Article
Medicine, General & Internal
Maidina Abuduwaili, Hidehiko Takigawa, Ryo Yuge, Hajime Teshima, Takahiro Kotachi, Yuji Urabe, Masanori Ito, Kazuhiro Sentani, Naohide Oue, Shiro Oka, Yasuhiko Kitadai, Shinji Tanaka
Summary: This study aimed to investigate the relationship between NHPH infection and gastritis and gastric cancer development. The results showed no significant difference in NHPH infection rates based on different Hp infection statuses, and the NHPH infection rates in gastric cancer patients were similar to those in patients with gastritis-related diseases reported in previous studies. A comparison between NHPH-positive and negative patients showed no significant differences in atrophic gastritis status, serum gastritis markers, or clinicopathological characteristics of gastric cancer.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Review
Immunology
Yang Guo, Xue-Shan Cao, Meng-Ge Zhou, Bo Yu
Summary: Gastric cancer is a leading cause of cancer-related deaths worldwide. The gastric microbiota, including both Helicobacter pylori and non-H. pylori microbes, plays a critical role in the development of gastric cancer. Dysbiosis of the gastric microbiota, with a decrease in non-H. pylori microbes, occurs following H. pylori infection. As gastric lesions progress, there is a decrease in H. pylori and an increase in non-H. pylori microbes. The roles of H. pylori and non-H. pylori microbes differ at different stages of gastric carcinogenesis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Helge Waldum, Reidar Fossmark
Summary: Despite a decrease in prevalence over the past few decades, gastric cancer remains a significant global cause of death, with Helicobacter pylori infection reduction being a key factor. The carcinogenic effects of H. pylori are likely due to hypergastrinemia and autoimmune gastritis, while long-term use of proton pump inhibitors may also predispose individuals to ECL cell neoplasia. Additionally, gastric polyps, although generally low in malignant potential, can still pose a cancer risk and share some common risk factors and mechanisms with gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
M. C. Mommersteeg, I Simovic, B. Yu, S. A. van Nieuwenburg, I. M. J. Bruno, M. Doukas, E. J. Kuipers, M. C. W. Spaander, M. P. Peppelenbosch, N. Castano-Rodriguez, G. M. Fuhler
Summary: The SNP in the ATG16L1 gene is associated with increased intestinal endoplasmic reticulum stress and progression of gastric cancer induced by H. pylori. Individuals with the G-allele are more prone to developing gastric cancer.
Article
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, and its development is influenced by genetic predisposition, environmental factors, and Helicobacter pylori infection. Matrix metalloproteinases (MMPs) play an active role in the progression of gastric cancer, with bacterial dependence being less significant in later stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Alain P. Gobert, Mohammad Asim, Thaddeus M. Smith, Kamery J. Williams, Daniel P. Barry, Margaret M. Allaman, Kara M. McNamara, Caroline V. Hawkins, Alberto G. Delgado, M. Blanca Piazuelo, John A. Rathmacher, Keith T. Wilson
Summary: Stomach cancer is a leading cause of cancer death, primarily caused by Helicobacter pylori infection, which induces inflammation and DNA damage. 2-hydroxybenzylamine (2-HOBA), derived from buckwheat seeds, is effective in reducing gastritis, gastric dysplasia, and carcinogenesis caused by H. pylori infection in mice and gastric epithelial cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Zhaolai Hua, Le Xu, Jiahui Zhu, Ling Xiao, Bin Lu, Jianping Wu, Zhenfeng Wu, Qihai Zhou, Junfeng Zhang
Summary: Objective of this study was to investigate the effect of Helicobacter pylori (Hp) infection on gastric mucosal microbiota in patients with chronic gastritis. The study found that virulent Hp infection alters gastric microbiota, reduces microbial diversity, and enhances the symbiotic relationship between Helicobacter bacteria and non-Helicobacter bacteria in patients with chronic gastritis. These findings provide new evidence for treating Hp infection by improving gastric microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Reuben Veysey-Smith, Andrew R. Moore, Senthil Murugesan, Laszlo Tiszlavicz, Graham J. Dockray, Andrea Varro, D. Mark Pritchard
Summary: This study demonstrated that PPI use, Helicobacter pylori infection, and atrophic gastritis significantly increased fasting serum gastrin concentrations. However, some patients with potential risk factors for hypergastrinaemia still showed normal fasting serum gastrin concentrations.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Microbiology
Sushil Kumar, Girijesh Kumar Patel, Uday C. Ghoshal
Summary: Gastric cancer is associated with chronic inflammation, parasitic infections, dietary habits, and host genetic factors. Research on the process of H. pylori-induced inflammation and gastric precursor lesions suggests that gut microbiota and parasitic infections may modulate risk, while genetic polymorphisms and exosomes play a role in the development of gastric carcinoma.
