Journal
DIGESTIVE DISEASES AND SCIENCES
Volume 57, Issue 8, Pages 2038-2044Publisher
SPRINGER
DOI: 10.1007/s10620-012-2134-3
Keywords
Antioxidant; Boswellia serrata; Inflammation; Oxidative stress; Radical scavenger; Ulcerative colitis
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Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundo de Incentivo a Pesquisa e Eventos of the Hospital de Clinicas de Porto Alegre (HCPA) [110215]
- Laboratorio de Hepatologia e Gastroenterologia Experimental (HCPA/UFRGS) of the Universidade Federal do Rio Grande do Sul (UFRGS)
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To evaluate the antioxidant effect of an extract of the plant Boswellia serrata in an experimental model of acute ulcerative colitis induced by administration of acetic acid (AA) in rats. The extract of B. serrata (34.2 mg/kg/day) was administered orally by gavage for 2 days before and after induction of colitis with AA diluted to 4 % and in a volume of 4 ml. The anal sphincter pressure in the groups treated with B. serrata showed a significant increase compared to the colitis group (P < 0.001). Histological analysis of treated animals showed less edema with preservation of mucosal crypts. Lipid peroxidation showed a significant decrease in the treated groups compared to the colitis group (P < 0.001). The superoxide dismutase (SOD) enzyme activity showed a significant reduction in the treated groups compared to the colitis group (P < 0.001), the glutathione peroxidase (GPx) significantly increased in the treated groups compared to colitis group (P < 0.05), and the same was the result for enzyme activity glutathione (GSH; P < 0.05). The extract of B. serrata has active antioxidant substances that exert protective effects in acute experimental colitis.
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