Article
Allergy
Orianne Dumas, Riku Erkkola, Eija Bergroth, Kohei Hasegawa, Jonathan M. Mansbach, Pedro A. Piedra, Tuomas Jartti, Carlos A. Camargo
Summary: This study aimed to investigate the association between severe bronchiolitis profiles identified by clustering and childhood asthma. The results showed that children with a history of wheezing and/or eczema and rhinovirus infection had a higher risk of developing childhood asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Virology
Malgorzata Kobialka, Teresa Jackowska, August Wrotek
Summary: RSV hospitalizations are associated with risk factors such as age (up to 3 months), prematurity, and presence of apnea. Protective factors include older age and presence of fever.
Review
Biochemistry & Molecular Biology
Alessandro Rocca, Carlotta Biagi, Sara Scarpini, Arianna Dondi, Silvia Vandini, Luca Pierantoni, Marcello Lanari
Summary: Respiratory syncytial virus (RSV) is the main cause of acute respiratory tract infections in children worldwide, and while only symptomatic treatment is available, passive immune prevention methods are being developed for all infants. The high cost of passive immunoprophylaxis limits its prescription to high-risk children, though most hospitalized RSV-infected children do not fully meet the criteria for immune prophylaxis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Zaid Haddadin, Stockton Beveridge, Kailee Fernandez, Danielle A. Rankin, Varvara Probst, Andrew J. Spieker, Tiffanie M. Markus, Laura S. Stewart, William Schaffner, Mary Lou Lindegren, Natasha Halasa
Summary: Respiratory syncytial virus (RSV) is the leading cause of acute respiratory infections (ARIs) in hospitalized children. RSV-positive children were more likely to be hospitalized, require intensive care unit admission, and receive oxygen compared with children positive for other viruses. Higher viral load, White race, younger age, and higher severity score were independently associated with hospitalization in RSV-positive children.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Keisuke Okamoto, Tomohiro Morio, Yoshikazu Nakamura, Hiroshi Hataya, Koichi Mizuta, Masaaki Mori
Summary: The study revealed an increase in the percentage of children with Down syndrome in Japan receiving Palivizumab, and a significant decrease in the RSV-associated hospitalization rate for children born between 2013-2015 without congenital heart disease and born at a gestational age >= 36 weeks.
Article
Agriculture, Dairy & Animal Science
Sherri A. Powledge, Taylor B. McAtee, Amelia R. Woolums, T. Robin Falkner, John T. Groves, Merilee Thoresen, Robert Valeris-Chacin, John T. Richeson
Summary: Vaccination with modified-live virus (MLV) did not have a clear impact on the health or growth of high-risk calves, but intranasal MLV vaccination was associated with increased carriage of Histophilus somni (Hs) in the naris and reduced culture of Mannheimia haemolytica (Mh) from lung tissue samples. This suggests that intranasal MLV vaccination can alter the microbial community in the respiratory tract of cattle.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Pediatrics
Sergei Elber-Dorozko, Liya Kerem, Dana Wolf, Shlomit Brodie, Yackov Berkun, Rebecca Brooks, Oded Breuer
Summary: This study examines the clinical significance of thrombocytosis (platelets > 500 x 10(9)/L) in children admitted with an influenza-like illness. Younger age, rather than the type of viral infection, is associated with a high platelet count. Thrombocytosis is independently associated with increased risk for prolonged hospital stay and admission to the pediatric intensive care unit.
Article
Pediatrics
Jonathan M. Mansbach, Ying (Shelly) Qi, Janice A. Espinola, Kohei Hasegawa, Henry T. Puls, Ashley F. Sullivan, Carlos A. Camargo
Summary: In a prospective cohort study, it was found that infants born late pre-term (gestational age 34-36.9 weeks) had a 35% higher risk of developing asthma by the age of 5 compared to full-term infants.
JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Einat Shmueli, Ori Goldberg, Meir Mei-Zahav, Patrick Stafler, Ophir Bar-On, Hagit Levine, Guy Steuer, Huda Mussaffi, Yulia Gendler, Hannah Blau, Dario Prais
Summary: Infants with chronic diseases hospitalized due to RSV bronchiolitis had longer hospitalizations and higher rates of transfer to the pediatric intensive care unit (PICU). Children with multiple comorbidities, especially those with Down's syndrome, are at particularly high risk for severe hospitalization.
PEDIATRIC PULMONOLOGY
(2021)
Article
Multidisciplinary Sciences
Stijn P. Andeweg, Rutger M. Schepp, Jan van de Kassteele, Liesbeth Mollema, Guy A. M. Berbers, Michiel van Boven
Summary: RSV infection is a common occurrence in children, with the majority experiencing it before the age of 2. Age and birthdate are significant predictors of RSV infection probability, with children born in summer having a higher likelihood of infection.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Lise Beier Havdal, Hakon Boas, Terese Bekkevold, Anne-Marte Bakken Kran, Astrid Elisabeth Rojahn, Ketil Stordal, Sara Debes, Henrik Dollner, Svein Arne Nordbo, Bjorn Barstad, Elisebet Haarr, Liliana Vazquez Fernandez, Britt Nakstad, Christopher Inchley, Elmira Flem
Summary: Young age, comorbidity, and having siblings were identified as risk factors for more severe disease in children hospitalized with RSV infection.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen
Summary: Based on a study in South African children, the burden of RSV-associated illness was estimated, with newborns and infants being the most affected group. Implementing maternal vaccination and monoclonal antibody products for this group can help reduce the disease burden.
