Article
Biochemistry & Molecular Biology
Eszter Becskehazi, Marietta Margareta Korsos, Eleonora Gal, Laszlo Tiszlavicz, Zsofia Hoyk, Maria A. Deli, Zoltan Marton Kohler, Aniko Keller-Pinter, Attila Horvath, Kata Cseko, Zsuzsanna Helyes, Peter Hegyi, Viktoria Venglovecz
Summary: The study suggests that smoking affects the function of ion transporters, playing a role in the development of smoking-induced esophageal diseases. In metaplastic cells, CSE treatment increased the activity and protein expression of NHE-1, reducing proliferation in a NHE-1-dependent manner. Contrarily, in normal cells, the expression and activity of NHE-1 decreased due to smoke exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ahmed Sam Beydoun, Kaleigh A. Stabenau, Kenneth W. Altman, Nikki Johnston
Summary: Esophageal adenocarcinoma (EAC) is increasing rapidly and has a poor prognosis, often preceded by Barrett's esophagus (BE). This review provides an overview of BE, EAC, and the progression from BE to EAC. The definition, diagnosis, epidemiology, and risk factors for both conditions are discussed, with special attention given to areas of debate. The progression from BE to EAC is likely driven by inflammatory pathways, pepsin exposure, upregulation of growth factor pathways, and mitochondrial changes. Surveillance is conducted through serial endoscopic evaluation, with shorter intervals recommended for high-risk features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Tarek Sawas, Saam Dilmaghani, Lovekirat Dhaliwal, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka
Summary: The study found that compared to BE patients, EAC patients had significantly lower rates of heartburn, diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome. Therefore, optimal strategies for screening for prevalent EAC may need to be adjusted.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Jennifer M. Kolb, Mindy Chen, Anna Tavakkoli, Jazmyne Gallegos, Jack O'Hara, Wyatt Tarter, Camille J. Hochheimer, Bryan Golubski, Noa Kopplin, Lilly Hennessey, Anita Kalluri, Shalika Devireddy, Frank I. Scott, Gary W. Falk, Amit G. Singal, Ravy K. Vajravelu, Sachin Wani
Summary: Most EAC patients do not have a previous BE diagnosis, indicating a failure of current screening practices. Understanding patient attitudes and barriers is crucial for improving BE screening adherence.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Clinical Neurology
Hyewon Kim, Soorack Ryu, Hong Jin Jeon, Sungwon Roh
Summary: This study aimed to examine the association between lifestyle factors and suicide-related outcomes. Data from the Korea National Health and Nutrition Examination Survey in 2015 and 2017 were analyzed, and lifestyle factors including smoking, physical activity, alcohol intake, and the Healthy Eating Index (HEI) were identified. The results showed that smoking and heavy drinking were associated with an increased risk of suicide-related outcomes, while high-quality diets and non-heavy drinking were associated with a decreased risk. The associations between lifestyle factors and suicide-related outcomes were stronger in people with depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Seo Yeon Yoon, You Hyun Park, Hyo Jeong Lee, Dae Ryong Kang, Yong Wook Kim
Summary: This study found associations between lifestyle factors and the development of Parkinson's disease (PD) in a Korean population. Smoking had an inverse association with PD in men, while alcohol consumption and physical activity were related to reduced PD development in both sexes. Regular health screening showed a consistent relationship between lifestyle factors and PD development, while lifestyle factors in those without regular health screening had a decreased relationship with PD.
