Article
Gastroenterology & Hepatology
Marialaura Cuomo, Alessandra Carobbio, Marina Aloi, Patrizia Alvisi, Claudia Banzato, Luca Bosa, Matteo Bramuzzo, Angelo Campanozzi, Giulia Catassi, Lorenzo D'Antiga, Monica Di Paola, Enrico Felici, Maria Teresa Fioretti, Simona Gatti, Francesco Graziano, Sara Lega, Paolo Lionetti, Antonio Marseglia, Massimo Martinelli, Francesca Musto, Naire Sansotta, Luca Scarallo, Giovanna Zuin, Lorenzo Norsa
Summary: Exclusive enteral nutrition is the first choice for inducing remission in pediatric Crohn's disease, but adherence to this treatment can be challenging for children. This study aimed to identify factors predictive of nonadherence and nonremission. The results showed that colonic involvement and high fecal calprotectin levels at diagnosis were associated with reduced adherence to exclusive enteral nutrition.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Kawthar Boumessid, Frederick Barreau, Emmanuel Mas
Summary: Crohn's disease, an inflammatory bowel disease, is on the rise globally. Dietary therapy with Modulen(R), a formula enriched with polymeric TGF-beta 2, is recommended as a first-line option for inducing clinical remission and mucosal healing, especially for children. Further well-designed studies are needed to improve knowledge and optimize therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Sara Sila, Marko Jelic, Ivana Trivic, Arjana Tambic Andrasevic, Sanja Kolacek, Iva Hojsak
Summary: This study investigated the changes in the intestinal microbiota of children with Crohn's disease (CD) before, during, and after exclusive enteral nutrition (EEN). Stool samples were collected at different time points and a molecular approach was used for analysis. The study found that the microbiota composition changed significantly after two months of EEN discontinuation and remained mostly unchanged over a year of follow-up.
Article
Chemistry, Medicinal
Agata Wasilewska, Katarzyna Ponanta-Gawron, Beata Burtan, Charissa Stephen Chandra Sagaran, Mariusz Duplaga, Kinga Kowalska-Duplaga
Summary: This study retrospectively analyzed liver enzyme abnormalities in pediatric CD patients during exclusive enteral nutrition (EEN). The study found that 42% of the children had elevated liver enzymes, with 38% experiencing transient elevation. Patients with higher protein/energy ratio were more likely to have liver enzyme abnormalities.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Medicine, General & Internal
Roma Herman, Paulina Dumnicka, Stanislaw Pieczarkowski, Krzysztof Fyderek
Summary: Mucosal healing is the main treatment goal of Crohn's disease, and the Mucosal Inflammation Noninvasive Index (MINI) shows promise in distinguishing mucosal healing from inflammation. This study evaluated MINI in monitoring remissions induced by exclusive enteral nutrition in pediatric CD patients, and found that MINI is superior to fecal calprotectin in predicting disease relapse.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Lucia Gonzalez-Torres, Ana Moreno-Alvarez, Ana Estefania Fernandez-Lorenzo, Rosaura Leis, Alfonso Solar-Boga
Summary: This systematic review analyzed the effectiveness of partial enteral nutrition (PEN) as a remission induction therapy in Crohn's disease (CD). The results suggest that PEN combined with a highly restrictive diet seems to be as effective as exclusive enteral nutrition (EEN) in inducing CD remission, but further studies are needed to confirm this finding.
Article
Endocrinology & Metabolism
Jair G. Marques, Tobias Schwerd, Philip Bufler, Sibylle Koletzko, Berthold Koletzko
Summary: Exclusive enteral nutrition therapy leads to changes in the metabolic profile of pediatric Crohn's Disease patients, including a decrease in compounds related to diet and a bacterial metabolite. The reduction of phosphatidic acid metabolite PA(15:1/18:0) is correlated with disease activity. During exclusive enteral nutrition therapy, there is an increase in phosphatidylethanolamines and one lactosylceramide.
Article
Nutrition & Dietetics
Yao Lv, Yue Lou, Ana Liu, Qi Cheng, Gan Yang, Cuifang Xu, Youyou Luo, Jingan Lou, Jindan Yu, Youhong Fang, Hong Zhao, Kerong Peng, Yan Ni, Jie Chen
Summary: Exclusive enteral nutrition (EEN) treatment can improve gut microbiome and bile acid (BA) metabolism of patients with Crohn's disease (CD). The study involved 27 newly diagnosed pediatric CD patients and 27 healthy controls. The findings suggest that EEN treatment can restore GM structure and secondary BA metabolism, and the abundance of Firmicutes bacteria and the balance of primary and secondary BAs are associated with CD severity and mucosal inflammation.
