Review
Gastroenterology & Hepatology
Chin Kimg Tan, Danielle Ho, Lai Mun Wang, Rahul Kumar
Summary: Drug-induced autoimmune hepatitis is a specific type of drug-induced liver injury which shares similar clinical features with idiopathic autoimmune hepatitis. Early identification and treatment often result in a favorable outcome.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Masayuki Ueno, Hiroyuki Takabatake, Takahisa Kayahara, Youichi Morimoto, Kenji Notohara, Motowo Mizuno
Summary: This study investigated the long-term outcomes of drug-induced autoimmune-like hepatitis (DI-ALH) caused by pulse steroid therapy. The study found that among the patients who developed acute liver injury within 3 months after the therapy, 5 were diagnosed with DI-ALH. Not tapering off prednisolone after the therapy was a significant risk factor for the subsequent development of DI-ALH. Prednisolone was effective for treating DI-ALH and could be safely withdrawn once remission was achieved.
HEPATOLOGY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Raul J. Andrade, Guruprasad P. Aithal, Ynto S. de Boer, Rodrigo Liberal, Alexander Gerbes, Arie Regev, Benedetta Terziroli Beretta-Piccoli, Christoph Schramm, David E. Kleiner, Eleonora De Martin, Gerd A. Kullak-Ublick, Guido Stirnimann, Harshad Devarbhavi, John M. Vierling, Michael P. Manns, Marcial Sebode, Maria Carlota Londono, Mark Avigan, Mercedes Robles-Diaz, Miren Garcia-Cortes, Edmond Atallah, Michael Heneghan, Naga Chalasani, Palak J. Trivedi, Paul H. Hayashi, Richard Taubert, Robert J. Fontana, Sabine Weber, Ye Htun Oo, Yoh Zen, Anna Licata, M. Isabel Lucena, Giorgina Mieli-Vergani, Diego Vergani, Einar S. Bjornsson
Summary: Drug-induced liver injury (DILI) can mimic various liver disorders, including autoimmune-like hepatitis (ALH). ALH shares many clinical, biochemical, immunological, and histological features with autoimmune hepatitis (AIH). However, patients with ALH rarely require long-term immunosuppression and the condition often resolves spontaneously after withdrawal of the implicated drug. There is limited understanding of ALH due to the lack of specific diagnostic markers.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yooyun Chung, Maura Morrison, Yoh Zen, Michael A. Heneghan
Summary: This study aimed to evaluate the clinical characteristics, histology, and long-term outcomes of DI-AILH compared with AIH. It found that DI-AILH patients were more likely to present with jaundice and higher levels of bilirubin, while AIH patients had higher rates of immunosuppression use and more advanced fibrosis. The simplified AIH histology criteria identified atypical histology in some DI-AILH cases. DI-AILH patients were at risk of (sub)acute liver failure, emphasizing the importance of early discussions with a transplant center.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Hasan Ali, Taqi Rizvi, Mumtaz Niazi, Mark Galan, Nikolaos Pyrsopoulos
Summary: This case study presents a potential link between syphilitic hepatitis and autoimmune hepatitis, suggesting that treatment for syphilis may trigger an autoimmune response. Autoimmune hepatitis is a chronic liver disease that is believed to result from a combination of genetic and environmental factors.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Eszter Nagy, Zsolt Homik, Tamas Smausz, Judit Kopniczky, Mate Nafradi, Tunde Alapi, David Kokai, Katalin Burian, Piroska Szabo-Revesz, Rita Ambrus, Bela Hopp
Summary: The number of water insoluble and poorly soluble drug compounds has increased, leading to an increased interest in particle size reduction techniques to improve drug dissolution rates, transport characteristics, and bioavailability. Laser ablation has been proven to be an effective method for producing nanometer and micrometer-sized drug particles without causing significant chemical damage. In this study, we used nanosecond laser ablation to reduce the size of meloxicam particles for pulmonary drug delivery. The ablated particles showed excellent solubility and anti-inflammatory properties, making laser ablation a promising method for the development of drug formulations.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Sabine Weber, Alexander L. L. Gerbes
Summary: This study aimed to identify the distinguishing features of drug-induced autoimmune hepatitis (DI-AIH) compared to drug-induced liver injury (DILI) and idiopathic autoimmune hepatitis (AIH), in order to define the DI-AIH phenotype. The results showed that DI-AIH patients had similar clinical features to DILI and AIH patients, with the only difference being a higher Roussel Uclaf Causality Assessment Method (RUCAM) score in DI-AIH patients. DI-AIH patients often relapsed after discontinuation of corticosteroids and required long-term immunosuppressive treatment. However, no other phenotypical differences were found between DI-AIH and DILI.