Article
Biotechnology & Applied Microbiology
Natividad Viguria, Ana Navascues, Regina Juanbeltz, Alberto Echeverria, Carmen Ezpeleta, Jesus Castilla
Summary: This study evaluated the effectiveness of palivizumab in preventing respiratory syncytial virus infections in high-risk children under 2 years old. The results showed a significant reduction in laboratory-confirmed cases and hospitalizations among children who received palivizumab. However, even with palivizumab prophylaxis, the risk of illness remains high, indicating the need for additional preventive measures.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Kieran Dee, Verena Schultz, Joanne Haney, Laura A. Bissett, Callum Magill, Pablo R. Murcia
Summary: Virus-virus interactions can impact the infection dynamics of respiratory viruses. In this study, 3-dimensional cultures of airway epithelium were used to show that SARS-CoV-2 replication is impaired in coinfections with influenza A or respiratory syncytial virus.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
G. Lui, C. K. Wong, M. Chan, K. C. Chong, R. Wong, I Chu, M. Zhang, T. Li, D. S. C. Hui, N. Lee, P. K. S. Chan
Summary: This study aimed to investigate the viral kinetics, host inflammatory response, and their correlation with disease severity in older adults with RSV infection. The results showed that inflammatory cytokine IL-6 was independently associated with severe disease, while RSV viral load was not associated with disease severity.
JOURNAL OF INFECTION
(2021)
Article
Obstetrics & Gynecology
Alison M. Helfrich, Cade M. Nylund, Matthew D. Eberly, Matilda B. Eide, David R. Stagliano
EARLY HUMAN DEVELOPMENT
(2015)
Article
Pediatrics
Craig P. Dobson, Matilda Eide, Cade M. Nylund
JOURNAL OF PEDIATRICS
(2015)
Article
Psychology, Developmental
Elizabeth Hisle-Gorman, Donna Harrington, Cade M. Nylund, Kenneth P. Tercyak, Bruno J. Anthony, Gregory H. Gorman
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2015)
Article
Pediatrics
Christopher M. Stark, Philip L. Rogers, Matthew D. Eberly, Cade M. Nylund
PEDIATRIC RESEARCH
(2015)
Article
Pediatrics
Christopher M. Stark, Cade M. Nylund
JOURNAL OF PEDIATRICS
(2016)
Article
Pediatrics
Daniel J. Adams, Cade M. Nylund
JOURNAL OF PEDIATRICS
(2016)
Article
Pediatrics
Katherine Shedlock, Apryl Susi, Gregory H. Gorman, Elizabeth Hisle-Gorman, Christine R. Erdie-Lalena, Cade M. Nylund
JOURNAL OF PEDIATRICS
(2016)
Article
Gastroenterology & Hepatology
Thomas M. Diehl, Daniel J. Adams, Cade M. Nylund
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2018)
Article
Gastroenterology & Hepatology
Steve B. Min, Minou Le-Carlson, Namita Singh, Cade M. Nylund, Jennifer Gebbia, Kelly Haas, Simon Lo, Neel Mann, Gil Y. Melmed, Shervin Rabizadeh, Marla C. Dubinsky
INFLAMMATORY BOWEL DISEASES
(2013)
Article
Gastroenterology & Hepatology
Mazen I. Abbas, Cade M. Nylund, Carol J. Bruch, Luzviminda G. Nazareno, Philip L. Rogers
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2013)
Article
Pediatrics
Cade M. Nylund, Matilda Eide, Gregory H. Gorman
JOURNAL OF PEDIATRICS
(2014)
Review
Allergy
Eric A. Pasman, Bruce Ong, Claire P. Witmer, Cade M. Nylund
CURRENT ALLERGY AND ASTHMA REPORTS
(2020)
Article
Medicine, General & Internal
Kyle Sexton, Apryl Susi, Elizabeth Lee, Elizabeth Hisle-Gorman, Michael Rajnik, Jayasree Krishnamurthy, Cade M. Nylund
Summary: The COVID-19 pandemic has significantly impacted well-child visits and vaccinations, leading to a decline in both rates across all demographic groups. The consequences of missed appointments and vaccinations remain unknown.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychology, Developmental
Daniel J. Adams, Apryl Susi, Christine R. Erdie-Lalena, Gregory Gorman, Elizabeth Hisle-Gorman, Michael Rajnik, Marilisa Elrod, Cade M. Nylund
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2016)
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)