CLINICAL NUTRITION
(2023)
Article
Gastroenterology & Hepatology
David I. F. Wands, Laura Gianolio, David C. Wilson, Richard Hansen, Iain Chalmers, Paul Henderson, Konstantinos Gerasimidis, Richard K. Russell
Summary: In pediatric patients with CD in Scotland, the usage rates of EEN have not changed over the past 7.5 years, except during the COVID-19 pandemic, despite an increase in biologic use. Combination induction has emerged as a new trend.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Nutrition & Dietetics
Darja Urlep, Rok Orel, Patricija Kunstek, Evgen Benedik
Summary: This study evaluated the clinical and endoscopic rates of remission in children with active Crohn's disease (CD) treated with partial enteral nutrition (PEN) combined with a modified Crohn's disease exclusion diet (mCDED). The study found that PEN + mCDED could potentially induce clinical and endoscopic remission in pediatric CD patients. The results provide evidence for the use of PEN + mCDED in the treatment of pediatric CD.
Article
Nutrition & Dietetics
Hannes Hoelz, Jeannine Heetmeyer, Anastasia Tsakmaklis, Andreas Hiergeist, Kolja Siebert, Federica De Zen, Deborah Haecker, Amira Metwaly, Klaus Neuhaus, Andre Gessner, Maria J. G. T. Vehreschild, Dirk Haller, Tobias Schwerd
Summary: Background: Exclusive enteral nutrition (EEN) is effective for pediatric Crohn's disease (CD) but relapse rates are high after return to regular diet. This study explored the use of autologous fecal microbiota transfer (FMT) for maintaining the benefits of EEN. Methods: Fecal material from pediatric CD patients was turned into FMT capsules, with microbial composition analyzed before and after processing. Results: FMT capsules were successfully generated in most deliveries, but there was variability in stool weight and consistency. Microbial composition was not significantly altered by processing, but samples often had low microbial richness and positive results for potential pathogens or drug resistance genes. Conclusions: Autologous capsule-FMT may not be suitable for maintenance therapy in pediatric CD patients due to high pathogen burden, low microbial diversity, and practical limitations of EEN-conditioned fecal material.
Article
Gastroenterology & Hepatology
Mohammad Hassan Sohouli, Somaye Fatahi, Fatemeh Farahmand, Hosein Alimadadi, Shaikh Sanjid Seraj, Pejman Rohani
Summary: This study investigated the potential effects of EEN on pediatric Crohn's disease activity index (PCDAI), inflammation, and biochemical parameters. The results showed that EEN significantly improved the PCDAI score and biochemical parameters, indicating its beneficial effects as induction therapy in pediatric patients with CD.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Shuyan Li, Peiwei Li, Hongling Sun, Wen Hu, Shurong Hu, Yan Chen, Minfang Lv
Summary: This study investigated the adherence to EEN among CD patients and its relationship with medication belief, finding that high medication belief, residency, medical insurance, and history of enteral nutrition therapy were factors affecting EEN adherence. The study also showed that the type of enteral nutrition, taste, storage, and convenience of purchase were not associated with EEN adherence. More research is needed to explore the role of improving patients' beliefs in increasing adherence.