Article
Biotechnology & Applied Microbiology
Jinglei Liu, Fangxu Zhang, Zheming Zhang, Chunning Zheng
Summary: This study found that Everolimus has a pharmacological role in protecting gastric epithelial cells from H.pylori-induced damage. It achieves this by reducing oxidative stress and inhibiting inflammatory response, as well as inhibiting the attachment of monocytes to epithelial cells.
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Lusheng Song, Minkyo Song, Charles S. Rabkin, Stacy Williams, Yunro Chung, Jennifer Van Duine, Linda M. Liao, Kailash Karthikeyan, Weimin Gao, Jin G. Park, Yanyang Tang, Jolanta Lissowska, Ji Qiu, Joshua LaBaer, M. Constanza Camargo
Summary: This study evaluated humoral responses to a nearly complete H. pylori immunoproteome among GC cases and controls, finding higher prevalence of certain antibodies in controls and lower seroprevalence in GC cases, suggesting immune protection and potential changes in specific proteins.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Maya Olaisen, Arnar Flatberg, Atle van Beelen Granlund, Elin Synnove Royset, Tom Christian Martinsen, Arne Kristian Sandvik, Reidar Fossmark
Summary: The study found that the microbiome in the inflamed and proximal noninflamed ileal mucosa is similar in patients with Crohn's disease (CD). Additionally, Crohn's disease patients had a significantly different microbiome compared to healthy controls.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Endocrinology & Metabolism
Magnus Kjellman, Ulrich Knigge, Staffan Welin, Espen Thiis-Evensen, Henning Gronbaek, Camilla Schalin-Jantti, Halfdan Sorbye, Maiken Thyregod Joergensen, Viktor Johanson, Saara Metso, Helge Waldum, Jon Arne Soreide, Tapani Ebeling, Fredrik Lindberg, Kalle Landerholm, Goran Wallin, Farhad Salem, Maria del Pilar Schneider, Roger Belusa
Summary: The study investigates a plasma protein multi-biomarker strategy for improving diagnostic accuracy in patients with SI-NETs, especially in those with normal CgA levels. The results indicate the potential utility of this multi-biomarker strategy for early detection of SI-NETs and potentially detecting recurrence after radical primary resection.
NEUROENDOCRINOLOGY
(2021)
Article
Oncology
Eivind Ness-Jensen, Erling Audun Bringeland, Fredrik Mattsson, Patricia Mjones, Jesper Lagergren, Jon Erik Gronbech, Helge Lyder Waldum, Reidar Fossmark
Summary: The study conducted in Norway revealed that hypergastrinemia is associated with an increased risk of developing gastric adenocarcinoma, especially in the proximal stomach and intestinal histological type. However, there was no significant association found for gastric adenocarcinoma with distal location and diffuse histological type.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Gastroenterology & Hepatology
Holmfridur Helgadottir, Sigrun H. Lund, Sveinbjorn Gizurarson, Helge Waldum, Einar S. Bjornsson
Summary: In healthy volunteers, serum gastrin levels significantly increased after four-day PPI therapy, along with a significant rise in serum esomeprazole concentration. There were no significant sex-related differences in terms of pharmacokinetic parameters, and no significant correlation was found between the AUC and gastrin levels on day 5.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Helge Waldum, Reidar Fossmark
Summary: Despite a decrease in prevalence over the past few decades, gastric cancer remains a significant global cause of death, with Helicobacter pylori infection reduction being a key factor. The carcinogenic effects of H. pylori are likely due to hypergastrinemia and autoimmune gastritis, while long-term use of proton pump inhibitors may also predispose individuals to ECL cell neoplasia. Additionally, gastric polyps, although generally low in malignant potential, can still pose a cancer risk and share some common risk factors and mechanisms with gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Helge Waldum
Summary: The rational treatment of diseases, especially cancers, relies on understanding their causes and development processes. The classification of tumors should consider both organ and cell of origin. Hormones and the ability of cells to divide play crucial roles in cancer development.