Article
Immunology
Jianheng Hao, Weili Sun, Huichao Xu
Summary: This article investigates the pathogenesis of Con A-induced liver injury in mice, discusses the role of non-coding RNA and the signaling pathways involved in this model, and also mentions the advantages and limitations of this model, providing research directions for future studies on the treatment of AIH.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Rheumatology
Marianna Mitratza, Bart Klijs, A. Elisabeth Hak, Jan W. P. F. Kardaun, Anton E. Kunst
Summary: This study aimed to assess the mortality rate of systemic autoimmune diseases (SAIDs) and found that SAIDs contribute to mortality through multiple comorbidities, with particularly strong associations with diseases of the musculoskeletal system, genitourinary system, and influenza.
Article
Biochemistry & Molecular Biology
Peng Wang, Yuqi Wang, Hui Liu, Xiaoxu Han, Yunyun Yi, Xin Wang, Xin Li
Summary: This study found that serum triglyceride (TG) levels are closely related to the prognosis and overall survival of patients with autoimmune hepatitis (AIH) cirrhosis. Lower TG levels were associated with the severity of cirrhosis and increased risk of death in AIH cirrhosis patients.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Pharmacology & Pharmacy
Chen Huang, Yi Shen, Mengyi Shen, Xiaoli Fan, Ruoting Men, Tinghong Ye, Li Yang
Summary: This study revealed decreased peripheral Treg frequency and abnormal intrahepatic Treg infiltration in AIH. It is associated with glucose metabolism reprogramming, resulting in decreases and functional impairments in the Treg population, which promotes AIH development. Targeting glucose metabolism may provide novel insights for the treatment of AIH.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Zhengyi Shi, Xiangli Zhao, Fei Song, Zhangrong Hou, Xincai Hao, Jieru Guo, Lingjuan Sun, Hao Feng, Meng Wu, Peiling Xie, Xiaosheng Tan, Gang Chen, Changxing Qi, Yonghui Zhang
Summary: Four undescribed compounds were isolated from Hypericum longistylum and showed remarkable immunosuppressive activities. One of these compounds demonstrated protective effects against autoimmune hepatitis in a mouse model.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Medicine, General & Internal
Eric Landa, Ismail Ganim, Erika Vigandt, Talhah Siraj, Ying Zhu
Summary: Drug-induced pancreatitis is a serious condition, with over 525 drugs identified by the WHO as potential causes. Leading drugs like mesalamine, azathioprine, and simvastatin are well-known triggers. Incidence has increased in recent years, accounting for up to 5% of cases in some studies. Early recognition and removal of offending agents are crucial in managing this condition.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Eva Navarro-Ruiz, Covadonga Alvarez-Alvarez, M. Angeles Pena, Carlos Torrado-Salmeron, Zaid Dahma, Paloma Marina de la Torre-Iglesias
Summary: The aim of this research is to develop new colonic release systems for meloxicam, a non-steroidal anti-inflammatory drug, with pH and time-dependent vehicles. Eudragit(R) polymers are commonly used in the design of colonic release formulations due to their mucoadhesiveness and pH-dependent release. The CNM multiparticulate system, composed of Eudragit(R) NM and cellulose, showed the best release option with sustained release of meloxicam.
