad, Farshad Zare, Nastaran Karimi, Saba Maleki, Antonio L. Teixeira, George Perry, Nima Rezaei
Summary: This systematic review evaluated the accuracy of long non-coding RNAs (lncRNAs) in identifying Alzheimer's disease (AD) through meta-analysis. The results showed that lncRNAs had high accuracy in identifying AD and could be considered a promising diagnostic biomarker for the disease.
Review
Immunology
Soren Nooraei, Alireza Sarkar Lotfabadi, Milad Akbarzadehmoallemkolaei, Nima Rezaei
Summary: Vaccination is the most effective method for preventing and reducing the impact of infectious diseases in animals and humans. Adjuvants are substances that enhance the immune response and can improve the body's immune reactions. Nanoparticles have shown promise as more effective adjuvants due to their ability to target antigen-presenting cells and easily cross biological barriers.
Review
Oncology
Kimia Kazemzadeh, Sadra Behrouzieh, Nima Rezaei
Summary: This article reviews the potential immune-related side effects of immunotherapy in treating leukemia, including effects on different body systems such as cardiovascular and neurologic systems. Being aware of these side effects can lead to better clinical decision-making and proactive management in case of occurrence.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Review
Oncology
Sara Mahdiabadi, Sara Momtazmanesh, Amirali Karimi, Nima Rezaei
Summary: This study conducted a meta-analysis of randomized controlled trials to evaluate the efficacy of immune checkpoint inhibitors (ICIs) for metastatic melanoma. The results showed that ICIs are associated with improved overall survival and can assist clinicians in choosing the optimal treatment approach.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Review
Virology
Hanie Karimi, Vahid Mansouri, Nima Rezaei
Summary: This paper discusses the hypothesis of antibody transmission through the placenta and breast milk following SARS-CoV-2 infection or vaccination, while considering the potential harm and benefits to the fetus/infant.
Review
Multidisciplinary Sciences
Mahdi Masrour, Shaghayegh Khanmohammadi, Parisa Fallahtafti, Nima Rezaei
Summary: The study found that lncRNAs could be used as diagnostic biomarkers for HNSCC, but further investigation is needed to validate clinical efficacy and elucidate mechanisms. High-throughput sequencing and bioinformatics should be used to ascertain expression profiles.
Article
Neurosciences
Mahsa Golshani Nasab, Arash Heidari, Mohammadreza Sedighi, Narges Shakerian, Mona Mirbeyk, Amene Saghazadeh, Nima Rezaei
Summary: This article discusses the relationship between dietary inflammatory index (DII) and neuropsychiatric disorders (NPDs), finding that a proinflammatory diet is associated with depression, anxiety, stress, and sleep disorders. The effects of genetic backgrounds, dietary patterns, and the gut microbiome on DII are also discussed. Future research should evaluate causality through RCTs and explore personalized medicine interventions using information about DII in NPDs.
REVIEWS IN THE NEUROSCIENCES
(2023)
Article
Immunology
Hamidreza Ebrahimian, Maryam Akhtari, Maassoumeh Akhlaghi, Elham Farhadi, Ahmadreza Jamshidi, Gholam Hossein Alishiri, Mahdi Mahmoudi, Mahmood Tavallaie
Summary: This study investigated the expression of TP53, BAX, FOXO1, and RB1 genes in peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) patients. It was found that the expression levels of these genes were significantly reduced in RA PBMCs. TP53 and FOXO1 expression were negatively correlated with miR-16-5p, miR-335-5p, and miR-34a-5p. The study suggests that the abnormal expression of these genes may be associated with the development and severity of RA.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Review
Neurosciences
Ghazaleh Ghaffaripour Jahromi, Sepideh Razi, Nima Rezaei
Summary: This comprehensive review explores the pathophysiological models of depression and the relationship between NLRP3 inflammasome activation and depression. By adopting the inflammatory theory, the central role of NLRP3 inflammasome activation in depression is explained and supported by evidence from human studies and animal models. The activation of the inflammasome is not limited to the central nervous system, but extends to the gut and peripheral immune systems, affecting the balance of the microbiota-gut-brain axis.