Review
Surgery
Kjersti Ausen, Reidar Fossmark, Olav Spigset, Hilde Pleym
Summary: Local use of tranexamic acid can reduce blood loss comparable to intravenous prophylactic use without significant systemic adverse effects, but there is a lack of high-quality randomized controlled trials. Prolonged exposure to high local concentrations is discouraged, and direct contact with the central nervous system may cause seizures.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Gastroenterology & Hepatology
Eivind Ness-Jensen, Erling Audun Bringeland, Patricia Mjones, Jesper Lagergren, Jon Erik Gronbech, Helge Waldum, Reidar Fossmark
Summary: This population-based study suggests that hypergastrinemia may not increase the risk of mortality in patients with gastric adenocarcinoma.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Marianne Beck, Erling A. Bringeland, Gunnar Qvigstad, Reidar Fossmark
Summary: Stomach cancer may be missed during upper endoscopy, especially when located in the upper part of the stomach, of Lauren's diffuse histologic type, and in patients with previous Billroth II operation. Missed cancers were diagnosed at earlier stages compared to non-missed cancers. An ulceration was more common in patients with shorter time interval between the first endoscopy and the cancer diagnosis, highlighting the importance of factors associated with missed stomach cancers in the early diagnosis of cancer.
Letter
Gastroenterology & Hepatology
Maya Olaisen, Reidar Fossmark
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Medicine, General & Internal
Elfrid Christine Smith Sandvik, Kristin Matre Aasarod, Gjermund Johnsen, Dag Arne Lihaug Hoff, Bard Kulseng, Asne Ask Hyldmo, Hallvard Graeslie, Siren Nymo, Jorunn Sandvik, Reidar Fossmark
Summary: Severe obesity is a significant risk factor for non-alcoholic fatty liver disease (NAFLD). Roux-en-Y gastric bypass (RYGB) surgery has long-term effects on NAFLD-related fibrosis. Data analysis from severe obese patients who underwent RYGB surgery showed a decrease in proportions with advanced fibrosis and improvement in fibrosis scores after 11.6 years.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Maya Olaisen, Mathias L. Richard, Vidar Beisvag, Atle van Beelen Granlund, Elin S. Royset, Olivier Rue, Tom Christian Martinsen, Arne Kristian Sandvik, Harry Sokol, Reidar Fossmark
Summary: The study found that the mucosa-associated mycobiota in the ileum of patients with CD is altered compared to healthy controls, and an increase in the abundance of Malassezia is associated with disease progression.
FRONTIERS IN MEDICINE
(2022)
Editorial Material
Gastroenterology & Hepatology
Reidar Fossmark, Peter Lefstad Dalsbo, Kjell Morten Rokseth, Oyvind Hauso
Article
Medicine, General & Internal
Reidar Fossmark, Rune Johannessen, Gunnar Qvigstad, Patricia Mjones
Summary: Gastric neuroendocrine tumors (NETs) and signet ring cell carcinomas may have a common origin, with chronic atrophic gastritis, hypoacidity, and hypergastrinemia as shared risk factors.
MEDICINA-LITHUANIA
(2022)
