Journal
DIGESTIVE DISEASES AND SCIENCES
Volume 58, Issue 5, Pages 1264-1270Publisher
SPRINGER
DOI: 10.1007/s10620-012-2513-9
Keywords
Matrix metalloproteinase-14; Gastric cancer; Immunohistochemistry; Prognosis
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Funding
- National Natural Science Foundation of China [31270812]
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Matrix metalloproteinase-14 (MMP-14) has been considered to play an important role in invasion and metastasis of human solid tumor. The present study aimed to investigate the association of MMP-14 with overall survival in human gastric cancer. Gastric cancer and adjacent normal specimens were collected from 205 patients who had not received neoadjuvant chemotherapy. MMP-14 expression was investigated by immunohistochemistry assay and staining evaluation results were analyzed statistically in relation to overall survival of patients. MMP-14 expression proved to be increased in gastric cancer compared with that in normal tissues. It was also proved that MMP-14 expression was associated with tumor invasion, metastasis, and TNM stage while no correlations were detected between MMP-14 expression and age, sex, differentiation status, or Lauren's classification. Moreover, patients with gastric cancer of MMP-14-positive expression tend to have worse overall survival compared with those with MMP-14 negative expression. The present study confirmed the over-expression of MMP-14 in human gastric cancer and its association with tumor progression. It also provided the first evidence that MMP-14 expression in gastric cancer was an independent negative prognostic factor of patients.
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