Article
Immunology
Giorgia Paldino, Maria Felicia Faienza, Marco Cappa, Andrea Pietrobattista, Donatella Capalbo, Mariella Valenzise, Vito Lampasona, Annamaria Cudini, Elena Carbone, Olivia Pagliarosi, Giuseppe Maggiore, Mariacarolina Salerno, Corrado Betterle, Alessandra Fierabracci
Summary: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) syndrome is a rare monogenic disease caused by AIRE gene mutations. The classic diagnosis is based on the presence of chronic mucocutaneous candidiasis, chronic hypoparathyroidism, and Addison's disease. European patients usually have less non-endocrine autoimmunity, while American patients tend to develop organ-specific non-endocrine manifestations early in life. The Ferre-Lionakis criteria could allow an expedited diagnosis in European patients, emphasizing the importance of evaluating the presence and age of appearance of autoimmune hepatitis and autoimmune enteropathy.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Medicine, General & Internal
Eva Lizarralde Palacios, Alfonso Gutierrez Macias, Mayte Ramiz Martinez, Mikel Escalante Boleas
Letter
Gastroenterology & Hepatology
Lara Palacios-Garcia, Alfonso Gutierrez-Macias, Paula Garcia-Gonzalez, Alazne Lartategi-Iraurgi
GASTROINTESTINAL ENDOSCOPY
(2016)
Letter
Gastroenterology & Hepatology
Itziar Calvo Zorrilla, Alfonso Gutierrez Macias, Carlos Loureiro Gonzalez, Miriam Lopez Martinez
GASTROENTEROLOGIA Y HEPATOLOGIA
(2017)
Letter
Gastroenterology & Hepatology
Izaskun Pizarro Carbajo, Alfonso Gutierrez Macias, Markel Cea Gomez, Itxaso Lombide Aguirre
GASTROENTEROLOGIA Y HEPATOLOGIA
(2018)
Article
Infectious Diseases
Galo Peralta, Maria Lamelo, Patricia Alvarez-Garcia, Maria Velasco, Alberto Delgado, Juan Pablo Horcajada, Maria Montero, Maria Pia Roiz, Maria Carmen Farinas, Juan Alonso, Luis Martinez Martinez, Alfonso Gutierrez-Macias, Jose Angel Alava, Azucena Rodriguez, Ana Fleites, Vicente Navarro, Elia Sirvent, Jose Antonio Capdevila
BMC INFECTIOUS DISEASES
(2012)
Editorial Material
Gastroenterology & Hepatology
S. K. Mantoo, J. Rao
Letter
Infectious Diseases
Alfonso Gutierrez Macias, Joseba Basurto-Hoyuelos, Luciano Ramos-Prada, Eva Lizarralde-Palacios
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2014)
Letter
Medicine, General & Internal
Alfonso Gutierrez Macias, Eva Lizarralde Palacios, Itziar Olabarria Santurtun, Pedro Martinez Odriozola
Editorial Material
Medicine, General & Internal
Eva Lizarralde Palacios, Alfonso Gutierrez Macias, Pedro Martinez Odriozola, Felipe Miguel de la Villa
Letter
Medicine, General & Internal
A. Gutierrez Macias, J. Ibarmia Lahuerta, M. Alvarez De Castro, E. Lizarralde Palacios
REVISTA CLINICA ESPANOLA
(2011)
Letter
Medicine, General & Internal
Pablo Ruiz Sada, Lara Palacios Garcia, Itziar Garmendia Antia, Alfonso Gutierrez Macias
Article
Medicine, General & Internal
Pablo Ruiz Sada, Alfonso Gutierrez Macias, Itziar Garmendia Antia, Miriam Lopez Martinez
Article
Medicine, General & Internal
Ana Moreno-Rodrigo, Josu Baraia-Etxaburu, Alfonso Gutierrez-Macias, Oscar Luis Ferrero Beneitez
Article
Urology & Nephrology
P. Martinez-Odriozola, A. Gutierrez-Macias, I. Moina Eguren, J. Arrieta Lezama
CLINICAL NEPHROLOGY
(2008)