Review
Gastroenterology & Hepatology
Leonardo H. Eusebi, Andrea Telese, Giovanna G. Cirota, Rehan Haidry, R. Maurizio Zagari, Franco Bazzoli, Alexander C. Ford
Summary: Gastro-esophageal reflux (GER) symptoms are associated with an increased odds of Barrett's esophagus (BE), especially when the symptoms occur weekly. However, GER symptoms have low sensitivity and specificity for predicting BE, except for a strong association with long segment BE. Screening individuals with weekly GER symptoms may be beneficial to rule out long segment BE.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Psychology, Multidisciplinary
Anem Iftikhar, Mohammad Islam, Simon Shepherd, Sarah Jones, Ian Ellis
Summary: Lifestyle factors, including alcohol consumption and smoking, play a significant role in the development of head and neck cancers. Promoting healthy lifestyle choices is crucial for improving health and preventing diseases. Stress is known to contribute to the adoption of unhealthy habits such as alcohol and smoking. Understanding the impact of stress on lifestyle choices and exploring the underlying mechanisms can facilitate the development of prevention measures.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sabrina E. Wang, Bradley J. Kendall, Allison M. Hodge, Suzanne C. Dixon-Suen, S. Ghazaleh Dashti, Enes Makalic, Elizabeth M. Williamson, Robert J. S. Thomas, Graham G. Giles, Dallas R. English
Summary: This study examined the demographic and lifestyle risk factors for GERD and BE in an Australian cohort. Different risk factors were identified for these two conditions, with males and smokers having a higher risk. These findings are important for the development of clinical risk prediction models for early detection of BE.
DISEASES OF THE ESOPHAGUS
(2022)
Review
Oncology
Lu Zhang, Binyu Sun, Xi Zhou, QiongQiong Wei, Sicheng Liang, Gang Luo, Tao Li, Muhan Lu
Summary: This article briefly describes the etiology and clinical significance of intestinal metaplasia in Barrett's esophagus, as well as its impact on diagnosis, monitoring, and treatment according to different guidelines. The basis for endoscopic diagnosis and identification techniques of goblet cells in Barrett's esophagus are explored, along with current treatment methods related to the condition.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Oncology
Anant Madabhushi, Paula Toro, Joseph E. Willis
Summary: The study by Waterhouse and colleagues described the development of an artificial intelligence approach combined with spectral imaging for improving endoscopic detection of Barrett's esophagus-related neoplasia. A spectral endoscope was developed to define multispectral data correlated with histopathology, and a convolutional neural network was trained to distinguish Barrett's esophagus from Barrett's esophagus neoplasia. The results suggest the potential utility of artificial intelligence in the diagnosis of Barrett's esophagus.
Article
Gastroenterology & Hepatology
Majid Alsahafi, Hebah Mimish, Fatma Salem, Mohammed Hijazi, Emad Aljahdli, Hani Jawa, Salim Bazarah, Rana Bokhary, Yousef Qari, Mahmoud Mosli
Summary: BE was reported endoscopically in 0.64% and histologically confirmed in 0.32% of this cohort of Saudi patients. Male gender was the only factor associated with BE.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Leonardo H. Eusebi, Andrea Telese, Giovanna G. Cirota, Rehan Haidry, Rocco M. Zagari, Franco Bazzoli, Alexander C. Ford
Summary: Gastro-oesophageal reflux is the main risk factor for Barrett's oesophagus, with alcohol consumption and hiatal hernia showing the strongest association with its development. Other potential risk factors such as smoking and obesity did not show significant correlation.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Medicine, General & Internal
Peter M. M. Stawinski, Karolina N. N. Dziadkowiec, Lily A. A. Kuo, Juan Echavarria, Shreyas Saligram
Summary: Barrett's esophagus (BE) is a premalignant mucosal transformation characterized by the replacement of esophageal squamous epithelium with metaplastic columnar epithelium. It is associated with an increased risk of esophageal adenocarcinoma and is often caused by gastroesophageal reflux disease. Screening for BE is selective based on risk factors and is not recommended for the general population. Diagnosis involves endoscopic recognition, targeted biopsies, and histologic confirmation of columnar metaplasia. This review provides a comprehensive overview of the epidemiology, pathogenesis, screening, and advanced techniques for detecting and eradicating Barrett's esophagus.
Review
Medicine, General & Internal
Maja Mejza, Ewa Malecka-Wojciesko
Summary: Barrett's esophagus is a precancerous condition of the esophagus, characterized by a salmon-colored lining and the presence of columnar epithelium with goblet cells. It is associated with esophageal adenocarcinoma, a tumor with poor survival rates and increasing incidence. The diagnosis and management of Barrett's esophagus remain a topic of ongoing debate. This article provides an overview of current recommendations and new discoveries in this field.
JOURNAL OF CLINICAL MEDICINE
(2023)