PATIENT PREFERENCE AND ADHERENCE
(2021)
Article
Gastroenterology & Hepatology
Susanna Meade, Kamal V. Patel, Raphael P. Luber, Dearbhaile O'Hanlon, Andra Caracostea, Polychronis Pavlidis, Sailish Honap, Cheran Anandarajah, Nyree Gryffin, Sebastian Zeki, Shuvra Ray, Joel Mawdsley, Mark A. Samaan, Simon H. Anderson, Amir Darakhshan, Katie Adams, Andrew Williams, Jeremy D. Sanderson, Miranda Lomer, Peter M. Irving
Summary: This study found that pre-operative oral enteral nutrition in patients with Crohn's disease undergoing surgery was associated with reduced postoperative complications, particularly non-surgical complications and infectious complications.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Nutrition & Dietetics
Pradeep Kakkadasam Rmaswamy
Summary: The study showed that polymeric exclusive enteral nutrition (EEN) with oral polymeric formula is well tolerated, safe, and effective for inducing clinical and biochemical remission in adults with active Crohn's disease (CD). Patients receiving EEN for more than 6 weeks achieved remission more frequently.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Moftah H. Alhagamhmad, Andrew S. Day, Daniel A. Lemberg, Steven T. Leach
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2017)
Review
Pathology
Andrew S. Day, Steven T. Leach, Daniel A. Lemberg
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2017)
Letter
Gastroenterology & Hepatology
Robert N. Lopez, Nitin Gupta, Daniel A. Lemberg
JOURNAL OF CROHNS & COLITIS
(2018)
Review
Gastroenterology & Hepatology
Robert N. Lopez, Steven T. Leach, Daniel A. Lemberg, Gilles Duvoisin, Richard B. Gearry, Andrew S. Day
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2017)
Article
Pediatrics
Andrew S. Day, Gaithri Mylvaganam, Nollaig Shalloo, Cathy Clarkson, Steven T. Leach, Daniel A. Lemberg
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2017)
Article
Gastroenterology & Hepatology
Inbar Weinstein-Nakar, Gili Focht, Peter Church, Thomas D. Walters, Guila Abitbol, Sudha Anupindi, Laureline Berteloot, Jessie M. Hulst, Frank Ruemmele, Daniel A. Lemberg, Steven T. Leach, Ruth Cytter, Mary-Louise Greer, Anne M. Griffiths, Dan Turner
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2018)
Article
Gastroenterology & Hepatology
G. Ravenscroft, S. Pannell, G. O'Grady, R. Ong, H. C. Ee, F. Faiz, L. Marns, H. Goel, P. Kumarasinghe, E. Sollis, P. Sivadorai, M. Wilson, A. Magoffin, S. Nightingale, M. -L. Freckmann, E. P. Kirk, R. Sachdev, D. A. Lemberg, M. B. Delatycki, M. A. Kamm, C. Basnayake, P. J. Lamont, D. J. Amor, K. Jones, J. Schilperoort, M. R. Davis, N. G. Laing
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Review
Pediatrics
Bianca J. Galgut, Daniel A. Lemberg, Andrew S. Day, Steven T. Leach
FRONTIERS IN PEDIATRICS
(2018)
Editorial Material
Gastroenterology & Hepatology
Daniel A. Lemberg, Andrew S. Day
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2019)
Review
Multidisciplinary Sciences
Fathalla Ali, Kei Lui, Alex Wang, Andrew S. Day, Steven T. Leach
JOURNAL OF THE ROYAL SOCIETY OF NEW ZEALAND
(2020)
Review
Pediatrics
Emma Wong, Kei Lui, Andrew S. Day, Steven T. Leach
Summary: This review highlights the impact of modern birth practices on neonatal gut microbiome development and discusses potential strategies for microbiome engineering to promote long term health.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Review
Medicine, General & Internal
Pui Yin Wong, Carmen Yip, Daniel A. Lemberg, Andrew S. Day, Steven T. Leach
Summary: The development of microbiome begins before birth with vertical transmission from mother to infant. After birth, the developing microbiome is vulnerable to various influences and can in turn affect the health and development of the host infant. This review aims to investigate factors contributing to the development of disease-causing or dysbiotic microbiome.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Adriaan G. Volkers, Laura Appleton, Richard B. Gearry, Christopher M. Frampton, Floris A. E. de Voogd, Annemieke M. Peters van Ton, Steven T. Leach, Daniel A. Lemberg, Andrew S. Day
Summary: This study evaluated the performance of fecal biomarkers FC, CHI3L1, S100A12, and OPG in children with Crohn's disease and compared them with other measures of disease activity. The results showed that FC correlated with both endoscopic and clinical disease activity and was the only biomarker that differentiated between active and inactive ileal CD. CHI3L1 also predicted clinical disease activity and correlated highly with FC.
GASTROINTESTINAL DISORDERS
(2022)
Review
Gastroenterology & Hepatology
N. Mitrev, N. Vande Casteele, C. H. Seow, J. M. Andrews, S. J. Connor, G. T. Moore, M. Barclay, J. Begun, R. Bryant, W. Chan, C. Corte, S. Ghaly, D. A. Lemberg, V. Kariyawasam, P. Lewindon, J. Martin, R. Mountifield, G. Radford-Smith, P. Slobodian, M. Sparrow, C. Toong, D. van Langenberg, M. G. Ward, R. W. Leong
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2017)
Article
Nutrition & Dietetics
Moftah H. Alhagamhmad, Daniel A. Lemberg, Andrew S. Day, Li-Zsa Tan, Chee Y. Ooi, Usha Krishnan, Nitin Gupta, John S. Munday, Steven T. Leach
CLINICAL NUTRITION
(2017)